HRP20240473T1 - Pripravci za liječenje patogenih infekcija - Google Patents
Pripravci za liječenje patogenih infekcija Download PDFInfo
- Publication number
- HRP20240473T1 HRP20240473T1 HRP20240473TT HRP20240473T HRP20240473T1 HR P20240473 T1 HRP20240473 T1 HR P20240473T1 HR P20240473T T HRP20240473T T HR P20240473TT HR P20240473 T HRP20240473 T HR P20240473T HR P20240473 T1 HRP20240473 T1 HR P20240473T1
- Authority
- HR
- Croatia
- Prior art keywords
- acid
- preparation
- anhydrous
- oxidizing
- liquid medium
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 2
- 208000015181 infectious disease Diseases 0.000 title 1
- 230000001717 pathogenic effect Effects 0.000 title 1
- 230000001590 oxidative effect Effects 0.000 claims 8
- 239000002253 acid Substances 0.000 claims 6
- 238000002360 preparation method Methods 0.000 claims 6
- 239000007788 liquid Substances 0.000 claims 4
- XTEGARKTQYYJKE-UHFFFAOYSA-M Chlorate Chemical compound [O-]Cl(=O)=O XTEGARKTQYYJKE-UHFFFAOYSA-M 0.000 claims 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 2
- 238000010521 absorption reaction Methods 0.000 claims 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 2
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 1
- ZKQDCIXGCQPQNV-UHFFFAOYSA-N Calcium hypochlorite Chemical compound [Ca+2].Cl[O-].Cl[O-] ZKQDCIXGCQPQNV-UHFFFAOYSA-N 0.000 claims 1
- 239000004155 Chlorine dioxide Substances 0.000 claims 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- 229960004543 anhydrous citric acid Drugs 0.000 claims 1
- BLUAFEHZUWYNDE-NNWCWBAJSA-N artemisinin Chemical compound C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2OC(=O)[C@@H]4C BLUAFEHZUWYNDE-NNWCWBAJSA-N 0.000 claims 1
- 229960004191 artemisinin Drugs 0.000 claims 1
- 229930101531 artemisinin Natural products 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 229940005989 chlorate ion Drugs 0.000 claims 1
- XTEGARKTQYYJKE-UHFFFAOYSA-N chloric acid Chemical compound OCl(=O)=O XTEGARKTQYYJKE-UHFFFAOYSA-N 0.000 claims 1
- 229940005991 chloric acid Drugs 0.000 claims 1
- 235000019398 chlorine dioxide Nutrition 0.000 claims 1
- QBWCMBCROVPCKQ-UHFFFAOYSA-M chlorite Chemical compound [O-]Cl=O QBWCMBCROVPCKQ-UHFFFAOYSA-M 0.000 claims 1
- 229910001919 chlorite Inorganic materials 0.000 claims 1
- 229910052619 chlorite group Inorganic materials 0.000 claims 1
- 229940005993 chlorite ion Drugs 0.000 claims 1
- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical compound OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 239000000174 gluconic acid Substances 0.000 claims 1
- 235000012208 gluconic acid Nutrition 0.000 claims 1
- 229960000443 hydrochloric acid Drugs 0.000 claims 1
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 claims 1
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 239000007937 lozenge Substances 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 230000014759 maintenance of location Effects 0.000 claims 1
- 239000001630 malic acid Substances 0.000 claims 1
- 235000011090 malic acid Nutrition 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- 239000006186 oral dosage form Substances 0.000 claims 1
- 235000006408 oxalic acid Nutrition 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims 1
- 235000015497 potassium bicarbonate Nutrition 0.000 claims 1
- 239000011736 potassium bicarbonate Substances 0.000 claims 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 1
- 235000017557 sodium bicarbonate Nutrition 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Claims (1)
1. Farmaceutski pripravak koji sadrži kruti pripravak bez otapala,
koji sadrži jednu ili više oksidirajućih komponenti odabranih od natrijevog, kalijevog, magnezijevog ili kalcijevog hipoklorita, klorita ili klorata, artemisinin oksidirajuće komponente,
koji sadrži bezvodnu kiselinu odabranu od bezvodne limunske kiseline, glukonske kiseline, mliječne kiseline, oksalne kiseline, vinske kiseline, jabučne kiseline, askorbinske kiseline, stearinske kiseline ili smjese dviju ili više navedenih kiselina,
pri čemu se navedena jedna ili više oksidirajućih komponenti mogu dispergirati ili otopiti u vodenom tekućem mediju, i
pri čemu disperzija ili otapanje navedene jedne ili više oksidirajućih komponenti u vodenom tekućem mediju koji sadrži bezvodnu kiselinu sadržanu u krutom pripravku bez otapala, rezultira oslobađanjem ili stvaranjem hipokloritnog iona ili hipokloraste kiseline, kloritnog iona ili kloridne kiseline, kloratnog iona ili klorne kiseline, molekularnog ili ionskog klorovog dioksida unutar vodenog tekućeg medija,
pri čemu navedeni pripravak sadrži količinu oksidirajuće komponente koja ne prelazi oko 5% m/m ukupne težine pripravka, za apsorpciju kroz usta ili bukalnu šupljinu toplokrvnog sisavca,
pri čemu je navedena jedna ili više oksidirajućih komponenti blisko pomiješana s bezvodnom kiselinom, i
naznačen time što je navedeni farmaceutski pripravak predviđen kao oralni oblik doziranja u obliku topive pastile za zadržavanje u ustima ili bukalnoj šupljini toplokrvnog subjekta sisavca, za oslobađanje navedene jedne ili više oksidirajućih komponenti u vodeni tekući medij koji sadrži bezvodnu kiselinu, istodobnim oslobađanjem navedene bezvodne kiseline u sadržaj sline bukalne šupljine i time omogućava izravnu sistemsku apsorpciju oksidirajuće komponente kroz usta ili bukalnu šupljinu toplokrvnog subjekta sisavca,
u kojoj pripravak sadrži udio natrijevog bikarbonata ili kalijevog bikarbonata ili njihove kombinacije, koji je veći od oko 30% m/m ukupne težine pripravka.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH599202017 | 2017-05-04 | ||
| EP18723791.2A EP3618826B1 (en) | 2017-05-04 | 2018-05-04 | Compositions for the treatment of pathogenic infections |
| PCT/EP2018/061607 WO2018202897A1 (en) | 2017-05-04 | 2018-05-04 | Compositions and treatment procedures for the treatment of pathogenic infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20240473T1 true HRP20240473T1 (hr) | 2024-07-05 |
Family
ID=91668307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20240473TT HRP20240473T1 (hr) | 2017-05-04 | 2018-05-04 | Pripravci za liječenje patogenih infekcija |
Country Status (3)
| Country | Link |
|---|---|
| ES (1) | ES2975418T3 (hr) |
| HR (1) | HRP20240473T1 (hr) |
| RS (1) | RS65512B1 (hr) |
-
2018
- 2018-05-04 HR HRP20240473TT patent/HRP20240473T1/hr unknown
- 2018-05-04 ES ES18723791T patent/ES2975418T3/es active Active
- 2018-05-04 RS RS20240554A patent/RS65512B1/sr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2975418T3 (es) | 2024-07-05 |
| RS65512B1 (sr) | 2024-06-28 |
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