HU212898B - Synergetic fungicidal compositions - Google Patents

Description

The present invention relates to a synergistic fungicidal composition for controlling phytopathogenic fungi.

The invention thus relates to compositions having well-utilized fungicidal properties.

German Patent No. 151,404 discloses a class of aniline-pyrimidine compounds having fungicidal activity. It has been found that particularly valuable fungicidal compositions are obtained by combining one of the compounds described in this patent, namely 2-anilino-4,6-dimethylpyrimidine, known as pyrimethanil, with a fungicide of another chemical class.

Accordingly, the invention relates to a fungicidal composition which

(a) 2-anilino-4,6-dimethylpyrimidine; and

(b) it contains a fungicidal compound selected from:

(b () is a conazole-type steroid demethylation inhibitor; or (b ₂ ) tetrachloroisophthalonitrile (chlorothalonil), (b ₃ ) (RS) -1- [3- (4-tert-butylphenyl) -2- methylpropyl] piperidine (phenpropidine), (b ₄ ) manganese ethylene bis (dithiocarmabate) polymer zinc salt complex (mancozeb), (b ₅ ) tetramethylthiuram disulfide (thiram), (b ₆₎ ) 3- (3,5-Dichlorophenyl) -N-isopropyl-2,4-dioxoimidazolidine-1-carboxamide (iprodione), (by) 3- (3,5-Dichlorophenyl) -5- methyl 5-vinyl-1,3-oxazolidine-2,4-dione (vinclozoline), (b _g ) methyl 1- (butylcarbamoyl) -benzimidazol-2-ylcarbamate (benomyl) (b ₉ ) dimethyl - [4,4 '- (o-Phenylene) bis (3-methylthioallophanate] (thiophanate-methyl), (b, _O ) 5-methylisoxazol-3-ol (himexazole), ( b _n ) a-2-chloro-N- (2,6-xylyl) acetamido-γ-butyrolactone (ofurac), (b ₁₂ ) methyl (E) -methoximino [a- (o-tolyloxy) -o-tolyl] acetate, - (BAS 490 F) and (bj ₃ ) methyl (E) -2- {2- [6- (cyanophenoxy) pyrimidin-4-yloxy] phenyl} -3- methoxyacrylate (ICIA 5504).

The ratio of 2-anilino-4,6-dimethylpyridine to component b) is 25: 1 to 1:25 (w / w).

Conazole-type compounds are defined as imidazole or 1,2,4-triazole-based compounds containing halogenated phenyl according to ISO Standard 257. These compounds include, for example:

prochlorase - 1- [N-propyl-N-2- (2,4,6-trichlorophenoxy) ethylcarbamoyl] imidazole (and its metal complexes, especially manganese or copper complexes), propiconazole -1- (2- (2) , 4-dichlorophenyl) -4-propyl-1,3-dioxolan-2-ylmethyl] -1H-1,2,4-triazole, fluzilazole bis (4-fluorophenyl) (methyl) - (1 H -), 2,4-triazol-1-ylmethyl) silane,

