EP2863747A4 - Novel cabergoline derivatives - Google Patents

Novel cabergoline derivatives

Info

Publication number
EP2863747A4
EP2863747A4 EP12879191.0A EP12879191A EP2863747A4 EP 2863747 A4 EP2863747 A4 EP 2863747A4 EP 12879191 A EP12879191 A EP 12879191A EP 2863747 A4 EP2863747 A4 EP 2863747A4
Authority
EP
European Patent Office
Prior art keywords
derivatives
novel
novel cabergoline
cabergoline derivatives
cabergoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP12879191.0A
Other languages
German (de)
French (fr)
Other versions
EP2863747A1 (en
Inventor
Jian Zhang
Thomas A Armer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MAP Pharmaceuticals Inc
Original Assignee
MAP Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MAP Pharmaceuticals Inc filed Critical MAP Pharmaceuticals Inc
Publication of EP2863747A1 publication Critical patent/EP2863747A1/en
Publication of EP2863747A4 publication Critical patent/EP2863747A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP12879191.0A 2012-06-22 2012-06-22 Novel cabergoline derivatives Withdrawn EP2863747A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2012/043687 WO2013191704A1 (en) 2012-06-22 2012-06-22 Novel cabergoline derivatives

Publications (2)

Publication Number Publication Date
EP2863747A1 EP2863747A1 (en) 2015-04-29
EP2863747A4 true EP2863747A4 (en) 2015-12-23

Family

ID=49769156

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12879191.0A Withdrawn EP2863747A4 (en) 2012-06-22 2012-06-22 Novel cabergoline derivatives

Country Status (11)

Country Link
EP (1) EP2863747A4 (en)
JP (1) JP2015525239A (en)
CN (1) CN104822264A (en)
AU (1) AU2012382929A1 (en)
BR (1) BR112014031945A2 (en)
CA (1) CA2876321A1 (en)
HK (1) HK1208997A1 (en)
IL (1) IL236310A0 (en)
RU (1) RU2014153672A (en)
SG (1) SG11201408567PA (en)
WO (1) WO2013191704A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3253753A4 (en) * 2015-01-20 2018-06-27 Xoc Pharmaceuticals, Inc Ergoline compounds and uses thereof
CN106866656A (en) * 2017-02-28 2017-06-20 西南交通大学 One class ergoline derivatives and its purposes in prevention and treatment mental illness
EP3530651A1 (en) * 2018-02-21 2019-08-28 Adamed sp. z o.o. Indole and benzimidazole derivatives as dual 5-ht2a and 5-ht6 receptor antagonists

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526892A (en) * 1981-03-03 1985-07-02 Farmitalia Carlo Erba, S.P.A. Dimethylaminoalkyl-3-(ergoline-8'βcarbonyl)-ureas
WO1990012796A1 (en) * 1989-04-21 1990-11-01 Schering Aktiengesellschaft Berlin Und Bergkamen 8-beta-substituted ergolines, a process for manufacturing them, and their use
US5705510A (en) * 1993-08-18 1998-01-06 Alcon Laboratories, Inc. Use of cabergoline and related ergoline derivatives for controlling intraocular pressure
CZ287176B6 (en) * 1997-10-03 2000-10-11 Galena A. S. Process for preparing ergoline derivatives
WO2004069252A1 (en) * 2003-02-05 2004-08-19 Pharmacia Italia Spa Cabergoline for the prophylactic treatment of migraine
WO2005085243A2 (en) * 2004-03-04 2005-09-15 Richter Gedeon Vegyészeti Gyár Rt. Process for the preparation of cabergoline
US7217822B2 (en) * 2005-03-17 2007-05-15 Synthon Ip Inc. Process for making cabergoline
EP2067780A1 (en) * 2007-12-07 2009-06-10 Axxonis Pharma AG Ergoline derivatives as selective radical scavengers for neurons
WO2010081036A2 (en) * 2009-01-09 2010-07-15 President And Fellows Of Harvard College Fluorine containing compounds and methods of use thereof
WO2013095708A1 (en) * 2011-12-21 2013-06-27 Map Pharmaceuticals, Inc. Novel neuromodulatory compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK338789A (en) * 1988-07-15 1990-01-16 Schering Ag 2-SUBSTITUTED ERGOLINYLURINE DERIVATIVES AND PROCEDURES FOR THE PRODUCTION THEREOF, THEIR USE AS MEDICINES AND INTERMEDIATES FOR THE PRODUCTION THEREOF
GB0307377D0 (en) * 2003-03-31 2003-05-07 Merad Pharmaceuticals Ltd Ergoline derivatives
GB0511060D0 (en) * 2005-05-31 2005-07-06 Novartis Ag Organic compounds
AU2010237100A1 (en) * 2009-04-15 2011-10-27 Astrazeneca Ab Imidazole substituted pyrimidines useful in the treatment of glycogen synthase kinase 3 related disorders such as Alzheimer's disease

