HRP20171005T1 - Imidazopyrrolidinone compounds - Google Patents
Imidazopyrrolidinone compoundsInfo
- Publication number
- HRP20171005T1 HRP20171005T1 HRP20171005TT HRP20171005T HRP20171005T1 HR P20171005 T1 HRP20171005 T1 HR P20171005T1 HR P20171005T T HRP20171005T T HR P20171005TT HR P20171005 T HRP20171005 T HR P20171005T HR P20171005 T1 HRP20171005 T1 HR P20171005T1
- Authority
- HR
- Croatia
- Prior art keywords
- imidazopyrrolidinone
- compounds
- imidazopyrrolidinone compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261591001P | 2012-01-26 | 2012-01-26 | |
| US201261669902P | 2012-07-10 | 2012-07-10 | |
| CNPCT/CN2012/086703 | 2012-12-14 | ||
| EP13711952.5A EP2807164B1 (en) | 2012-01-26 | 2013-01-25 | Imidazopyrrolidinone compounds |
| PCT/IB2013/050655 WO2013111105A1 (en) | 2012-01-26 | 2013-01-25 | Imidazopyrrolidinone compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20171005T1 true HRP20171005T1 (en) | 2017-09-22 |
Family
ID=47997596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20171005TT HRP20171005T1 (en) | 2012-01-26 | 2017-07-03 | Imidazopyrrolidinone compounds |
Country Status (44)
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0811643D0 (en) | 2008-06-25 | 2008-07-30 | Cancer Rec Tech Ltd | New therapeutic agents |
| US8440693B2 (en) | 2009-12-22 | 2013-05-14 | Novartis Ag | Substituted isoquinolinones and quinazolinones |
| US8969341B2 (en) | 2011-11-29 | 2015-03-03 | Novartis Ag | Pyrazolopyrrolidine compounds |
| US8815926B2 (en) * | 2012-01-26 | 2014-08-26 | Novartis Ag | Substituted pyrrolo[3,4-D]imidazoles for the treatment of MDM2/4 mediated diseases |
| EP2855483B1 (en) | 2012-05-24 | 2017-10-25 | Novartis AG | Pyrrolopyrrolidinone compounds |
| WO2014100065A1 (en) | 2012-12-20 | 2014-06-26 | Merck Sharp & Dohme Corp. | Substituted imidazopyridines as hdm2 inhibitors |
| WO2014115077A1 (en) | 2013-01-22 | 2014-07-31 | Novartis Ag | Substituted purinone compounds |
| EP2948453B1 (en) | 2013-01-22 | 2017-08-02 | Novartis AG | Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the p53/mdm2 interaction |
| US8975417B2 (en) | 2013-05-27 | 2015-03-10 | Novartis Ag | Pyrazolopyrrolidine derivatives and their use in the treatment of disease |
| CA2913697A1 (en) * | 2013-05-27 | 2014-12-04 | Novartis Ag | Imidazopyrrolidinone derivatives and their use in the treatment of disease |
| MX2015016425A (en) | 2013-05-28 | 2016-03-03 | Novartis Ag | Pyrazolo-pyrrolidin-4-one derivatives and their use in the treatment of disease. |
| PT3004108T (en) | 2013-05-28 | 2018-01-24 | Novartis Ag | Pyrazolo-pyrrolidin-4-one derivatives as bet inhibitors and their use in the treatment of disease |
| KR20160086930A (en) * | 2013-11-21 | 2016-07-20 | 노파르티스 아게 | Pyrrolopyrrolone derivatives and their use as bet inhibitors |
| TW201605450A (en) | 2013-12-03 | 2016-02-16 | 諾華公司 | Combination of Mdm2 inhibitor and BRAF inhibitor and their use |
| KR102283895B1 (en) * | 2013-12-23 | 2021-07-30 | 노파르티스 아게 | Pharmaceutical combinations |
| CN105848682A (en) * | 2013-12-23 | 2016-08-10 | 诺华股份有限公司 | Pharmaceutical combinations |
| JOP20200094A1 (en) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | Antibody molecules to pd-1 and uses thereof |
| JOP20200096A1 (en) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | Antibody molecules to tim-3 and uses thereof |
