HK51197A - Platelet blocking peptides - Google Patents
Platelet blocking peptidesInfo
- Publication number
- HK51197A HK51197A HK51197A HK51197A HK51197A HK 51197 A HK51197 A HK 51197A HK 51197 A HK51197 A HK 51197A HK 51197 A HK51197 A HK 51197A HK 51197 A HK51197 A HK 51197A
- Authority
- HK
- Hong Kong
- Prior art keywords
- blocking peptides
- platelet
- oligopeptides
- platelet blocking
- fibrinogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70546—Integrin superfamily
- C07K14/70557—Integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
Abstract
The present invention provides oligopeptides corresponding to regions of the GPIIIa protein, which are capable of specifically binding aggregation mediators, such as fibrinogen. The oligopeptides will typically comprise at least about 5 to 20 amino acids, and are thus non-immunogenic and easy to produce, formulate and administer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21364188A | 1988-06-30 | 1988-06-30 | |
US33696289A | 1989-04-12 | 1989-04-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK51197A true HK51197A (en) | 1997-04-25 |
Family
ID=26908261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK51197A HK51197A (en) | 1988-06-30 | 1997-04-17 | Platelet blocking peptides |
Country Status (7)
Country | Link |
---|---|
US (1) | US5705606A (en) |
EP (1) | EP0422125B1 (en) |
JP (1) | JP2892726B2 (en) |
AT (1) | ATE144535T1 (en) |
DE (1) | DE68927379T2 (en) |
HK (1) | HK51197A (en) |
WO (1) | WO1990000178A1 (en) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU639409B2 (en) * | 1987-12-10 | 1993-07-29 | La Jolla Cancer Research Foundation | Conformationally stabilized cell adhesion peptides |
US5827821A (en) * | 1987-12-10 | 1998-10-27 | The Burnham Institute | Conformationally stabilized cell adhesion peptides |
US5851839A (en) * | 1989-06-16 | 1998-12-22 | Cor Therapeutics, Inc. | Platelet aggregation inhibitors |
US5384309A (en) * | 1989-07-17 | 1995-01-24 | Genentech, Inc. | Cyclized peptides and their use as platelet aggregation inhibitors |
US5780303A (en) * | 1990-04-06 | 1998-07-14 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US5648330A (en) * | 1990-04-06 | 1997-07-15 | La Jolla Cancer Research Foundation | Method and composition for treating vascular graft occlusion |
DK0527798T3 (en) * | 1990-04-06 | 1997-12-15 | Jolla Cancer Res Found | Method and composition for the treatment of thrombosis |
US6521594B1 (en) | 1990-04-06 | 2003-02-18 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US5612311A (en) | 1990-04-06 | 1997-03-18 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US5342830A (en) * | 1990-11-16 | 1994-08-30 | Cor Therapeutics, Inc. | Antithrombosis agents |
US5177188A (en) * | 1990-12-03 | 1993-01-05 | The Scripps Research Institute | Methods and compositions for diagnosing chronic immune thrombocytopenic purpura |
IE62682B1 (en) * | 1990-12-03 | 1995-02-22 | Scripps Research Inst | Method and compositions for diagnosing chronic immune thrombocytopenic purpura |
DK0578728T3 (en) * | 1991-04-05 | 1999-04-12 | Genentech Inc | Platelet aggregation inhibitors, which have high specificity for GP IIbIIIa |
US5589458A (en) * | 1992-11-13 | 1996-12-31 | Thomas Jefferson University | Compounds that inhibit T cell proliferation and methods for using the same |
CA2180140A1 (en) * | 1993-12-27 | 1995-07-06 | Jeffrey I. Weitz | Methods and compositions for inhibiting thrombogenesis |
US6808698B1 (en) | 1999-03-26 | 2004-10-26 | Bristol-Myers Squibb Pharma Company | Method for localization of blood clots |
US6254852B1 (en) | 1999-07-16 | 2001-07-03 | Dupont Pharmaceuticals Company | Porous inorganic targeted ultrasound contrast agents |
US6685914B1 (en) | 1999-09-13 | 2004-02-03 | Bristol-Myers Squibb Pharma Company | Macrocyclic chelants for metallopharmaceuticals |
WO2003003988A2 (en) * | 2001-07-06 | 2003-01-16 | Oregon Health & Science University | Peptides which modulate blood coagulation and methods of use thereof |
GB0315754D0 (en) * | 2003-07-04 | 2003-08-13 | Univ Aberdeen | Pharmaceutical compositions |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4578079A (en) * | 1982-08-04 | 1986-03-25 | La Jolla Cancer Research Foundation | Tetrapeptide |
US4889919A (en) * | 1986-08-13 | 1989-12-26 | Zymogenetics, Inc. | Biologically active PDGF derived A-chain homodimers |
US4766073A (en) * | 1985-02-25 | 1988-08-23 | Zymogenetics Inc. | Expression of biologically active PDGF analogs in eucaryotic cells |
US4801542A (en) * | 1984-10-12 | 1989-01-31 | Zymogenetics, Inc. | Expression of biologically active PDGF analogs in eucaryotic cells |
US4789734A (en) * | 1985-08-06 | 1988-12-06 | La Jolla Cancer Research Foundation | Vitronectin specific cell receptor derived from mammalian mesenchymal tissue |
DE3751632T2 (en) * | 1986-08-13 | 1996-06-13 | Zymogenetics Inc | Expression of biologically active PDGF analogs in eukaryotic cells |
ES2091749T3 (en) * | 1987-04-22 | 1996-11-16 | Chiron Corp | PRODUCTION BY RECOMBINATION OF POLYPEPTIDES FROM THE A CHAIN OF THE PLATELET-DERIVED GROWTH FACTOR (FCDP). |
EP0325224B1 (en) * | 1988-01-22 | 1996-07-31 | ZymoGenetics, Inc. | Methods of producing secreted receptor analogs |
US5149780A (en) * | 1988-10-03 | 1992-09-22 | The Scripps Research Institute | Peptides and antibodies that inhibit integrin-ligand binding |
WO1993007169A1 (en) * | 1991-10-04 | 1993-04-15 | Chiron Corporation | Peptide inhibitors of platelet adhesion |
-
1989
- 1989-06-30 AT AT89908344T patent/ATE144535T1/en not_active IP Right Cessation
- 1989-06-30 WO PCT/US1989/002893 patent/WO1990000178A1/en active IP Right Grant
- 1989-06-30 EP EP89908344A patent/EP0422125B1/en not_active Expired - Lifetime
- 1989-06-30 JP JP1508028A patent/JP2892726B2/en not_active Expired - Fee Related
- 1989-06-30 DE DE68927379T patent/DE68927379T2/en not_active Expired - Fee Related
-
1993
- 1993-12-21 US US08/170,596 patent/US5705606A/en not_active Expired - Lifetime
-
1997
- 1997-04-17 HK HK51197A patent/HK51197A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO1990000178A1 (en) | 1990-01-11 |
JP2892726B2 (en) | 1999-05-17 |
EP0422125A1 (en) | 1991-04-17 |
EP0422125A4 (en) | 1992-07-08 |
ATE144535T1 (en) | 1996-11-15 |
EP0422125B1 (en) | 1996-10-23 |
JPH04503661A (en) | 1992-07-02 |
DE68927379D1 (en) | 1996-11-28 |
DE68927379T2 (en) | 1997-02-20 |
US5705606A (en) | 1998-01-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |