HK1216505A1 - 用於眼科應用的醌基氧化氮供體化合物 - Google Patents

用於眼科應用的醌基氧化氮供體化合物

Info

Publication number
HK1216505A1
HK1216505A1 HK16104472.1A HK16104472A HK1216505A1 HK 1216505 A1 HK1216505 A1 HK 1216505A1 HK 16104472 A HK16104472 A HK 16104472A HK 1216505 A1 HK1216505 A1 HK 1216505A1
Authority
HK
Hong Kong
Prior art keywords
nitric oxide
ophthalmic use
donating compounds
oxide donating
quinone based
Prior art date
Application number
HK16104472.1A
Other languages
English (en)
Inventor
Ennio Ongini
Nicoletta Almirante
Laura Storoni
Original Assignee
Nicox Science Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Science Ireland filed Critical Nicox Science Ireland
Publication of HK1216505A1 publication Critical patent/HK1216505A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HK16104472.1A 2012-10-23 2016-04-19 用於眼科應用的醌基氧化氮供體化合物 HK1216505A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12189549 2012-10-23
PCT/EP2013/071148 WO2014063923A1 (en) 2012-10-23 2013-10-10 Quinone based nitric oxide donating compounds for ophthalmic use

Publications (1)

Publication Number Publication Date
HK1216505A1 true HK1216505A1 (zh) 2016-11-18

Family

ID=47046480

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16104472.1A HK1216505A1 (zh) 2012-10-23 2016-04-19 用於眼科應用的醌基氧化氮供體化合物

Country Status (8)

Country Link
US (1) US9446015B2 (zh)
EP (1) EP2911656B1 (zh)
JP (1) JP6405312B2 (zh)
CN (1) CN104994845B (zh)
CA (1) CA2888837C (zh)
ES (1) ES2841993T3 (zh)
HK (1) HK1216505A1 (zh)
WO (1) WO2014063923A1 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2764654T3 (es) * 2014-11-19 2020-06-04 Nicox Sa Combinaciones de prostaglandinas y donantes de óxido nítrico
CN105218377B (zh) * 2015-09-14 2017-10-27 西安交通大学 一种羟基酪醇no供体衍生物及其制备方法和应用
CN108341775B (zh) * 2017-01-25 2021-03-16 重庆常捷医药有限公司 一种瑞巴派特中间体的合成方法
WO2019121488A1 (en) * 2017-12-21 2019-06-27 Nicox S.A. Nitric oxide releasing hyaluronic esters
CN112566670A (zh) 2018-08-06 2021-03-26 尼科斯股份有限公司 一氧化氮释放第5型磷酸二酯酶抑制剂

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60149521A (ja) 1984-01-18 1985-08-07 Eisai Co Ltd 高眼圧・緑内障治療・予防用点眼剤
WO1994021248A1 (de) * 1993-03-15 1994-09-29 Byk Nederland Bv Verwendung von substituierten alkylnitraten zur behandlung des krankhaft erhöhten augeninnendruckes
AU679834B2 (en) * 1994-01-19 1997-07-10 Byk Nederland Bv Nitroxy group-containing benzylamine derivatives and their use for treating cardiovascular diseases, as well as increased intra-ocular pressure
TWI246421B (en) * 1998-12-03 2006-01-01 Alcon Mfg Ltd Use of neurotrophic factor stimulators for the treatment of ophthalmic neurodegenerative diseases
GB2349385A (en) * 1999-04-30 2000-11-01 Teijin Ltd Organic nitrates and nitrites useful against heart disease
JP2005539089A (ja) * 2002-07-03 2005-12-22 ニトロメッド インコーポレーティッド ニトロソ化非ステロイド性抗炎症化合物、組成物および使用方法
US20020168424A1 (en) 2002-07-31 2002-11-14 Dr. Mohsen Shahinpoor Nitric oxide (NO) donor+cGMP-PDE5 inhibitor as a topical drug for glaucoma
WO2005068421A1 (en) * 2004-01-05 2005-07-28 Nicox, S.A. Prostaglandin nitrooxyderivatives
WO2006091716A2 (en) * 2005-02-24 2006-08-31 Nitromed, Inc. Nitric oxide enhancing diuretic compounds, compositions and methods of use
WO2009004990A1 (ja) * 2007-06-29 2009-01-08 Kyowa Hakko Kirin Co., Ltd. Fp受容体作動薬
WO2009007814A1 (en) * 2007-07-11 2009-01-15 Pfizer Inc. Inhibitors of carbonic anhydrase
DK2220030T3 (en) * 2007-11-06 2016-04-11 Edison Pharmaceuticals Inc 4- (P-QUINONYL) -2-HYDROXYBUTANAMIDDERIVATER TO TREAT mitochondrial
EP2606022A2 (en) 2010-08-16 2013-06-26 Santhera Pharmaceuticals (Schweiz) AG Novel benzoquinone derivatives and use thereof as modulators of mitochondrial function
CA2839390C (en) * 2011-10-24 2015-09-15 Nicox S.A. Quinone based nitric oxide donating compounds
US9079821B2 (en) * 2011-10-24 2015-07-14 Nicox Science Ireland Quinone based nitric oxide donating compounds

Also Published As

Publication number Publication date
US20150283106A1 (en) 2015-10-08
JP6405312B2 (ja) 2018-10-17
EP2911656A1 (en) 2015-09-02
WO2014063923A1 (en) 2014-05-01
CN104994845B (zh) 2017-11-17
US9446015B2 (en) 2016-09-20
CA2888837A1 (en) 2014-05-01
CN104994845A (zh) 2015-10-21
EP2911656B1 (en) 2020-12-02
CA2888837C (en) 2021-02-16
JP2015536310A (ja) 2015-12-21
ES2841993T3 (es) 2021-07-12

Similar Documents

Publication Publication Date Title
HK1204253A1 (zh) 醫用磁強計
EP2859405A4 (en) ADAPTER FOR GLASSES
AU347188S (en) Adapter
GB2500805B (en) Removable blast protection
HK1210709A1 (zh) 外用組合物
EP2937099A4 (en) APOPOTOSIS INDUCING AGENT
HK1197054A1 (zh) 醌基氧化氮供體化合物
HK1216505A1 (zh) 用於眼科應用的醌基氧化氮供體化合物
HK1206976A1 (zh) 外用劑組合物
HK1210718A1 (zh) 抗白癬菌症外用液劑
HK1200109A1 (zh) 眼科用組合物
HK1200113A1 (zh) 眼科用組合物
HK1220371A1 (zh) 用於眼科應用的醌基氧化氮供體化合物
GB201205189D0 (en) Novel medical use
GB201215502D0 (en) Medical use
GB201201805D0 (en) Speculum
GB2500568B (en) Adaptor
PL2800573T3 (pl) Mieszanina oftalmiczna
EP2822721A4 (en) ADAPTER
ZA201500206B (en) Protective devices for shoulders
IL233477B (en) Ophthalmic composition
GB201211308D0 (en) Compounds for use
GB201206393D0 (en) Use
ZA201306673B (en) Protective band
TWM433571U (en) Detachable eyeglasses