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526892A (en) * 1981-03-03 1985-07-02 Farmitalia Carlo Erba, S.P.A. Dimethylaminoalkyl-3-(ergoline-8'βcarbonyl)-ureas
WO1990012796A1 (en) * 1989-04-21 1990-11-01 Schering Aktiengesellschaft Berlin Und Bergkamen 8-beta-substituted ergolines, a process for manufacturing them, and their use
US5705510A (en) * 1993-08-18 1998-01-06 Alcon Laboratories, Inc. Use of cabergoline and related ergoline derivatives for controlling intraocular pressure
CZ287176B6 (en) * 1997-10-03 2000-10-11 Galena A. S. Process for preparing ergoline derivatives
WO2004069252A1 (en) * 2003-02-05 2004-08-19 Pharmacia Italia Spa Cabergoline for the prophylactic treatment of migraine
WO2005085243A2 (en) * 2004-03-04 2005-09-15 Richter Gedeon Vegyészeti Gyár Rt. Process for the preparation of cabergoline
US7217822B2 (en) * 2005-03-17 2007-05-15 Synthon Ip Inc. Process for making cabergoline
EP2067780A1 (en) * 2007-12-07 2009-06-10 Axxonis Pharma AG Ergoline derivatives as selective radical scavengers for neurons
WO2010081036A2 (en) * 2009-01-09 2010-07-15 President And Fellows Of Harvard College Fluorine containing compounds and methods of use thereof
WO2013095708A1 (en) * 2011-12-21 2013-06-27 Map Pharmaceuticals, Inc. Novel neuromodulatory compounds

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
A. KEKEWSKA ET AL: "The Bulky N(6) Substituent of Cabergoline Is Responsible for Agonism of This Drug at 5-Hydroxytryptamine (5-HT)2A and 5-HT2B Receptors and Thus Is a Determinant of Valvular Heart Disease", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 338, no. 1, 1 July 2011 (2011-07-01), US, pages 381 - 391, XP055228644, ISSN: 0022-3565, DOI: 10.1124/jpet.111.181255 *
BRAMBILLA E ET AL: "Synthesis and nidation inhibitory activity of a new class of ergoline derivatives", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 24, no. 4, 1 July 1989 (1989-07-01), pages 421 - 426, XP023870591, ISSN: 0223-5234, [retrieved on 19890701], DOI: 10.1016/0223-5234(89)90087-1 *
MANTEGANI S ET AL: "Serotonergic ergoline derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 8, no. 9, 1 May 1998 (1998-05-01), pages 1117 - 1122, XP004137031, ISSN: 0960-894X, DOI: 10.1016/S0960-894X(98)00166-8 *
MIYAGI M ET AL: "DOPAMINE RECEPTOR AFFINITIES IN VITRO AND STEREOTYPIC ACTIVITIES IN VIVO OF CABERGOLINE IN RATS", BIOLOGICAL & PHARMACEUTICAL BULLETIN (OF JAPAN), PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO, JP, vol. 19, no. 9, 1 January 1996 (1996-01-01), pages 1210 - 1213, XP009040256, ISSN: 0918-6158 *
See also references of WO2013191704A1 *

Also Published As

Publication number Publication date
SG11201408567PA (en) 2015-02-27
WO2013191704A1 (en) 2013-12-27
JP2015525239A (en) 2015-09-03
HK1208997A1 (en) 2016-03-24
RU2014153672A (en) 2016-08-10
EP2863747A1 (en) 2015-04-29
BR112014031945A2 (en) 2017-06-27
IL236310A0 (en) 2015-02-26
CA2876321A1 (en) 2013-12-27
CN104822264A (en) 2015-08-05
AU2012382929A1 (en) 2015-02-05

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Inventor name: ARMER, THOMAS, A.

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