Description TECHNICAL FIELD [0001] The present invention relates to a coating particle and a method for producing a coating particle. Specifically, the present invention relates to a coating particle suitable for gastric soluble solid preparation, enteric soluble solid preparation, sustained-release solid preparation, bitterness-inhibiting solid preparation, and the like, and a method for producing coating particle. BACKGROUND ART [0002] Many medicinal components are compounds developing bitterness at the time of oral dosing. In order to increase compliance of patients by reducing or flavoring bitterness of the medicinal components, a method of coating a surface of a nuclear particle containing medicinal components with a sweet component, a flavor component or the like is proposed (see Patent Document 3 and the like). Furthermore, in order that the medicinal components orally dosed are dissolved in a specific site such as stomach or intestine, a method of coating a surface of a nuclear particle containing medicinal components with a gastric soluble material, an enteric soluble material or the like is known. Furthermore, in order to reduce the harmful effects of a drug to plants and the like and to sustain the effects such as insecticidal effect, bactericidal effect, and herbicidal effect over a long period of time, it is known that the discharge amount of pesticide active components is controlled by the coating of a nuclear particle. [0003] As a method for coating a surface of a nuclear particle with various components, a wet process such as a spray coating method or dip coating method, and a dry process such as a rotary mixing method or a twin-screw kneading method are known (see Patent Document 1, Patent Document 2 and Non-Patent Document 1). RELATED ART PATENT DOCUMENTS[0004] Patent Document 1 : JP-A-2007-105705 Patent Document 2: JP-A-9-132523 Patent Document 3: JP-A-2008-106048 NON-PATENT DOCUMENT [0005] Non-Patent Document 1 : Fukumori et al., "Design of dry functional particles using twin-screw continuous kneading machine", Kurimoto Technical Report No. 56 Further prior art cocuments are: [0006] Kauffman et al., "Raman spectroscopy of coated pharmaceutical tablets and physical models for mul tivariate calibration to tablet coating thickness", J.Pharm.Biomed.Analysis, vol. 43, p.39-48,2007; US 2001/006677 A1; WO 00/57881 A1; WO 99/53901 A1 ; and Gera et al., "Mechanical methods for dry particle coating processes and their applications in drug delivery and development", Recent Patents on Drug Delivery & Formulation, vol. 4, p. 58-81,2010. SUMMARY OF THE INVENTION PROBLEMS THAT THE INVENTION IS TO SOLVE [0007] In a wet process, in the case that a solvent of a coating base is water, there are problems that much energy is required for evaporation after spraying, and that, when components deteriorating by water are contained in a nuclear particle, the components deteriorate and use of such components is restricted. Furthermore, in the case that an organic solvent is used in as a solvent of the coating base, if removal of the organic solvent is not completely conducted, the organic solvent may remain. [0008] On the other hand, in a dry process involves, there may be cases that the coating ratio is decreased, and that due to low adhesion between a coating layer and a nuclear particle, and the coating layer tends to peel. [0009] In view of the above, the present invention has obj ects to provide a coating particle having decreased the above disadvantages and suitable for gastric soluble solid preparation, enteric soluble solid preparation, sustained-release solid preparation, bitterness-inhibiting solid preparation, and the like, and a method for producing the coating particle. MEANS FOR SOLVING THE PROBLEMS [0010] As a result of earnest investigations to solve the above problems, the present inventors found that by drycoating a nuclear particle with hydroxyalkyl cellulose and a binder, a coating particle suitable for gastric soluble solid preparation, enteric soluble solid preparation, sustained-release solid preparation, bitterness-inhibiting solid preparation, and the like are obtained. The present invention has been completed by further making investigations on the basis of the finding. [0011] That is, the present invention includes the following embodiments. <1> A coating particle containing a nuclear particle covered with a coating layer, in which the coating layer is a layer containing hydroxyalkyl cellulose and a binder, wherein the binder is at least one selected from the group consisting of polyalkylene glycol, polyalkylene glycol higher fatty acid ester, higherfat-ty acid, higher alcohol, higher alcohol ester and natural wax; and wherein the hydroxyalkyl cellulose has a volume average particle size of from 0.1 to 20 μίτι. <2> The coating particle according to the above <1 >, in which the binder is at least one selected from the group consisting of polyalkylene glycol, polyalkylene glycol higherfatty acid ester, higherfatty acid, higher alcohol, higher alcohol ester and natural wax. <3> The coating particle according to the above <1 > or <2>, in which the coating layerfurther contains an elution controlling base and/or silica. <4> A method for producing a coating particle, containing a first step of dry-coating a nuclear particle with hydroxyalkyl cellulose and a binder thereby adhesion-coating the nuclear particle with a coating layer; wherein