HRP20170192T1 - Farmacetuski pripravak za inhalacijsku uporabu koji sadrži kortikoid, te kinolon ili fuzidičnu kiselinu - Google Patents
Farmacetuski pripravak za inhalacijsku uporabu koji sadrži kortikoid, te kinolon ili fuzidičnu kiselinu Download PDFInfo
- Publication number
- HRP20170192T1 HRP20170192T1 HRP20170192TT HRP20170192T HRP20170192T1 HR P20170192 T1 HRP20170192 T1 HR P20170192T1 HR P20170192T T HRP20170192T T HR P20170192TT HR P20170192 T HRP20170192 T HR P20170192T HR P20170192 T1 HRP20170192 T1 HR P20170192T1
- Authority
- HR
- Croatia
- Prior art keywords
- quinolone
- weight
- pharmaceutical spray
- corticoid
- preparation according
- Prior art date
Links
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 title claims 24
- 239000003470 adrenal cortex hormone Substances 0.000 title claims 16
- RKHQGWMMUURILY-UHRZLXHJSA-N cortivazol Chemical compound C([C@H]1[C@@H]2C[C@H]([C@]([C@@]2(C)C[C@H](O)[C@@H]1[C@@]1(C)C2)(O)C(=O)COC(C)=O)C)=C(C)C1=CC1=C2C=NN1C1=CC=CC=C1 RKHQGWMMUURILY-UHRZLXHJSA-N 0.000 title claims 16
- IECPWNUMDGFDKC-UHFFFAOYSA-N Fusicsaeure Natural products C12C(O)CC3C(=C(CCC=C(C)C)C(O)=O)C(OC(C)=O)CC3(C)C1(C)CCC1C2(C)CCC(O)C1C IECPWNUMDGFDKC-UHFFFAOYSA-N 0.000 title claims 8
- IECPWNUMDGFDKC-MZJAQBGESA-N fusidic acid Chemical compound O[C@@H]([C@@H]12)C[C@H]3\C(=C(/CCC=C(C)C)C(O)=O)[C@@H](OC(C)=O)C[C@]3(C)[C@@]2(C)CC[C@@H]2[C@]1(C)CC[C@@H](O)[C@H]2C IECPWNUMDGFDKC-MZJAQBGESA-N 0.000 title claims 8
- 229960004675 fusidic acid Drugs 0.000 title claims 8
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000007921 spray Substances 0.000 claims 21
- 230000000699 topical effect Effects 0.000 claims 13
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims 10
- 229960003405 ciprofloxacin Drugs 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 3
- 229930195725 Mannitol Natural products 0.000 claims 3
- 229960000686 benzalkonium chloride Drugs 0.000 claims 3
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 3
- XTULMSXFIHGYFS-VLSRWLAYSA-N fluticasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(F)[C@@]4(C)C=CC(=O)C=C4[C@@H](F)C[C@H]3[C@@H]2C[C@H]1C)C(=O)SCF)C(=O)C1=CC=CO1 XTULMSXFIHGYFS-VLSRWLAYSA-N 0.000 claims 3
- 229960001469 fluticasone furoate Drugs 0.000 claims 3
- 235000010355 mannitol Nutrition 0.000 claims 3
- 239000000594 mannitol Substances 0.000 claims 3
- 210000002345 respiratory system Anatomy 0.000 claims 3
- 229960005294 triamcinolone Drugs 0.000 claims 3
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- GSDSWSVVBLHKDQ-UHFFFAOYSA-N 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=C2)=O)=C3N2C(C)COC3=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-UHFFFAOYSA-N 0.000 claims 1
- 206010001076 Acute sinusitis Diseases 0.000 claims 1
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims 1
- 206010009137 Chronic sinusitis Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 229940092705 beclomethasone Drugs 0.000 claims 1
- NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 claims 1
- 229960004436 budesonide Drugs 0.000 claims 1
- 208000027157 chronic rhinosinusitis Diseases 0.000 claims 1
- 229960000289 fluticasone propionate Drugs 0.000 claims 1
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims 1
- 229960002422 lomefloxacin Drugs 0.000 claims 1
- ZEKZLJVOYLTDKK-UHFFFAOYSA-N lomefloxacin Chemical compound FC1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNC(C)C1 ZEKZLJVOYLTDKK-UHFFFAOYSA-N 0.000 claims 1
- 229960002744 mometasone furoate Drugs 0.000 claims 1
- WOFMFGQZHJDGCX-ZULDAHANSA-N mometasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(Cl)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)C(=O)CCl)C(=O)C1=CC=CO1 WOFMFGQZHJDGCX-ZULDAHANSA-N 0.000 claims 1
- 239000007922 nasal spray Substances 0.000 claims 1
- 229940097496 nasal spray Drugs 0.000 claims 1
- 229960001180 norfloxacin Drugs 0.000 claims 1
- OGJPXUAPXNRGGI-UHFFFAOYSA-N norfloxacin Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 OGJPXUAPXNRGGI-UHFFFAOYSA-N 0.000 claims 1
- 229960001699 ofloxacin Drugs 0.000 claims 1
- 201000009890 sinusitis Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Otolaryngology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (20)
1. Farmaceutski sprej pripravak za uporabu u liječenju bolesti primjenom putem inhalacije ljudskom subjektu, koji sadrži barem jedan topikalni kortikoid i kinolon ili fuzidičnu kiselinu, naznačen time što je omjer težine topikalnog kortikoida prema težini kinolona ili fuzidične kiseline između 0.02 i 20 i količina kinolona ili fuzidične kiseline je manja od 1 mg.
