HRP20192132T1 - Antagonist nk-1/nk-3 receptora za liječenje valunga - Google Patents
Antagonist nk-1/nk-3 receptora za liječenje valunga Download PDFInfo
- Publication number
- HRP20192132T1 HRP20192132T1 HRP20192132TT HRP20192132T HRP20192132T1 HR P20192132 T1 HRP20192132 T1 HR P20192132T1 HR P20192132T T HRP20192132T T HR P20192132TT HR P20192132 T HRP20192132 T HR P20192132T HR P20192132 T1 HRP20192132 T1 HR P20192132T1
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- Prior art keywords
- compound
- formula
- xrd
- treatment
- use according
- Prior art date
Links
- 206010060800 Hot flush Diseases 0.000 title claims 3
- 102000002002 Neurokinin-1 Receptors Human genes 0.000 title 1
- 108010040718 Neurokinin-1 Receptors Proteins 0.000 title 1
- 102000002003 Neurokinin-3 Receptors Human genes 0.000 title 1
- 108010040716 Neurokinin-3 Receptors Proteins 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 2
- 208000033830 Hot Flashes Diseases 0.000 claims 2
- 150000008064 anhydrides Chemical class 0.000 claims 2
- 229910052802 copper Inorganic materials 0.000 claims 2
- 239000010949 copper Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 238000000634 powder X-ray diffraction Methods 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Multicomponent Fibers (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Claims (6)
1. Spoj formule (A) ili njegova farmaceutski prihvatljiva sol
za uporabu u liječenju valunga.
2. Spoj formule (A) za uporabu prema patentnom zahtjevu 1, gdje je spoj (A) u kristalnom anhidriranom obliku.
3. Spoj formule (A) za uporabu prema patentnim zahtjevima 1 ili 2, pri čemu je spoj formule (A) u obliku kristalnog anhidrida 1, naznačen time što osigurava rendgenski difraktogram praha (XRD) izražen preko 2 teta kuteva i dobiven pomoću difraktometra koji koristi Kα rendgensko zračenje bakra, i gdje XRD kristalogram sadrži pikove 2 teta ugla na 4.3±0.1, 7.9±0.1, 9.8±0.1, 10.7±0.1, 10.8±0.1, 13.3±0.1, 14.0±0.1, 15.1±0.1 stupnjeva, što odgovara redom d-rastojanju od 20.4, 11.1, 9.0, 8.3, 8.2, 6.6, 6.3 i 5.9 angstrema (Å).
4. Farmaceutska kompozicija za uporabu u liječenju valunga koja sadrži spoj formule (A) ili njegovu farmaceutski prihvatljivu sol
i farmaceutski prihvatljive ekscipijense.
5. Farmaceutska kompozicija za uporabu prema patentnom zahtjevu 4, gdje je spoj formule (A) u kristalnom anhidriranom obliku.
