HK1244825A1 - Gas6抑制劑的抗纖維化活性 - Google Patents

Gas6抑制劑的抗纖維化活性

Info

Publication number
HK1244825A1
HK1244825A1 HK18104170.4A HK18104170A HK1244825A1 HK 1244825 A1 HK1244825 A1 HK 1244825A1 HK 18104170 A HK18104170 A HK 18104170A HK 1244825 A1 HK1244825 A1 HK 1244825A1
Authority
HK
Hong Kong
Prior art keywords
antifibrotic activity
gas6 inhibitor
gas6
inhibitor
antifibrotic
Prior art date
Application number
HK18104170.4A
Other languages
English (en)
Inventor
Yu Rebecca Miao
Raymond Tabibiazar
Amato J Giaccia
Mihalis Kariolis
Original Assignee
Aravive Biologics Inc
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aravive Biologics Inc, Univ Leland Stanford Junior filed Critical Aravive Biologics Inc
Publication of HK1244825A1 publication Critical patent/HK1244825A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/10—Protein-tyrosine kinases (2.7.10)
    • C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
HK18104170.4A 2014-12-18 2018-03-27 Gas6抑制劑的抗纖維化活性 HK1244825A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462093937P 2014-12-18 2014-12-18
PCT/US2015/066498 WO2016100738A2 (en) 2014-12-18 2015-12-17 Antifibrotic activity of gas6 inhibitor

Publications (1)

Publication Number Publication Date
HK1244825A1 true HK1244825A1 (zh) 2018-08-17

Family

ID=56127858

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18104170.4A HK1244825A1 (zh) 2014-12-18 2018-03-27 Gas6抑制劑的抗纖維化活性

Country Status (7)

Country Link
US (1) US10876176B2 (zh)
EP (1) EP3233902B1 (zh)
AU (1) AU2015364437B2 (zh)
CA (1) CA2971406A1 (zh)
ES (1) ES2834618T3 (zh)
HK (1) HK1244825A1 (zh)
WO (1) WO2016100738A2 (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2931265B3 (en) * 2012-12-14 2023-04-05 The Board of Trustees of the Leland Stanford Junior University Modified axl peptides and their use in inhibition of axl signaling in anti-metastatic therapy
CN109715157A (zh) * 2016-08-24 2019-05-03 亚尼塔公司 用于治疗癌症的组合
JP7286179B2 (ja) * 2017-11-04 2023-06-05 アラヴァイヴ バイオロジクス，インコーポレイテッド Ａｘｌデコイ受容体を用いる転移性癌の治療方法
WO2020186256A1 (en) * 2019-03-14 2020-09-17 Aravive Inc Methods of treating immunoglobulin a nephropathy (igan) using axl decoy receptors
WO2021026337A1 (en) * 2019-08-07 2021-02-11 Icahn School Of Medicine At Mount Sinai Method of treating keloids
EP4087539A4 (en) * 2020-01-06 2023-12-27 Aravive Inc. METHOD FOR TREATING CLEAR CELL RENAL CARCINOMA (CCRCC) USING AXL DECOY RECEPTORS
CN112225703B (zh) * 2020-09-28 2022-03-11 广州智睿医药科技有限公司 一种治疗或预防与lrrk2激酶或异常lrrk2突变激酶活性相关疾病的药物
GB202104037D0 (en) * 2021-03-23 2021-05-05 Bergenbio Asa Combination therapy
US11945785B2 (en) 2021-12-30 2024-04-02 Biomea Fusion, Inc. Pyrazine compounds as inhibitors of FLT3

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
EP0394827A1 (en) 1989-04-26 1990-10-31 F. Hoffmann-La Roche Ag Chimaeric CD4-immunoglobulin polypeptides
US6737056B1 (en) * 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
WO2004108748A2 (en) * 2002-09-24 2004-12-16 Dow, Kenneth, Centocor, Inc. Growth arrest specific gene 6 peptides, antibodies, compositions, methods and uses
WO2008098139A2 (en) * 2007-02-07 2008-08-14 The Regents Of The University Of Colorado Axl tyrosine kinase inhibitors and methods of making and using the same
WO2009062112A2 (en) * 2007-11-09 2009-05-14 The Salk Institute For Biological Studies Use of tam receptor inhibitors as antimicrobials
PT2525824T (pt) * 2010-01-22 2017-07-13 Univ Leland Stanford Junior Inibição da sinalização de axl em terapêutica antimetastática
US9074192B2 (en) * 2010-01-22 2015-07-07 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of AXL signaling in anti-metastatic therapy
WO2013090776A1 (en) * 2011-12-15 2013-06-20 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of axl/gas6 signaling in the treatment of disease
EP2931265B3 (en) * 2012-12-14 2023-04-05 The Board of Trustees of the Leland Stanford Junior University Modified axl peptides and their use in inhibition of axl signaling in anti-metastatic therapy

Also Published As

Publication number Publication date
US20180057898A1 (en) 2018-03-01
WO2016100738A2 (en) 2016-06-23
EP3233902B1 (en) 2020-09-09
EP3233902A4 (en) 2018-08-08
US10876176B2 (en) 2020-12-29
AU2015364437B2 (en) 2020-10-01
ES2834618T3 (es) 2021-06-18
EP3233902A2 (en) 2017-10-25
WO2016100738A3 (en) 2016-09-09
CA2971406A1 (en) 2016-06-23
AU2015364437A1 (en) 2017-07-06

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