| KR20220126813A (en) | 2014-03-14 | 2022-09-16 | 노파르티스 아게 | Antibody molecules to lag-3 and uses thereof |
| TW201613576A (en) | 2014-06-26 | 2016-04-16 | Novartis Ag | Intermittent dosing of MDM2 inhibitor |
| MA41044A (en) | 2014-10-08 | 2017-08-15 | Novartis Ag | COMPOSITIONS AND METHODS OF USE FOR INCREASED IMMUNE RESPONSE AND CANCER TREATMENT |
| US9988452B2 (en) | 2014-10-14 | 2018-06-05 | Novartis Ag | Antibody molecules to PD-L1 and uses thereof |
| WO2016100882A1 (en) | 2014-12-19 | 2016-06-23 | Novartis Ag | Combination therapies |
| JP6692826B2 (en) | 2015-03-10 | 2020-05-13 | アドゥロ バイオテック，インク． | Compositions and methods for activation of "interferon gene stimulator" dependent signaling |
| PL3317301T3 (en) | 2015-07-29 | 2021-11-15 | Novartis Ag | Combination therapies comprising antibody molecules to lag-3 |
| EP3878465A1 (en) | 2015-07-29 | 2021-09-15 | Novartis AG | Combination therapies comprising antibody molecules to tim-3 |
| TWI750129B (en) * | 2015-08-03 | 2021-12-21 | 瑞士商諾華公司 | Gdf-15 as a haematological toxicity biomarker |
| MX2018001903A (en) * | 2015-08-14 | 2018-06-20 | Novartis Ag | Mdm2 inhibitors for treating uveal melanoma. |
| US20190060309A1 (en) * | 2015-08-28 | 2019-02-28 | Novartis Ag | Mdm2 inhibitors and combinations thereof |
| EP3341023A1 (en) * | 2015-08-28 | 2018-07-04 | Novartis AG | Combination therapy using pi3k inhbitor and mdm2 inhibitor |
| GB201517217D0 (en) | 2015-09-29 | 2015-11-11 | Astex Therapeutics Ltd And Cancer Res Technology Ltd | Pharmaceutical compounds |
| GB201517216D0 (en) | 2015-09-29 | 2015-11-11 | Cancer Res Technology Ltd And Astex Therapeutics Ltd | Pharmaceutical compounds |
| RS63125B1 (en) | 2015-11-03 | 2022-05-31 | Janssen Biotech Inc | Antibodies specifically binding pd-1 and their uses |
| AU2016369537B2 (en) | 2015-12-17 | 2024-03-14 | Novartis Ag | Antibody molecules to PD-1 and uses thereof |
| ES2858151T3 (en) | 2016-05-20 | 2021-09-29 | Hoffmann La Roche | PROTAC-Antibody Conjugates and Procedures for Use |
| WO2018009466A1 (en) | 2016-07-05 | 2018-01-11 | Aduro Biotech, Inc. | Locked nucleic acid cyclic dinucleotide compounds and uses thereof |
| CN109982702A (en) * | 2016-11-15 | 2019-07-05 | 诺华股份有限公司 | The dosage and scheme of HDM2-p53 interaction inhibitor |
| WO2018092064A1 (en) | 2016-11-18 | 2018-05-24 | Novartis Ag | Combinations of mdm2 inhibitors and bcl-xl inhibitors |
| ES2902874T3 (en) * | 2016-11-22 | 2022-03-30 | Novartis Ag | Chemical process for preparing imidazopyrrolidinone derivatives and their intermediates |
| WO2018158225A1 (en) | 2017-02-28 | 2018-09-07 | Les Laboratoires Servier | Combination of a bcl-2 inhibitor and a mdm2 inhibitor, uses and pharmaceutical compositions thereof |
| CN110418790B (en) * | 2017-03-06 | 2022-05-17 | 罗欣药业(上海)有限公司 | Imidazopyrrolone compounds as p53-MDM2 inhibitors |
| GB201704965D0 (en) | 2017-03-28 | 2017-05-10 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| GB201704966D0 (en) | 2017-03-28 | 2017-05-10 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| AU2018242612B2 (en) * | 2017-03-31 | 2020-05-21 | Novartis Ag | Dose and regimen for an HDM2-p53 interaction inhibitor in hematological tumors |
| CA3057558A1 (en) | 2017-04-05 | 2018-10-11 | Boehringer Ingelheim International Gmbh | Anticancer combination therapy |
