HN2011003005A - [1,2,4] triazolo [4,3-b] piridazinas como ligandos del receptor de androgenos. - Google Patents
[1,2,4] triazolo [4,3-b] piridazinas como ligandos del receptor de androgenos.Info
- Publication number
- HN2011003005A HN2011003005A HN2011003005A HN2011003005A HN2011003005A HN 2011003005 A HN2011003005 A HN 2011003005A HN 2011003005 A HN2011003005 A HN 2011003005A HN 2011003005 A HN2011003005 A HN 2011003005A HN 2011003005 A HN2011003005 A HN 2011003005A
- Authority
- HN
- Honduras
- Prior art keywords
- piridazinas
- triazolo
- ligands
- androgen
- receiver
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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-
- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Reproductive Health (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Pulmonology (AREA)
- Pregnancy & Childbirth (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A COMPUESTOS BICICLICOS DE FORMULA (I) (I) EN DONDE R1, R2, R3, R4, R5, X1, X2, Y k, m, n y p SON TAL COMO SE DEFIENE EN LA DESCRICION. LA PRESENTE INVENCION TAMBIEN SE REFIERE A PROCESOS PARA LA PREPARACION DE DICHOS COMPUESTOS, COMPOSICIONES FRAMACETICAS QUE LOS CONTIENEN Y SU USO EWN EL TRTAMIENTO DE AFECCIONES ASOCIADAS CON EL RECPTOR DE ANDROGENOS, EN PARTICULAR EL CANCER DE PROSTATA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17700509P | 2009-05-11 | 2009-05-11 | |
US21864609P | 2009-06-19 | 2009-06-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
HN2011003005A true HN2011003005A (es) | 2014-06-30 |
Family
ID=42237253
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HN2011003005A HN2011003005A (es) | 2009-05-11 | 2011-11-11 | [1,2,4] triazolo [4,3-b] piridazinas como ligandos del receptor de androgenos. |
Country Status (25)
Country | Link |
---|---|
US (1) | US20100292222A1 (es) |
EP (1) | EP2430024A1 (es) |
JP (1) | JP2012526790A (es) |
KR (1) | KR20120034645A (es) |
CN (1) | CN102482280A (es) |
AR (1) | AR076571A1 (es) |
AU (1) | AU2010247190A1 (es) |
BR (1) | BRPI1011363A2 (es) |
CA (1) | CA2759884A1 (es) |
CL (1) | CL2011002812A1 (es) |
CO (1) | CO6460764A2 (es) |
CR (1) | CR20110593A (es) |
CU (1) | CU20110205A7 (es) |
EA (1) | EA201101604A1 (es) |
EC (1) | ECSP11011451A (es) |
HN (1) | HN2011003005A (es) |
IL (1) | IL216144A0 (es) |
MX (1) | MX2011012055A (es) |
NI (1) | NI201100198A (es) |
PE (1) | PE20120473A1 (es) |
SG (1) | SG175726A1 (es) |
TW (1) | TW201043633A (es) |
UY (1) | UY32623A (es) |
WO (1) | WO2010131022A1 (es) |
ZA (1) | ZA201108723B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20120603A1 (es) | 2009-02-10 | 2012-06-14 | Astrazeneca Ab | Derivados de triazolo[4,3-b]piridazina y sus usos para el cancer de prostata |
JP6247992B2 (ja) * | 2014-04-17 | 2017-12-13 | 株式会社ダイセル | ハロゲン化合物の製造方法 |
NO2719005T3 (es) * | 2014-07-28 | 2018-01-20 | ||
CN105272927A (zh) * | 2015-11-17 | 2016-01-27 | 华中药业股份有限公司 | 一种制备氯氮卓的新方法 |
JP6635999B2 (ja) * | 2017-10-13 | 2020-01-29 | 株式会社ダイセル | カリウム塩の製造方法、及びカリウム塩 |
CN114341125A (zh) * | 2019-05-02 | 2022-04-12 | 星座制药公司 | Trex1调节剂 |
EP4023649A1 (en) * | 2020-12-30 | 2022-07-06 | Industrial Technology Research Institute | Androgen receptor binding bifunctional molecules |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE35956E (en) * | 1991-01-09 | 1998-11-10 | Roussel Uclaf | Phenylimidazolidines having antiandrogenic activity |
US5411981A (en) * | 1991-01-09 | 1995-05-02 | Roussel Uclaf | Phenylimidazolidines having antiandrogenic activity |
US20040102360A1 (en) * | 2002-10-30 | 2004-05-27 | Barnett Stanley F. | Combination therapy |
