HK1208997A1 - Novel cabergoline derivatives - Google Patents

Novel cabergoline derivatives

Info

Publication number
HK1208997A1
HK1208997A1 HK15109927.2A HK15109927A HK1208997A1 HK 1208997 A1 HK1208997 A1 HK 1208997A1 HK 15109927 A HK15109927 A HK 15109927A HK 1208997 A1 HK1208997 A1 HK 1208997A1
Authority
HK
Hong Kong
Prior art keywords
derivatives
novel
novel cabergoline
cabergoline derivatives
cabergoline
Prior art date
Application number
HK15109927.2A
Other languages
Chinese (zh)
Inventor
Jian Zhang
Thomas A Armer
Original Assignee
Map Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Map Pharmaceuticals Inc filed Critical Map Pharmaceuticals Inc
Publication of HK1208997A1 publication Critical patent/HK1208997A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK15109927.2A 2012-06-22 2015-10-12 Novel cabergoline derivatives HK1208997A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2012/043687 WO2013191704A1 (en) 2012-06-22 2012-06-22 Novel cabergoline derivatives

Publications (1)

Publication Number Publication Date
HK1208997A1 true HK1208997A1 (en) 2016-03-24

Family

ID=49769156

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15109927.2A HK1208997A1 (en) 2012-06-22 2015-10-12 Novel cabergoline derivatives

Country Status (11)

Country Link
EP (1) EP2863747A4 (en)
JP (1) JP2015525239A (en)
CN (1) CN104822264A (en)
AU (1) AU2012382929A1 (en)
BR (1) BR112014031945A2 (en)
CA (1) CA2876321A1 (en)
HK (1) HK1208997A1 (en)
IL (1) IL236310A0 (en)
RU (1) RU2014153672A (en)
SG (1) SG11201408567PA (en)
WO (1) WO2013191704A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107428745A (en) * 2015-01-20 2017-12-01 Xoc制药股份有限公司 Ergoline compound and application thereof
CN106866656A (en) * 2017-02-28 2017-06-20 西南交通大学 One class ergoline derivatives and its purposes in prevention and treatment mental illness
EP3530651A1 (en) * 2018-02-21 2019-08-28 Adamed sp. z o.o. Indole and benzimidazole derivatives as dual 5-ht2a and 5-ht6 receptor antagonists

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526892A (en) * 1981-03-03 1985-07-02 Farmitalia Carlo Erba, S.P.A. Dimethylaminoalkyl-3-(ergoline-8'βcarbonyl)-ureas
DK338789A (en) * 1988-07-15 1990-01-16 Schering Ag 2-SUBSTITUTED ERGOLINYLURINE DERIVATIVES AND PROCEDURES FOR THE PRODUCTION THEREOF, THEIR USE AS MEDICINES AND INTERMEDIATES FOR THE PRODUCTION THEREOF
DE3913756A1 (en) * 1989-04-21 1990-10-25 Schering Ag 8 (BETA) SUBSTITUTED ERGOLINE, METHOD FOR THE PRODUCTION AND USE THEREOF
WO1995005176A1 (en) * 1993-08-18 1995-02-23 Alcon Laboratories, Inc. Use of ergoline derivatives for the treatment of glaucoma
CZ287176B6 (en) * 1997-10-03 2000-10-11 Galena A. S. Process for preparing ergoline derivatives
JP2006516596A (en) * 2003-02-05 2006-07-06 ファルマシア イタリア ソチエタ ペル アツィオニ Cabergoline for the prevention and treatment of migraine
GB0307377D0 (en) * 2003-03-31 2003-05-07 Merad Pharmaceuticals Ltd Ergoline derivatives
HUP0400517A3 (en) * 2004-03-04 2006-05-29 Richter Gedeon Vegyeszet Process for producing cabergoline
WO2006097345A1 (en) * 2005-03-17 2006-09-21 Synthon Argentina S.A. Improved process for making cabergoline
GB0511060D0 (en) * 2005-05-31 2005-07-06 Novartis Ag Organic compounds
EP2083008A1 (en) * 2007-12-07 2009-07-29 Axxonis Pharma AG Ergoline derivatives as selective radical scavengers for neurons
US20120095217A1 (en) * 2009-01-09 2012-04-19 Tobias Ritter Fluorine containing compounds and methods of use thereof
AR076300A1 (en) * 2009-04-15 2011-06-01 Astrazeneca Ab DERIVATIVES OF PIRIMIDIN REPLACED IMIDAZOLS, INHIBITORS OF GSK3, PHARMACEUTICAL COMPOSITIONS CONTAINING THEMSELVES AND USES OF THE SAME IN THE TREATMENT OF ALZHEIMER, ACUTE NEURODEGENERATIVE DISEASES, DIABETES AND OTHER DISEASES.
EP2793583A4 (en) * 2011-12-21 2015-08-12 Map Pharmaceuticals Inc Novel neuromodulatory compounds

Also Published As

Publication number Publication date
AU2012382929A1 (en) 2015-02-05
CN104822264A (en) 2015-08-05
SG11201408567PA (en) 2015-02-27
JP2015525239A (en) 2015-09-03
WO2013191704A1 (en) 2013-12-27
EP2863747A4 (en) 2015-12-23
BR112014031945A2 (en) 2017-06-27
CA2876321A1 (en) 2013-12-27
IL236310A0 (en) 2015-02-26
RU2014153672A (en) 2016-08-10
EP2863747A1 (en) 2015-04-29

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