| UY37695A (en) | 2017-04-28 | 2018-11-30 | Novartis Ag | BIS 2’-5’-RR- (3’F-A) (3’F-A) CYCLE DINUCLEOTIDE COMPOUND AND USES OF THE SAME |
| WO2018237173A1 (en) | 2017-06-22 | 2018-12-27 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
| US11413284B2 (en) | 2017-09-12 | 2022-08-16 | Novartis Ag | Protein kinase C inhibitors for treatment of uveal melanoma |
| KR102613659B1 (en) | 2017-10-02 | 2023-12-15 | 노파르티스 아게 | Methods for manufacturing pharmaceutical products |
| CN111163781B (en) | 2017-10-12 | 2023-05-16 | 诺华股份有限公司 | Combination of MDM2 inhibitors and ERK inhibitors for the treatment of cancer |
| CN111655288A (en) | 2017-11-16 | 2020-09-11 | 诺华股份有限公司 | Combination therapy |
| US11339171B2 (en) * | 2017-12-29 | 2022-05-24 | Gan & Lee Pharmaceuticals | MDM2 inhibitors |
| EP3511334A1 (en) * | 2018-01-16 | 2019-07-17 | Adamed sp. z o.o. | 1,2,3',5'-tetrahydro-2'h-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrole]-2,3'-dione compounds as therapeutic agents activating tp53 |
| US11639355B2 (en) | 2018-03-12 | 2023-05-02 | Luoxin Pharmaceutical (Shanghai) Co., Ltd. | Substituted pyrrolo[3,4-d]imidazoles as MDM2-p53 inhibitors |
| US20210363254A1 (en) | 2018-03-20 | 2021-11-25 | Novartis Ag | Pharmaceutical combinations |
| TW202015726A (en) | 2018-05-30 | 2020-05-01 | 瑞士商諾華公司 | Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies |
| AR116109A1 (en) | 2018-07-10 | 2021-03-31 | Novartis Ag | DERIVATIVES OF 3- (5-AMINO-1-OXOISOINDOLIN-2-IL) PIPERIDINE-2,6-DIONA AND USES OF THE SAME |
| WO2020128894A1 (en) | 2018-12-20 | 2020-06-25 | Novartis Ag | Combinations of a hdm2-p53 interaction inhibitor and a bcl2 inhibitor and their use for treating cancer |
| MX2021007392A (en) | 2018-12-20 | 2021-08-24 | Novartis Ag | Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives. |
| WO2020128620A1 (en) | 2018-12-21 | 2020-06-25 | Novartis Ag | Use of il-1beta binding antibodies |
| KR20210107730A (en) | 2018-12-21 | 2021-09-01 | 노파르티스 아게 | Use of IL-1 beta antibodies in the treatment or prevention of myelodysplastic syndrome |
| US10610280B1 (en) | 2019-02-02 | 2020-04-07 | Ayad K. M. Agha | Surgical method and apparatus for destruction and removal of intraperitoneal, visceral, and subcutaneous fat |
| EP3924055B1 (en) | 2019-02-15 | 2024-04-03 | Novartis AG | Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| MX2021009763A (en) | 2019-02-15 | 2021-09-08 | Novartis Ag | 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof. |
| WO2020202052A1 (en) | 2019-04-04 | 2020-10-08 | Novartis Ag | Siremadlin succinate |
| CN114096541B (en) * | 2019-09-12 | 2023-04-04 | 罗欣药业(上海)有限公司 | Crystal form of p53-MDM2 inhibitor and preparation method thereof |
| WO2021053489A1 (en) | 2019-09-16 | 2021-03-25 | Novartis Ag | Use of an mdm2 inhibitor for the treatment of myelofibrosis |
| US20220348651A1 (en) | 2019-09-18 | 2022-11-03 | Novartis Ag | Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies |
| AU2020406350A1 (en) | 2019-12-20 | 2022-08-11 | Novartis Ag | Uses of anti-TGF-beta antibodies and checkpoint inhibitors for the treatment of proliferative diseases |
| GB201919219D0 (en) | 2019-12-23 | 2020-02-05 | Otsuka Pharma Co Ltd | Cancer biomarkers |
| JP2023531676A (en) | 2020-06-23 | 2023-07-25 | ノバルティス アーゲー | Dosing Regimens Containing 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione Derivatives |