hexakon- azole - α-butyl-α- (2,4-dichlorophenyl) -1Η-1,2,4-triazole-1-ethanol, tebukon- azole - α- [2- (4-chlorophenyl) ethyl] -α-1,1-dimethylethyl) -1Η-1,2,4-triazole-1-ethanol, difenoko- fluconazole - 1- {2- (2-chloro-4- (4-chlorophenoxy) phenyl] -4-methyl-1,3-dioxolan-2-yl] methyl} -1,5-1,2,4-triazole, bromu- fluconazole - 1 - {[4-bromo-2- (2,4-dichloro-phenyl) -tetrahydro-2-furanyl] -methyl} -1H-1,2,4-triazole. ciprokon- azole - α- (4-chlorophenyl) -α- (1-cyclopropylethyl) -1Η-1,2,4-triazole-1-ethanol, dinikon- azole - 1- (2,4-dichlorophenyl) -4,4-dimethyl-2- (1H-1,2,4-triazol-1-yl) pen-1-en-3-ol, fenbuko- fluconazole - 4- (4-chlorophenyl) -2-phenyl-2- (1 H -1,2,4-triazol-1-ylmethyl) butyronitrile, imibenko- fluconazole -4-chlorobenzyl-N- (2,4-dichlorophenyl) -2- (1H-1,2,4-triazol-1-yl) thioacetamidate, tetrakon- azole - 2- (2,4-dichlorophenyl) -3- (1 H -1,2,4-triazol-1-yl) propyl-1,1,2,2-tetrafluoroethyl ether, miklobuta- nil - 2- (4-chlorophenyl) -2- (1 H -1,2,4-triazol-1-ylmethyl) hexanenitrile, penkon- azole - 1- (2,4-dichloro-3-propyl-phenyl-ethyl) -1H-1,2,4-triazole, flukvin- fluconazole - 3- (2,4-dichlorophenyl) -6-fluoro-2- (1H-1,2,4-triazol-1-yl) -4 (3H) -quinazolinone, azakon- azole - 1 - {[2- (2,4-dichlorophenyl) -1,3-dioxalan-2-yl] methyl} -1,5-1,2,4-triazole, imazalil - 1- (p-allyloxy-2,4-dichlorophenylethyl) imidazole, triflumi- benzene - (E) -4-chloro-α, α, α-trifluoro-N- (1-imidazol-yl-2-propoxyethylidene) -o-toluidine, tritikon- azole - 5- (4-chlorophenyl) methylene-2,2-dimethyl-1- (1 (-1,2,4-triazol-1-ylmethyl) cycloheptanol, metkon- azole - 5- (4-chlorobenzyl) -2,2-dimethyl-1- (1H-1,2,4-triazol-1-ylmethyl) cyclopentanol.

and fungicide 1- (4-chlorophenyl) -2- (1H-1,2,4-triazol-1-yl) cycloheptanol, code SSF 109.

Examples of fungicidal compounds useful as component b) are disclosed in a very large number of patent applications, such as European Patent Applications 178,826, 203,606, 203,608,

HU 212 898 Β

206,523, 229,974, 226,917, 242,070, 242,081,

243,014, 251,082, 256,667, 260,794, 260,832,

267,734, 270,252, 273,572, 274,825, 278,595,

291 196, 299 694, 307 101, 307 103, 310 954,

312,221, 312,243, 329,011, and 336,211. Specific examples of compounds of this type are given in BAS 490F and ICIA 5504.

The names cited for the above compounds are unregistered common names. The corresponding chemical structures described above can be found, for example, in the ninth edition of the "Pesticide Manual", published in 1991 by the British Crop Protection Council. The full chemical names for common names not included in the "Pesticide Manual" are also listed above.

It has been found that the compositions of the present invention have a significant, unexpected additional effect over the individual components, and this synergistic effect is proven in many cases. Growth in crop yields is also observed.

The weight ratio of components (a) and (b) can be varied within wide limits. As mentioned, suitable ranges are those in which the weight ratio of component (a) to component (b) is from 25: 1 to 1:25, preferably from 5: 1 to 1: 5.

It is noted that of course other pesticides may be used in combination with the above-described active ingredients which do not have any deleterious effect on the interaction between the fungicidal components; this does not in itself constitute a substantial departure from the invention.

The compositions of the invention are effective against a wide range of fungi. Such fungi include, for example, Erysiphe graminis (corn flour) on cereals such as wheat, barley, oats and rye, as well as other leaf diseases such as Septoria nodorum (septic leaf spot), Rhynchosporium secalis , Pseudocercosporella herpotrichoides (leaf blotch), and Puccinia graminis (black or stem rust of cereals). Certain compositions of the invention may be used to control seed-borne organisms, such as Tilletia caries (wheatgrass) on wheat, Ustilago nuda (powdery mildew) and Ustilago hordei (fungus) on the barley, Pyrenophora avos (on the oat) and Pyrenophora graminis (barley helminthosporium spotted) in barley. The compositions of the present invention are also useful in controlling Pyricularia oryzae (rice angina) in rice, Venturia inaequalis in horticultural plants such as apple trees, Sphaerotheca pannosa (black powdery mildew), against Botrytis cinerea, against lawn and lawn, against Sclerotinia homeocarpa and against stored crops such as citrus fruits, potatoes, sugar beets, apples, pears, etc. microorganisms responsible for rot occurring during storage (such as Penicillium spp., Aspergillus spp. and Botrytis spp.). Fungicides which can be controlled using the compositions of the invention include Helminthosporium spp. and Cercospora spp. too.

