HK1246657A1 - 具有祖先序列的因子viii蛋白、表達載體和與其相關的用途 - Google Patents

具有祖先序列的因子viii蛋白、表達載體和與其相關的用途

Info

Publication number
HK1246657A1
HK1246657A1 HK18106190.5A HK18106190A HK1246657A1 HK 1246657 A1 HK1246657 A1 HK 1246657A1 HK 18106190 A HK18106190 A HK 18106190A HK 1246657 A1 HK1246657 A1 HK 1246657A1
Authority
HK
Hong Kong
Prior art keywords
expression vectors
factor viii
uses related
viii proteins
ancestral sequences
Prior art date
Application number
HK18106190.5A
Other languages
English (en)
Inventor
H Trent Spencer
Christopher B Doering
Philip M Zakas
Eric Gaucher
Original Assignee
Univ Emory
Georgia Tech Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Emory, Georgia Tech Res Inst filed Critical Univ Emory
Publication of HK1246657A1 publication Critical patent/HK1246657A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
HK18106190.5A 2015-01-30 2018-05-14 具有祖先序列的因子viii蛋白、表達載體和與其相關的用途 HK1246657A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562109964P 2015-01-30 2015-01-30
PCT/US2016/015092 WO2016123200A1 (en) 2015-01-30 2016-01-27 Factor viii proteins having ancestral sequences, expression vectors, and uses related thereto

Publications (1)

Publication Number Publication Date
HK1246657A1 true HK1246657A1 (zh) 2018-09-14

Family

ID=56544270

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18106190.5A HK1246657A1 (zh) 2015-01-30 2018-05-14 具有祖先序列的因子viii蛋白、表達載體和與其相關的用途

Country Status (5)

Country Link
US (3) US10654910B2 (zh)
EP (1) EP3250226B1 (zh)
ES (1) ES2819123T3 (zh)
HK (1) HK1246657A1 (zh)
WO (1) WO2016123200A1 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2819123T3 (es) 2015-01-30 2021-04-15 Univ Emory Proteínas del factor VIII que tienen secuencias ancestrales, vectores de expresión, y usos relacionados con ellos
US10894960B2 (en) 2016-08-30 2021-01-19 Children's Hospital Medical Center Compositions and methods for nucleic acid transfer
EP3622065A1 (en) 2017-05-09 2020-03-18 Emory University Clotting factor variants and their use
US20200347116A1 (en) * 2017-11-01 2020-11-05 Queen's University At Kingston Von willebrand factor proteins for treating bleeding disorders
EP3775194B1 (en) 2018-04-12 2023-06-28 Biotest AG De-immunized factor viii molecule and pharmaceutical compositions comprising the same
EP3773690A1 (en) * 2018-04-13 2021-02-17 INSERM (Institut National de la Santé et de la Recherche Médicale) New vaccinal strategy
US10842885B2 (en) 2018-08-20 2020-11-24 Ucl Business Ltd Factor IX encoding nucleotides
WO2020168362A1 (en) 2019-02-15 2020-08-20 Crispr Therapeutics Ag Gene editing for hemophilia a with improved factor viii expression
EP3962532A4 (en) * 2019-04-29 2023-06-14 Children's Hospital Medical Center COMPOSITIONS WITH OPTIMIZED LIGAND AND METHODS OF USE THEREOF
WO2021043757A1 (en) 2019-09-02 2021-03-11 Biotest Ag Factor viii protein with increased half-life
WO2023092864A1 (en) * 2021-11-25 2023-06-01 Sichuan Real&Best Biotech Co., Ltd. Engineered human fviii with enhanced secretion ability and clotting activity

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003100053A1 (en) * 2002-05-22 2003-12-04 The Children's Hospital Of Philadelphia Compositions and methods for the treatment of hemophilia a
EP1424344A1 (en) * 2002-11-29 2004-06-02 Aventis Behring Gesellschaft mit beschränkter Haftung Modified cDNA factor VIII and its derivates
US8637448B2 (en) * 2010-09-14 2014-01-28 University Of Rochester Recombinant factor VIII having enhanced stability following mutation at the A1-C2 domain interface
MY165089A (en) * 2010-11-05 2018-02-28 Baxalta Inc A new variant of antihemophilic factor viii having increased specific activity
US10370430B2 (en) 2012-02-15 2019-08-06 Bioverativ Therapeutics Inc. Recombinant factor VIII proteins
ES2819123T3 (es) 2015-01-30 2021-04-15 Univ Emory Proteínas del factor VIII que tienen secuencias ancestrales, vectores de expresión, y usos relacionados con ellos

Also Published As

Publication number Publication date
US11897938B2 (en) 2024-02-13
EP3250226A4 (en) 2018-10-03
EP3250226B1 (en) 2020-07-15
EP3250226A1 (en) 2017-12-06
US11046750B2 (en) 2021-06-29
US20200277356A1 (en) 2020-09-03
US20180009873A1 (en) 2018-01-11
US20210388055A1 (en) 2021-12-16
ES2819123T3 (es) 2021-04-15
US10654910B2 (en) 2020-05-19
WO2016123200A1 (en) 2016-08-04

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