2. Farmaceutski sprej pripravak prema zahtjevu 1, gdje je omjer težine topikalnog kortikoida prema težini kinolona ili fuzidične kiseline između 0.4 i 2 i količina kinolona ili fuzidične kiseline je između 10 i 400 µg.
3. Farmaceutski sprej pripravak prema zahtjevu 2, gdje je omjer težine topikalnog kortikoida prema težini kinolona ili fuzidične kiseline između 0.5 i 1.5 i količina kinolona ili fuzidične kiseline je između 70 i 150 µg.
4. Farmaceutski sprej pripravak prema zahtjevu 3, gdje je omjer težine topikalnog kortikoida prema težini kinolona 1.34 i količina kinolona je 93 µg.
5. Farmaceutski sprej pripravak prema zahtjevu 3, gdje je omjer težine topikalnog kortikoida prema težini kinolona 1 i količina kinolona je 75 µg.
6. Farmaceutski sprej pripravak prema zahtjevu 3, gdje je omjer težine topikalnog kortikoida prema težini kinolona 0.5 i količina kinolona je 75 µg.
7. Farmaceutski sprej pripravak prema jednom od prethodnih zahtjeva, u kojem se topikalni kortikoid odabire iz skupine koju čine sljedeće molekule: mometazon furoat, budezonid, beklometazon, flutikazon furoat, flutikazon propionat, triamcinolon.
8. Farmaceutski sprej pripravak prema jednom od prethodnih zahtjeva, u kojem se kinolon odabire iz skupine koju čine sljedeće molekule: ofloksacin, norfloksacin, ciprofloksacin, lomefloksacin, leksofloksacin.
9. Farmaceutski sprej pripravak prema zahtjevu 7 ili 8 gdje je kortikoid flutikazon furoat i kinolon je ciprofloksacin.
10. Farmaceutski sprej pripravak prema zahtjevu 7 ili 8 gdje je kortikoid triamcinolon i kinolon je ciprofloksacin.
11. Farmaceutski sprej pripravak prema jednom od prethodnih zahtjeva, dalje sadrži farmaceutski prikladnu pomoćnu tvar kao manitol i/ili benzalkonijev klorid.
12. Farmaceutski sprej pripravak prema jednom od prethodnih zahtjeva gdje je omjer težine topikalnog kortikoida prema težini kinolona između 0.25 i 1, količina kinolona je između 75 µg i 100 µg, topikalni kortikoid je flutikazon furoat i kinolon je ciprofloksacin, pomoćne tvari su barem manitol i benzalkonijev klorid.
13. Farmaceutski sprej pripravak prema jednom od zahtjeva 1 do 11, gdje je omjer težine topikalnog kortikoida prema težini kinolona između 0.25 i 1, količina kinolona je između 75 µg i 100 µg, topikalni kortikoid je triamcinolon i kinolon je ciprofloksacin, pomoćne tvari su barem manitol i benzalkonijev klorid.
14. Farmaceutski sprej pripravak prema jednom od prethodnih zahtjeva za uporabu u liječenju gornjih dišnih puteva.
15. Farmaceutski sprej pripravak prema zahtjevu 14 za uporabu u liječenju sinusitisa, posebno akutnog ili kroničnog sinusitisa.
16. Farmaceutski sprej pripravak prema jednom od zahtjeva 1 do 13 za uporabu u liječenju donjih dišnih puteva.
17. Farmaceutski sprej pripravak prema zahtjevu 16 za uporabu u liječenju mukoviskidoze.
18. Farmaceutski pripravak koji sadrži nekoliko potisaka spreja prema jednom od prethodnih zahtjeva, naznačen time što je u obliku spreja za nos.
19. Potisak spreja farmaceutskog pripravka prema jednom od prethodnih zahtjeva za uporabu u liječenju bolesti prema zahtjevu 1, gdje primjena jednom dnevno i za jednu nosnicu sadrži 50 do 300 µg topikalnog kortikoida i od 150 do 400 µg kinolona.
