HRP20200763T1 - Liječenje dijabetesa tip 1 uz pomoć glp-1 i protutijela protiv il-21 - Google Patents

Info

Publication number

HRP20200763T1

HRP20200763T1 HRP20200763TT HRP20200763T HRP20200763T1 HR P20200763 T1 HRP20200763 T1 HR P20200763T1 HR P20200763T T HRP20200763T T HR P20200763TT HR P20200763 T HRP20200763 T HR P20200763T HR P20200763 T1 HRP20200763 T1 HR P20200763T1

Authority

HR

Croatia

Prior art keywords

glp

inhibitor

function

agonist

intended

Prior art date

2014-05-07

Links

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• Global Dossier
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• 206010067584 Type 1 diabetes mellitus Diseases 0.000 title claims 2
• 101100337060 Caenorhabditis elegans glp-1 gene Proteins 0.000 title 1
• 108010074108 interleukin-21 Proteins 0.000 claims 25
• 239000003112 inhibitor Substances 0.000 claims 21
• 239000003877 glucagon like peptide 1 receptor agonist Substances 0.000 claims 18
• 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 9
• 102100025101 GATA-type zinc finger protein 1 Human genes 0.000 claims 2
• 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 claims 2
• DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical group C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 2
• 101001010621 Homo sapiens Interleukin-21 Proteins 0.000 claims 2
• YSDQQAXHVYUZIW-QCIJIYAXSA-N Liraglutide Chemical group C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCC)C(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 YSDQQAXHVYUZIW-QCIJIYAXSA-N 0.000 claims 2
• 108010019598 Liraglutide Proteins 0.000 claims 2
• 229960002701 liraglutide Drugs 0.000 claims 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims 2
• 102100027211 Albumin Human genes 0.000 claims 1
• 108010088751 Albumins Proteins 0.000 claims 1
• 241000801930 Apterona helix Species 0.000 claims 1
• 101800004266 Glucagon-like peptide 1(7-37) Proteins 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 238000002360 preparation method Methods 0.000 claims 1
• GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 claims 1