6. Farmaceutska kompozicija za uporabu prema patentnim zahtjevima 4 ili 5, gdje je spoj formule (A) u obliku kristalnog anhidrida 1, naznačena time što osigurava rendgenski difraktogram praha (XRD) izražen preko 2 teta kuteva i dobiven pomoću difraktometra koji koristi Kα rendgensko zračenje bakra, i gdje XRD kristalogram sadrži pikove 2 teta kuta na 4.3±0.1, 7.9±0.1, 9.8±0.1, 10.7±0.1, 10.8±0.1, 13.3±0.1, 14.0±0.1, 15.1±0.1 stupnjeva, što redom odgovara d-razmaku od 20.4, 11.1, 9.0, 8.3, 8.2, 6.6, 6.3 i 5.9 angstrema (Å).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562162870P | 2015-05-18 | 2015-05-18 | |
| EP16723107.5A EP3297631B1 (en) | 2015-05-18 | 2016-05-16 | Nk-1/nk-3 receptor antagonist for the treatment of hot flushes |
| PCT/EP2016/060945 WO2016184829A1 (en) | 2015-05-18 | 2016-05-16 | Dual nk-1/nk-3 receptor antagonists for the treatment of sex-hormone-dependent diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20192132T1 true HRP20192132T1 (hr) | 2020-02-21 |
Family
ID=56008636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20192132TT HRP20192132T1 (hr) | 2015-05-18 | 2019-11-27 | Antagonist nk-1/nk-3 receptora za liječenje valunga |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US10195205B2 (hr) |
| EP (2) | EP3574907B1 (hr) |
| JP (1) | JP6902682B2 (hr) |
| KR (1) | KR102704783B1 (hr) |
| CN (4) | CN114306347A (hr) |
| AU (2) | AU2016264034B2 (hr) |
| BR (1) | BR112017024852B1 (hr) |
| CA (1) | CA2984591A1 (hr) |
| CY (1) | CY1122180T1 (hr) |
| DK (1) | DK3297631T3 (hr) |
| ES (1) | ES2753539T3 (hr) |
| HR (1) | HRP20192132T1 (hr) |
| HU (1) | HUE047732T2 (hr) |
| LT (1) | LT3297631T (hr) |
| MX (2) | MX2017012720A (hr) |
| PL (1) | PL3297631T3 (hr) |
| PT (1) | PT3297631T (hr) |
| RS (1) | RS59608B1 (hr) |
| RU (1) | RU2743206C2 (hr) |
| SI (1) | SI3297631T1 (hr) |
| WO (1) | WO2016184829A1 (hr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6159870B2 (ja) | 2013-03-15 | 2017-07-05 | アッヴィ・インコーポレイテッド | 月経出血過多および子宮類線維腫の処置に使用するための組成物 |
| US10774091B2 (en) * | 2018-03-14 | 2020-09-15 | KaNDy Therapeutics Limited | Soft gelatin capsule formulation |
| CN112261942A (zh) * | 2018-04-19 | 2021-01-22 | 艾伯维公司 | 治疗重度月经出血的方法 |
| CN114728906B (zh) | 2019-11-15 | 2024-08-20 | 康堤医疗有限公司 | 制备nt-814的关键中间体6-氯-4-(4-氟-2-甲基苯基)吡啶-3-胺的新化学方法 |
| KR20240023691A (ko) * | 2020-08-12 | 2024-02-22 | 스프루스 바이오사이언시스 인코포레이티드 | 다낭성 난소 증후군을 치료하기 위한 방법 및 조성물 |
| WO2023147135A1 (en) * | 2022-01-31 | 2023-08-03 | Acer Therapeutics, Inc. | Nk receptor antagonists for treatment of prostate cancer |
| EP4431512A1 (en) * | 2023-03-16 | 2024-09-18 | Bayer Consumer Care AG | Novel dual nk-1/nk-3 receptor antagonists |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100316571B1 (ko) * | 1994-05-27 | 2002-05-30 | 파올로 비지, 엔리꼬 카쭐라니 | 타키키닌nk3수용체길항제로서퀴놀린유도체 |
| DE69515666T2 (de) * | 1994-07-22 | 2000-07-06 | Medical College Of Hampton Roads, Norfolk | VERWENDUNG VON GnRH-ANTAGONISTEN ZUR HERSTELLUNG EINES MEDIKAMENTS ZUR BEHANDLUNG GONADEN-STEROID ABHÄNGIGER ERKRANKUNGEN |
| GB9907571D0 (en) | 1999-04-06 | 1999-05-26 | Zeneca Ltd | Compounds |
| ATE367811T1 (de) * | 2000-06-12 | 2007-08-15 | Univ Rochester | Methode zur behandlung von hitzewallungen, durch verwendung eines tachikinin-rezeptor antagonisten |
