EP2863747A4 - Novel cabergoline derivatives - Google Patents
Novel cabergoline derivativesInfo
- Publication number
- EP2863747A4 EP2863747A4 EP12879191.0A EP12879191A EP2863747A4 EP 2863747 A4 EP2863747 A4 EP 2863747A4 EP 12879191 A EP12879191 A EP 12879191A EP 2863747 A4 EP2863747 A4 EP 2863747A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- derivatives
- novel
- novel cabergoline
- cabergoline derivatives
- cabergoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2012/043687 WO2013191704A1 (en) | 2012-06-22 | 2012-06-22 | Novel cabergoline derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2863747A1 EP2863747A1 (en) | 2015-04-29 |
EP2863747A4 true EP2863747A4 (en) | 2015-12-23 |
Family
ID=49769156
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP12879191.0A Withdrawn EP2863747A4 (en) | 2012-06-22 | 2012-06-22 | Novel cabergoline derivatives |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP2863747A4 (en) |
JP (1) | JP2015525239A (en) |
CN (1) | CN104822264A (en) |
AU (1) | AU2012382929A1 (en) |
BR (1) | BR112014031945A2 (en) |
CA (1) | CA2876321A1 (en) |
HK (1) | HK1208997A1 (en) |
IL (1) | IL236310A0 (en) |
RU (1) | RU2014153672A (en) |
SG (1) | SG11201408567PA (en) |
WO (1) | WO2013191704A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3253753A4 (en) * | 2015-01-20 | 2018-06-27 | Xoc Pharmaceuticals, Inc | Ergoline compounds and uses thereof |
CN106866656A (en) * | 2017-02-28 | 2017-06-20 | 西南交通大学 | One class ergoline derivatives and its purposes in prevention and treatment mental illness |
EP3530651A1 (en) * | 2018-02-21 | 2019-08-28 | Adamed sp. z o.o. | Indole and benzimidazole derivatives as dual 5-ht2a and 5-ht6 receptor antagonists |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4526892A (en) * | 1981-03-03 | 1985-07-02 | Farmitalia Carlo Erba, S.P.A. | Dimethylaminoalkyl-3-(ergoline-8'βcarbonyl)-ureas |
WO1990012796A1 (en) * | 1989-04-21 | 1990-11-01 | Schering Aktiengesellschaft Berlin Und Bergkamen | 8-beta-substituted ergolines, a process for manufacturing them, and their use |
US5705510A (en) * | 1993-08-18 | 1998-01-06 | Alcon Laboratories, Inc. | Use of cabergoline and related ergoline derivatives for controlling intraocular pressure |
CZ287176B6 (en) * | 1997-10-03 | 2000-10-11 | Galena A. S. | Process for preparing ergoline derivatives |
WO2004069252A1 (en) * | 2003-02-05 | 2004-08-19 | Pharmacia Italia Spa | Cabergoline for the prophylactic treatment of migraine |
WO2005085243A2 (en) * | 2004-03-04 | 2005-09-15 | Richter Gedeon Vegyészeti Gyár Rt. | Process for the preparation of cabergoline |
US7217822B2 (en) * | 2005-03-17 | 2007-05-15 | Synthon Ip Inc. | Process for making cabergoline |
EP2067780A1 (en) * | 2007-12-07 | 2009-06-10 | Axxonis Pharma AG | Ergoline derivatives as selective radical scavengers for neurons |
WO2010081036A2 (en) * | 2009-01-09 | 2010-07-15 | President And Fellows Of Harvard College | Fluorine containing compounds and methods of use thereof |
WO2013095708A1 (en) * | 2011-12-21 | 2013-06-27 | Map Pharmaceuticals, Inc. | Novel neuromodulatory compounds |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK338789A (en) * | 1988-07-15 | 1990-01-16 | Schering Ag | 2-SUBSTITUTED ERGOLINYLURINE DERIVATIVES AND PROCEDURES FOR THE PRODUCTION THEREOF, THEIR USE AS MEDICINES AND INTERMEDIATES FOR THE PRODUCTION THEREOF |
GB0307377D0 (en) * | 2003-03-31 | 2003-05-07 | Merad Pharmaceuticals Ltd | Ergoline derivatives |
GB0511060D0 (en) * | 2005-05-31 | 2005-07-06 | Novartis Ag | Organic compounds |
AU2010237100A1 (en) * | 2009-04-15 | 2011-10-27 | Astrazeneca Ab | Imidazole substituted pyrimidines useful in the treatment of glycogen synthase kinase 3 related disorders such as Alzheimer's disease |
-
2012
- 2012-06-22 SG SG11201408567PA patent/SG11201408567PA/en unknown
- 2012-06-22 CN CN201280075321.7A patent/CN104822264A/en active Pending
- 2012-06-22 BR BR112014031945A patent/BR112014031945A2/en not_active IP Right Cessation
- 2012-06-22 EP EP12879191.0A patent/EP2863747A4/en not_active Withdrawn
- 2012-06-22 JP JP2015518385A patent/JP2015525239A/en active Pending
- 2012-06-22 CA CA2876321A patent/CA2876321A1/en not_active Abandoned
- 2012-06-22 RU RU2014153672A patent/RU2014153672A/en unknown