The compositions of the invention can be used in a variety of forms. Most conveniently, aqueous formulations are often formulated shortly before use. One method of preparing a so-called "tank mix" formulation is to mix commercially available formulations of the active ingredients with a specific amount of water. In addition to tank mixing immediately prior to use, formulations containing 2-anilino-4,6-dimethylpyrimidine may also be formulated as a higher concentration primary composition diluted with water or other diluent prior to use. These compositions may contain, in addition to the active compounds, surfactants. Examples of such formulations include the following.

The composition may be, for example, a dispersible solution in which the active compounds are dissolved together with a dispersant in a water-soluble solvent. Alternatively, the active compounds in the form of a finely divided powder together with a dispersant can be mixed with water to form a paste or cream, optionally added to an oil-in-water emulsion to form a dispersion of the active compounds in an aqueous oil emulsion.

An emulsifiable concentrate contains the active compounds dissolved in a water-soluble solvent which can be converted to an emulsion with water in the presence of an emulsifier.

Granular solids containing the active compounds together with powdered diluents such as kaolin can be granulated by known methods. Alternatively, the active compounds may be adsorbed or absorbed on a pregranular diluent such as fuller earth, attapulgite or limestone.

The dispersible or wettable powder contains the active ingredients in admixture with a suitable surfactant and an inert powder diluent such as porcelain earth.

Another suitable concentrate is a free-flowing suspension concentrate, which may be prepared by grinding the active compounds with water, wetting agent and suspending agent.

In some circumstances, it may be necessary to combine two different types of formulations. Such is, for example, the concentrate in which the first component is emulsifiable in the form of a concentrate and the second component is in the form of a dispersed powder.

Formulations for direct application to vegetation by direct application to plants, when used as the sole active ingredient, preferably have a concentration in the range of 0.001% to 10% by weight, particularly preferably 0.005% to 5% by weight.

Formulations of active substance with a value in the range of Β 218 898, but may be used for aerial spraying, up to a maximum content of 40% by weight.

The compositions of the invention are particularly well suited for the treatment of seeds, in particular cereal seeds, in particular for the control of diseases transmitted by the seeds. Various types of formulations may be employed in conventional seed treatment, such as powders, organic solvent solutions, or aqueous formulations, such as free-flowing suspension concentrates. When the cereal grains are stored in a warehouse or container, in some cases it may be more convenient to treat the storage space with a composition according to the invention instead of handling the cereal grains directly, or the two methods may be used side by side. Suitable amounts of 2-anilino-4,6-dimethylpyrimidine per kg of seed (in the range of 0.005 g to 5.0 g, e.g. 0.01 g to 1.0 g for 1 kg of seed) are suitable for seed treatment. It falls.

Alternatively, the application of the compositions of the invention directly to the plants, for example by spraying or dusting, may be effected when the fungi begin to appear on the plants or as a suitable measure before the fungi appear. In both cases, foliar spraying is the preferred application method. When applied directly to the plant, the application rate is from 0.005 kg to 2 kg per hectare, preferably from 0.1 kg / ha to 1 kg / ha.

The invention includes a method for controlling phytopathogenic fungi, comprising applying to said fungi or a site thereof a mixture according to the invention.

The invention will be further illustrated by the following example; the example describes in vitro experiments in which a synergistic effect was observed.

EXAMPLE

The 2-anilino-4,6-dimethylpyrimidine and fungicides of component (b) were incorporated into molten agar in amounts that provided the desired concentration of active ingredient in the agar. The molten agar was then poured into Petri dishes and allowed to solidify. At the center of each plate was a 5 mm mycelial plug of agar culture of selected fungi with the mycelial surface facing down. The dishes were incubated at 20 ° C. Colonies were then measured at different time points, and the percentage inhibition of growth was calculated by comparing with the growth of a standard agar dish. The Petri dish used as a standard was inoculated as described above but did not contain any active ingredient.

The Colby equation (Colby S. R., "Calculating Synergistic and Antagonistic Responses of Herbicide Combinations", Weeds 1967 15, 20-22) was used to demonstrate the synergistic effect between the active ingredients. According to this method, the so-called "expected" percent inhibition of growth of the preparation is calculated from the comparison with untreated control according to the following equation:

in which

A is the percentage inhibition of 2-anilino-4,6-dimethylpyrimidine used alone at a given concentration; and

B is the percentage inhibition of component (b) used alone at a given concentration. If the observed inhibition of the mixture is greater than the value of E, the result demonstrates a synergistic effect.