the binder is at least one selected from the group consisting of polyalkylene glycol, polyalkylene glycol higher fatty acid ester, higher fatty acid, higheralcohol, higheralcohol esterand natural wax; and wherein the hydroxyalkyl cellulose has a volume average particle size of from 0.1 to 20 μίτι. <5> The method for producing a coating particle according to the above <4>, further containing a second step of dry-coating the particle obtained in the first step with an elution controlling base and a binder. <6> The method for producing a coating particle according to the above <4>, further containing a third step of overcoating the particle obtained in the first step with silica. <7> The method for producing a coating particle according to the above <4> or <5>, further containing a second step of dry-coating the particle obtained in the first step with an elution controlling base and a binder, and a third step of overcoating the particle obtained control an elution rate of medical agents, and has excellent fluidity. The coating particle of the present invention is suitable for gastric soluble solid preparation, enteric soluble solid preparation, sustained-release solid preparation, bitterness-inhibiting solid bulk powder and coating particles obtained in Examples 1 to 3. MODE FOR CARRYING OUT THE INVENTION [0012] The term "coating particle(s)" used in the present invention means "coated particle(s)". [0013] The coating particle of the present invention contains a nuclear particle covered with a coating layer. The coating layer is a layer containing hydroxyalkyl cellulose and a [0014] The nuclear particle used in the present invention may be a particle consisting of an effective ingredient itself (drugs in the case of, for example, medical drugs and agricultural chemicals), may be a particle containing a mixture of a carrier and a drug, may be a particle containing a carrier covered with a drug, and may be a particle containing a drug-free carrier. The nuclear particle can be used without particular limitation so long as it does not cause losing shape during operation. The nuclear particle is not particularly limited by its volume average particle size, but one having the volume average particle size of from 30 to 1,000 μίτι is preferred, and one having the volume average particle size of from 50 to 500 μίτι is more preferred. [0015] Examples of the nuclear particle that can be used include pills, granules, powdered drugs, single crystal of drugs, aggregates of drug powders, lactose particles, hydroxyapatite, calcium carbonate particles; and crystal cellulose granules, sucrose spherical granules and mannitol spherical granules commercially available as coating nuclear particles in the field of preparations. [0016] The nuclear particle may be release-controlling preparations such as quick-release preparations and continuous-release preparations (sustained-release preparations). The nuclear particle may contain conventional additives. Examples of the additives include diluents, disintegrators, binders, lubricants, colorants, pH regulators, pH buffering agents, surfactants, sustained-release agents, stabilizers, acidulants, flavoring agents, fluidizers, cooling agents, sweeteners, umami components, and sweetness enhancers. Those additives are used in the amount generally used in the field of preparations. [0017] Examples of drugs that are effective ingredients of medical drugs include painkillers, antipyretic analgesics, headache cures, antitussives, expectorants, tranquillizers, antispasmodics, antihistamines, anti-allergic agents, antiplasmin agents, bronchodilators, asthma drugs, antidiabetic drugs, agents for liver disease, antiulcer drugs, gastric treatment drugs, stomachics and di-gestants, gastrointestinal tract motility activation drugs, antihypertensive agents, antianginal drugs, hypotensive drugs, antihypotensive drugs, lipid-lowering drugs, hormone drugs, antibiotics, antiviral agents, sulfa drugs, anti-inflammatory drugs, psychotropic agents, intraocular pressure lowing drugs, antiemetics, antidiarrheal drugs, gout remedy, antiarrhythmics, vasoconstrictors, digestives, sleep or hypnotic inducing drugs, sympathetic blocking agents, anemia drugs, antiepileptic drugs, anti-vertigenous drugs, disequilibrium drugs, tuberculosis drugs, vitamin deficiency drugs, antidementia drugs, drugs for treatment of urine incontinence, antidizziness drugs, oral bactericides, parasiticide, vitamin preparations, amino acids, and minerals. Specific examples include agents for affecting central nervous system (ace-toaminophenone, aspirin, indomethacin, ibuprofen, naproxen, diclofenac sodium, meclofenoxate hydrochloride, chlorpromazine, trimethine sodium, milnacipran hydrochloride, phénobarbital, and the like), agents for affecting peripheral nervous system (etomidoline, tolp-erisone hydrochloride, ethylpipethanate bromide, meth-ylbenactyzium bromide, flopropione, and the like), hemostatics (carbazochrome sodium sulfonate, protamine sulfate, and the like), cardiovascular preparations (amino-phylline, etilefrine hydrochloride, diltiazem hydrochloride, digitoxin, captopril, and the like), agents affecting respiratory organs (ephedrine hydrochloride, clorprena-line hydrochloride, oxeladin citrate, cloperastine, sodium cromaglycate, and the like), agents affecting digestive organs (berberine chloride, loperamide hydrochloride, ci- metidine, ranitidine