HU181842B - Spraying device for pharmaceutical aerosol preparations - Google Patents

Abstract

The invention relates to a sprayer used, in particular for the introduction of aerosols in the respiratory or buccal routes of pharmaceutical products. According to the invention, the sprayer comprises a receptacle having at its upper end a tubular end portion of a hollow end inwardly provided in said portion with some inner ribs which come into contact with the container, allowing the air to penetrate into the head, both said portion as well as an upper tubular portion having inner dimensions larger than those of an intermediate portion of the head wherein, in the interior, a nozzle and a seat are provided together by a channel. In the upper end portion a safety and closure part of this portion is inserted in the upper portion to prevent undesired opening of the container, provided at an outer end with a closure closing it having an edge which is in contact with an inner end which is being inclined being free and being provided with a lower recess in which the tubular body passes, such that by moving downwardly of the head, the inner end of said article contacts a valve support and is unable to realize the opening of the container.

Description

German Democratic Republic

Aerosol dispenser for pharmaceutical aerosol formulations

2

The present invention relates to a nebulizer for pharmaceutical aerosol formulations, such as inhalation or pharmaceutical formulations for oral administration.

Pharmaceutical formulations are often formulated as "sprays" for improved revenue. In these cases, the active ingredients are contained in a pressurized gas bottle. In order to deliver the active ingredient to the parts of the body to be treated, nebulizers of various designs are used. For inhalants, for example, the nebuliser is intended to deliver the composition orally to the respiratory tract. Most of these inhalers are used to combat asthma.

In order to ensure that the active ingredients of these formulations are rapidly and safely delivered to the lung bladders, the construction of a nebulizer is crucial.

Inhalation of pharmaceutical aerosol formulations is generally accomplished by means of nebulizers 20 having a rectangular and tubular metering unit. In these cases, one leg of the rectangular metering unit is placed on the core tube of the valve of the pressure gas cylinder, while the other leg is inserted into the mouth of the person being treated during use. The 25 gas cylinders must be held down with the valve in use.

It is also known to have an atomizer in which one leg of the rectangular metering unit, which is placed on the valve, is not surrounded. A cap is used to prevent contamination of the mouth ³⁰ . The disadvantage of this design is that the valve core tube may break at the elbow point of the nebulizer during use, rendering the entire structure unusable. A further drawback is that when the nozzle is depressed, the gap between the pressure gas cylinder and the nozzle may be closed. This, in turn, prevents inhalation and consequently leads to imperfect inhalation.

In addition, if, for example, the subject is carried in the pocket by the subject to be treated, accidental actuation of the above structures is not prevented.

Another embodiment is known in which one leg of the rectangular dispenser is extended as a guide sleeve and extends to the bottom of the pressure gas cylinder. This design, on the one hand, is very material-intensive and, on the other hand, the guide sleeve must be made of transparent material in order to be able to read the label of the filling. In the case of a difference in the diameter of the pressure gas cylinder, this device does not provide the inlet air for inhalation.

Also known is a nebulizer device which is provided with air inlets at the upper point of the nebulizer. A disadvantage of this design is that these openings may become contaminated when carrying the charge.

In a further known embodiment, after removing the lid, an inner tube is to be pulled out of the tube entering the mouth, thereby releasing the lock in the valve and then actuating the nebulizer.

This last-mentioned nebulizer requires significantly higher manufacturing costs and its handling is quite complicated and difficult, considering that asthmatic patients often use such structures in a panic state, whereby its easy and quick handling is a crucial consideration.

It is an object of the present invention to overcome the above shortcomings.

Accordingly, it is an object of the present invention to provide an aerosolization device for pharmaceutical aerosol formulations which eliminates core fractures resulting from non-uniaxial fitting of the tube and the nebulizer, and whereby inadvertent operation and inhalation of air inlet and inlet air is prevented. . It is also an objective that the nebulizer structure is simple in construction and handling, and requires relatively little material use.

To accomplish this object, we have started with a nebulizer for pharmaceutical aerosol formulations having a rectangular tubular metering unit and a locking or securing unit 30. This has been further developed in accordance with the present invention by providing the locking overlock fuse unit as an open, oblique-cut cylinder on one side, with a recess on its side and an expanding portion of the dosing unit and a guide sleeve having its inner circumference is provided with at least three equally spaced grooves along the circumference.

The atomizer is placed vertically on the pressure gas bottle. In the retracted position of the locking or securing unit, the core tube is located in the recess. In this condition, actuation is precluded because the side surfaces of the closure and fuse assembly on both sides of the core tube rest on the valve seat.

When the closure or fuse assembly is pulled out, the core tube extends into the nebulizer, so that when the metering unit is pressed, the valve of the pressure gas cylinder can be operated. The guide sleeve surrounds the diaphragm of the pressurized gas cylinder, thereby eliminating misalignment due to improper assembly.

The grooves on the inside of the guide sleeve provide a constant supply of air.

The invention will now be described in more detail with reference to the drawing, which shows an exemplary embodiment of the invention.

In the drawing:

Fig. 1 is a sectional view of an exemplary embodiment of the nebulizer according to the invention with a pressurized gas cylinder;

Figure 2 is a top plan view of a locking or securing assembly;

Figure 3 is a sectional view taken along line III-ΠΙ in Figure 2;

Figure 4 is a sectional view of the dispensing unit according to the invention;

Figure 5 is a side view of the solution of Figure 4;

Figure 6 is a bottom view of the solution of Figure 4.

When the nebulizer is not in use, the metering unit 1 of the closing or securing unit 2 is retracted. Meanwhile, the core tube 9 is located in the recess 4 of the closure and locking unit 2, and the two protruding legs of the locking and locking unit 2 are resting on the valve holder, thereby preventing the valve from being actuated. Figure 1 shows an embodiment of the nebulizer according to the invention without the closing or securing unit 2.

The closure or locking unit 2 is also intended to protect the metering unit 1 from being contaminated when in position. The dispensing unit 1 is provided with a spray unit 3 consisting _{of a} nozzle 3 _A and a connection sleeve 3 _B (Fig. 4). One leg of the dispensing unit 1 has an expanding portion 5 to which a guide sleeve 7 is then connected. The inner surface of the guide sleeve 7 has grooves 6. At least three such air inlet grooves 6 are required according to the invention, which are evenly distributed along the circumference of the guide sleeve 7. In this case, the guide sleeve 7 is provided with four grooves 6 (Fig. 6). The guide sleeve 7 surrounds the pressurized gas cylinder 8, thereby eliminating the kernel fracture resulting from the non-uniaxial introduction of the pressurized gas cylinder 8.

Claims (1)

Spraying device for pharmaceutical aerosol formulations having a rectangular tubular metering unit (1) and a locking or securing unit (2), characterized in that it is formed on one side of the closing or securing unit (2) as an open, oblique cut cylinder. 4) is provided with a flange on the sealed side, and the expanding portion of the dispensing unit (1) has a guide sleeve ⁵⁵ (5) and a connecting sleeve (7) connected thereto, at least three longitudinally spaced along the periphery of the guide sleeve a groove (6) is provided.