The following tables show the results demonstrating the synergistic nature of the effect observed for the given amounts.

1) Proclorase a) Pyricularia oryzae

2 Anilinopyrido 4,6-dimethyl- pyrimidine concentration (Ppm) prochloraz concentration (Ppm) % Inhibition observed Expected inhibition [E (%)] 0.25 0 3 0.5 0 1 5.0 0 18 0 0.25 85 0 0.05 76 0.25 0.05 88 76.1 0.25 0.25 94 85.5 0.5 0.05 85 76.3 0.5 0.25 88 85.9 5.0 0.05 85 80.3 5.0 0.25 91 87.7

2) Chlorothalonil a) Botrytis cinerea

2 Anilinopyrido 4,6-dimethyl- pyrimidine concentration (Ppm) chlorothalonil concentration (Ppm) % Inhibition observed Expected inhibition [E (%)] 0.25 0 22 1.25 0 56 0 0.05 1 0 0.25 7 0 1.25 22

HU 212 898 Β

2 Anilinopyrido 4,6-dimethyl- pyrimidine concentration (Ppm) chlorothalonil concentration (Ppm) % Inhibition observed Expected inhibition [E (%) 1 0.25 0.05 33 23 0.25 0.25 44 27 0.25 1.25 59 38 1.25 1.25 79 66

3) Fenpropidin a) Botrytis cinerea

2 Anilinopyrido 4,6-dimethyl- pyrimidine concentration (Ppm) fenpropidin concentration (Ppm) % Inhibition observed Expected inhibition [NIGHT 0.25 0 22 0 0.25 9 0 1.25 39 0.25 0.25 31 29 0.25 1.25 77 52

3) Fenpropidin

(b) Gaeumannomyces graminis

2 Anilinopyrido 4,6-dimethyl- pyrimidine concentration (Ppm) fenpropidin concentration (Ppm) % Inhibition observed Expected inhibition [E (%)] 0.25 0 6 0 0.05 11 0 0.25 39 0 1.25 72 0.25 0.05 31 17 0.25 0.25 68 42 0.25 1.25 94 74

4) Propiconazole

(a) Pseudocercosporella herpotrichoides

2 Anilinopyrido 4,6-dimethyl- pyrimidine concentration (Ppm) propiconazole concentration (Ppm) % Inhibition observed Expected inhibition [E (%) 1 0.05 0 12 0.25 0 56 0 0.05 4 0.05 0.05 42 16 0.25 0.05 71 58

5) Fluzilazole a) Botrytis cinerea

2 Anilinopyrido 4,6-dimethyl- pyrimidine concentration (Ppm) flusilazole concentration (Ppm) % Inhibition observed Expected inhibition [E (%) 1 1.25 0 42 0 0.05 38 0 0.25 59 1.25 0.05 84 64 1.25 0.25 95 76

6) Mankoceb a) Pyricularia oryzae

2 Anilinopyrido 4,6-dimethyl- pyrimidine concentration (Ppm) mancozeb concentration (Ppm) % Inhibition observed Expected inhibition [E (%) 3 0.05 0 1 0.25 0 23 0 0.05 3 0.05 0.05 22 4 0.25 0.05 54 26

7) Tiram

(a) Botrytis cinerea

2 Anilinopyrido 4,6-dimethyl- pyrimidine concentration (Ppm) Thiram concentration (ppm) % Inhibition observed Expected inhibition [E (%)] 0.05 0 5 0.25 0 24 1.25 0 33 0 1.25 29 0.05 1.25 55 32 0.25 1.25 75 46 1.25 1.25 69 52

8) Iprodion

(a) Botrytis cinerea

2 Anilinopyrido 4,6-dimethyl- pyrimidine concentration (Ppm) Iprodione concentration (ppm) % Inhibition observed Expected inhibition [E (%)] 0.25 0 44 0 0.05 13 0.25 0.05 76 51

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9) Epoxiconazole a) Botrytis ciné re

12) Diniconazole a) Botrytis cinerea

2 Anilinopyrido 4,6-dimethyl- pyrimidine concentration (Ppm) Epoxiconazole Concentration (ppm) % Inhibition observed Expected inhibition [E (%)] 0.05 0 4 0.25 0 17 1.25 0 30 0 1.25 71 0.05 1.25 80 73 0.25 1.25 89 76 1.25 1.25 93 80