hydrochloride, famotidine, and the like), coronary vasodilators (nifedipine, nicardipine, verapamil, and the like), vitamin preparations (ascorbic acid, thiamine hydrochloride, calcium pantothenate, riboflavin butyrate, and the like), preparations for metabolic disease (camostat mesilate, mizoribine, lysozyme chloride, and the like), antiallergic agents (cyproheptadine hydrochloride, diphenhydramine hydrochloride, alimemazine tartrate, suplatast tosilate, diphenhydramine maleate, and the like), chemotherapeutics (aciclovir, enoxacin, ofloxacin, pipemidic acid trihydrate, levofloxacin, and the like), and antibiotics (erythromycin, cefcapene pivoxil hydrochloride, cefteram pivoxil, cefpodoxime proxetil, cefaclor, cefalexin, clarithramycin, rokitamycin, and the like). [0018] Examples of the drugs that are effective ingredients of agricultural chemicals include antibacterial agents, antiviral agents, bactericides, acaricides, insecticides, nematicides, rat poisons, herbicides, plant growth regulators, fertilizers, and safeners. [0019] Of the compounds that are effective ingredients of drugs and agricultural chemicals, compounds having salt forming sites encompass physiologically or pharmaceutically allowable salts (particularly, medically or ag-richemically allowable salts), and the like. [0020] Examples of the diluents include starches such as corn starch, potato starch, wheat starch, rice starch, partially pregelatinized starch, pregelatinized starch, and porous starch; sugars orsugaralcohols, such as lactose, fructose, glucose, D-mannitol, sorbitol and trehalose; anhydrous calcium phosphate; crystalline cellulose; precipitated calcium carbonate; and calcium silicate. [0021] Examples of the disintegrators include car-boxymethyl cellulose, calcium carboxymethyl cellulose, sodium carboxymethyl starch, croscarmellose sodium, crospovidone, low substituted hydroxypropyl cellulose and hydroxypropyl starch. [0022] Examples of the binders include crystalline cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, polyvinyl pyrrolidone, and gum Arabic powder. [0023] Examples of the lubricants include magnesium stearate, calcium stearate, talc, sucrose esters of fatty acids, and sodium stearyl fumarate. [0024] Examples of the colorants include edible dyes such as edible yellow No. 5, edible red No. 2, and edible blue No 2; edible lake dyes; and iron sesquioxide. [0025] Examples of the pH regulators include citrates, phosphates, carbonates, tartrates, fumarates, acetates, and amino acid salts. [0026] Examples of the pH buffering agents include citric acid-sodium citrate buffering agents. [0027] Exam pies of the surfactants includesodium lau-ryl sulfates, polysorbates and polyoxyethylene polyoxy-propylene glycols. [0028] Examples of the stabilizers include tocopherol, tetrasodium edetate, nicotinic acid amide, and cyclodex-trins. [0029] Examples of the acidulants include ascorbic ac id, citric acid, tartaric acid, and malic acid. [0030] Examples of the flavoring agents include menthol, a peppermint oil, a lemon oil and vanillin. [0031] Examples of the fluidizers include light anhydrous silicic acid, and hydrated silicon dioxide. [0032] Examples of the cooling agents include terpene compounds (monoterpene alcohols and the like) such as camphor and borneol; essential oils, essences or powders, containing the terpene compounds; essential oils, essences or powders of peppermint, spearmint, cool mint or the like; products obtained by adsorbing the essential oils or essences on powdery carriers (such as dextrin); and products obtained by mixing the essential oils or essences with diluents (such as gum Arabic) and liquid bases (water, alcohol and the like) and forming into a granular material. [0033] Examples of the sweeteners include non-glu-cide type sweeteners, sugar alcohols and sugars. The non-glucide type sweeteners can use any of synthetic sweeteners and natural sweeteners. [0034] Examples of umami components include amino acid-based umami components (amino acid or its salt, forexample, glutamicacid, sodium glutamate, potassium glutamate, glutamic hydrochloride, sodium guanylate, in-osinicacid, sodium inosinate, arginine-glutamate, asparaginic acid, sodium aspartate, glycin or alanine), peptide-based umami components (dipeptide such as L-glutamyl-L-glutamicacid or L-glutamyl-L-serin; tripeptide such as tri-L-glutamic acid or L-glutamyl-L-glycyl-L-serin; and the like), and carboxylic acid-based umami components (carboxylate such as sodium succinate). [0035] Sweetness enhancers (or saltiness enhancers) having saltiness (salty taste) may be contained. Examples of the sweetness enhancers include sodium chloride, potassium chloride, and phosphates (potassium hy-drogenphosphate, sodium hydrogenphosphate, or the like). In many cases, the sweetness enhancers (or saltiness enhancers) are neutral salts, for example, a salt that dissociates as sodium ion and/or chlorine ion (chloride ion). [0036] Further examples of the components that can be contained in the nuclear particle include oxidation inhibitors, antioxidants, dispersants, suspension agents, solubilizing agents, thickeners (water-soluble polymers such as carboxyvinyl polymer, polyvinyl alcohol and gelatin; cellulose ethers such as carboxymethyl cellulose; and the like), antiseptics or preservatives (parabens such as methylparaben and butylparaben), bactericides or antimicrobial agents (benzoic acids such as sodium