HRP20191503T1 - Sustav za isporuku lijeka koji sadrži ne-steroidni protuupalni lijek (nsaid) i progestogeni spoj i postupci za proizvodnju - Google Patents
Sustav za isporuku lijeka koji sadrži ne-steroidni protuupalni lijek (nsaid) i progestogeni spoj i postupci za proizvodnju Download PDFInfo
- Publication number
- HRP20191503T1 HRP20191503T1 HRP20191503T HRP20191503T1 HR P20191503 T1 HRP20191503 T1 HR P20191503T1 HR P20191503 T HRP20191503 T HR P20191503T HR P20191503 T1 HRP20191503 T1 HR P20191503T1
- Authority
- HR
- Croatia
- Prior art keywords
- indomethacin
- delivery system
- frame
- levonorgestrel
- contained
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 7
- 230000000757 progestagenic effect Effects 0.000 title claims 3
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 238000012377 drug delivery Methods 0.000 title 1
- 230000003637 steroidlike Effects 0.000 title 1
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims 16
- 229960000905 indomethacin Drugs 0.000 claims 9
- WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 claims 5
- 229960004400 levonorgestrel Drugs 0.000 claims 5
- 229920001296 polysiloxane Polymers 0.000 claims 3
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000000583 progesterone congener Substances 0.000 claims 2
- 238000013270 controlled release Methods 0.000 claims 1
- -1 ethynyl vinyl Chemical group 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0039—Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/10—Processes of additive manufacturing
- B29C64/106—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/10—Processes of additive manufacturing
- B29C64/106—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
- B29C64/118—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2023/00—Use of polyalkenes or derivatives thereof as moulding material
- B29K2023/04—Polymers of ethylene
- B29K2023/08—Copolymers of ethylene
- B29K2023/083—EVA, i.e. ethylene vinyl acetate copolymer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
- B29K2105/0005—Condition, form or state of moulded material or of the material to be shaped containing compounding ingredients
- B29K2105/0035—Medical or pharmaceutical agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2031/00—Other particular articles
- B29L2031/753—Medical equipment; Accessories therefor
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Reproductive Health (AREA)
- Manufacturing & Machinery (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Mechanical Engineering (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (6)
1. Intrauterini sustav za isporuku, koji sadrži indometacin i levonorgestrel, naznačen time, da je indometacin sadržan u materijalu okvira i da se levonorgestrel nalazi u spremniku na bazi silikona koji je pričvršćen za okvir, naznačen time što okvir sadrži kopolimer etinilvinilacetata sa 16% sadržajem vinilacetata (EVA 5).
2. Postupak za proizvodnju okvira intrauterinog sustava za isporuku, koji sadrži indometacin i levonorgestrel, pri čemu je indometacin sadržan u okviru i levonorgestrel je sadržan u spremniku na bazi silikona koji je pričvršćen na okvir, naznačen time, što se smjesa kopolimera etinilvinilacetata sa 16% sadržajem vinilacetata (EVA 5) i Indometacina obrađuju pod uvjetima 3-D postupka tiskanja.
3. Postupak prema patentnom zahtjevu 2, naznačen time što intrauterini sustav za isporuku za kontrolirano otpuštanja progestogena ili lijeka koji ima progestogensku aktivnost tijekom duljeg vremenskog razdoblja i na razini potrebnoj za kontracepciju, te sustav obuhvaća konstrukciju tijela i najmanje jedan spremnik na bazi silikona koji sadrži jezgru i po izboru membranu koja okružuje jezgru, jezgra i membrana se u osnovi sastoje od istog ili različitog polimernog pripravka, naznačen time što navedeni intrauterini sustav za isporuku sadrži levonorgestrel kao progestogen ili lijek koji ima progestogenu aktivnost.
