HRP20210496T1 - Novi pripravci i postupci liječenja raka - Google Patents
Novi pripravci i postupci liječenja raka Download PDFInfo
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- HRP20210496T1 HRP20210496T1 HRP20210496TT HRP20210496T HRP20210496T1 HR P20210496 T1 HRP20210496 T1 HR P20210496T1 HR P20210496T T HRP20210496T T HR P20210496TT HR P20210496 T HRP20210496 T HR P20210496T HR P20210496 T1 HRP20210496 T1 HR P20210496T1
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- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 1
- 229960004355 vindesine Drugs 0.000 claims 1
- UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 claims 1
- 229960002066 vinorelbine Drugs 0.000 claims 1
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 claims 1
- ZPUHVPYXSITYDI-HEUWMMRCSA-N xyotax Chemical compound OC(=O)[C@@H](N)CCC(O)=O.O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 ZPUHVPYXSITYDI-HEUWMMRCSA-N 0.000 claims 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (14)
1. Kombinacija koja sadrži:
prvo sredstvo, kojeg se bira iz skupine koju čine 2-(1-hidroksietil)nafto[2,3-b]furan-4,9-dion, 2-acetil-7-klornafto[2,3-b]furan-4,9-dion, 2-acetil-7-fluornafto[2,3-b]furan-4,9-dion, 2-acetilnafto[2,3-b]furan-4,9-dion, 2-etilnafto[2,3-b]furan-4,9-dion i njegova farmaceutski prihvatljiva sol ili solvat, ili farmaceutski pripravak koji sadrži prvo sredstvo; i
drugo sredstvo;
naznačena time što je namijenjena upotrebi u:
(i) postupku inhibiranja matičnih stanica raka radi liječenja raka kod subjekta, gdje se postupak sastoji u primjeni na subjektu prve količine prvog sredstva radi inhibiranja populacije matičnih stanica raka, te a druge količine drugog sredstva radi inhibiranja više normalnih stanica raka;
(ii) postupku liječenja subjekta od raka koji ne reagira na standardno liječenje, gdje se postupak sastoji u primjeni na subjektu terapijski djelotvorne količine prvog sredstva i drugog sredstva;
(iii) postupku liječenja ili sprječavanja recidiva raka kod subjekta, gdje se postupak sastoji u primjeni na subjektu terapijski djelotvorne količine prvog sredstva i drugog sredstva;
(iv) postupku liječenja ili sprječavanja metastaza raka kod subjekta, gdje se postupak sastoji u primjeni na subjektu terapijski djelotvorne količine prvog sredstva i drugog sredstva; ili
(v) postupku inhibiranja matičnih stanica raka radi liječenja raka kod subjekta, gdje se postupak sastoji u primjeni na subjektu terapijski djelotvorne količine prvog sredstva i drugog sredstva, gdje je drugo sredstvo protutumorsko sredstvo kojeg se bira iz skupine koju čine sredstvo koje oštećuje DNA, protumitotsko sredstvo, te antimetabolitno sredstvo.
2. Kombinacija namijenjena upotrebi u skladu s patentnim zahtjevom 1, naznačena time što je prvo sredstvo 2-acetilnafto[2,3-b]furan-4,9-dion, ili njegova farmaceutski prihvatljiva sol ili solvat.
3. Kombinacija namijenjena upotrebi u skladu s patentnim zahtjevom 1 ili 2, naznačena time što je drugo sredstvo:
(a) sredstvo koje oštećuje DNA, koje je alkilirajuće sredstvo, inhibitor topoizomeraze i/ili interkalator DNA;
(b) protumitotsko sredstvo, kojeg se bira između paklitaksela, taksola, docetaksela, BMS-275183, Xyotaxa, Tocosala, vinorelbina, vinkristina, vinblastina, vindesina, vinzolidina, etopozida, tenipozida, iksabepilona, larotaksela, ortataksela, tesetaksela, te ispinesiba; i/ili
(c) antimetabolitno sredstvo, kojeg se bira između fluoruracila (5-FU), floksuridina, metotreksata, kapecitabina, Arranona, leukovorina, hidroksiuree, tiogvanina, merkaptopurin, citarabina, pentostatina, fludarabin-fosfata, kladribina, asparaginaze, gemcitabina, pemetrekseda, bortezomiba, aminopterina, raltitrekseda, klofarabina, enocitabina, sapacitabina, te azacitidina.