benzoate), antistatic agents, corrigents or masking agents, odor improving agents, defoaming agents, tonicity agents, and soothing agents. Those additives can be used alone or in combination of two or more thereof. A method for producing the nuclear particle is not particularly limited, and the general granulation methods can be employed. [0037] The hydroxyalkyl cellulose used in the coating layer is obtained by, forexample, acting sodium hydrox- ide to cellulose as a raw material to form alkali cellulose, and subjecting the alkali cellulose and alkylene oxide to a substitution reaction. After the substitution reaction, an acid such as acetic acid or hydrochloric acid can be added to the reaction liquid to neutralize sodium hydroxide, followed by purification. A part or a whole of-OH groups in a glucose ring unit of cellulose is substituted by -0-(R-0)m-H group. R represents a divalent alkyl group, m is a natural number of 1 or more. The R is preferably an ethylene group or a propylene group, and particularly preferably a propylene group. [0038] The hydroxyalkyl cellulose is that the content of a hydroxyalkyl group (-(R-0)m-H) is a range of preferably from 40 to 80% by weight, and more preferably from 53 to 78% by weight, based on the total weight of the hydroxyalkyl cellulose. The content of a hydroxyalkyl group can be obtained by, for example, a method by USP 24 (United States Pharmacopeia). [0039] Examples of the alkylene oxide used in the substitution reaction include ethylene oxide and propylene oxide. Of those, propylene oxide is preferably used in the present invention. When the substitution reaction is conducted using propylene oxide, hydroxypropyl cellulose is obtained. [0040] The hydroxyalkyl cellulose has a viscosity at 20°C of a 2% aqueous solution in a range of preferably from 2.0 to 4,000 mPa-s, more preferably from 2.0 to 2,000 mPa-s, and still more preferably from 2.0 to 1,000 mPa-s. The viscosity can be measured using, for example, a B-type viscometer. The viscosity is a parameter showing the degree of polymerization of hydroxyalkyl cellulose. When the viscosity is increased, tensile strength of a solid preparation obtained tends to be slightly increased. When the viscosity is decreased, disintegration time of a solid preparation obtained tends to be shortened. [0041] The hydroxyalkyl cellulose used in the present invention has a volume average particle size of preferably from 0.1 to 20 μίτι, and more preferably from 0.1 to 10 μίτι. The shape of the hydroxyalkyl cellulose particle is not particularly limited, but an amorphous shape or a fiber shape is preferred. In the present invention, the volume average particle size is a value of particle size D50 of integrated value 50% in a particle size distribution obtained in a measurement underthe conditions of air pressure: 3.5 kgf/cm2 and focus length: 100 mm using a laser diffraction type particle size distribution measuring instrument (for example, LDSA-2400, manufactured by Higashi Nippon Computer). The particle shape can be observed with a scanning electron microscope (for example, JSM-7330, manufactured by JEOL Ltd.). [0042] The content of the hydroxyalkyl cellulose in the coating layer is not particularly limited, but is preferably from 5 to 70% by weight, and more preferably from 10 to 60% by weight, based on the coating particle. [0043] The binder used in the coating layer is not particularly limited so long as it has a function to bind the nuclear particle and the coating layer. [0044] Examples of the binder include an organic fatty acid (lauric acid, palmitic acid, myristic acid, stearic acid or the like), an esterderivative oforganicfatty acid, higher alcohol (cetyl alcohol, stearyl alcohol or the like), glycerin fatty acid ester (glyceryl monostearate or the like), polyethylene glycols (macrogol 6000 and the like), and a waxlike substance such as natural wax (carnauba wax, rice wax or the like). Of those, at least one selected from the group consisting of polyalkylene glycol, polyalkylene glycol higher fatty acid ester, higher fatty acid, higher alcohol, higher alcohol ester and natural wax is preferred, and polyethylene glycol is particularly preferred. The binder is preferably a hydrophilic binder. Furthermore, a binder having a melting point of from 40 to 70°C is preferred, and a binder having a melting point of from 50 to 65°C is particularly preferred. [0045] The binder has a volume average particle size of preferably from 1 to 100 μίτι, more preferably from 1 to 50 μίτι, and still more preferably from 1 to 20 μίτι. [0046] The content of the binder in the coating layer is not particularly limited. However, the content is preferably from 0.1 to 20% by weight, and more preferably from 0.5 to 15% by weight, in the coating particle. [0047] The weight ratio between the hydroxylalkyl cellulose and the binder (hydroxyalkyl cellulose/binder) in the coating layer is not particularly limited. However, the weight ratio is preferably from 99/1 to 50/50, and more preferably from 95/5 to 70/30. [0048] The coating layer may contain other coating base, other than the hydroxyalkyl cellulose and the binder. The coating base has a volume average particle size of preferably from 0.1 to 100 μίτι, and more preferably from 0.1 to 50 μίτι. [0049] Examples of the other coating base include a polymer base, an inorganic granular material, and an effective ingredient such as a drug. Furthermore, the