HU193481B - Bleaching and antibacterial, antiviral furthermore fungicide composition - Google Patents

Abstract

The present invention relates to bleaching and bactericidal, viricidal and fungicidal compositions for washing, bleaching, disinfecting and cleaning processes at 20 to 90 ° C, preferably 30 to 60 ° C. The composition comprises 10 to 90% by weight of peroxy compound and 90 to 10% by weight of 1,5-diacylhexahydro-1,3,5-triazine-2,4-dione, preferably sodium perborate, sodium carbonate peroxide or urea. hydrogen peroxide mole compound and 1.5 diacetyl hexa-hydro-1,3,5-triazine 2,4-dione. -1-

Description

BACKGROUND OF THE INVENTION The present invention relates to a bleaching and bactericidal, viricidal and fungicidal agent suitable for use in washing, bleaching, disinfecting and cleaning processes at very low temperatures.

Commercially available cleaners and detergents contain inorganic peroxy compounds, particularly sodium perborate and sodium carbonate peroxy hydrate. It is known that these oxygen-containing bleaches have only a limited bleaching effect below 80 ° C. Antimicrobial activity with conventional detergents can also be achieved above 80 ° C. In the case of heat-sensitive textiles, the sole use of such agents for bleaching and disinfection has only a minor effect.

Special disinfectants such as formaldehyde, phenols, quaternary ammonium salts, heterocyclic compounds (DD 135 287) are generally used to achieve satisfactory antimicrobial activity at moderate temperatures (40 to 60 ° C). They contain relatively high concentrations of disinfectant so that their applicability is limited to a narrow area.

Existing dermatological health requirements do not allow these agents to be used as household detergents.

The proposed antimicrobial hexahydro-1,3,5-lirazin-2,4 diol (DHT) according to DD 149 678 exhibits good antimicrobial activity at about 60 ° C and eliminates this disadvantage, but the oxygen release in peroxide detergents is not improves the bleaching effect at temperatures up to 60 C. The effect corresponds to the typical catalase action of peroxides.

It is known that at low temperatures a better bleaching effect can be achieved with organic peroxide derivatives, in particular with organic peroxides. These peracids have satisfactory antimicrobial activity even at low temperatures, even at low application concentrations. However, the incorporation of such compounds into powder detergents and their handling, as well as their storage stability, is problematic.

It is also known that inorganic peroxide derivatives can be bleached below 80 ° C by the addition of an activator, especially reactive organic N acyl and Oacyl derivatives, and exhibit good antimicrobial activity. Suitable activators include, for example, tetraacetylglycoluryl, tetraacetylethyl diamine, triacetyl cyanurate, pentaacetyl glucose, acetyl salicylic acid and diacetyl diketopiperazine, where tetraacetyl ethylene diamine is already used in detergents. Such compounds react with inorganic peroxide derivatives in aqueous solution to form organic peracids such as per acetic acid which, at low temperatures, have good bleaching activity 2 and antimicrobial activity. One of the main requirements when selecting a suitable activator is the high degree of perhydrolysis leading to the desired formation of organic peracids and possibly a slight tendency to hydrolysis in an alkaline medium which would result in premature loss of activator effect by the formation of inactive salts of organic peracids. Premature reaction of the activator and the inorganic peracid carrier should also be prevented during the storage of commercially available detergents.

Known activators do not solve these problems. The widespread use is hampered by the fact that activators with adequate storage stability have to be used at relatively high concentrations, but do not have the appropriate activating effect and high raw material costs. No generally valid structure-effect relationship is known.

A further disadvantage of known activators is that they are formed during the formation of organic peracids, which do not have a positive effect on the further washing and disinfection process.

It is an object of the present invention to provide a bleaching and bactericidal, viricidal and fungicidal agent for washing, bleaching, disinfecting and cleaning purposes which has good bleaching and broad-spectrum antimicrobial activity at particularly low temperatures. The use of an agent of the present invention at higher temperatures should not lead to more fiber damage than conventional oxidizing bleaches. The storage stability of the bleach, bactericide, virucide and fungicide in bleach disinfectant cleaners shall be ensured, the concentration of application shall be as low as possible and the administration can be solved by conventional technologies. It is another object of the present invention to provide a sustained antimicrobial activity.

