HU9402511D0 - A new method for quantitative assessment of p-glycoprotein-related multidrug resistance in tumor cells - Google Patents

A new method for quantitative assessment of p-glycoprotein-related multidrug resistance in tumor cells

Info

Publication number
HU9402511D0
HU9402511D0 HU9402511A HU9402511A HU9402511D0 HU 9402511 D0 HU9402511 D0 HU 9402511D0 HU 9402511 A HU9402511 A HU 9402511A HU 9402511 A HU9402511 A HU 9402511A HU 9402511 D0 HU9402511 D0 HU 9402511D0
Authority
HU
Hungary
Prior art keywords
glycoprotein
calcein
tumor cells
new method
specimen
Prior art date
Application number
HU9402511A
Other languages
English (en)
Other versions
HUT72700A (en
HU217108B (hu
Inventor
Balazs Sarkadi
Zsolt Hollo
Laszlo Homolya
Original Assignee
Sarkadi
Hollo
Homolya
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sarkadi, Hollo, Homolya filed Critical Sarkadi
Priority to HU9402511A priority Critical patent/HU217108B/hu
Publication of HU9402511D0 publication Critical patent/HU9402511D0/hu
Priority to CA2198731A priority patent/CA2198731C/en
Priority to EP95930671A priority patent/EP0784699B1/en
Priority to PCT/HU1995/000042 priority patent/WO1996006945A1/en
Priority to ES95930671T priority patent/ES2137538T3/es
Priority to AT95930671T priority patent/ATE182179T1/de
Priority to DE69510809T priority patent/DE69510809T2/de
Publication of HUT72700A publication Critical patent/HUT72700A/hu
Priority to US08/928,528 priority patent/US5872014A/en
Publication of HU217108B publication Critical patent/HU217108B/hu
Priority to US09/840,791 priority patent/US6391656B2/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
HU9402511A 1994-08-31 1994-08-31 Eljárás daganatok multidrogrezisztenciáját okozó fehérje aktivitásának in vitro mennyiségi kimutatására biológiai mintákban HU217108B (hu)

Priority Applications (9)

Application Number Priority Date Filing Date Title
HU9402511A HU217108B (hu) 1994-08-31 1994-08-31 Eljárás daganatok multidrogrezisztenciáját okozó fehérje aktivitásának in vitro mennyiségi kimutatására biológiai mintákban
DE69510809T DE69510809T2 (de) 1994-08-31 1995-08-31 Test- und reagenziensatz für die quantitative in vitro bestimmung der aktivität von proteinen, die mehrfachresistenz gegen chemotherapeutika in tumoren verursachen, in biologischen proben
ES95930671T ES2137538T3 (es) 1994-08-31 1995-08-31 Metodo de analisis y kit de reactivos para la determinacion cuantitativa in vitro, en muestras biologicas, de la actividad de proteinas que causan resistencia a multiples farmacos en tumores.
EP95930671A EP0784699B1 (en) 1994-08-31 1995-08-31 Assay and reagent kit for the quantitative in vitro determination in biological specimens of the activity of proteins causing multi-drug resistance in tumors
PCT/HU1995/000042 WO1996006945A1 (en) 1994-08-31 1995-08-31 Assay and reagent kit for the quantitative in vitro determination in biological specimens of the activity of proteins causing multi-drug resistance in tumors
CA2198731A CA2198731C (en) 1994-08-31 1995-08-31 Assay and reagent kit for the quantitative in vitro determination in biological specimens of the activity of proteins causing multi-drug resistance in tumors
AT95930671T ATE182179T1 (de) 1994-08-31 1995-08-31 Test- und reagenziensatz für die quantitative in vitro bestimmung der aktivität von proteinen, die mehrfachresistenz gegen chemotherapeutika in tumoren verursachen, in biologischen proben
US08/928,528 US5872014A (en) 1994-08-31 1997-09-12 Assay for multi-drug resistance
US09/840,791 US6391656B2 (en) 1994-08-31 2001-04-23 Assay and reagent kit for evaluation of multi-drug resistance in cells