| US20230313313A1 (en) | 2020-08-27 | 2023-10-05 | Otsuka Pharmaceutical Co., Ltd. | Biomarkers for cancer therapy using mdm2 antagonists |
| TW202218665A (en) | 2020-09-21 | 2022-05-16 | 德國阿爾伯特路德維希弗萊堡大學 | Mdm2 inhibitors for use in the treatment or prevention of hematologic neoplasm relapse after hematopoietic cell transplantation |
| GB202103080D0 (en) | 2021-03-04 | 2021-04-21 | Otsuka Pharma Co Ltd | Cancer biomarkers |
| TW202304979A (en) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | USES OF ANTI-TGFβ ANTIBODIES AND OTHER THERAPEUTIC AGENTS FOR THE TREATMENT OF PROLIFERATIVE DISEASES |
| AR125874A1 (en) | 2021-05-18 | 2023-08-23 | Novartis Ag | COMBINATION THERAPIES |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| WO2023067483A1 (en) | 2021-10-19 | 2023-04-27 | Novartis Ag | Pharmaceutical combinations comprising an mdm2 inhibitor, a bcl2 inhibitor and a hypomethylating agent and uses thereof for the treatment of haematological malignancies |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR901228A (en) | 1943-01-16 | 1945-07-20 | Deutsche Edelstahlwerke Ag | Ring gap magnet system |
| GB1524747A (en) | 1976-05-11 | 1978-09-13 | Ici Ltd | Polypeptide |
| EP0100172B1 (en) | 1982-07-23 | 1987-08-12 | Imperial Chemical Industries Plc | Amide derivatives |
| GB8327256D0 (en) | 1983-10-12 | 1983-11-16 | Ici Plc | Steroid derivatives |
| US5093330A (en) | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
| US5010099A (en) | 1989-08-11 | 1991-04-23 | Harbor Branch Oceanographic Institution, Inc. | Discodermolide compounds, compositions containing same and method of preparation and use |
| US5395855A (en) | 1990-05-07 | 1995-03-07 | Ciba-Geigy Corporation | Hydrazones |
| NZ243082A (en) | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
| AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| TW225528B (en) | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| BR9207175A (en) | 1992-10-28 | 1995-12-12 | Genentech Inc | Composition containing vascular endothelial cell growth factor antagonist polypeptide monoclonal antibody amino acid sequence and method of treatment of tumor in mammal |
| GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
| US5508300A (en) | 1994-01-14 | 1996-04-16 | Pfizer Inc. | Dihydro pyrazolopyrroles, compositions and use |
| WO1996030347A1 (en) | 1995-03-30 | 1996-10-03 | Pfizer Inc. | Quinazoline derivatives |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| US5843901A (en) | 1995-06-07 | 1998-12-01 | Advanced Research & Technology Institute | LHRH antagonist peptides |
| US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| CZ1598A3 (en) | 1995-07-06 | 1998-04-15 | Novartis Ag | Pyrrolopyrimidines and process for preparing thereof |
| US5760041A (en) | 1996-02-05 | 1998-06-02 | American Cyanamid Company | 4-aminoquinazoline EGFR Inhibitors |
| GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| CN100503580C (en) | 1996-04-12 | 2009-06-24 | 沃尼尔·朗伯公司 | Irreversible inhibitor of tyrosine kinase |
| BR9709959A (en) | 1996-06-24 | 2000-05-09 | Pfizer | Tricyclic derivatives of substituted phenylamino for the treatment of hyperproliferative diseases |
| JP2001500851A (en) | 1996-08-30 | 2001-01-23 | ノバルティス アクチエンゲゼルシャフト | Process for producing epothilone and intermediate products obtained during the process |