The object of the present invention has been solved by the preparation of an agent in which a peroxide derivative is combined with an activator having antimicrobial properties, the agent being an effective bleaching agent and a bactericidal, viricidal and fungicidal agent at 20 to 90 ° C. preparation.

The composition of the invention contains 10 to 90% by weight of one or more peroxide derivatives and 90 to 10% by weight of 1.5 diacyl hexahydro-1,3,5-triazine 2,4-dione (DAHT), optionally known as washing, bleaching, disinfectant and / or or with detergent components,

More particularly, the composition of the present invention comprises 30 to 70% by weight of a peroxide derivative and 70 to 30% by weight of 1.5 diacyl hexahydro-1,3,5-triazine-2,4 dione. A preferred combination consists of sodium perborate, sodium carbonate peroxohydrate or urea perhydrate and 1.5 diacetyl hexahydro-1,3,5-triazine 2,4 dione.

1,5-Diacyl-hexahydro-1,3,5-triazine can be prepared by subsequent acylation of formaldehyde and urea 2,4-2193481, for example as described by A. Piskala, I. Gut, Coll. Czech. Chem., Cmmun 27, 1562 (1962) or G. Ostrogovich, R. Vidac, Rev. Chim (Bucharest), 20 (10) 606 (1960).

The bleaching and bactericidal, viricidal and fungicidal compositions preferably contain, in addition to the combination of 5 to 95% by weight, preferably 1050% by weight of the invention, further known disinfectant components.

It is also advantageous to add the combination to a known detergent composition in an amount of 1 to 30% by weight, preferably 5 to 15% by weight.

Surprisingly, perhydrolysis and hydrolysis of the 1,5 diacetylhexahydro-1,3,5-triazine 2,4-dione bleach activator is complete and the remaining hexahydro 1,3,5-triazine 2,4-dione base group is not oxidatively degraded under the washing conditions. Thus, the disinfectant effect of the compound disclosed in DD-A-149 678 can be utilized, so that the specific antimicrobial activity of organic peracids, which are only effective for a short time in alkaline solution, is the hexahydro 1,3,5-triazine 2,4-di 1,5-diacetylhexahydro-1,3,5-triazine-2,4-dione has a significantly higher activating activity against inorganic peroxide derivatives compared to known activators and has good storage stability in detergent bleach disinfectants and detergents

Dia cetyl diketopiperazine has a similar activating effect. However, this prior art activator is particularly sensitive to hydrolysis and is thus virtually useless in detergents.

The composition of the present invention is non-skin and mucosal, non-toxic and non-corrosive for use in both industry and household applications. Application experiments show that, against conventional peroxide-containing bleaching agents and known activators, no increased fiber loss effect is observed on treated fabrics.

The invention is illustrated by the following examples.

Example 1

A bleach and antimicrobial agent was prepared from 50 wt.% Sodium perborate and 50 w / w 1.5 diacetylhexahydro 1,3,5 triazine 2.4 dione gels.

For the preparation of low temperature bleach and anti-microbial detergent, 14% by weight of the agent of the invention and 86% of conventional detergent without perborate were added (Formula A). Comparatively, weights of the following known bleach activators were tested:

pentaacetyl glucose Formula B acetyl salicylic acid Form C tetraacetyl ethylene diamine Form D tetraacetyl glycoluril Form E diacetyldicopiperazine Form F

The efficacy of the composition of the invention was tested in a Scourotester laboratory washing machine (washing time: 35 minutes, concentration: 5 g / l, fleet ratio: 1:80, temperature: 60 ° C) under conditions similar to practice.

We used a cotton green dyed B textile fabric with a sensitivity to oxidants equivalent to that of Immedial dyed BTM dyed textiles.

Evaluation was based on the difference in the degree of remission (R) measured before and after washing.