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9402511A HU217108B (hu) 1994-08-31 1994-08-31 Eljárás daganatok multidrogrezisztenciáját okozó fehérje aktivitásának in vitro mennyiségi kimutatására biológiai mintákban

Publications (3)

Publication Number Publication Date
HU9402511D0 true HU9402511D0 (en) 1994-10-28
HUT72700A HUT72700A (en) 1996-05-28
HU217108B HU217108B (hu) 1999-11-29

Family

ID=10985550

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9402511A HU217108B (hu) 1994-08-31 1994-08-31 Eljárás daganatok multidrogrezisztenciáját okozó fehérje aktivitásának in vitro mennyiségi kimutatására biológiai mintákban

Country Status (7)

Country Link
US (1) US5872014A (hu)
EP (1) EP0784699B1 (hu)
AT (1) ATE182179T1 (hu)
DE (1) DE69510809T2 (hu)
ES (1) ES2137538T3 (hu)
HU (1) HU217108B (hu)
WO (1) WO1996006945A1 (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020042079A1 (en) * 1994-02-01 2002-04-11 Sanford M. Simon Methods and agents for measuring and controlling multidrug resistance
US6277655B1 (en) * 1994-10-13 2001-08-21 Solvo Biotechnology Assay and reagent kit for evaluation of multi-drug resistance in cells
US6162616A (en) * 1997-04-16 2000-12-19 Millennium Pharmaceuticals, Inc. Multidrug resistance-associated polypeptide
HUP0002557A3 (en) * 2000-07-03 2004-08-30 Solvo Biotechnologiai Kft Simple quantitative fluorescent assay method for determining the activity of transport proteins of interest
WO2002023186A2 (en) * 2000-09-15 2002-03-21 Virco Bvba System and method for optimizing drug therapy for the treatment of diseases
US20030036049A1 (en) * 2001-01-03 2003-02-20 Medis El Ltd. Optical method for testing sensitivity of cells
EP1448766A2 (en) * 2001-09-27 2004-08-25 University Of Delaware Coisogenic eukaryotic cell collections
WO2005116648A2 (en) * 2004-05-25 2005-12-08 Solvo Biotechnology, Inc. Method and reagent kit for evaluation of multidrug-resistance activity
US7795019B2 (en) * 2006-11-10 2010-09-14 Absorption Systems Group, Llc Stable cell lines and methods for evaluating gastrointestinal absorption of chemicals
US7838256B2 (en) 2007-02-23 2010-11-23 Board Of Regents Of The University Of Nebraska Assay and kit for drug efflux transporter activity
US8445271B2 (en) 2010-05-03 2013-05-21 Enzo Life Sciences, Inc. Processes and kits for determining multi-drug resistance of cells
HU231387B1 (hu) 2017-10-25 2023-06-28 Cellpharma Kft. Fluoreszcens festékfelhalmozódási vizsgálat
EP3570028A1 (en) 2018-05-15 2019-11-20 MDQuest Kft. Assessing responsiveness of rheumatoid arthritis patients to biological treatment
HUP2100005A1 (hu) 2018-05-15 2021-03-29 Navolab Diagnosztika Kft Rheumatoid arthrits páciensek biológiai terápiára adott válasz készségének becslése

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281061A (en) * 1979-07-27 1981-07-28 Syva Company Double antibody for enhanced sensitivity in immunoassay
US5407653A (en) * 1991-06-26 1995-04-18 Brigham And Women's Hospital Evaluation of the multidrug resistance phenotype
US5314805A (en) * 1991-10-28 1994-05-24 Molecular Probes, Inc. Dual-fluorescence cell viability assay using ethidium homodimer and calcein AM

Also Published As

Publication number Publication date
ATE182179T1 (de) 1999-07-15
DE69510809D1 (de) 1999-08-19
EP0784699B1 (en) 1999-07-14
HUT72700A (en) 1996-05-28
DE69510809T2 (de) 2000-03-16
ES2137538T3 (es) 1999-12-16
HU217108B (hu) 1999-11-29
EP0784699A1 (en) 1997-07-23
WO1996006945A1 (en) 1996-03-07
US5872014A (en) 1999-02-16