| DE69724269T2 (en) | 1996-09-06 | 2004-06-09 | Obducat Ab | METHOD FOR ANISOTROPE ETCHING STRUCTURES IN CONDUCTIVE MATERIALS |
| DE19638745C2 (en) | 1996-09-11 | 2001-05-10 | Schering Ag | Monoclonal antibodies against the extracellular domain of the human VEGF receptor protein (KDR) |
| CA2265630A1 (en) | 1996-09-13 | 1998-03-19 | Gerald Mcmahon | Use of quinazoline derivatives for the manufacture of a medicament in the treatment of hyperproliferative skin disorders |
| EP0837063A1 (en) | 1996-10-17 | 1998-04-22 | Pfizer Inc. | 4-Aminoquinazoline derivatives |
| ATE408612T1 (en) | 1996-11-18 | 2008-10-15 | Biotechnolog Forschung Gmbh | EPOTHILONES E AND F |
| US6441186B1 (en) | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
| CO4950519A1 (en) | 1997-02-13 | 2000-09-01 | Novartis Ag | PHTHALAZINES, PHARMACEUTICAL PREPARATIONS THAT UNDERSTAND THEM AND THE PROCESS FOR THEIR PREPARATION |
| CO4940418A1 (en) | 1997-07-18 | 2000-07-24 | Novartis Ag | MODIFICATION OF A CRYSTAL OF A DERIVATIVE OF N-PHENYL-2-PIRIMIDINAMINE, PROCESSES FOR ITS MANUFACTURE AND USE |
| GB9721069D0 (en) | 1997-10-03 | 1997-12-03 | Pharmacia & Upjohn Spa | Polymeric derivatives of camptothecin |
| US6194181B1 (en) | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
| AU758526B2 (en) | 1998-02-25 | 2003-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues therof |
| CN1152031C (en) | 1998-08-11 | 2004-06-02 | 诺瓦提斯公司 | Isoquinoline derivatives with angiogenesis inhibiting activity |
| GB9824579D0 (en) | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
| UA71587C2 (en) | 1998-11-10 | 2004-12-15 | Шерінг Акцієнгезелльшафт | Anthranilic acid amides and use thereof as medicaments |
| KR20070087132A (en) | 1998-11-20 | 2007-08-27 | 코산 바이오사이언시즈, 인코포레이티드 | Recombinant methods and materials for producing epothilone and epothilone derivatives |
| IL143596A0 (en) | 1998-12-22 | 2002-04-21 | Genentech Inc | Vascular endothelial cell growth factor antagonists and uses thereof |
| CA2366857C (en) | 1999-03-30 | 2010-12-14 | Novartis Ag | Phthalazine derivatives for treating inflammatory diseases |
| PE20010306A1 (en) | 1999-07-02 | 2001-03-29 | Agouron Pharma | INDAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM USEFUL FOR THE INHIBITION OF PROTEIN KINASE |
| GB0018891D0 (en) | 2000-08-01 | 2000-09-20 | Novartis Ag | Organic compounds |
| PL213199B1 (en) | 2000-08-10 | 2013-01-31 | Pharmacia Italia Spa | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| PE20020354A1 (en) | 2000-09-01 | 2002-06-12 | Novartis Ag | HYDROXAMATE COMPOUNDS AS HISTONE-DESACETILASE (HDA) INHIBITORS |
| US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| TWI238824B (en) | 2001-05-14 | 2005-09-01 | Novartis Ag | 4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives |
| GB0119249D0 (en) | 2001-08-07 | 2001-10-03 | Novartis Ag | Organic compounds |
| MXPA04005906A (en) * | 2001-12-18 | 2004-09-13 | Hoffmann La Roche | Cis-2,4,5- triphenyl-imidazolines and their use in the treatment of tumors. |
| WO2003095625A2 (en) | 2002-05-13 | 2003-11-20 | 3-Dimensional Pharmaceuticals, Inc. | Method for cytoprotection through mdm2 and hdm2 inhibition |
| CA2514733A1 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| US7145012B2 (en) * | 2003-04-23 | 2006-12-05 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
| WO2005110996A1 (en) | 2004-05-18 | 2005-11-24 | F.Hoffmann-La Roche Ag | Novel cis-imidazolines |
