HK1213939A1 - 再生用於在神經系統中治療疾病和損傷的功能性神經元 - Google Patents

再生用於在神經系統中治療疾病和損傷的功能性神經元

Info

Publication number
HK1213939A1
HK1213939A1 HK16101711.8A HK16101711A HK1213939A1 HK 1213939 A1 HK1213939 A1 HK 1213939A1 HK 16101711 A HK16101711 A HK 16101711A HK 1213939 A1 HK1213939 A1 HK 1213939A1
Authority
HK
Hong Kong
Prior art keywords
injury
disease
treatment
nervous system
functional neurons
Prior art date
Application number
HK16101711.8A
Other languages
English (en)
Inventor
Gong Chen
Lei Zhang
Zheng Wu
Yuchen Chen
Fan Wang
Ziyuan Guo
Original Assignee
Penn State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Penn State Res Found filed Critical Penn State Res Found
Publication of HK1213939A1 publication Critical patent/HK1213939A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0356—Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HK16101711.8A 2012-07-19 2016-02-18 再生用於在神經系統中治療疾病和損傷的功能性神經元 HK1213939A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261673471P 2012-07-19 2012-07-19
US201361762506P 2013-02-08 2013-02-08
PCT/US2013/051277 WO2014015261A1 (en) 2012-07-19 2013-07-19 Regenerating functional neurons for treatment of disease and injury in the nervous system

Publications (1)

Publication Number Publication Date
HK1213939A1 true HK1213939A1 (zh) 2016-07-15

Family

ID=49947049

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16101711.8A HK1213939A1 (zh) 2012-07-19 2016-02-18 再生用於在神經系統中治療疾病和損傷的功能性神經元

Country Status (4)

Country Link
US (5) US10561742B2 (zh)
CN (7) CN104870634A (zh)
HK (1) HK1213939A1 (zh)
WO (1) WO2014015261A1 (zh)

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CN104870634A (zh) * 2012-07-19 2015-08-26 宾夕法尼亚州研究基金会 再生用于在神经系统中治疗疾病和损伤的功能性神经元
CN103667190A (zh) * 2012-09-07 2014-03-26 上海吉凯基因化学技术有限公司 一种诱导形成神经元的方法和组合物
WO2016086052A1 (en) * 2014-11-25 2016-06-02 International Stem Cell Corporation Derivation of nueral crest stem cells and uses thereof
US9840542B2 (en) 2015-09-11 2017-12-12 Nomadogen Biotechnologies Inc. Methods and compositions for the packaging of nucleic acids into microglial exosomes for the targeted expression of polypeptides in neural cells
EP3383495B1 (en) * 2015-12-04 2021-01-20 The Penn State Research Foundation Chemical reprogramming of human glial cells into neurons with small molecule cocktail
CN116763942A (zh) 2016-02-18 2023-09-19 宾州研究基金会 脑内生成gaba能神经元
US10342221B2 (en) * 2016-08-19 2019-07-09 University Of Southern California Generation of an inducible pericyte-specific CRE mouse model
WO2018160712A1 (en) * 2017-02-28 2018-09-07 The Penn State Research Foundation Regenerating functional neurons for treatment of neural injury caused by disruption of blood flow
CN112203676A (zh) * 2018-02-02 2021-01-08 宾州研究基金会 治疗脑损伤的方法和材料
CN110133272A (zh) * 2018-02-09 2019-08-16 北京大学 用于从生物体液中富集或检测星形胶质细胞来源的外泌体的方法
CN112312928A (zh) * 2018-04-11 2021-02-02 加利福尼亚大学董事会 非神经元细胞向神经元的重编程、以及治疗神经退行性疾病和病症的方法和组合物
CA3157518A1 (en) * 2019-10-17 2021-04-22 Gong Chen Regenerating functional neurons for treatment of neurological disorders
JP2022552003A (ja) * 2019-10-17 2022-12-14 ザ・ペン・ステイト・リサーチ・ファウンデイション 脊髄損傷およびａｌｓの治療のための機能的ニューロンの再生
EP4045526A4 (en) * 2019-10-17 2023-11-15 The Penn State Research Foundation REGENERATION OF FUNCTIONAL NEURONS FOR THE TREATMENT OF HEMORRHAGIC STROKE
CN111227981B (zh) * 2020-01-13 2023-01-17 中国医科大学附属盛京医院 一种神经母细胞瘤肾上腺原位移植瘤动物模型的构建方法
WO2022072309A1 (en) * 2020-09-29 2022-04-07 NeuExcell Therapeutics Inc. Ascl1 vector
IL301750A (en) * 2020-09-29 2023-05-01 Neuexcell Therapeutics Inc Neuro vector D1 and DLX2
CA3197321A1 (en) * 2020-09-29 2022-04-07 NeuExcell Therapeutics Inc. Neurod1 vector
US20220098255A1 (en) * 2020-09-29 2022-03-31 NeuExcell Therapeutics Inc. Neurod1 combination vector
WO2022072324A1 (en) * 2020-09-29 2022-04-07 NeuExcell Therapeutics Inc. Isl1 and lhx3 vector
US20220160825A1 (en) * 2020-11-25 2022-05-26 The Penn State Research Foundation Brain repair after traumatic brain injury through neurod1-mediated astrocyte-to-neuron conversion
CN117015389A (zh) 2021-03-31 2023-11-07 暨南大学 一种形成gaba能神经元的药物和方法
WO2023168346A2 (en) * 2022-03-04 2023-09-07 The Board Of Regents Of The University Of Texas System Methods for neural regeneration and uses thereof
FR3133386A1 (fr) 2022-03-10 2023-09-15 HOLDING FINANCIERE CIUCH En abrégé "H.F.C." Dispositif transfert a convoyeurs transversaux imbriques
CN117070477A (zh) * 2022-05-10 2023-11-17 纽伦捷生物医药科技（上海）有限公司 重组溶瘤病毒的重编程的功能性片段、组合及其应用

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Also Published As

Publication number Publication date
US20190117797A1 (en) 2019-04-25
US20170304463A1 (en) 2017-10-26
US10201619B2 (en) 2019-02-12
CN113559282A (zh) 2021-10-29
CN113413469A (zh) 2021-09-21
CN113512565A (zh) 2021-10-19
US9717804B2 (en) 2017-08-01
US10561742B2 (en) 2020-02-18
CN104870634A (zh) 2015-08-26
US20150250900A1 (en) 2015-09-10
US20140024599A1 (en) 2014-01-23
CN113559280A (zh) 2021-10-29
CN114601937A (zh) 2022-06-10
CN113559281A (zh) 2021-10-29
WO2014015261A1 (en) 2014-01-23
US20220072153A1 (en) 2022-03-10
US11167044B2 (en) 2021-11-09

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