HK1211947A1 - 基於氟化的環氧酮的化合物及其作為蛋白酶體抑制劑的用途 - Google Patents

基於氟化的環氧酮的化合物及其作為蛋白酶體抑制劑的用途

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Publication number
HK1211947A1
HK1211947A1 HK15112672.3A HK15112672A HK1211947A1 HK 1211947 A1 HK1211947 A1 HK 1211947A1 HK 15112672 A HK15112672 A HK 15112672A HK 1211947 A1 HK1211947 A1 HK 1211947A1
Authority
HK
Hong Kong
Prior art keywords
epoxyketone
fluorinated
based compounds
proteasome inhibitors
proteasome
Prior art date
Application number
HK15112672.3A
Other languages
English (en)
Inventor
Abdelmalik Slassi
Peter Dove
Original Assignee
Fluorinov Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fluorinov Pharma Inc filed Critical Fluorinov Pharma Inc
Publication of HK1211947A1 publication Critical patent/HK1211947A1/zh

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
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    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
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HK15112672.3A 2012-08-14 2015-12-24 基於氟化的環氧酮的化合物及其作為蛋白酶體抑制劑的用途 HK1211947A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261682836P 2012-08-14 2012-08-14
PCT/CA2013/050620 WO2014026282A1 (en) 2012-08-14 2013-08-13 Fluorinated epoxyketone-based compounds and uses thereof as proteasome inhibitors

Publications (1)

Publication Number Publication Date
HK1211947A1 true HK1211947A1 (zh) 2016-06-03

Family

ID=50101155

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15112672.3A HK1211947A1 (zh) 2012-08-14 2015-12-24 基於氟化的環氧酮的化合物及其作為蛋白酶體抑制劑的用途

Country Status (8)

Country Link
US (2) US9441012B2 (zh)
EP (1) EP2885314A4 (zh)
JP (1) JP2015526433A (zh)
CN (1) CN104797591A (zh)
AU (1) AU2013302269A1 (zh)
CA (1) CA2881999A1 (zh)
HK (1) HK1211947A1 (zh)
WO (1) WO2014026282A1 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2881986A1 (en) * 2012-08-21 2014-02-27 Fluorinov Pharma Inc. Fluorinated epoxyketone-based tetrapeptide compounds and uses thereof as proteasome inhibitors
JP6608442B2 (ja) * 2014-07-14 2019-11-20 セントラックス インターナショナル，インコーポレイテッド 酵素阻害に用いられるエポキシケトン化合物
WO2016123707A1 (en) * 2015-02-03 2016-08-11 Trillium Therapeutics Inc. Process for the synthesis of difluoromethyl ether-based compounds
CN105622458A (zh) * 2015-12-22 2016-06-01 中国药科大学 (s)-4-氨基-2-甲基-5-苯基戊-1-烯-3-酮的制备方法
US11446315B2 (en) * 2016-11-03 2022-09-20 Pf Argentum Ip Holdings Llc Enhancement of CD47 blockade therapy by proteasome inhibitors
US10199261B1 (en) * 2017-07-19 2019-02-05 Globalfoundries Inc. Via and skip via structures
US10689416B2 (en) 2017-12-30 2020-06-23 Unity Biotechnology, Inc. Peptide-based proteasome inhibitors for treating conditions mediated by senescent cells and for treating cancer
CN111269140A (zh) * 2018-12-05 2020-06-12 上海奥博生物医药技术有限公司 一种拉考沙胺的制备方法
CN110092813B (zh) * 2019-06-05 2021-05-11 南京师范大学 一种三肽环氧丙烷衍生物及其制备方法和用途
WO2021048852A1 (en) 2019-09-11 2021-03-18 Yeda Research And Development Co. Ltd. Methods of treating breast cancer
CN115768744B (zh) * 2020-04-27 2024-06-28 奧土择破利悟 作为ubr盒结构域配体的化合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4990448A (en) * 1989-08-04 1991-02-05 Bristol-Myers Company Bu-4061T
PL2030981T3 (pl) * 2004-05-10 2014-12-31 Onyx Therapeutics Inc Związki do enzymatycznej inhibicji proteasomu
US7737112B2 (en) * 2004-12-07 2010-06-15 Onyx Therapeutics, Inc. Composition for enzyme inhibition
PT2623113T (pt) * 2005-11-09 2017-07-14 Onyx Therapeutics Inc Compostos para inibição de enzimas
JP5226679B2 (ja) * 2006-06-19 2013-07-03 プロテオリックス， インコーポレイテッド 酵素阻害のための化合物
CN100462344C (zh) * 2007-04-29 2009-02-18 浙江三美化工股份有限公司 一种利用氯乙烯法合成HCFC-151a的生产方法
WO2011136905A2 (en) 2010-04-07 2011-11-03 Onyx Therapeutics, Inc. Crystalline peptide epoxyketone immunoproteasome inhibitor
CA2881986A1 (en) * 2012-08-21 2014-02-27 Fluorinov Pharma Inc. Fluorinated epoxyketone-based tetrapeptide compounds and uses thereof as proteasome inhibitors

Also Published As

Publication number Publication date
JP2015526433A (ja) 2015-09-10
CA2881999A1 (en) 2014-02-20
US20160347792A1 (en) 2016-12-01
CN104797591A (zh) 2015-07-22
EP2885314A1 (en) 2015-06-24
AU2013302269A1 (en) 2015-03-12
US9441012B2 (en) 2016-09-13
EP2885314A4 (en) 2016-02-10
US20150203534A1 (en) 2015-07-23
WO2014026282A1 (en) 2014-02-20

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