HU217306B - Feed additive composition - Google Patents

Abstract

The stone growth according to the invention is 100 parts by weight of total weight <% - 2> by weight from 0.1 to 30 parts by weight of Tőyőcerin from 1010, from 1.5 to 30 parts by weight of glucose mannose, more preferably from 0.2 to 2.0 parts by weight of vitamin E, and sodium by weight. from cyclamate, from 0.1 to 2.0 parts by weight, from 20 to 30 parts by weight of a premix containing 0.04 to 0.05% by weight of sodium selenite, and to 100 parts by weight of carrier, preferably a feed lotion. ŕ

Description

The present invention relates to a feed additive composition.

Feed additives that can be used in feed serve a variety of purposes. For example, some feed additives have a high fat content and are thus useful for increasing pig weight gain.

Such a feed additive is described in HU 202 376.

Another class of feed additives contains active ingredients that have a disinfectant effect or help balance the gut flora of animals.

In the healthy animal body, the intestinal flora is in a state of equilibrium, i.e., the bacterial flora required for digestion is over 90% by weight and the harmful flora is under 10% by weight. As a result of infections and other adverse effects, the proportion of strain flora required for digestion may fall below 90% by weight, while the proportion of harmful flora accompanying the digestion may increase to above 10%.

Bacteria that produce lactic and fatty acids, such as Toyo bacillus (Bacillus toyoi), make up a significant proportion of the main flora.

Among the microorganisms of the accompanying flora, mention should be made, inter alia, of clostridia, staphylococci and E. coli.

A known preparation is Toyocerin, available from Lohmann GmbH (DE).

This preparation contains live but dried spores of Toyo bacillus.

The product is administered to the animal in admixture with feed.

In the animal's intestine, the spores germinate and become part of the intestinal flora.

Toyo bacteria suppress unwanted bacterial germs in the anterior intestinal tract, such as E. coli, and prevent them from multiplying. Such an effect not only advantageously prevents the diarrhea of the animal but also promotes the growth of the animal.

The bacterial germs in Toyocerin are killed when they are excreted from the gut, so they are not harmful to the environment.

The active ingredient content of Toyocerin is given by the amount of Colon Formed Unit (CFU) in 1 g of substance.

The Toyocerin 10 ¹⁰ mean a product with a substance containing 10 g 1 ^{1 ()} items in CFU.

Particularly in young animals, equilibrium in the gut flora can easily be reached.

Low pressures (such as nutrient changes, shed changes), adverse climatic and housing conditions may already result in an increased number of E. coli and other pathogenic bacteria in the animal body.

The administration of Toyocerin restores proper balance and improves the digestion of the animal.

Experiments were conducted on various animals such as pigs, cattle, sheep, poultry, and the effect of the administration of Toyocerin was investigated.

Surprisingly, it has been found that the addition of a feed additive composition containing glucomannan protein in addition to Toyocerin to animals at an early stage of growth, and unexpectedly, increases the weight gain of the animals.

We have found that this synergistic composition can be supplemented with minerals.

The amount of Toyocerin used in such a feed additive composition can be greatly reduced while still producing an unexpected weight gain.

The present invention thus relates to a feed additive composition comprising, for a total amount of 100 parts by weight, Toyocerin 101 ⁽ from 0.1 to 30 parts by weight, glucomannan protein from 1.5 to 30 parts by weight) and, if desired, 0 to vitamin E. It contains from 2 to 2.0 parts by weight, from 0.1 to 2.0 parts by weight of sodium cyclamate, from 20 to 30 parts by weight of a premix containing from 0.04 to 0.05% by weight of sodium selenite - and the necessary amount of carrier, preferably feed, for 100 parts by weight.

The feed additive composition of the invention may be marketed as a premix or further diluted with feed lime (calcium carbonate) in the form of a premix.

The composition of the invention has the advantage that it can be incorporated into any conventional feed and contributes to an increase in body weight of the animals beyond known additives.

However, the use of less than the recommended amount of active ingredient in the composition of the invention is sufficient to achieve a better result than known.

In addition, the feed additive composition can be used to prevent digestive and respiratory diseases and as a stress relieving additive.

Feedstuff additive of the invention is the amount of drug administered to a mixture feed, the feed 100 gram of 0.1 to 600 mg Toyocerin contain 10 ^l0 -100 eth and 0.1 g of gluco-mannan-protein.

Example 1

Preparation of a feed additive composition

As a first step, 45% by weight of sodium selenite is diluted with 38% by weight of feed lime to 0.045% by weight. 0.1 parts by weight of 45% by weight of sodium selenite are mixed with 99.9 parts by weight of 38% by weight of feed lime.

The following components are then added to the powder mixer:

Toyocerin 10.0 ^, 2.33 parts by weight, 20% by weight of glucomannan protein (Bio-Mos, available from Alltech Hungary, HU), vitamin E (Rovomix E 50, manufactured by Hofffnann-LaRoche). Fr) 2.67 parts by weight, 1.33 parts by weight of sodium cyclamate, 29.33 parts by weight of sodium selenite 0.045% and 44.34 parts by weight of feed lime 38%.

The mixture is homogenized and a premix of the premixture is prepared by mixing 85 parts by weight of 38% feed with 15 parts by weight.

The premix can be added to known feeds such as soybean meal, meat meal or cereal meal.

HU 217 306 Β

The premix is mixed with feed components for sows 7 to 10 weeks prior to farrowing. days to weaning.

Example 2

Preparation of a feed additive composition

In all cases, the procedure of Example 1 was followed and the active ingredient content of each component was the same as that of Example 1.