additives exemplified as the additives that can be contained in the nuclear particle can be used as the other coating base. [0050] Examples of the polymer base include a synthetic polymer and a natural polymer. The examples specifically include an acrylic polymer, a bioerodible polymer, and a polyvinyl polymer. [0051] Examples of the acrylic polymer include ami-noalkyl methacrylate copolymer E and a methacrylic acid-methyl methacrylate copolymer. Examples of the bioerodible polymer include a homopolymer or a copolymer comprising L-lactic acid, D-lactic acid, DL-lactic acid, glycolic acid, ε-caprolactone, N-methylpyrrolidone or the like, mixtures of those polymers, polycaptolactam, chitin, and chitosan. Examples of the polyvinyl polymer include polyvinyl acetal diethylaminoacetate and a PVA copolymer. [0052] As the polymer base, use can be preferably made of elution controlling bases such as an enteric soluble coating base, a gastric soluble coating base, a water-insoluble coating base, a sustained-release coating base, and a water-soluble coating base. Of those, a wa- ter-insoluble coating base is exemplified as the preferred polymer base. Those polymer bases can be used alone or in combination of two or more thereof. Examples of the preferred combination include a combination of a water-insoluble coating base and an enteric soluble coating base, and a combination of a water-insoluble coating base and a water-soluble coating base. [0053] As the enteric soluble coating base, use can be made of a polymer that is substantially insoluble in an acidic liquid and is soluble in an alkali liquid. Examples thereof include methacrylic acid copolymer LD (Eudragit L30D55, manufactured by Evonik), methacrylic acid copolymer L (Eudragit L100, manufactured by Evonik), methacrylic acid copolymer S (Eudragit S100, manufactured by Evonik), hydroxypropyl methyl cellulose phtha-late (HPMCP), hydroxypropyl methyl cellulose acetate succinate (AQOAT), carboxymethyl ethyl cellulose (CMEC), cellulose acetate phthalate (CAP), polyvinyl acetate phthalate (PVAP), cellulose acetate trimellitate (CAT), Aquateric (CAP aqueous dispersion), and zein. [0054] As the water-insoluble coating base, use can be made of a material that does not almost dissolve in water but dissolves or uniformly disperses in an organic solvent such as methanol, ethanol, propanol, isopropanol, oracetone. Examples thereof include ethyl cellulose; a water-insoluble natural resin such as shellac; and a water-insoluble acrylic polymersuch as aminoalkyl methacrylate copolymer RS (Eudragit RS, manufactured by Evonik) or methacrylic acid copolymer RSPO (Eudragit RSPO, manufactured by Evonik). Of those, a water-in-soluble acrylic polymer is preferred. [0055] Examples of the water-soluble coating base include methyl cellulose, sodium carboxymethyl cellulose and polyvinyl pyrrolidone. [0056] Examples of the inorganic granular material include talc, sodium chloride, sodium citrate, soft silicic anhydride (silica), precipitated calcium carbonate, magnesium stearate, calcium stearate, and titanium oxide. Of those, silica is preferred. Fluidity of a solid preparation is increased by compounding the inorganic granular material. [0057] The coating particle of the present invention can be obtained by coating the nuclear particle with the coating layer using the conventional coating method. [0058] Examples of the coating method include methods described in publications such as Handbooks of Granulation (The Association of Powder Process Industry and Engineering, JAPAN, Ohmusha Ltd.), Formulation Design of Oral Dosage Forms (Edited by Prof. Mit-suru Hashida, Kyoto University, Graduate Schools, Faculty of Pharmaceutical Sciences, Yakugyo Jiho), Particle Design Engineering (The Society of PowderTechnology, JAPAN, Sangyo Tosho Co.), and Particle Design and Preparation Technology (The Society of Powder Technology, JAPAN, sectional meeting of preparation and particle design, Director: Yoshiaki Kawashima, Yakugyo Jiho). A dry-coating method is preferred in the present invention. [0059] The dry-coating method is a method of mixing a nuclear particle with hydroxyalkyl cellulose, a binder and other coating base such as an elution controlling base and silica (hereinafterthose are referred to as "powder for a coating layer"), and stirring those, thereby adhesion-coating the surface of the nuclear particle with the powderfor a coating layer. To facilitate the adhesioncoating of the nuclear particle with the powderfor a coating layer, the stirring is preferably conducted while heating. The temperature at stirring is the vicinity of a melting point of a binder, preferably a temperature 0.5 to 10°C lower than the melting point, and more preferably a temperature 0.5 to 7°C lower than the melting point. In the case that the binder is polyethylene glycol, the temperature at stirring is preferably from 40 to 120°C, and more preferably from 45 to 100°C. Where the temperature is too high, nuclear particles fuse with each other or powders for a coating layer fuse with each other, and aggregates tend to be formed. Where the temperature is too low, the coating rate tends to be decreased. The temperature at stirring means a temperature of a stirring tank. [0060] Examples of the stirring machine used in the dry-coating include Henschel mixer (trade name, manufactured by Mitsui Mining Co., Ltd.), SUPERMIXER (trade name, manufactured by Kawata