Similar Documents

Publication Publication Date Title
HU9402511D0 (en) A new method for quantitative assessment of p-glycoprotein-related multidrug resistance in tumor cells
DE69631738D1 (de) Medizinische implantierbare Vorrichtung für elektrochemische Messungen von Bluteigenschaften
Plappert et al. Changes in the repair capacity of blood cells as a biomarker for chronic low‐dose exposure to ionizing radiation
DK221090D0 (da) Fremgangsmaade og apparat til diagnostisk analyse ved stroemmaaling
EP1099102A4 (en) TRACE DETECTION OF ANALYTES BY ARTIFICIAL OLFAKTOMETRY
BR9508959A (pt) "Detecção e tratamento de cancer"
AU5045885A (en) Disposable sterilization biological and chemical test pack
HK1040533A1 (zh) 監察蛋白脢體抑制劑藥物活動的方法
AU5350290A (en) Factor sensitive reagent for testing of blood coagulation
EP0277237A4 (en) METHOD AND PROBE FOR SCREENING FOR BACTERIA IN SAMPLES.
EP0752872A4 (en) NADH OXIDASE AS TARGET MOLECULE IN DIAGNOSIS AND THERAPY
Freilich et al. Imipramine binding to alpha‐1‐acid glycoprotein in normal subjects and cardiac patients
EP0360871A4 (en) Method for measuring biological activity of antithrombin iii and reagents for the measurement
FR2846426B1 (fr) Procede de dosage du ngf pour le diagnostic in vitro du cancer du sein et utilisation en therapie
IT8423926A0 (it) Metodo diagnostico per la valutazione di parametri clinici mediante prelievo diretto dimateriali biologici e dispositivoper la sua attuazione.
Bohr et al. DNA repair in lymphocytes from patients with secondary leukemia as measured by strand rejoining and unscheduled DNA synthesis
Hauschild The use of serological tumor markers for malignant melanoma
ATE344454T1 (de) Oxydativer stoffwechsel in glatten muskelzellen: verfahren in beziehung dazu
Patel et al. Combined use of serum enzyme levels as tumor markers in cervical carcinoma patients
Fish et al. Changes in serum acute phase proteins in breast cancer patients receiving methotrexate infusion therapy
GB8414363D0 (en) Carrying out clinical chemical and biological testing
AU4518889A (en) Method for the detection of multiple drug resistant tumor cells and verapamil probes useful therein
Hara et al. A single cell gel electrophoresis technique for the detection of DNA damage induced by ACNU, an alkylating agent or irradiation in murine glioma cell lines
Yoshida et al. Rapid rejoing of X-ray-induced DNA single-strand breaks in tuberous sclerosis fibroblasts
Nigam et al. Some biochemical markers in various neoplasms: A multivariate analysis

Legal Events

Date Code Title Description
DFD9 Temporary protection cancelled due to non-payment of fee
DNF4 Restoration of lapsed final protection
HPC4 Succession in title of patentee

Owner name: SOLVO BIOTECHNOLOGIAI KFT., HU

GB9A Succession in title

Owner name: SOLVO BIOTECHNOLOGIAI ZRT., HU

Free format text: FORMER OWNER(S): DR. SARKADI BALAZS, HU; DR. HOLLO ZSOLT, HU; HOMOLYA LASZLO, HU; SOLVO BIOTECHNOLOGIAI KFT., HU

HC9A Change of name, address

Owner name: SOLVO BIOTECHNOLOGIAI ZRT., HU

Free format text: FORMER OWNER(S): DR. SARKADI BALAZS, HU; DR. HOLLO ZSOLT, HU; HOMOLYA LASZLO, HU; SOLVO BIOTECHNOLOGIAI KFT., HU; SOLVO BIOTECHNOLOGIAI ZRT., HU

QB4A Exploitation contract

Name of requester: MDQUEST KFT., HU