The following components are coated in the powder mixer:

Toyocerin O ^lo 1 from 1.67 parts by weight, 25% gluco-mannan-protein 46.67 parts by weight, 50 Rovimix E from 2.67 part by weight, sodium ciklamátból 1.33 part by weight, 0.045% by weight sodium 29.33 parts by weight of selenite, 18.33 parts by weight of feed lime 38%.

For the premix preparation, 85 parts by weight of a 38 wt% feed mix are mixed with 15 parts by weight of the above composition.

The feed additive is used in a pig feed.

Example 3

Preparation of a feed additive composition

In each case, the procedure of Example 1 was followed, and the active ingredient content of each component was the same as that of Example 1.

The following components are coated in the powder mixer:

Toyocerin 10 ^µl 1.67 parts by weight, 25% by weight glucomannan protein 33.33 parts by weight, sodium cyclamate 1.33 parts by weight, 0.045% by weight sodium selenite 29.33 parts by weight, 38% by weight fodder lime 34, 34 parts by weight.

For the premix preparation, 85 parts by weight of a 38 wt% feed mix are mixed with 15 parts by weight of the above composition.

The feed additive is used in feed for pigs for fattening and fattening.

Example 4 (Effectology)

The experiment was carried out during the pre-rearing season for pigs for fattening up to a body weight of about 35 kg.

During the experiment, sows were placed and fed 7-10 days prior to expected farrowing.

Piglets are fed 24-hour-old piglets.

The milk was weaned at 28 days.

The pigs were then placed in a broodstock establishment, after which they moved into the fattening pig sector after 50 days.

The experiment lasted for a total of 78 days.

The sows were fed the following formula for sows:

Conventional sow feed concentrate 20 parts by weight Groats 30 parts by weight

Groats 30 parts by weight

Barley 20 parts by weight

The composition of the feed for piglets:

In breeder: Salinomycines prestarter (factory mix).

Nutrition in the battery: starter pig feed, consisting of starter malt concentrate 26 parts of maize grits 30 parts of wheat groats 20 parts of barley groats 30 parts

In the control group I, no additives were added to the above composition.

II. In the control group, no supplement was used for sow feed, with 500 mg glucomannan protein per kg of prestarter in the feeder, and 250 mg glucomannan protein per kg of starter feed.

AIII. In the control group, 60 mg of Toyocerin 10 ¹⁰ additive per kg of feed was added to the sow feed, and 100 mg of Toyo30 cerin 10 ^{10 was added} to 1 kg of perstarter and starter pig feed.

In the experimental group consuming the feed supplemented by the present invention, 10 g of the additive of Example 1 was mixed per kg of sow feed.

Thus, 1 kg of feed contained 3.5 x ^{10 8} CFU units of Toyocerin and 35 75 mg of glucomannan protein active ingredient.

To the prestarter and 1 kg of starter pig feed, 10 g of the additive of Example 2 was mixed.

Thus, 1 kg of feed contained 2.5 x ^{10 8} CFU units of Toyocerin and 40 175 mg of glucomannan protein.

Feeding was done in the same way for all four groups.

The result of the experiment is as follows:

denomination Control group I. II. control group difference %-the III. control group difference %-the Experimental group difference %-the Number of sows, pcs 16 15 - 17 - 18 - Propagation per sow, pcs 7.63 7.93 +3.9 7.53 -1.0 7.72 + 1.2 Live reproduction, pcs 122 119 - 128 - 139 - Death, pcs 18 14 - 17 - 12 - Mortality,% 14.75 11.76 -2.99 -20.3% 13.28 -1.47 -10.0% 8.63 -6.12 -41.5% Going to the fattening house (78 days), pcs 104 105 - 111 - 127 - Fattening weight, kg / pc 30.6 31.2 + 2.0 33.6 + 9.8 39.9 +30.4 Weight gainer, total weight 3182.4 3276 - 3729.6 - 5061.6 -

HU 217 306 Β

Table (continued)

denomination Control group I. II. control group difference %-the III. control group difference %-the Experimental group difference %-the Total feed, kg 10661 10418 - 11226 - 12097 - Racial. feed, kg / mg 3.35 3.18 X She" 1 1 3.01 -0.34 -10.1% 2.39 -0.96 -28.7% Daily weight gain, g 392 400 +2.0 431 + 9.9% 512 +30.6 Amount of live reproductive weight, kg / pc 26.09 27.53 + 5.5 29.13 + 11.7 36.41 +39.6 Live weight per sow, kg / pc 198.9 218.4 +9.8 219.4 + 10.3 281.2 +41.4

The table below shows the following.

Percentage change in mass of live reproduction, if any

Change in control group I is considered 0%,

II. control group: 5.5%,

III. 11.7% in the control group and 39.6% in the experimental group.

The change in live weight per sow, if any

Change in control group I is considered 0,

II. control group: 9.8%.

III. 10.3% in the control group and 41.4% in the experimental group.

It follows from the above that the composition according to the invention has an unexpected advantage.

Claims (2)

PATENT CLAIMS 1. A feed additive composition, characterized by: 20 for a total amount of 100 parts by weight of 0.1 to 30 parts by weight of Toyocerin 10 * °, 1.5 to 30 parts by weight of glucomannan protein, and 0.2 to 2.0 parts by weight of vitamin E and 0 parts by weight of sodium cyclamate. From 20 to 30 parts by weight of the premixture containing from 1 to 1.0 parts by weight, from 0.04 to 0.05% by weight of sodium 25 selenite, and the necessary amount of carrier, preferably feed, for 100 parts by weight. Composition according to Claim 1, characterized in that the sodium selenite is contained in the form of a premix bound to lime.