| UA91027C2 (en) * | 2004-09-22 | 2010-06-25 | Янссен Фармацевтика Н.В. | Inhibitors of the interaction between mdm2 and p53 |
| US20060069085A1 (en) | 2004-09-28 | 2006-03-30 | Rulin Zhao | Preparation of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones |
| CA2589830A1 (en) | 2005-01-05 | 2006-07-13 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase inhibitors |
| WO2007068637A1 (en) | 2005-12-12 | 2007-06-21 | Nerviano Medical Sciences S.R.L. | Substituted pyrrolo-pyrazole derivatives active as kinase inhibitors |
| WO2007096334A1 (en) | 2006-02-24 | 2007-08-30 | Pfizer Italia Srl | Pyrrolopyrrolones active as kinase inhibitors |
| WO2008034039A2 (en) | 2006-09-15 | 2008-03-20 | Nexuspharma Inc. | Novel tetrahydro-isoquinolines |
| US8101644B2 (en) | 2007-03-30 | 2012-01-24 | Shionogi & Co., Ltd. | Pyrrolinone derivative and pharmaceutical composition comprising the same |
| US8642660B2 (en) | 2007-12-21 | 2014-02-04 | The University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| EP2336109A4 (en) | 2008-09-25 | 2012-05-02 | Shionogi & Co | Novel pyrrolinone derivative and medicinal composition containing same |
| US20120208204A1 (en) | 2009-06-03 | 2012-08-16 | The Brigham And Women's Hospital, Inc. | Compositions and Methods for Inhibiting Tumor Growth |
| US8440693B2 (en) | 2009-12-22 | 2013-05-14 | Novartis Ag | Substituted isoquinolinones and quinazolinones |
| US20120065210A1 (en) | 2010-09-15 | 2012-03-15 | Xin-Jie Chu | Substituted hexahydropyrrolo[1,2-c]imidazolones |
| GB201016880D0 (en) | 2010-10-07 | 2010-11-17 | Riotech Pharmaceuticals Ltd | Phosphodiesterase inhibitors |
| US8969341B2 (en) * | 2011-11-29 | 2015-03-03 | Novartis Ag | Pyrazolopyrrolidine compounds |
| US8815926B2 (en) * | 2012-01-26 | 2014-08-26 | Novartis Ag | Substituted pyrrolo[3,4-D]imidazoles for the treatment of MDM2/4 mediated diseases |
| EP2855483B1 (en) | 2012-05-24 | 2017-10-25 | Novartis AG | Pyrrolopyrrolidinone compounds |
-
2013
- 2013-01-24 US US13/748,790 patent/US8815926B2/en active Active
- 2013-01-24 JO JOP/2013/0025A patent/JO3357B1/en active
- 2013-01-24 UY UY0001034591A patent/UY34591A/en active IP Right Grant
- 2013-01-25 JP JP2014553845A patent/JP5865519B2/en active Active
- 2013-01-25 KR KR1020167035785A patent/KR20160150292A/en not_active Application Discontinuation
- 2013-01-25 TW TW105143227A patent/TW201713644A/en unknown
- 2013-01-25 EA EA201491423A patent/EA027130B1/en not_active IP Right Cessation
- 2013-01-25 PT PT137119525T patent/PT2807164T/en unknown
- 2013-01-25 LT LTEP13711952.5T patent/LT2807164T/en unknown
- 2013-01-25 CU CUP2014000091A patent/CU24336B1/en unknown
- 2013-01-25 PE PE2014001168A patent/PE20141655A1/en active IP Right Grant
- 2013-01-25 AP AP2014007810A patent/AP2014007810A0/en unknown
- 2013-01-25 MY MYPI2014002033A patent/MY177242A/en unknown
- 2013-01-25 BR BR112014018475-5A patent/BR112014018475B1/en active IP Right Grant
- 2013-01-25 DK DK13711952.5T patent/DK2807164T3/en active
- 2013-01-25 ES ES13711952.5T patent/ES2632430T3/en active Active
- 2013-01-25 EP EP16161001.9A patent/EP3064502A1/en not_active Withdrawn
- 2013-01-25 NZ NZ627277A patent/NZ627277A/en unknown
- 2013-01-25 EA EA201790134A patent/EA201790134A3/en unknown
- 2013-01-25 TW TW102103027A patent/TWI579284B/en active