4. Postupak prema patentnom zahtjevu 2, naznačen time što rasponi indometacina iznose 5 - 40 masenih %.
5. Postupak prema patentnom zahtjevu 4, naznačen time što količine indometacina iznose 5 ili 15 ili 30 masenih %.
6. Postupak prema patentnom zahtjevu 4 ili 5, naznačen time što je indometacin amorfan ili α-indometacin.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562106073P | 2015-01-21 | 2015-01-21 | |
| EP16701276.4A EP3247327B1 (en) | 2015-01-21 | 2016-01-20 | Drug delivery system comprising a non-steroidal anti-inflammatory (nsaid) and a progestogenic compound and methods for manufacturing |
| PCT/EP2016/051135 WO2016116502A1 (en) | 2015-01-21 | 2016-01-20 | Drug delivery system comprising a non-steroidal anti-inflammatory (nsaid) and a progestogenic compound and methods for manufacturing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20191503T1 true HRP20191503T1 (hr) | 2019-11-29 |
Family
ID=55221395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20191503 HRP20191503T1 (hr) | 2015-01-21 | 2019-08-20 | Sustav za isporuku lijeka koji sadrži ne-steroidni protuupalni lijek (nsaid) i progestogeni spoj i postupci za proizvodnju |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20180008536A1 (hr) |
| EP (1) | EP3247327B1 (hr) |
| JP (1) | JP6756718B2 (hr) |
| CN (1) | CN107205921B (hr) |
| CA (1) | CA2974167C (hr) |
| DK (1) | DK3247327T3 (hr) |
| ES (1) | ES2748776T3 (hr) |
| HR (1) | HRP20191503T1 (hr) |
| HU (1) | HUE046267T2 (hr) |
| LT (1) | LT3247327T (hr) |
| PL (1) | PL3247327T3 (hr) |
| PT (1) | PT3247327T (hr) |
| RS (1) | RS59148B1 (hr) |
| SI (1) | SI3247327T1 (hr) |
| WO (1) | WO2016116502A1 (hr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160342769A1 (en) * | 2015-05-23 | 2016-11-24 | Vitae Industries, Inc. | Systems for making personalized medicine |
| WO2017165624A1 (en) | 2016-03-23 | 2017-09-28 | The University Of North Carolina At Chapel Hill | Geometrically complex intravaginal rings, systems and methods of making the same |
| CN106109245A (zh) * | 2016-08-16 | 2016-11-16 | 华南农业大学 | 一种采用3d打印技术制备得到的抗癌药物及方法 |
| CN106113513B (zh) * | 2016-09-08 | 2018-02-06 | 中南大学 | 3d打印药物的方法及3d打印药物外壳 |
| AU2018340266A1 (en) * | 2017-09-27 | 2020-03-05 | Bayer Oy | A method for modifying release of a therapeutically active agent from an elastomeric matrix |
| EP3501543A1 (en) * | 2017-12-19 | 2019-06-26 | Delim Cosmetics & Pharma S.r.l. | Method for manufacturing vaginal drug delivery systems using a three dimensional printer |
| CN108175930A (zh) * | 2018-01-22 | 2018-06-19 | 中国人民解放军军事科学院军事医学研究院 | 一种3d打印的阴道给药装置 |
| EP3590501A1 (en) * | 2018-07-06 | 2020-01-08 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | Manufacturing process and system for manufacturing a 3d printed drug delivery product |
| US20210347115A1 (en) * | 2018-10-25 | 2021-11-11 | Make Composites, Inc. | Systems and methods of printing with fiber-reinforced materials |
| WO2022122122A1 (en) | 2020-12-08 | 2022-06-16 | Symrise Ag | Medicament for fighting inflammatory conditions of human skin (i) |
| EP4352156A1 (en) | 2021-05-14 | 2024-04-17 | Braskem America, Inc. | Ethylene-vinyl ester polymers for additive-manufacture feedstock |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2457979A1 (en) | 2001-08-31 | 2003-03-06 | Schering Oy | A delivery system |