Table 1

Recipe A B C D E F R 18.5 13.9 13.9 15.9 16.2 18.7

To assess storage stability, 28 g of Formulation F formulation was filled into CEK boxes and stored at 20-25 ° C for 50 weeks at 5070 relative air humidity and then measured for active oxygen loss (jo).

spreadsheet

Recipe A B C D E F

Active Oxygen Loss (Jo) 26 18 40 24 25 80

Example 2

To test the antimicrobial efficacy, we have prepared the following bleach and antimicrobial agent:

11.8 jo. 1.5 diacetylhexahydro 1.3.5 triazine 2.4 dione and 88.2 jo. Sodium perborate

Of this agent, 17% by weight was mixed with 83% by weight of a conventional detergent containing no perborate (Formula G). To provide conditions similar to practice, sterile linen pieces were soaked in standard test germ suspension for 15 minutes. After drying, the linen pieces were placed in detergent solution according to Formula G and kept at the test temperature for 60 minutes and then rinsed twice with distilled water. The material samples were then placed on a suitable medium containing an antimicrobial excipient.

Evaluation was performed after incubation for 6 days at 37 ° C on the basis of the following items:

- complete killing of test germs

- satisfactory efficiency

- medium efficiency

- poor efficiency

- no effect.

The following microorganisms were used as test germs:

(1) Staphylococcus aureus SG 511 (2) Escherichia coli FMH 3 (3) Pseudomonas eruginosa RDL 1

Comparison was made with an agent containing the same amount of hexahydro-1,3,5-triazine-2,4 dione (Formula H).

-3193481

Table 3

Temperature 40 C 50 ° C 60 Germ test $ 1 2 1 2 3 1 2 G recipe 0 0 0 0 0 0 0 0 H formula 3 0 3 2 0 0 0 0

Example 3

Low temperature bleach and antimicrobial 0.5% detergent solution (Formula I) was prepared from 84% by weight non-bleach detergent, 8% by weight hydrogen peroxide (30%) and 8% by weight 1,5-diacetylhexahydro-1,3 , 5-triazine-2,4-dione bleach activator. The efficacy of the bleach activator of the present invention was tested using A-I formulations. The experimental conditions and evaluation were the same as described in Example 1.

Table 4

Recipe A B C D E FI R 18.5 13.9 13.9 15.8 16.2 18.7 18.1

Example 4

A bleaching and antimicrobial agent was prepared from 38.5% by weight of urea hydrogen peroxide and 61.5% by weight of 1,5-diacetylhexahydro-1,3,5-triazine 2,4-dione. Of this agent, 23% by weight was mixed with 77% by weight of a conventional perborate-free detergent (Formula K). For comparison, standard formulations containing no bleach activator were used. The efficacy of the agent of the invention was tested for A K formulations. Experimental conditions and evaluation were performed as described in Example 1.

Table 5 Recipe

A B C D E F I K R 18.5 13.9 13.9 15.9 16.2 18.7 18.1 18.4

Claims (5)

PATENT CLAIMS Bleaching and bactericidal, viricidal and fungicidal agents for washing, bleaching, disinfecting and cleaning purposes at temperatures between 20 and 90 ° C, preferably 10 to 30 ° C and 60 ° C, characterized in that 10 to 90% by weight of one or more peroxide derivatives and 90 to 10% by weight of 1,5-diacylhexahydro15 with known detergent-bleach, disinfectant and / or cleaning components Contains a component consisting of -1,3,5-triazine-2,4-dione. 2. An agent according to claim 1, characterized in that 30 to 70% by weight of one or more peroxide derivatives and 70 to 30% by weight of 1,5-dia20 cyhexahydro-1,3,5-triazine-2,4 contains a dione component. 3. An agent according to claim 1 or 2, characterized in that it is formed from sodium perborate, sodium carbonate peroxohydrate or a molar compound of carbamide hydrogon peroxide and 1,5-diacetylhexahydro-1,3,5-triazine-2. , Contains a 4-dione component. An agent according to any one of claims 1 to 3, characterized in that it is present in an amount of 5 to 95% by weight 30% to 10% to 50% by weight of a combination according to the invention with known disinfectants. 5. An agent according to any one of claims 1 to 3, characterized in that it is in the range of 1-30% by weight, 35 preferably contains from 5 to 15% by weight of a combination according to the invention with known compositions and detergents.