Mfg. Co., Ltd.), Q Mixer (trade name, manufactured by Mitsui Mining Co., Ltd.), Mechanofusion System (trade name, manufactured by Hosokawa Micron Corporation), Mechanomill (trade name, manufactured by Okada Seiko Co., Ltd.), a twin-screw kneader, a vortex mixer, a vibration mill, and a V-type mixing machine. In a treatment of a small amount, a rotary evaporator can be used. [0061] In the present invention, dry-coating can be performed by mixing all of hydroxyalkyl cellulose, a binder, and other coating base such as an elution controlling base and silica with the nuclear particle, followed by stirring. Furthermore, in the present invention, the coating particle obtained by dry-coating the nuclear particle with hydroxyalkyl cellulose and a binder (first step), and then dry-coating with an elution controlling base and a binder (second step) is preferred; the coating particle obtained by dry-coating the nuclear particle with hydroxyalkyl cellulose and a binder (first step), and then overcoating with silica (third step) is more preferred; and the coating particle obtained by dry-coating the nuclear particle with hydroxyalkyl cellulose and a binder (first step), dry-coating with an elution controlling base and a binder (second step), and then overcoating with silica (third step) is still more preferred. The coating particles obtained by the dry-coating have excellent fluidity and sustained releas-ability. [0062] Furthermore, the powderfor a coating layer may be subjected to the dry-coating by one operation, and the powder for a coating layer may be subjected to the dry-coating by dividing into two or more operations. [0063] If necessary, after the coating, the solid preparation as the coating particle of the present invention can be subjected to other coating such as film coating, sug- arcoating, thin-film sugarcoating, sugarless sugarcoating, or thin-film sugarless sugarcoating. In the case that the solid preparation is obtained as coating granules, fine granules ordrug particles, it can be compressed together with other diluents to form tablets. Alternatively, a capsule is filled with the solid preparation to form a capsule preparation. Furthermore, the solid preparation can directly be packed as granules or fine granules, and taken. Alternatively, the solid preparation can be formed into a preparation to be dissolved before use, an oral-disintegrating tablet, a sustained-release preparation, a film sheet preparation, a gummi preparation, or a jelly preparation. EXAMPLE [0064] The present invention is described in more detail by reference to Examples, but the present invention is not construed as being limited to those Examples. Example 1 [0065] To a conical flask with a 50 ml in capacity was charged 2.0 g of an acetaminophen bulk powder having a particle size in a range of from 75 to 106 μίτι. The flask was put on a rotary evaporator. [0066] To this were added 0.1 g of hydroxypropyl cellulose having a volume average particle size of 6.27 μίτι (trade name:HPC-H, manufactured by Nippon Soda Co., Ltd.) and 0.01 g of polyethylene glycol having a volume average particle size of 11.23 μίτι (PEG 6000; melting point: 55 to 60°C), followed by mixing at room temperature for 1 minute. The flask was then dipped in a constant temperature liquid tank of 55°C, and rotated at 77 rpm for 10 minutes. This operation was repeated 15 times. [0067] To this were added 0.1 g of methacrylic acid copolymer having a volume average particle size of 8.87 μίτι (water-insoluble coating base: Eudragit RSPO; manufactured by Evonik) and 0.01 g of polyethylene glycol having a volume average particle size of 11.23 μίτι (PEG 6000; melting point: 55 to 60°C), followed by mixing at room temperature for 1 minute. Theflaskwas then dipped in a constant temperature liquid tankof 55°C, and rotated at 77 rpm for 10 minutes. This operation was repeated 5 times. [0068] The particles treated were taken out of the flask, and classified using a 53 μίτι sieve by an air jet sieve (AJS) method for 1 minute. The coating particles having a coating rate of 80.1% were obtained in a yield of 89.57%. [0069] The coating rate is a value obtained by subtracting a weight of acetaminophen charged from a weight of coating particles after classification, and dividing the value thus obtained, by the total weight of hydroxypropyl cellulose, polyethylene glycol and methacrylic acid copolymer used in the coating treatment. Example 2 [0070] To a conical flask with a 50 ml in capacity was charged 2.0 g of an acetaminophen bulk powder having a particle size in a range of from 75 to 106 μίτι. The flask was put on a rotary evaporator. [0071] To this were added 0,1 g of hydroxypropyl cellulose having a volume average particle size of 6.27 μίτι (trade name: HPC-H, manufactured by Nippon Soda Co., Ltd.) and 0.01 g of polyethylene glycol having a volume average particle size of 11.23 μίτι (PEG 6000; melting point: 55 to 60°C), followed by mixing at room temperature for 1 minute. Theflaskwas then dipped in a constant temperature liquid tank of 55°C, and rotated at 77 rpm for 10 minutes. This operation was repeated 10 times. [0072] To this were added 0.1 g of methacrylic acid copolymer having a volume average particle size of 8.87 μίτι (Eudragit RSPO; manufactured by Evonik) and 0.01 g of polyethyleneglycol having a volume average particle size of 11.23 μίτι (PEG 6000; melting point: 55 to 60°C), followed by mixing at room temperature