| US7833545B2 (en) | 2003-04-29 | 2010-11-16 | The General Hospital Corporation | Methods and devices for the sustained release of multiple drugs |
| US7862552B2 (en) * | 2005-05-09 | 2011-01-04 | Boston Scientific Scimed, Inc. | Medical devices for treating urological and uterine conditions |
| CN100441156C (zh) | 2006-09-30 | 2008-12-10 | 华中科技大学 | 一种复合材料宫内节育器 |
| US20150374521A1 (en) * | 2008-01-17 | 2015-12-31 | Elixir Medical Corporation | Biodegradable endoprostheses and methods for their fabrication |
| EP2140860A1 (en) | 2008-07-03 | 2010-01-06 | Bayer Schering Pharma Oy | An improved method of contraception |
| SG184244A1 (en) * | 2010-04-03 | 2012-11-29 | Praful Doshi | Medical devices including medicaments and methods of making and using same |
| EP2708213A1 (en) * | 2012-09-13 | 2014-03-19 | PAT&Co bvba | Multipurpose ethylene vinyl acetate fibrous drug delivery systems for long-term implantation or insertion |
| US20140099351A1 (en) * | 2012-10-04 | 2014-04-10 | Axxia Pharmaceuticals, Llc | Process for making controlled release medical implant products |
| US10441689B2 (en) * | 2014-08-10 | 2019-10-15 | Louisiana Tech Research Corporation | Methods and devices for three-dimensional printing or additive manufacturing of bioactive medical devices |
-
2016
- 2016-01-20 HU HUE16701276A patent/HUE046267T2/hu unknown
- 2016-01-20 SI SI201630366T patent/SI3247327T1/sl unknown
- 2016-01-20 WO PCT/EP2016/051135 patent/WO2016116502A1/en active Application Filing
- 2016-01-20 LT LTEP16701276.4T patent/LT3247327T/lt unknown
- 2016-01-20 RS RS20191088A patent/RS59148B1/sr unknown
- 2016-01-20 PL PL16701276T patent/PL3247327T3/pl unknown
- 2016-01-20 EP EP16701276.4A patent/EP3247327B1/en active Active
- 2016-01-20 CA CA2974167A patent/CA2974167C/en active Active
- 2016-01-20 DK DK16701276T patent/DK3247327T3/da active
- 2016-01-20 ES ES16701276T patent/ES2748776T3/es active Active
- 2016-01-20 CN CN201680006751.1A patent/CN107205921B/zh active Active
- 2016-01-20 PT PT167012764T patent/PT3247327T/pt unknown
- 2016-01-20 US US15/544,326 patent/US20180008536A1/en not_active Abandoned
- 2016-01-20 JP JP2017538373A patent/JP6756718B2/ja active Active
-
2019
- 2019-08-20 HR HRP20191503 patent/HRP20191503T1/hr unknown
-
2023
- 2023-06-05 US US18/329,268 patent/US20240009116A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018502878A (ja) | 2018-02-01 |
| JP6756718B2 (ja) | 2020-09-16 |
| RS59148B1 (sr) | 2019-09-30 |
| CN107205921B (zh) | 2021-03-16 |
| EP3247327B1 (en) | 2019-08-07 |
| US20240009116A1 (en) | 2024-01-11 |
| CN107205921A (zh) | 2017-09-26 |
| LT3247327T (lt) | 2019-10-10 |
| SI3247327T1 (sl) | 2019-10-30 |
| WO2016116502A1 (en) | 2016-07-28 |
| CA2974167A1 (en) | 2016-07-28 |
| PT3247327T (pt) | 2019-10-24 |
| EP3247327A1 (en) | 2017-11-29 |
| HUE046267T2 (hu) | 2020-02-28 |
| PL3247327T3 (pl) | 2020-02-28 |
| US20180008536A1 (en) | 2018-01-11 |
| CA2974167C (en) | 2023-05-16 |
| ES2748776T3 (es) | 2020-03-17 |
| DK3247327T3 (da) | 2019-10-28 |
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