4. Kombinacija namijenjena upotrebi u skladu s patentnim zahtjevom 3(a), naznačena time što:
(a) alkilirajuće sredstvo se bira između klorambucila, ciklofosfamida, ifosfamida, mekloretamina, melfalana, uracilnog iperita, tiotepe, busulfana, karmustina, lomustina, streptozocina, karboplatina, cisplatina, satraplatina, oksaliplatina, altretamina, ET-743, XL119, dakarbazina, klormetina, bendamustina, trofosfamida, uramustina, fotemustina, nimustina, prednimustina, ranimustina, semustina, nedaplatina, triplatina, tetranitrata, manosulfana, treosulfana, temozolomida, karbokvona, triazikvon, trietilenmelamina, te prokarbazin;
(b) inhibitor topoizomeraze se bira između doksorubicina, daunorubicina, epirubicina, idarubicina, antracendiona, mitoksantron, mitomicina C, bleomicina, daktinomicina, plikatomicina, irinotekana, kamptotecina, rubitekana, belotekana, etopozida, tenipozida, te topotekana; i/ili
(c) interkalator DNA se bira između proflavina, doksorubicina, daunorubicina, daktinomicina, te talidomida.
5. Kombinacija namijenjena upotrebi u skladu s bilo kojim od patentnih zahtjeva 1 do 4, naznačena time što je prvo sredstvo 2-acetilnafto[2,3-b]furan-4,9-dion, a drugo sredstvo se bira iz skupine koju čine paklitaksel, gemcitabin, kapecitabin, fluoruracil (5-FU), leukovorin, oksaliplatin, karboplatin, temozolomid, bortezomib, te irinotekan.
6. Kombinacija namijenjena upotrebi u skladu s bilo kojim od patentnih zahtjeva 1-5, naznačena time što se rak bira iz skupine koju čine rak dojke, rak glave i vrata, rak pluća, rak jajnika, rak gušterače, kolorektalni karcinom, rak prostate, karcinom bubrežnih stanica, melanom, hepatocelularni karcinomi, rak vrata maternice, karcinom endometrija, sarkomi, rak pločastih stanica, tumori na mozgu, rakovi želuca, gastrointestinalni rakovi, rak mokraćnog mjehura, multipli mijelom, leukemija, te limfom.
