HRP20040131A2 - A hydroxamic acid thrombospondin peptide analog that inhibits aggrecanase activity - Google Patents

A hydroxamic acid thrombospondin peptide analog that inhibits aggrecanase activity

Info

Publication number
HRP20040131A2
HRP20040131A2 HR20040131A HRP20040131A HRP20040131A2 HR P20040131 A2 HRP20040131 A2 HR P20040131A2 HR 20040131 A HR20040131 A HR 20040131A HR P20040131 A HRP20040131 A HR P20040131A HR P20040131 A2 HRP20040131 A2 HR P20040131A2
Authority
HR
Croatia
Prior art keywords
hydroxamic acid
peptide analog
aggrecanase activity
thrombospondin peptide
inhibits aggrecanase
Prior art date
Application number
HR20040131A
Other languages
English (en)
Inventor
Tortorella Michael
Wang Jinhai
Rodney
Original Assignee
Enzyme Systems Prducts Inc./(Icn Biomedicals)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzyme Systems Prducts Inc./(Icn Biomedicals) filed Critical Enzyme Systems Prducts Inc./(Icn Biomedicals)
Publication of HRP20040131A2 publication Critical patent/HRP20040131A2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
HR20040131A 2001-07-09 2004-02-09 A hydroxamic acid thrombospondin peptide analog that inhibits aggrecanase activity HRP20040131A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30398901P 2001-07-09 2001-07-09
PCT/US2002/021780 WO2003005956A2 (en) 2001-07-09 2002-07-09 A hydroxamic acid thrombospondin peptide analog that inhibits aggrecanase activity

Publications (1)

Publication Number Publication Date
HRP20040131A2 true HRP20040131A2 (en) 2005-12-31

Family

ID=23174550

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20040131A HRP20040131A2 (en) 2001-07-09 2004-02-09 A hydroxamic acid thrombospondin peptide analog that inhibits aggrecanase activity

Country Status (8)

Country Link
US (1) US20030114529A1 (ja)
EP (1) EP1480946A2 (ja)
JP (1) JP2005504021A (ja)
CN (1) CN1568306A (ja)
CA (1) CA2453346A1 (ja)
HR (1) HRP20040131A2 (ja)
RU (1) RU2004100273A (ja)
WO (1) WO2003005956A2 (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0318625A (pt) * 2003-12-04 2006-10-31 Wyeth Corp biaril sulfonamidas e métodos para usar as mesmas
ZA200605248B (en) * 2003-12-15 2007-10-31 Japan Tobacco Inc Cyclopropane compounds and pharmaceutical use thereof
US7696307B2 (en) * 2004-04-12 2010-04-13 The Trustees Of The University Of Pennsylvania Function and regulation of ADAMTS-1

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599361A (en) * 1985-09-10 1986-07-08 G. D. Searle & Co. Hydroxamic acid based collagenase inhibitors
US5594106A (en) * 1993-08-23 1997-01-14 Immunex Corporation Inhibitors of TNF-α secretion

Also Published As

Publication number Publication date
WO2003005956A2 (en) 2003-01-23
WO2003005956A3 (en) 2004-09-23
US20030114529A1 (en) 2003-06-19
JP2005504021A (ja) 2005-02-10
CA2453346A1 (en) 2003-01-23
EP1480946A2 (en) 2004-12-01
CN1568306A (zh) 2005-01-19
RU2004100273A (ru) 2005-06-27

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Legal Events

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Payment date: 20040706

Year of fee payment: 3

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