HRP20090158T1 - Substituted pyrroles, compositions containing same, method for making same and use thereof - Google Patents
Substituted pyrroles, compositions containing same, method for making same and use thereofInfo
- Publication number
- HRP20090158T1 HRP20090158T1 HR20090158T HRP20090158T HRP20090158T1 HR P20090158 T1 HRP20090158 T1 HR P20090158T1 HR 20090158 T HR20090158 T HR 20090158T HR P20090158 T HRP20090158 T HR P20090158T HR P20090158 T1 HRP20090158 T1 HR P20090158T1
- Authority
- HR
- Croatia
- Prior art keywords
- substituted
- same
- compositions containing
- independently selected
- substituted pyrroles
- Prior art date
Links
- 239000000203 mixture Chemical class 0.000 title 1
- 150000003233 pyrroles Chemical class 0.000 title 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 125000000842 isoxazolyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000004426 substituted alkynyl group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Produkt koji odgovara sljedećoj formuli (I), ,u kojoj: A-1-Ar je: gdje svaki X1, X2, X3 i X4 je neovisno odabran između N i CH, igdje A je odabran između po izboru supstituiranog fenila, pirazolila i izoksazolila; L je NH-CO-NH; Ra je H; R1 je H; R2 i R5 su neovisno odabrani iz grupe koja se sastoji od: H, halogena, R'2, OR'2, NHR'2, NHCOR'2, NHCONHR'2, NHSO2R'2, u kojoj svaki R'2, R'3 i R'4 je neovisno odabran iz grupe koja se sastoji od H, alkila, alkenila, alkinila, arila, heteroarila, cikloalkila, heterocikloalkila, supstituiranog alkila, supstituiranog alkilena, supstituiranog alkinila, supstituiranog arila, supstituiranog heteroarila, supstituiranog cikloalkila, supstituiranog heterociklila. Patent sadrži još 8 patentnih zahtjeva.A product corresponding to the following formula (I), in which: A-1-Ar is: wherein each X1, X2, X3 and X4 is independently selected from N and CH, wherein A is selected from optionally substituted phenyl, pyrazolyl and isoxazolyl ; L is NH-CO-NH; Ra is H; R1 is H; R2 and R5 are independently selected from the group consisting of: H, halogen, R'2, OR'2, NHR'2, NHCOR'2, NHCONHR'2, NHSO2R'2, wherein each R'2, R ' 3 and R'4 is independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, substituted alkyl, substituted alkylene, substituted alkynyl, substituted aryl, substituted heteroaryl, substituted cycloalkyl . The patent contains 8 more patent claims.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0501354A FR2881742B1 (en) | 2005-02-10 | 2005-02-10 | SUBSTITUTED PYRROLES, COMPOSITIONS CONTAINING SAME, METHOD OF MANUFACTURE AND USE |
| PCT/FR2006/000286 WO2006084996A1 (en) | 2005-02-10 | 2006-02-08 | Substituted pyrroles, compositions containing same, method for making same and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20090158T1 true HRP20090158T1 (en) | 2009-05-31 |
Family
ID=35478244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20090158T HRP20090158T1 (en) | 2005-02-10 | 2009-03-17 | Substituted pyrroles, compositions containing same, method for making same and use thereof |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US7592365B2 (en) |
| EP (1) | EP1851198B1 (en) |
| JP (1) | JP2008530061A (en) |
| KR (1) | KR20070101317A (en) |
| CN (1) | CN101115716A (en) |
| AR (1) | AR052571A1 (en) |
| AT (1) | ATE419234T1 (en) |
| AU (1) | AU2006212106A1 (en) |
| BR (1) | BRPI0606955A2 (en) |
| CA (1) | CA2596822A1 (en) |
| CR (1) | CR9231A (en) |
| CY (1) | CY1108916T1 (en) |
| DE (1) | DE602006004566D1 (en) |
| DK (1) | DK1851198T3 (en) |
| DO (1) | DOP2006000028A (en) |
| EA (1) | EA013060B1 (en) |
| ES (1) | ES2319926T3 (en) |
| FR (1) | FR2881742B1 (en) |
| GT (1) | GT200600048A (en) |
| HR (1) | HRP20090158T1 (en) |
| IL (1) | IL184488A0 (en) |
| MA (1) | MA29248B1 (en) |
| MX (1) | MX2007008789A (en) |
| MY (1) | MY142082A (en) |
| NO (1) | NO20074528L (en) |
| PA (1) | PA8661601A1 (en) |
| PE (1) | PE20061086A1 (en) |
| PL (1) | PL1851198T3 (en) |
| PT (1) | PT1851198E (en) |
| RS (1) | RS50806B (en) |
| SI (1) | SI1851198T1 (en) |
| TN (1) | TNSN07241A1 (en) |
| TW (1) | TW200640858A (en) |
| UY (1) | UY29371A1 (en) |
| WO (1) | WO2006084996A1 (en) |