7. Kombinacija koja sadrži:
prvo sredstvo, kojeg se bira iz skupine koju čine 2-(1-hidroksietil)nafto[2,3-b]furan-4,9-dion, 2-acetil-7-klornafto[2,3-b]furan-4,9-dion, 2-acetil-7-fluornafto[2,3-b]furan-4,9-dion, 2-acetilnafto[2,3-b]furan-4,9-dion, 2-etilnafto[2,3-b]furan-4,9-dion i njegova farmaceutski prihvatljiva sol ili solvat, ili farmaceutski pripravak koji sadrži prvo sredstvo; i
drugo sredstvo;
naznačena time što je namijenjena upotrebi u:
(i) postupak inhibiranja aktivnosti puta Stat3 u stanici in vivo, koji se sastoji u primjeni na stanici djelotvorne količine prvog sredstva kao inhibitora puta Stat3 i drugog sredstva, tako da u se najmanju ruku smanji aberantna aktivnost puta Stat3 u stanici;
(ii) postupku liječenja ili sprječavanja poremećaja povezanog s aberantnom aktivnošću puta Stat3 kod subjekta, gdje se postupak sastoji u primjeni na subjektu terapijski djelotvorne količine prvog sredstva i drugog sredstva, tako da se najmanju ruku smanji aberantna aktivnost puta Stat3 u stanici;
(iii) postupku inhibiranja matičnih stanica raka radi liječenja raka kod subjekta, gdje se postupak sastoji u primjeni na subjektu prve količine prvog sredstva radi inhibiranja populacije matičnih stanica raka, te a druge količine drugog sredstva radi inhibiranja više normalnih stanica raka;
(iv) postupku liječenja subjekta od raka koji ne reagira na standardno liječenje, gdje se postupak sastoji u primjeni na subjektu terapijski djelotvorne količine prvog sredstva i drugog sredstva;
(v) postupku liječenja ili sprječavanja recidiva raka kod subjekta, gdje se postupak sastoji u primjeni na subjektu terapijski djelotvorne količine prvog sredstva i drugog sredstva;
(vi) postupku liječenja ili sprječavanja metastaza raka kod subjekta, gdje se postupak sastoji u primjeni na subjektu terapijski djelotvorne količine prvog sredstva i drugog sredstva;
(vii) postupku inhibiranja matičnih stanica raka radi liječenja raka kod subjekta, gdje se postupak sastoji u primjeni na subjektu terapijski djelotvorne količine prvog sredstva i drugog sredstva; ili
(viii) postupku liječenja raka kod subjekta, gdje se postupak sastoji u primjeni na subjektu prve količine prvog protutumorskog sredstva radi inhibiranja aktivnosti puta Stat3 i druge količine drugog sredstva kao inhibitora matičnih stanica raka radi inhibiranja aktivnosti različitog puta;
gdje se drugo sredstvo bira iz skupine koju čine sredstvo koje cilja na receptor čimbenika rasta i inhibitor tirozinskih kinaza.
8. Kombinacija namijenjena upotrebi u skladu s patentnim zahtjevom 7, naznačena time što je prvo sredstvo 2-acetilnafto[2,3-b]furan-4,9-dion, ili njegova farmaceutski prihvatljiva sol ili solvat.
9. Kombinacija namijenjena upotrebi u skladu s patentnih zahtjeva 7 ili 8, naznačena time što su druga sredstva:
(a) sredstvo koje cilja na receptor čimbenika rasta, kojeg se bira između gefitiniba, erlotiniba, PD153035, cetuksimaba, bevacizumab, panitumumaba, trastuzumaba, te protutijelo protiv c-Met;
(b) inhibitor tirozinskih kinaza, kojeg se bira između erlotiniba, sutenta, lapatiniba, sorafeniba, vandetaniba, aksitiniba, bosutiniba, cediraniba, dasatiniba, gefitiniba, imatiniba, lestaurtiniba i ARQ197.
10. Kombinacija namijenjena upotrebi u skladu s bilo kojim od patentnih zahtjeva 7 do 9, naznačena time što je prvo sredstvo 2-acetilnafto[2,3-b]furan-4,9-dion, ili njegova farmaceutski prihvatljiva sol ili solvat, a drugo sredstvo se bira iz skupine koju čine panitumumab, cetuksimab, bevacizumab, sorafenib, te imatinib.
11. Kombinacija namijenjena upotrebi u skladu s bilo kojim od patentnih zahtjeva 7 do 9, naznačena time što je prvo sredstvo 2-acetilnafto[2,3-b]furan-4,9-dion, a drugo sredstvo je inhibitor tirozinskih kinaza.
12. Kombinacija namijenjena upotrebi u skladu s bilo kojim od patentnih zahtjeva 7, dijelovi (iii) do (viii), te 8-11, naznačena time što se rak bira iz skupine koju čine rak dojke, rak glave i vrata, rak pluća, rak jajnika, rak gušterače, kolorektalni karcinom, rak prostate, karcinom bubrežnih stanica, melanom, hepatocelularni karcinomi, rak vrata maternice, karcinom endometrija, sarkomi, rak pločastih stanica, tumori na mozgu, rakovi želuca, gastrointestinalni rakovi, rak mokraćnog mjehura, multipli mijelom, leukemija, te limfom.
