HU180620B - Process for preparing derivatives of 2,3-indole-dione - Google Patents

Process for preparing derivatives of 2,3-indole-dione Download PDF

Info

Publication number
HU180620B
HU180620B HU80802878A HU287880A HU180620B HU 180620 B HU180620 B HU 180620B HU 80802878 A HU80802878 A HU 80802878A HU 287880 A HU287880 A HU 287880A HU 180620 B HU180620 B HU 180620B
Authority
HU
Hungary
Prior art keywords
formula
compound
methyl
pharmaceutically acceptable
acid addition
Prior art date
Application number
HU80802878A
Other languages
English (en)
Hungarian (hu)
Inventor
Graham A Fothergill
John M Osbond
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HU180620B publication Critical patent/HU180620B/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/38Oxygen atoms in positions 2 and 3, e.g. isatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HU80802878A 1979-12-07 1980-12-03 Process for preparing derivatives of 2,3-indole-dione HU180620B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7942324 1979-12-07

Publications (1)

Publication Number Publication Date
HU180620B true HU180620B (en) 1983-03-28

Family

ID=10509706

Family Applications (1)

Application Number Title Priority Date Filing Date
HU80802878A HU180620B (en) 1979-12-07 1980-12-03 Process for preparing derivatives of 2,3-indole-dione

Country Status (16)

Country Link
US (1) US4395559A (cg-RX-API-DMAC10.html)
EP (1) EP0030380A1 (cg-RX-API-DMAC10.html)
JP (1) JPS5695167A (cg-RX-API-DMAC10.html)
AR (1) AR226869A1 (cg-RX-API-DMAC10.html)
AU (1) AU6494680A (cg-RX-API-DMAC10.html)
DK (1) DK522180A (cg-RX-API-DMAC10.html)
ES (1) ES8205770A1 (cg-RX-API-DMAC10.html)
FI (1) FI803727L (cg-RX-API-DMAC10.html)
GR (1) GR72136B (cg-RX-API-DMAC10.html)
HU (1) HU180620B (cg-RX-API-DMAC10.html)
IL (1) IL61603A0 (cg-RX-API-DMAC10.html)
MC (1) MC1357A1 (cg-RX-API-DMAC10.html)
NO (1) NO803693L (cg-RX-API-DMAC10.html)
NZ (1) NZ195702A (cg-RX-API-DMAC10.html)
PT (1) PT72176B (cg-RX-API-DMAC10.html)
ZA (1) ZA807494B (cg-RX-API-DMAC10.html)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4593106A (en) * 1984-06-04 1986-06-03 Smithkline Beckman Corporation 4-[2-(dialkylamino)ethyl]-7-hydroxyisatins
US4847863A (en) * 1985-10-03 1989-07-11 Watson Bruce W Expandable modular data modem
AR016384A1 (es) * 1997-07-30 2001-07-04 Smithkline Beecham Corp Inhibidores de caspasas, composiciones farmaceuticas que comprenden dichos inhibidores de caspasas y uso de los inhibidores de caspasas para prepararun medicamento util para el tratamiento de apoptosis y desordenes asociados con excesiva actividad de la convertosa il-1 beta.
ATE473759T1 (de) 1998-05-22 2010-07-15 Univ Leland Stanford Junior Bifunktionelle moleküle sowie darauf basierende therapien.
EP1554572B1 (en) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
CN101287411B (zh) 2005-04-28 2013-03-06 普罗秋斯生物医学公司 药物信息系统及其用途
EP2063905B1 (en) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
HUE059078T2 (hu) 2009-02-20 2022-10-28 Enhanx Biopharm Inc Glutation-alapú hatóanyagszállító rendszer
KR101909711B1 (ko) 2009-05-06 2018-12-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1778174A (en) * 1926-05-30 1930-10-14 Gen Aniline Works Inc Substituted isatins and process of preparing them
GB1069343A (en) * 1963-09-10 1967-05-17 Ici Ltd Propanolamine derivatives
CH472404A (de) * 1966-03-04 1969-05-15 Sandoz Ag Verfahren zur Herstellung neuer Indolderivate
SE379196B (cg-RX-API-DMAC10.html) * 1971-06-24 1975-09-29 Sandoz Ag
US4137331A (en) * 1974-06-19 1979-01-30 Sandoz Ltd. 3-Piperidino-2-hydroxypropoxy substituted-2-indolinones
US4212804A (en) * 1978-12-04 1980-07-15 Sandoz, Inc. Process for the preparation of optionally substituted 2,3-indolinediones

Also Published As

Publication number Publication date
PT72176B (en) 1982-07-05
FI803727A7 (fi) 1981-06-08
NZ195702A (en) 1984-09-28
FI803727L (fi) 1981-06-08
PT72176A (en) 1981-01-01
MC1357A1 (fr) 1981-08-10
DK522180A (da) 1981-06-08
AR226869A1 (es) 1982-08-31
IL61603A0 (en) 1981-01-30
JPS5695167A (en) 1981-08-01
ES497530A0 (es) 1982-07-01
US4395559A (en) 1983-07-26
NO803693L (no) 1981-06-09
GR72136B (cg-RX-API-DMAC10.html) 1983-09-20
ES8205770A1 (es) 1982-07-01
AU6494680A (en) 1981-06-11
EP0030380A1 (de) 1981-06-17
ZA807494B (en) 1981-11-25

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