EP2892618A4 - Method for selectively inhibiting the activity of acat1 in the treatment of alzheimer's disease - Google Patents

Method for selectively inhibiting the activity of acat1 in the treatment of alzheimer's disease

Info

Publication number
EP2892618A4
EP2892618A4 EP13835772.8A EP13835772A EP2892618A4 EP 2892618 A4 EP2892618 A4 EP 2892618A4 EP 13835772 A EP13835772 A EP 13835772A EP 2892618 A4 EP2892618 A4 EP 2892618A4
Authority
EP
European Patent Office
Prior art keywords
acat1
alzheimer
disease
activity
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP13835772.8A
Other languages
German (de)
French (fr)
Other versions
EP2892618A1 (en
Inventor
Ta-Yuan Chang
Catherine C Y Chang
Elena Bryleva
Stephanie Murphy
Maximillian A Rogers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dartmouth College
Original Assignee
Dartmouth College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/605,206 external-priority patent/US8802646B2/en
Application filed by Dartmouth College filed Critical Dartmouth College
Publication of EP2892618A1 publication Critical patent/EP2892618A1/en
Publication of EP2892618A4 publication Critical patent/EP2892618A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
EP13835772.8A 2012-09-06 2013-06-21 Method for selectively inhibiting the activity of acat1 in the treatment of alzheimer's disease Withdrawn EP2892618A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/605,206 US8802646B2 (en) 2008-10-08 2012-09-06 Method for selectively inhibiting the activity of ACAT1 in the treatment of alzheimer's disease
PCT/US2013/046990 WO2014039138A1 (en) 2012-09-06 2013-06-21 Method for selectively inhibiting the activity of acat1 in the treatment of alzheimer's disease

Publications (2)

Publication Number Publication Date
EP2892618A1 EP2892618A1 (en) 2015-07-15
EP2892618A4 true EP2892618A4 (en) 2016-03-16

Family

ID=50237525

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13835772.8A Withdrawn EP2892618A4 (en) 2012-09-06 2013-06-21 Method for selectively inhibiting the activity of acat1 in the treatment of alzheimer's disease

Country Status (4)

Country Link
EP (1) EP2892618A4 (en)
JP (1) JP2015529222A (en)
CA (1) CA2884082A1 (en)
WO (1) WO2014039138A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130017252A1 (en) * 2008-10-08 2013-01-17 Trustees Of Dartmouth College Method for Selectively Inhibiting the Activity of ACAT1 in the Treatment of Alzheimer's Disease

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2334125T3 (en) * 2002-11-04 2010-03-05 University Of Massachusetts SPECIFIC ARN INTERFERENCE OF ALELOS.
WO2010042292A1 (en) * 2008-10-08 2010-04-15 Trustees Of Dartmouth College Method for selectively inhibiting the activity of acat1 in the treatment of alzheimer's disease

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130017252A1 (en) * 2008-10-08 2013-01-17 Trustees Of Dartmouth College Method for Selectively Inhibiting the Activity of ACAT1 in the Treatment of Alzheimer's Disease

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2014039138A1 *

Also Published As

Publication number Publication date
EP2892618A1 (en) 2015-07-15
CA2884082A1 (en) 2014-03-13
WO2014039138A1 (en) 2014-03-13
JP2015529222A (en) 2015-10-05

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20150309

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAX Request for extension of the european patent (deleted)
RA4 Supplementary search report drawn up and despatched (corrected)

Effective date: 20160211

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 9/00 20060101AFI20160205BHEP

Ipc: A61K 31/713 20060101ALI20160205BHEP

Ipc: C07H 21/02 20060101ALI20160205BHEP

Ipc: A61K 31/7105 20060101ALI20160205BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN

18W Application withdrawn

Effective date: 20160605