20. Farmaceutski sprej pripravak prema jednom od zahtjeva 1 do 17 za uporabu u liječenju dišnih puteva, naznačen time što se taj pripravak mora primijeniti u obliku spreja dva puta u svaku nosnicu jednom ili dva puta dnevno.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11159067A EP2502616A1 (fr) | 2011-03-21 | 2011-03-21 | Composition pharmaceutique nasale |
| PCT/IB2012/051310 WO2012127407A1 (en) | 2011-03-21 | 2012-03-19 | Pharmaceutical composition for use in nasal administration containing corticoid, and a quinolone or fusidic acid |
| EP12717477.9A EP2688553B8 (en) | 2011-03-21 | 2012-03-19 | Pharmaceutical composition for use in inhalation containing a corticoid, and a quinolone or fusidic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20170192T1 true HRP20170192T1 (hr) | 2017-03-24 |
Family
ID=44597198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20170192TT HRP20170192T1 (hr) | 2011-03-21 | 2017-02-06 | Farmacetuski pripravak za inhalacijsku uporabu koji sadrži kortikoid, te kinolon ili fuzidičnu kiselinu |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9636350B2 (hr) |
| EP (2) | EP2502616A1 (hr) |
| ES (1) | ES2615932T3 (hr) |
| HR (1) | HRP20170192T1 (hr) |
| RU (1) | RU2614716C2 (hr) |
| WO (1) | WO2012127407A1 (hr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018069830A1 (en) | 2016-10-10 | 2018-04-19 | Dos Santos, Antonio | Pharmaceutical composition for the treatment of sinusitis and COPD |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3704907A1 (de) * | 1987-02-17 | 1988-08-25 | Bayer Ag | Topisch anwendbare zubereitungen von gyrase-inhibitoren in kombination mit kortikosteroiden |
| ES2065846B1 (es) * | 1993-04-20 | 1995-10-01 | Cusi Lab | Formulacion farmaceutica a base de un agente antiinflamatorio esteroidico o no esteroidico y un antibiotico pertenciente al grupo de los inhibidores de la adn girasa para su utilizacion topica oftalmica. |
| US20020061281A1 (en) | 1999-07-06 | 2002-05-23 | Osbakken Robert S. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
| US20010049366A1 (en) * | 2000-02-09 | 2001-12-06 | Alcon Universal Ltd. | Topical solution formulations containing an antibiotic and a corticosteroid |
| RU2279292C2 (ru) * | 2001-10-24 | 2006-07-10 | Пари Гмбх | Набор для приготовления фармацевтической композиции |
| EP1596823A2 (en) * | 2003-02-21 | 2005-11-23 | Sun Pharmaceuticals Industries Ltd. | A stable ophthalmic composition |
| AU2004222340B2 (en) | 2003-03-14 | 2009-11-12 | Intersect Ent, Inc. | Sinus delivery of sustained release therapeutics |
| US8912174B2 (en) * | 2003-04-16 | 2014-12-16 | Mylan Pharmaceuticals Inc. | Formulations and methods for treating rhinosinusitis |
| EP1894559A1 (en) | 2006-09-01 | 2008-03-05 | PARI Pharma GmbH | Means to solubilise steroids for inhalation |
| WO2009027762A2 (en) * | 2007-08-24 | 2009-03-05 | Wockhardt Research Centre | Liquid dosage forms of fluoroquinolone antibiotics or salt thereof for ophthalmic, otic and nasal administration |
| TW201010708A (en) * | 2008-06-02 | 2010-03-16 | Intervet Int Bv | Composition comprising an antibiotic and a corticosteroid |
| US9066861B2 (en) | 2009-01-21 | 2015-06-30 | Vanangamudi Subramaniam Sulur | Dermaceutical cream made using sodium fusidate and steroids |
-
2011
- 2011-03-21 EP EP11159067A patent/EP2502616A1/fr not_active Withdrawn
-
2012
- 2012-03-19 ES ES12717477.9T patent/ES2615932T3/es active Active
- 2012-03-19 RU RU2013144043A patent/RU2614716C2/ru active
- 2012-03-19 WO PCT/IB2012/051310 patent/WO2012127407A1/en active Application Filing
- 2012-03-19 EP EP12717477.9A patent/EP2688553B8/en active Active
- 2012-03-19 US US14/006,414 patent/US9636350B2/en active Active
-
2017
- 2017-02-06 HR HRP20170192TT patent/HRP20170192T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2615932T3 (es) | 2017-06-08 |
| EP2688553B8 (en) | 2017-04-05 |
| US20140296192A1 (en) | 2014-10-02 |
| EP2502616A1 (fr) | 2012-09-26 |
| US9636350B2 (en) | 2017-05-02 |
| WO2012127407A1 (en) | 2012-09-27 |
| RU2013144043A (ru) | 2015-04-27 |
| EP2688553A1 (en) | 2014-01-29 |
| EP2688553B1 (en) | 2016-11-16 |
| RU2614716C2 (ru) | 2017-03-28 |
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