| EP1192952A3 (en) | 2000-09-28 | 2003-03-26 | Pfizer Products Inc. | Combination, for treating depression and anxiety, containing an NK-3 receptor antagonist and a CNS penetrant NK-1 receptor antagonist |
| WO2002089802A2 (en) * | 2001-05-08 | 2002-11-14 | Schering Corporation | Use of neurokinin receptor antagonists to treat androgen-dependent diseases |
| WO2004004722A1 (en) * | 2002-07-03 | 2004-01-15 | Schering Corporation | 1-amido-4-phenyl-4-benzyloxymethyl-piperidine derivatives and related compounds as neurokinin-1(nk-1) antagonists for the treatment of emesis, depression, anxiety and cough |
| ES2310260T3 (es) | 2002-12-23 | 2009-01-01 | Janssen Pharmaceutica Nv | Derivados sustituidos de 4-(4-piperidin-4-il-piperazin-1-il)-azepan y su uso como antagonistas de la neuroquinina. |
| JO2696B1 (en) | 2002-12-23 | 2013-03-03 | شركة جانسين فارماسوتيكا ان. في | Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists |
| US7525659B2 (en) | 2003-01-15 | 2009-04-28 | Negevtech Ltd. | System for detection of water defects |
| PL1643998T3 (pl) | 2003-07-03 | 2008-01-31 | Hoffmann La Roche | Podwójni antagoniści NK1/NK3 do leczenia schizofrenii |
| JO2676B1 (en) | 2004-04-06 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines |
| JO2525B1 (en) * | 2004-04-08 | 2010-03-17 | شركة جانسين فارماسوتيكا ان. في | Derived 4-alkyl-and-4-canoelperidine derivatives and their use as anti-neroquin |
| JP2007537233A (ja) | 2004-05-12 | 2007-12-20 | ファイザー・プロダクツ・インク | Ｎｋ１及びｎｋ３アンタゴニストとしてのピペリジン誘導体 |
| DE102004033902A1 (de) | 2004-07-14 | 2006-02-16 | Zentaris Gmbh | Neue Tetrahydrocarbazolderivate mit verbesserter biologischer Wirkung und verbesserter Löslichkeit als Liganden für G-Protein gekoppelte Rezeptoren (GPCR's) |
| WO2006013205A1 (en) | 2004-08-04 | 2006-02-09 | Solvay Pharmaceuticals B.V. | Neurokinin-1 receptor antagonists for the treatment of conditions responsive to testosterone elevation |
| US20060030600A1 (en) | 2004-08-06 | 2006-02-09 | Patrick Schnider | Dual NK1/NK3 receptor antagonists for the treatment of schizophrenia |
| SI1928886T1 (sl) | 2005-09-09 | 2011-08-31 | Glaxosmithkline Llc | Derivati piridina in njihova uporaba pri zdravljenju psihotiäśnih motenj |
| AR056544A1 (es) * | 2005-09-29 | 2007-10-10 | Wyeth Corp | Derivados fenilaminopropanol y metodos de uso de los mismos |
| EP2137213A4 (en) * | 2007-03-27 | 2010-06-09 | Christopher M Hovens | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PROSTATE CANCER |
| CA2682506C (en) | 2007-04-20 | 2016-05-24 | F. Hoffmann-La Roche Ag | Pyrrolidine derivatives as dual nk1/nk3 receptor antagonists |
| GB0814340D0 (en) * | 2008-08-05 | 2008-09-10 | Smithkline Beecham Corp | Anhydrous crystol form fo a pyridine derivative |
| ES2440938T3 (es) * | 2009-08-27 | 2014-01-31 | Nerre Therapeutics Limited | Formas anhidrato de un derivado de piridina |
| US8415884B2 (en) | 2009-09-08 | 2013-04-09 | Tokyo Electron Limited | Stable surface wave plasma source |
| US8487102B2 (en) | 2010-04-20 | 2013-07-16 | Hoffmann-La Roche Inc. | Pyrrazolopyridine compounds as dual NK1/NK3 receptor antagonists |
| CN102958364A (zh) * | 2010-05-28 | 2013-03-06 | 德克萨斯大学系统董事会 | 低聚苯甲酰胺化合物及其用途 |