EP1796669B1 (en) * | 2004-10-01 | 2010-09-22 | Merck Sharp & Dohme Corp. | Aminopiperidines as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
US7572807B2 (en) * | 2005-06-09 | 2009-08-11 | Bristol-Myers Squibb Company | Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors |
WO2008109104A1 (en) * | 2007-03-07 | 2008-09-12 | The Regents Of The University Of California | Bivalent inhibitors of akt protein kinase |
PA8792501A1 (es) * | 2007-08-09 | 2009-04-23 | Sanofi Aventis | Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol,su procedimiento de preparación,su aplicación como medicamentos,composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met. |
BRPI0821676A2 (pt) * | 2007-12-21 | 2015-06-16 | Astrazeneca Ab | Composto, composição farmacêutica, e, processo para a preparação dos compostos. |
PE20120603A1 (es) * | 2009-02-10 | 2012-06-14 | Astrazeneca Ab | Derivados de triazolo[4,3-b]piridazina y sus usos para el cancer de prostata |
-
2010
- 2010-05-10 EP EP10718682A patent/EP2430024A1/en not_active Withdrawn
- 2010-05-10 CA CA2759884A patent/CA2759884A1/en not_active Abandoned
- 2010-05-10 KR KR1020117029458A patent/KR20120034645A/ko not_active Application Discontinuation
- 2010-05-10 EA EA201101604A patent/EA201101604A1/ru unknown
- 2010-05-10 MX MX2011012055A patent/MX2011012055A/es not_active Application Discontinuation
- 2010-05-10 WO PCT/GB2010/050750 patent/WO2010131022A1/en active Application Filing
- 2010-05-10 BR BRPI1011363A patent/BRPI1011363A2/pt not_active Application Discontinuation
- 2010-05-10 US US12/776,970 patent/US20100292222A1/en not_active Abandoned
- 2010-05-10 UY UY0001032623A patent/UY32623A/es not_active Application Discontinuation
- 2010-05-10 PE PE2011001945A patent/PE20120473A1/es not_active Application Discontinuation
- 2010-05-10 AU AU2010247190A patent/AU2010247190A1/en not_active Abandoned
- 2010-05-10 SG SG2011075371A patent/SG175726A1/en unknown
- 2010-05-10 JP JP2012510369A patent/JP2012526790A/ja active Pending
- 2010-05-10 CN CN2010800321943A patent/CN102482280A/zh active Pending
- 2010-05-11 AR ARP100101635A patent/AR076571A1/es unknown
- 2010-05-11 TW TW099114979A patent/TW201043633A/zh unknown
-
2011
- 2011-11-03 IL IL216144A patent/IL216144A0/en unknown
- 2011-11-10 CL CL2011002812A patent/CL2011002812A1/es unknown
- 2011-11-11 CR CR20110593A patent/CR20110593A/es unknown
- 2011-11-11 EC EC2011011451A patent/ECSP11011451A/es unknown
- 2011-11-11 CU CU20110205A patent/CU20110205A7/es unknown
- 2011-11-11 NI NI201100198A patent/NI201100198A/es unknown
- 2011-11-11 CO CO11154188A patent/CO6460764A2/es not_active Application Discontinuation
- 2011-11-11 HN HN2011003005A patent/HN2011003005A/es unknown
- 2011-11-28 ZA ZA2011/08723A patent/ZA201108723B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AR076571A1 (es) | 2011-06-22 |
JP2012526790A (ja) | 2012-11-01 |
CU20110205A7 (es) | 2012-03-15 |
CA2759884A1 (en) | 2010-11-18 |
IL216144A0 (en) | 2012-01-31 |
ZA201108723B (en) | 2013-05-29 |
MX2011012055A (es) | 2011-12-06 |
BRPI1011363A2 (pt) | 2016-03-15 |
WO2010131022A1 (en) | 2010-11-18 |
NI201100198A (es) | 2012-06-14 |
EA201101604A1 (ru) | 2012-05-30 |
AU2010247190A1 (en) | 2011-11-10 |
UY32623A (es) | 2010-12-31 |
CL2011002812A1 (es) | 2012-04-13 |
CN102482280A (zh) | 2012-05-30 |
US20100292222A1 (en) | 2010-11-18 |
ECSP11011451A (es) | 2011-12-30 |
SG175726A1 (en) | 2011-12-29 |
TW201043633A (en) | 2010-12-16 |
EP2430024A1 (en) | 2012-03-21 |
KR20120034645A (ko) | 2012-04-12 |
PE20120473A1 (es) | 2012-05-27 |
CR20110593A (es) | 2012-01-09 |
CO6460764A2 (es) | 2012-06-15 |
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