- 2012-06-22 AU AU2012382929A patent/AU2012382929A1/en not_active Abandoned
- 2012-06-22 WO PCT/US2012/043687 patent/WO2013191704A1/en active Application Filing
-
2014
- 2014-12-17 IL IL236310A patent/IL236310A0/en unknown
-
2015
- 2015-10-12 HK HK15109927.2A patent/HK1208997A1/en unknown
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4526892A (en) * | 1981-03-03 | 1985-07-02 | Farmitalia Carlo Erba, S.P.A. | Dimethylaminoalkyl-3-(ergoline-8'βcarbonyl)-ureas |
WO1990012796A1 (en) * | 1989-04-21 | 1990-11-01 | Schering Aktiengesellschaft Berlin Und Bergkamen | 8-beta-substituted ergolines, a process for manufacturing them, and their use |
US5705510A (en) * | 1993-08-18 | 1998-01-06 | Alcon Laboratories, Inc. | Use of cabergoline and related ergoline derivatives for controlling intraocular pressure |
CZ287176B6 (en) * | 1997-10-03 | 2000-10-11 | Galena A. S. | Process for preparing ergoline derivatives |
WO2004069252A1 (en) * | 2003-02-05 | 2004-08-19 | Pharmacia Italia Spa | Cabergoline for the prophylactic treatment of migraine |
WO2005085243A2 (en) * | 2004-03-04 | 2005-09-15 | Richter Gedeon Vegyészeti Gyár Rt. | Process for the preparation of cabergoline |
US7217822B2 (en) * | 2005-03-17 | 2007-05-15 | Synthon Ip Inc. | Process for making cabergoline |
EP2067780A1 (en) * | 2007-12-07 | 2009-06-10 | Axxonis Pharma AG | Ergoline derivatives as selective radical scavengers for neurons |
WO2010081036A2 (en) * | 2009-01-09 | 2010-07-15 | President And Fellows Of Harvard College | Fluorine containing compounds and methods of use thereof |
WO2013095708A1 (en) * | 2011-12-21 | 2013-06-27 | Map Pharmaceuticals, Inc. | Novel neuromodulatory compounds |
Non-Patent Citations (5)
Title |
---|
A. KEKEWSKA ET AL: "The Bulky N(6) Substituent of Cabergoline Is Responsible for Agonism of This Drug at 5-Hydroxytryptamine (5-HT)2A and 5-HT2B Receptors and Thus Is a Determinant of Valvular Heart Disease", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 338, no. 1, 1 July 2011 (2011-07-01), US, pages 381 - 391, XP055228644, ISSN: 0022-3565, DOI: 10.1124/jpet.111.181255 * |
BRAMBILLA E ET AL: "Synthesis and nidation inhibitory activity of a new class of ergoline derivatives", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 24, no. 4, 1 July 1989 (1989-07-01), pages 421 - 426, XP023870591, ISSN: 0223-5234, [retrieved on 19890701], DOI: 10.1016/0223-5234(89)90087-1 * |
MANTEGANI S ET AL: "Serotonergic ergoline derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 8, no. 9, 1 May 1998 (1998-05-01), pages 1117 - 1122, XP004137031, ISSN: 0960-894X, DOI: 10.1016/S0960-894X(98)00166-8 * |
MIYAGI M ET AL: "DOPAMINE RECEPTOR AFFINITIES IN VITRO AND STEREOTYPIC ACTIVITIES IN VIVO OF CABERGOLINE IN RATS", BIOLOGICAL & PHARMACEUTICAL BULLETIN (OF JAPAN), PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO, JP, vol. 19, no. 9, 1 January 1996 (1996-01-01), pages 1210 - 1213, XP009040256, ISSN: 0918-6158 * |
See also references of WO2013191704A1 * |
Also Published As
Publication number | Publication date |
---|---|
SG11201408567PA (en) | 2015-02-27 |
WO2013191704A1 (en) | 2013-12-27 |
JP2015525239A (en) | 2015-09-03 |
HK1208997A1 (en) | 2016-03-24 |
RU2014153672A (en) | 2016-08-10 |
EP2863747A1 (en) | 2015-04-29 |
BR112014031945A2 (en) | 2017-06-27 |
IL236310A0 (en) | 2015-02-26 |
CA2876321A1 (en) | 2013-12-27 |
CN104822264A (en) | 2015-08-05 |
AU2012382929A1 (en) | 2015-02-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20150112 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
|
DAX | Request for extension of the european patent (deleted) | ||
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: ZHANG, JIAN Inventor name: ARMER, THOMAS, A. |
|
RA4 | Supplementary search report drawn up and despatched (corrected) |
Effective date: 20151125 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61P 25/06 20060101ALI20151119BHEP Ipc: A61K 31/44 20060101AFI20151119BHEP Ipc: C07D 457/06 20060101ALI20151119BHEP Ipc: A61P 25/16 20060101ALI20151119BHEP Ipc: C07D 457/04 20060101ALI20151119BHEP |
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REG | Reference to a national code |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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