- 2013-01-25 SG SG11201403935VA patent/SG11201403935VA/en unknown
- 2013-01-25 UA UAA201407720A patent/UA115231C2/en unknown
- 2013-01-25 GE GEAP201313535A patent/GEP20166438B/en unknown
- 2013-01-25 WO PCT/IB2013/050655 patent/WO2013111105A1/en active Application Filing
- 2013-01-25 AR ARP130100227A patent/AR089807A1/en active IP Right Grant
- 2013-01-25 CA CA2860951A patent/CA2860951C/en active Active
- 2013-01-25 EP EP13711952.5A patent/EP2807164B1/en active Active
- 2013-01-25 RS RS20170670A patent/RS56197B1/en unknown
- 2013-01-25 CN CN201380016617.6A patent/CN104203952B/en active Active
- 2013-01-25 ES ES17182338T patent/ES2743962T3/en active Active
- 2013-01-25 MX MX2014009089A patent/MX353315B/en active IP Right Grant
- 2013-01-25 EP EP17182338.8A patent/EP3272754B1/en active Active
- 2013-01-25 AU AU2013213260A patent/AU2013213260B2/en active Active
- 2013-01-25 SI SI201330691T patent/SI2807164T1/en unknown
- 2013-01-25 KR KR1020147023313A patent/KR101694383B1/en active IP Right Grant
- 2013-01-25 PL PL13711952T patent/PL2807164T3/en unknown
-
2014
- 2014-07-10 US US14/327,639 patent/US20140343084A1/en not_active Abandoned
- 2014-07-14 CL CL2014001855A patent/CL2014001855A1/en unknown
- 2014-07-18 MA MA37217A patent/MA35869B1/en unknown
- 2014-07-21 IL IL233739A patent/IL233739A/en active IP Right Grant
- 2014-07-22 CR CR20140354A patent/CR20140354A/en unknown
- 2014-07-22 DO DO2014000170A patent/DOP2014000170A/en unknown
- 2014-07-23 TN TNP2014000319A patent/TN2014000319A1/en unknown
- 2014-07-24 CO CO14161419A patent/CO7010838A2/en active IP Right Grant
- 2014-07-25 GT GT201400164A patent/GT201400164A/en unknown
- 2014-07-25 NI NI201400083A patent/NI201400083A/en unknown
- 2014-07-25 PH PH12014501702A patent/PH12014501702B1/en unknown
- 2014-08-25 EC ECIEPI201415553A patent/ECSP14015553A/en unknown
- 2014-12-04 HK HK14112230.9A patent/HK1198761A1/en unknown
-
2015
- 2015-12-22 JP JP2015250003A patent/JP2016106095A/en not_active Withdrawn
-
2017
- 2017-02-23 JP JP2017031964A patent/JP2017125037A/en active Pending
- 2017-07-03 HR HRP20171005TT patent/HRP20171005T1/en unknown
- 2017-07-05 CY CY20171100717T patent/CY1119058T1/en unknown
-
2018
- 2018-04-23 HK HK18105237.2A patent/HK1245780B/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL268013A (en) | Tetrahydropyrazolopyrimidine compounds | |
| HK1245780B (en) | Imidazopyrrolidinone compounds | |
| IL237341A0 (en) | Pro-neurogenic compounds | |
| GB201209138D0 (en) | Compounds | |
| GB201214750D0 (en) | Compounds | |
| GB201215357D0 (en) | Compounds | |
| EP2887803A4 (en) | Pro-neurogenic compounds | |
| HK1206726A1 (en) | Imidazotriazinone compounds | |
| GB201204985D0 (en) | Compounds | |
| GB201204125D0 (en) | Compounds | |
| PL2836495T3 (en) | Tetrahydropyrrolothiazine compounds | |
| HK1211283A1 (en) | Compounds | |
| GB201209096D0 (en) | Compounds | |
| HK1206356A1 (en) | Lpar - substituted cyanopyrazole compounds lpar- | |
| GB201219820D0 (en) | Compounds | |
| GB201217310D0 (en) | Compounds | |
| GB201223429D0 (en) | Compounds | |
| GB201220029D0 (en) | Compounds | |
| GB201219819D0 (en) | Compounds | |
| GB201218799D0 (en) | Compounds | |
| GB201218774D0 (en) | Compounds | |
| GB201218776D0 (en) | Compounds | |
| GB201218758D0 (en) | Compounds | |
| GB201218018D0 (en) | Compounds | |
| GB201217312D0 (en) | Compounds |