| ZA (1) | ZA200706157B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2881426B1 (en) | 2005-02-03 | 2007-03-30 | Aventis Pharma Sa | SUBSTITUTED PYROLLES AND IMIDAZOLES, COMPOSITIONS CONTAINING THE SAME, PROCESS FOR FRABRICATION AND USE |
| NZ576291A (en) * | 2006-10-23 | 2011-10-28 | Lexicon Pharmaceuticals Inc | Process for preparing 5-alkyl-7h-pyrrolo[2,3-d]pyrimidine-2-ols |
| TW201111385A (en) | 2009-08-27 | 2011-04-01 | Biocryst Pharm Inc | Heterocyclic compounds as janus kinase inhibitors |
| US20120244141A1 (en) | 2010-09-28 | 2012-09-27 | Boehringer Ingelheim International Gmbh | Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors |
| WO2020034988A1 (en) * | 2018-08-14 | 2020-02-20 | 江苏豪森药业集团有限公司 | Salt of apoptosis signal-regulating kinase 1 inhibitor and crystal form thereof |
| WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0107901D0 (en) * | 2001-03-29 | 2001-05-23 | Cyclacel Ltd | Anti-cancer compounds |
| EP1436279B8 (en) * | 2001-09-21 | 2008-10-29 | Smithkline Beecham Corporation | Chemical compounds |
| US7307097B2 (en) | 2001-09-27 | 2007-12-11 | Smithkline Beechman Corporation | Chemical compounds |
| US20040138269A1 (en) * | 2002-10-11 | 2004-07-15 | Sugen, Inc. | Substituted pyrroles as kinase inhibitors |
| GB0229581D0 (en) * | 2002-12-19 | 2003-01-22 | Cyclacel Ltd | Use |
| AU2004221881A1 (en) * | 2003-03-13 | 2004-09-30 | Vertex Pharmaceuticals Incorporated | Compositions useful as protein kinase inhibitors |
| DE10354060A1 (en) | 2003-11-19 | 2005-06-02 | Merck Patent Gmbh | pyrrole |
| US7183285B2 (en) * | 2004-04-29 | 2007-02-27 | Pharmix Corp. | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase |
| FR2881426B1 (en) | 2005-02-03 | 2007-03-30 | Aventis Pharma Sa | SUBSTITUTED PYROLLES AND IMIDAZOLES, COMPOSITIONS CONTAINING THE SAME, PROCESS FOR FRABRICATION AND USE |
-
2005
- 2005-02-10 FR FR0501354A patent/FR2881742B1/en not_active Expired - Fee Related
-
2006
- 2006-02-02 DO DO2006000028A patent/DOP2006000028A/en unknown
- 2006-02-02 PA PA20068661601A patent/PA8661601A1/en unknown
- 2006-02-02 PE PE2006000135A patent/PE20061086A1/en not_active Application Discontinuation
- 2006-02-03 MY MYPI20060441A patent/MY142082A/en unknown
- 2006-02-08 EA EA200701688A patent/EA013060B1/en not_active IP Right Cessation
- 2006-02-08 JP JP2007554598A patent/JP2008530061A/en active Pending
- 2006-02-08 ES ES06709274T patent/ES2319926T3/en active Active
- 2006-02-08 WO PCT/FR2006/000286 patent/WO2006084996A1/en active Application Filing
- 2006-02-08 GT GT200600048A patent/GT200600048A/en unknown
- 2006-02-08 SI SI200630232T patent/SI1851198T1/en unknown
- 2006-02-08 DE DE602006004566T patent/DE602006004566D1/en active Active
- 2006-02-08 KR KR1020077018321A patent/KR20070101317A/en not_active Application Discontinuation
- 2006-02-08 PL PL06709274T patent/PL1851198T3/en unknown
- 2006-02-08 CN CNA2006800044573A patent/CN101115716A/en active Pending
- 2006-02-08 DK DK06709274T patent/DK1851198T3/en active
- 2006-02-08 EP EP06709274A patent/EP1851198B1/en active Active
- 2006-02-08 AT AT06709274T patent/ATE419234T1/en active
- 2006-02-08 BR BRPI0606955-0A patent/BRPI0606955A2/en not_active IP Right Cessation
- 2006-02-08 MX MX2007008789A patent/MX2007008789A/en active IP Right Grant
- 2006-02-08 AU AU2006212106A patent/AU2006212106A1/en not_active Withdrawn
- 2006-02-08 ZA ZA200706157A patent/ZA200706157B/en unknown
- 2006-02-08 CA CA002596822A patent/CA2596822A1/en not_active Abandoned
- 2006-02-08 AR ARP060100452A patent/AR052571A1/en unknown
- 2006-02-08 RS RSP-2009/0128A patent/RS50806B/en unknown
- 2006-02-08 PT PT06709274T patent/PT1851198E/en unknown
- 2006-02-09 TW TW095104288A patent/TW200640858A/en unknown
- 2006-02-10 UY UY29371A patent/UY29371A1/en unknown
-
2007
- 2007-06-26 TN TNP2007000241A patent/TNSN07241A1/en unknown
- 2007-07-06 CR CR9231A patent/CR9231A/en not_active Application Discontinuation
- 2007-07-08 IL IL184488A patent/IL184488A0/en unknown
- 2007-08-01 US US11/832,208 patent/US7592365B2/en not_active Expired - Fee Related
- 2007-08-13 MA MA30134A patent/MA29248B1/en unknown
- 2007-09-06 NO NO20074528A patent/NO20074528L/en not_active Application Discontinuation
-
2009
- 2009-03-17 HR HR20090158T patent/HRP20090158T1/en unknown
- 2009-03-23 CY CY20091100344T patent/CY1108916T1/en unknown
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