13. Kombinacija koja sadrži farmaceutski pripravak koji sadrži 2-acetilnafto[2,3-b]furan-4,9-dion, ili njegov farmaceutski prihvatljivi solvat, i
drugo sredstvo, kojeg se bira iz skupine koju čine paklitaksel, gemcitabin, kapecitabin, panitumumab, cetuksimab, fluoruracil (5-FU), leukovorin, oksaliplatin, bevacizumab, karboplatin, temozolomid, sorafenib, bortezomib, irinotekan i imatinib; naznačena time što je namijenjena upotrebi u:
(i) postupku liječenja subjekta od raka koji ne reagira na standardno liječenje, gdje se postupak sastoji u primjeni na subjektu terapijski djelotvorne količine farmaceutskog pripravka i drugog sredstva;
(ii) postupku liječenja ili sprječavanja recidiva raka kod subjekta, gdje se postupak sastoji u primjeni na subjektu terapijski djelotvorne količine farmaceutskog pripravka i drugog sredstva;
(iii) postupku liječenja ili sprječavanja metastaza raka kod subjekta, gdje se postupak sastoji u primjeni na subjektu terapijski djelotvorne količine farmaceutskog pripravka i drugog sredstva;
(iv) postupku liječenja raka kod subjekta, gdje se postupak sastoji u primjeni na subjektu prve količine farmaceutskog pripravka radi inhibiranja populacije matičnih stanica raka; i primjeni na subjektu druge količine drugog sredstva radi inhibiranja više normalnih stanica raka.
14. Kombinacija namijenjena upotrebi u skladu s patentnim zahtjevom 13, naznačena time što je rak rak dojke, rak glave i vrata, rak pluća, rak jajnika, rak gušterače, kolorektalni karcinom, rak prostate, karcinom bubrežnih stanica, melanom, hepatocelularni karcinomi, rak vrata maternice, karcinom endometrija, sarkomi, rak pločastih stanica, tumori na mozgu, rakovi želuca, gastrointestinalni rakovi, rak mokraćnog mjehura, multipli mijelom, leukemija, te limfom.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97114407P | 2007-09-10 | 2007-09-10 | |
| US1337207A | 2007-12-13 | 2007-12-13 | |
| EP16156278.0A EP3067054B1 (en) | 2007-09-10 | 2008-09-10 | Novel compositions and methods for cancer treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20210496T1 true HRP20210496T1 (hr) | 2021-05-14 |
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ID=66518952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20210496TT HRP20210496T1 (hr) | 2007-09-10 | 2021-03-26 | Novi pripravci i postupci liječenja raka |
Country Status (5)
| Country | Link |
|---|---|
| ES (2) | ES2713455T3 (hr) |
| HR (1) | HRP20210496T1 (hr) |
| HU (1) | HUE054409T2 (hr) |
| LT (1) | LT3067054T (hr) |
| PT (1) | PT3067054T (hr) |
-
2008
- 2008-09-10 ES ES16156335T patent/ES2713455T3/es active Active
- 2008-09-10 ES ES16156278T patent/ES2859699T3/es active Active
- 2008-09-10 LT LTEP16156278.0T patent/LT3067054T/lt unknown
- 2008-09-10 HU HUE16156278A patent/HUE054409T2/hu unknown
- 2008-09-10 PT PT161562780T patent/PT3067054T/pt unknown
-
2021
- 2021-03-26 HR HRP20210496TT patent/HRP20210496T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2859699T3 (es) | 2021-10-04 |
| HUE054409T2 (hu) | 2021-09-28 |
| PT3067054T (pt) | 2021-03-24 |
| LT3067054T (lt) | 2021-04-12 |
| ES2713455T3 (es) | 2019-05-21 |
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