10) Bromuconazole a) Sclerotinia sclerotiorum

2 Anilinopyrido 4,6-dimethyl- pyrimidine concentration (Ppm) Bromuconazole concentration (ppm) % Inhibition observed Expected inhibition [E (%) J 0.05 0 0 0.25 0 0 0 0.05 22 0.05 0.05 66 22 0.25 0.05 89 22

11) Ciproconazole a) Botrytis cinerea

2 Anilinopyrido 4,6-dimethyl- pyrimidine concentration (Ppm) Ciproconazole Concentration (ppm) % Inhibition observed Expected inhibition [E (%)] 0.25 0 11 1.25 0 23 0 1.25 60 0.25 1.25 75 65 1.25 1.25 81 70

11) Ciproconazole b) Sclerotium rolfsii

2 Anilinopyrido 4,6-dimethyl- pyrimidine concentration (Ppm) Ciproconazole Concentration (ppm) % Inhibition observed Expected inhibition [E (%)] 0.05 0 0 0.25 0 6 0 0.05 29 0.05 0.05 52 29 0.25 0.05 59 33

2 Anilinopyrido 4,6-dimethyl- pyrimidine concentration (Ppm) diniconazole concentration (Ppm) % Inhibition observed Expected inhibition [E (%)] 0.25 0 3 1.25 0 18 0 0.05 12 0 0.25 26 0 1.25 41 0.25 0.05 38 14 0.25 0.25 46 27 0.25 1.25 86 43 1.25 0.05 45 28 1.25 0.25 52 39 1.25 1.25 62 52 1

12) Diniconazole b) Sclerotinia sclerotiorum

2 Anilinopyrido 4,6-dimethyl- pyrimidine concentration (Ppm) diniconazole concentration (Ppm) % Inhibition observed Expected inhibition [E (%)] 0.25 0 1 1.25 0 9 0 0.05 1 0 0.25 2 0.25 0.05 42 0.25 0.25 52 1.25 0.05 43 10! 1.25 0.25 51 ¹¹

(13) Flucquinconazole (a) Fusarium nivale

2 Anilinopyrido 4,6-dimethyl- pyrimidine concentration (Ppm) Flucquinconazole Concentration (ppm) % Inhibition observed Expected inhibition [E (%)] 0.25 0 12 1.25 0 30 í 1 0 0.25 4 1 0 1.25 25 0.25 0.25 29 ¹⁶ 0.25 1.25 37 34 1.25 0.25 40 1.25 1.25 51 47

HU 212 898 Β

14) Tebuconazole a) Botrytis cinerea

2 Anilinopyrido 4,6-dimethyl- pyrimidine concentration (Ppm) tebuconazole concentration (Ppm) % Inhibition observed Expected inhibition [E (%)] 1.25 0 48 0 1.25 66 1.25 1.25 93 82

15) Vinclozolin a) Sclerotium rolfsii

2 Anilinopyrido 4,6-dimethyl- pyrimidine concentration (Ppm) vinclozolin concentration (Ppm) % Inhibition observed Expected inhibition [E (%)] 0.25 0 6 1.25 0 14 0 0.05 0 0.25 0.05 12 6 1.25 0.05 31 27

(16) Benomil (a) Fusarium nivale

2 Anilinopyrido 4,6-dimethyl- pyrimidine concentration (Ppm) Benomil concentration (ppm) % Inhibition observed Expected inhibition [E (%)] 0.25 0 22 0 0.01 0 0.25 0.01 38 22

17) Difenoconazole a) Botrytis cinerea

2 Anilinopyrido 4,6-dimethyl- pyrimidine concentration (Ppm) Difenoconazole concentration (ppm) % Inhibition observed Expected inhibition [E (%)] 1.25 0 30 0 1.25 47 1.25 1.25 72 63

18) Hexaconazole a) Botrytis cinerea

2 Anilinopyrido 4,6-dimethyl- pyrimidine concentration (Ppm) hexaconazole concentration (Ppm) % Inhibition observed Expected inhibition [E (%)] 1.25 0 18 0 0.05 18 0 0.25 41