for 1 minute. The flask was then dipped in a constant temperature liquid tank of 55°C, and rotated at 77 rpm for 10 minutes. This operation was repeated 10 times. [0073] The particles treated were taken out of the flask, and classified using a 53 μίτι sieve by an air jet sieve (AJS) method for 1 minute. The coating particles having a coating rate of 79.39% were obtained in a yield of 89.2%. [0074] The coating rate is a value obtained by subtracting a weight of acetaminophen charged from a weight of coating particles after classification, and dividing the value thus obtained, by the total weight of hydroxypropyl cellulose, polyethylene glycol and methacrylic acid copolymer used in the coating treatment. Example 3 [0075] To a conical flask with a 50 ml in capacity was charged 2.0 g of an acetaminophen bulk powder having a particle size in a range of from 75 to 106 μίτι. The flask was put on a rotary evaporator. [0076] To this were added 0.1 g of hydroxypropyl cellulose having a volume average particle size of 6.27 μίτι (trade name: HPC-H, manufactured by Nippon Soda Co., Ltd.) and 0.01 g of polyethylene glycol having a volume average particle size of 11.23 μίτι (PEG 6000; melting point: 55 to 60°C), followed by mixing at room temperature for 1 minute. Theflaskwas then dipped in a constant temperature liquid tank of 55°C, and rotated at 77 rpm for 10 minutes. This operation was repeated 20 times. [0077] The particles treated were taken out of the flask, and classified using a 53 μίτι sieve by an air jet sieve (AJS) method for 1 minute. The coating particles having a coating rate of 70.31% were obtained in a yield of 84.38%. [0078] The coating rate is a value obtained by subtracting a weight of acetaminophen charged from a weight of coating particles after classification, and dividing the value thus obtained, by the total weight of hydroxypropyl cellulose and polyethylene glycol used in the coating treatment. [0079] The coating particles obtained in Examples 1 to 3 and the acetaminophen bulk powder were subjected to an elution test. [0080] The elution test was carried out under the conditions of the number of revolutions of paddle: 100 rpm, 900 ml pure water and 37°C, in accordance with JAP XV paddle method. Elution concentration of acetaminophen was obtained from an absorbance (285 nm). The results are shown in Fig. 1. [0081] As shown in Fig. 1, the elution concentration of the acetaminophen bulk powder reached 90% after the elapse of 0.5 minute, and reached 100% after the elapse of 1 minute, The coating particles obtained in Examples 1 and 2 were that the elution concentration was 50% or less even after the elapse of about 1 minute, and the elution concentration reached about 95% afterthe elapse of 5 minute. The coating particle obtained in Example 3 was that the elution concentration was 25% or less after the elapse of about 1 minute, the elution concentration reached about 70% after the elapse of 5 minutes, and the elution concentration was about 90% afterthe elapse of 30 minutes. [0082] Furthermore, the solid preparation obtained by coating an acetaminophen bulk powder with a hydroxy-alkyl cellulose solution had adhesiveness and had poor fluidity. On the other hand, the coating particles obtained in Examples 1 to 3 each had excellent fluidity.Claims 1. A coated particle comprising a nuclear particle covered with a coating layer, wherein the coating layer is a layer comprising hydroxyalkyl cellulose and a binder wherein the binder is at least one selected from the group consisting of polyalkylene glycol, polyalkylene glycol higherfatty acid ester, higherfatty acid, higher alcohol, higher alcohol ester and natural wax; and wherein the hydroxyalkyl cellulose has a volume average particle size of from 0.1 to 20 μίτι 2. The coated particle according to claim 1, wherein the coating layer further comprises an elution controlling base and/or silica. 3. A method for producing a coated particle, comprising a first step of dry-coating a nuclear particle with hydroxyalkyl cellulose and a binder thereby adhesioncoating the nuclear particle with a coating layer; wherein the binder is at least one selected from the group consisting of polyalkylene glycol, polyalkylene glycol higherfatty acid ester, higherfatty acid, higher alcohol, higher alcohol ester and natural wax; and wherein the hydroxyalkyl cellulose has a volume average particle size of from 0.1 to 20 μίτι 4. The method for producing a coated particle according to claim 3, further comprising a second step of dry-coating the particle obtained in the first step with an elution controlling base and a binder. 5. The method for producing a coated particle according to claim 3, further comprising a third step of overcoating the particle obtained in the first step with silica. 6. The method for producing a coated particle according to claim 3 or 4, further comprising a second step of dry-coating the particle obtained in the first step with an elution controlling base and a binder, and a third step of overcoating the particle obtained in the second step with silica.Patentansprüche 1. Beschichtetes Teilchen umfassend ein Kernteilchen, welches mit einer Beschichtungsschicht bedeckt ist, worin die Beschichtungsschicht eine Schicht umfassend Hydroxyalkylcellulose und ein Bindemittel ist, wobei das Bindemittel mindestens eines ausgewählt aus der Gruppe bestehend aus Polyalkylenglycol, Ester aus Po ly alkyl eng ly col und höherer Fettsäure, höherer Fettsäure, höherem Alkohol, höherem Alkoholester und natürlichem Wachs ist; und worin die Hydroxyalkylcellulose eine volumenmittlere Teilchengröße von 0,1 bis 20 μίτι aufweist. 