| US9446029B2 (en) | 2010-07-27 | 2016-09-20 | Colorado State University Research Foundation | Use of NK-1 receptor antagonists in management of visceral pain |
| ES2376564B1 (es) | 2010-08-12 | 2013-01-24 | Manuel Vicente Salinas Martín | Utilización de anticuerpos contra los receptores nk1, nk2 y/o nk3, para producir apoptosis en las células tumorales y modificar el estroma, la inmunidad y la vascularización intra y peritumorales, como tratamiento del cáncer. |
| US20150272927A1 (en) | 2012-12-03 | 2015-10-01 | University Of Washington Through Its Center For Commercialization | Methods and compositions for treating vasomotor symptoms |
| GB201315846D0 (en) | 2013-09-05 | 2013-10-23 | Imp Innovations Ltd | Method for treating or preventing hot flushes |
| US10774091B2 (en) * | 2018-03-14 | 2020-09-15 | KaNDy Therapeutics Limited | Soft gelatin capsule formulation |
-
2016
- 2016-05-16 DK DK16723107T patent/DK3297631T3/da active
- 2016-05-16 RU RU2017134908A patent/RU2743206C2/ru active
- 2016-05-16 KR KR1020177036005A patent/KR102704783B1/ko active IP Right Grant
- 2016-05-16 AU AU2016264034A patent/AU2016264034B2/en active Active
- 2016-05-16 RS RS20191505A patent/RS59608B1/sr unknown
- 2016-05-16 MX MX2017012720A patent/MX2017012720A/es active IP Right Grant
- 2016-05-16 CN CN202210025860.5A patent/CN114306347A/zh active Pending
- 2016-05-16 CN CN202210026259.8A patent/CN114272242A/zh active Pending
- 2016-05-16 SI SI201630503T patent/SI3297631T1/sl unknown
- 2016-05-16 CN CN202210025858.8A patent/CN114306335A/zh active Pending
- 2016-05-16 JP JP2017554079A patent/JP6902682B2/ja active Active
- 2016-05-16 PL PL16723107T patent/PL3297631T3/pl unknown
- 2016-05-16 CA CA2984591A patent/CA2984591A1/en active Pending
- 2016-05-16 BR BR112017024852-2A patent/BR112017024852B1/pt active IP Right Grant
- 2016-05-16 CN CN201680025842.XA patent/CN107635557A/zh active Pending
- 2016-05-16 WO PCT/EP2016/060945 patent/WO2016184829A1/en active Application Filing
- 2016-05-16 EP EP19186140.0A patent/EP3574907B1/en active Active
- 2016-05-16 PT PT167231075T patent/PT3297631T/pt unknown
- 2016-05-16 EP EP16723107.5A patent/EP3297631B1/en active Active
- 2016-05-16 ES ES16723107T patent/ES2753539T3/es active Active
- 2016-05-16 LT LT16723107T patent/LT3297631T/lt unknown
- 2016-05-16 HU HUE16723107A patent/HUE047732T2/hu unknown
- 2016-05-18 US US15/157,430 patent/US10195205B2/en active Active
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2017
- 2017-10-03 MX MX2020011668A patent/MX2020011668A/es unknown
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2018
- 2018-11-06 US US16/182,572 patent/US20210128574A1/en not_active Abandoned
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2019
- 2019-10-17 CY CY20191101087T patent/CY1122180T1/el unknown
- 2019-11-27 HR HRP20192132TT patent/HRP20192132T1/hr unknown
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2020
- 2020-02-14 AU AU2020201074A patent/AU2020201074B2/en active Active
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2021
- 2021-02-10 US US17/173,069 patent/US20210236506A1/en active Pending
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