2 Anilinopyrido 4,6-dimethyl- pyrimidine concentration (Ppm) hexaconazole concentration (Ppm) % Inhibition observed Expected inhibition [E (%)] 0 1.25 75 1.25 0.05 38 32 1.25 0.25 55 51 1.25 1.25 88 79

19) Thiophanate methyl a) Botrytis cinerea

2 Anilinopyrido 4,6-dimethyl- pyrimidine concentration (Ppm) Thiophanate methyl concentration (ppm) % Inhibition observed Expected inhibition [E (%)] 1.25 0 8 0 1.25 1 1.25 1.25 24 15

20) Himexazol a) Botrytis cinerea

2 Anilinopyrido 4,6-dimethyl- pyrimidine concentration (Ppm) hymexazole concentration (Ppm) % Inhibition observed Expected inhibition HERE (%)] 0.25 0 26 1.25 0 40 0 1.25 11 0.25 1.25 51 34 1.25 1.25 87 47

21) Ofurác a) Fusarium nivale

2 Anilinopyrido 4,6-dimethyl- pyrimidine concentration (Ppm) Ofurac Concentration (ppm) % Inhibition observed Expected inhibition [E (%)] 1.25 0 44 0 0.05 2 1.25 0.05 58 46

22) BAS 490F a) Botrytis cinerea

2 Anilinopyrido 4,6-dimethyl- pyrimidine concentration (Ppm) BAS 490F concentration (ppm) % Inhibition observed Expected inhibition [E (%)] 0.05 0 1 1.25 0 37 0 0.05 23

HU 212 898 Β

Concentration of 2-Anilino-4,6-dimethylpyridine (ppm) BAS 490F concentration (ppm) % Inhibition observed Expected inhibition [E (%)] 0 1.25 35 0.05 1.25 46 35 1.25 0.05 65 52

23) ICIA 5504 (a) Botrytis cinerea

Concentration of 2-Anilino-4,6-dimethylpyridine (ppm) ICIA 5504 Concentration (ppm) % Inhibition observed Expected inhibition [E (%)] 0.05 0 3 0 0.05 12 0.05 0.05 29 15

PATENT CLAIMS

Claims (3)

PATENT CLAIMS CLAIMS 1. A fungicidal composition having a synergistic effect, wherein the composition is (a) 2-anilino-4,6-dimethylpyrimidine; and (b) it contains a fungicidal compound selected from: (bj) a conazole-type steroid demethylation inhibitor; or (b ₂ ) tetrachloroisophthalonitrile (chlorothalonil), (b ₃ ) (RS) -1- [3- (4-tert-butylphenyl) -2-methylpropyl] piperidine (fenpropidin), ( b ₄ ) manganese ethylene bis (dithiocarmabate) polymer zinc salt complex (mancoceb), (b ₅ ) tetramethylthiuram disulfide (thiram), (b ₆ ) 3- (3,5-dichlorophenyl) -N-isopropyl-2,4-dioxoimidazolidine-1-carboxamide (iprodione), (by) 3- (3,5-dichlorophenyl) -5-methyl-5-vinyl-1,3-oxazolidine2, 4-dione (vinclozoline), (bg) methyl 1- (butylcarbamoyl) -benzimidazol-2-ylcarbamate (benomyl) (b ₉ ) dimethyl- [4,4 '- (o-phenylene) - bis (3-methylthioallophanate) - (thiophanate-methyl), ( _b10 ) 5-methylisoxazol-3-ol - (himexazole), (b _n ) a-2-chloro-N- (2, 6-xylylacetamido-γ-butyrolactone (ofurac), (b _{) 2} ) methyl (E) -methoxyimino [α- (o-tolyloxy) -o-tolyl] acetate, - (BAS 490 F) and ( _b13 ) methyl (E) -2- {2- [6- (cyanophenoxy) pyrimidin-4-yloxy] phenyl} -3-methoxyacrylate (ICIA 5504), and (a) ) to component (b) in a weight ratio of 25: 1 to 1:25. 2. The composition of claim 1, wherein component (b) comprises tetrachloroisophthalonitrile (chlorothalonil). 3. The composition of claim 1, wherein the component (b) is 3- (2,4-dichlorophenyl) -6-fluoro-2- (1iaz-1,2,4-triazol-1-yl) -. Contains 4 (3H) -quinazolinone (flquinquonazole).