2. Beschichtetes Teilchen gemäß Anspruch 1, worin die Beschichtungsschicht ferner eine Abgabe-kon-trollierende Basis und/oder Siliziumdioxid enthält. 3. Verfahren zur Herstellung eines beschichteten Teilchens umfassend einen ersten Schritt des Trockenbeschichtens eines Kernteilchens mit Hydroxyalkylcellulose und einem Bindemittel unter Adhäsionsbeschichtung des Kernteilchens mit einer Beschichtungsschicht; worin das Bindemittel mindestens eines ausgewählt aus der Gruppe bestehend aus Polyalkylenglycol, Estern aus Polyalkylenglycol und höherer Fettsäure, höherer Fettsäure, höherem Alkohol, höherem Alkoholester und natürlichem Wachs ist; und worin die Hydroxyalkylcellulose eine volumenmittlere Teilchengröße von 0,1 bis 20 μίτι aufweist. 4. Verfahren zur Herstellung eines beschichteten Teilchens gemäß Anspruch 3, weiter umfassend einen zweiten SchrittdesTrockenbeschichtens des im ersten Schritt erhaltenen Teilchens mit einer Abgabe- kontrollierenden Basis und einem Bindemittel. 5. Verfahren zur Herstellung eines beschichteten Teilchens gemäß Anspruch 3, ferner umfassend einen dritten Schritt der Überbeschichtung des im ersten Schritt erhaltenen Teilchens mit Siliziumdioxid. 6. Verfahren zur Herstellung eines beschichteten Teilchens gemäß den Ansprüchen 3 oder 4, weiter umfassend einen zweiten Schritt des Trockenbeschichtens des im ersten Schritt erhaltenen Teilchens mit einer Abgabe-kontrollierenden Basis und einem Bindemittel, und einen dritten Schritt des Überbeschichtens des im zweiten Schritt erhaltenen Teilchens mit Siliziumdioxid.Revendications 1. Particule enrobée comprenant une particule nucléaire recouverte d’une couche de revêtement, dans laquelle la couche de revêtement est une couche comprenant de l’hydroxyalkylcellulose et un liant dans laquelle le liant est au moins un choisi dans le groupe constitué du polyalkylène glycol, d’un ester d’acide gras supérieur de polyalkylène glycol, d’un acide gras supérieur, d’un alcool supérieur, d’un ester d’alcool supérieur et d’une cire naturelle ; et dans laquelle l’hydroxyalkylcellulose a une taille de particule moyenne en volume de 0,1 à 20 μίτι. 2. Particule enrobée selon la revendication 1, dans laquelle la couche de revêtement comprend en outre une base de régulation de l’élution et/ou de la silice. 3. Procédé pour la production d’une particule enrobée, comprenant une première étape d’enrobage à sec d’une particule nucléaire avec de l’hydroxyalkylcellulose et un liant pour ainsi enrober par adhérence la particule nucléaire avec une couche de revêtement ; dans laquelle le liant est au moins un choisi dans le groupe constitué du polyalkylène glycol, d’un ester d’acide gras supérieur de polyalkylène glycol, d’un acide gras supérieur, d’un alcool supérieur, d’un ester d’alcool supérieur et d’une cire naturelle ; et dans laquelle l’hydroxyalkylcellulose a une taille de particule moyenne en volume de 0,1 à 20 μίτι. 4. Procédé pour la production d’une particule enrobée selon la revendication 3, comprenant en outre une seconde étape d’enrobage à sec de la particule obtenue à la première étape avec une base de régulation de l’élution et un liant. 5. Procédé pour la production d’une particule enrobée selon la revendication 3, comprenant en outre une troisième étape de surenrobage de la particule ob tenue à la première étape avec de la silice. 6. Procédé pour la production d’une particule enrobée selon la revendication 3 ou 4, comprenant en outre une seconde étape d’enrobage à sec de la particule obtenue à la première étape avec une base de régulation de l’élution et un liant, et une troisième étape de surenrobage de la particule obtenue à la seconde étape avec de la silice.
REFERENCES CITED IN THE DESCRIPTION
This list of references cited by the applicant is for the reader’s convenience only. It does not form part of the European patent document. Even though great care has been taken in compiling the references, errors or omissions cannot be excluded and the EPO disclaims all liability in this regard.
Patent documents cited in the description • JP2007105705 A[0004] • JP 9132523 A [0004] • JP2008106048 A[0004] • US 2001006677 A1 [0006] • WO 0057881 A1 [0006] • WO 9953901 A1 [0006]
Non-patent literature cited in the description • FUKUMORI et al. Design of dry functional particles using twin-screw continuous kneading machine. Ku-rimoto Technical Report No. 56 [0005] • KAUFFMAN et al. Raman spectroscopy of coated pharmaceutical tablets and physical models for multivariate calibration to tablet coating thickness. J. Pharm. Biomed.Analysis, vol. 43, 39-48, 2007 [0006] • GERA et al. Mechanical methods for dry particle coating processes and their applications in drug delivery and development. Recent Patents on Drug Delivery & Formulation, 2010, vol. 4, 58-81 [0006] • Handbooks of Granulation. The Association of Powder Process Industry and Engineering, JAPAN, Ohm-usha Ltd, [0058] • Formulation Design of Oral Dosage Forms. Mitsuru Hashida, Kyoto University, Graduate Schools, Faculty of Pharmaceutical Sciences, Yakugyo Jiho [0058] • Particle Design Engineering. The Society of Powder Technology, JAPAN, Sangyo Tosho Co, [0058] • Particle Design and Preparation Technology. The Society of Powder Technology [0058]