HK1207626A1 - Optically pure benzyl-4-chlorophenyl c-glucoside derivative -4- c- - Google Patents

Optically pure benzyl-4-chlorophenyl c-glucoside derivative -4- c-

Info

Publication number
HK1207626A1
HK1207626A1 HK15108213.7A HK15108213A HK1207626A1 HK 1207626 A1 HK1207626 A1 HK 1207626A1 HK 15108213 A HK15108213 A HK 15108213A HK 1207626 A1 HK1207626 A1 HK 1207626A1
Authority
HK
Hong Kong
Prior art keywords
chlorophenyl
optically pure
glucoside derivative
pure benzyl
benzyl
Prior art date
Application number
HK15108213.7A
Other languages
Chinese (zh)
Inventor
吳永謙
Original Assignee
四環醫藥控股集團有限公司 （商務中心） 號樓 山東軒竹醫藥科技有限公司 號
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 四環醫藥控股集團有限公司 （商務中心） 號樓 山東軒竹醫藥科技有限公司 號 filed Critical 四環醫藥控股集團有限公司 （商務中心） 號樓 山東軒竹醫藥科技有限公司 號
Publication of HK1207626A1 publication Critical patent/HK1207626A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/16—Preparation of ethers by reaction of esters of mineral or organic acids with hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06—Heterocyclic radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
HK15108213.7A 2014-01-03 2015-08-25 Optically pure benzyl-4-chlorophenyl c-glucoside derivative -4- c- HK1207626A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410004395.2A CN104761522B (en) 2014-01-03 2014-01-03 Optically pure benzyl-4-chlorophenyl C-glucoside derivatives

Publications (1)

Publication Number Publication Date
HK1207626A1 true HK1207626A1 (en) 2016-02-05

Family

ID=53643666

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15108213.7A HK1207626A1 (en) 2014-01-03 2015-08-25 Optically pure benzyl-4-chlorophenyl c-glucoside derivative -4- c-

Country Status (4)

Country Link
JP (1) JP6008892B2 (en)
KR (1) KR101837488B1 (en)
CN (2) CN104761522B (en)
HK (1) HK1207626A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105153137A (en) * 2015-09-17 2015-12-16 上海应用技术学院 Preparation method of empagliflozin
HUE051212T2 (en) * 2016-01-04 2021-03-01 Jeil Pharmaceutical Co Ltd C-glucoside derivative containing fused phenyl ring or pharmaceutically acceptable salt thereof, process for preparing same, and pharmaceutical composition comprising same
EP3466940B1 (en) * 2016-05-28 2021-11-17 Ji Lin Hui Sheng Bio-Pharmaceutical Co., Ltd. Crystal form of sodium-glucose cotransporter 2 inhibitor
CN108285439B (en) * 2017-01-09 2023-05-02 江苏天士力帝益药业有限公司 Carbonoside sodium glucose transport protein body 2 inhibitor
WO2019185026A1 (en) * 2018-03-30 2019-10-03 南京明德新药研发有限公司 Glucoside derivatives acting as inhibitors of sglts, and use thereof
CN110551088B (en) * 2018-06-01 2022-10-21 北京惠之衡生物科技有限公司 Deuterium-modified benzyl-4-chlorophenyl C-glycoside derivatives
CN112047915B (en) * 2019-06-05 2023-02-17 北京惠之衡生物科技有限公司 Novel preparation process of C-glycoside derivatives
CN110683998A (en) * 2019-11-20 2020-01-14 杭州华东医药集团浙江华义制药有限公司 Preparation method of empagliflozin intermediate
CN113045525B (en) * 2021-05-31 2021-09-17 北京惠之衡生物科技有限公司 Preparation method of C-glucoside derivative and preparation thereof
CN113248464B (en) * 2021-05-31 2021-10-26 北京惠之衡生物科技有限公司 Synthesis method of C-glycoside derivatives
CN113336733B (en) * 2021-05-31 2022-02-18 北京惠之衡生物科技有限公司 Preparation method of L-proline co-crystal of SGLT-2 inhibitor
CN113248554A (en) * 2021-06-25 2021-08-13 北京惠之衡生物科技有限公司 Method for synthesizing impurities of C-glucoside derivatives
CN113372315B (en) * 2021-08-12 2021-10-29 北京惠之衡生物科技有限公司 Method for synthesizing impurities of C-glucoside derivatives
CN115073271A (en) * 2022-06-08 2022-09-20 苏州敬业医药化工有限公司 Preparation method of 4' - (5-bromo-2-chlorobenzyl) phenol

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6515117B2 (en) * 1999-10-12 2003-02-04 Bristol-Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
EP1581543A4 (en) * 2003-01-03 2008-03-19 Bristol Myers Squibb Co Methods of producing c-aryl glucoside sglt2 inhibitors
WO2005092877A1 (en) * 2004-03-16 2005-10-06 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted benzol derivatives, drugs containing said compounds, the use thereof and method for the production thereof
US7772191B2 (en) * 2005-05-10 2010-08-10 Boehringer Ingelheim International Gmbh Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
MX358628B (en) * 2010-03-18 2018-08-28 Daiichi Sankyo Co Ltd Cycloalkyl-substituted imidazole derivative.
WO2012025857A1 (en) * 2010-08-23 2012-03-01 Hetero Research Foundation Cycloalkyl methoxybenzyl phenyl pyran derivatives as sodium dependent glucose co transporter (sglt2) inhibitors
EP2725031B1 (en) * 2011-06-25 2016-08-03 Xuanzhu Pharma Co., Ltd. C-glycoside derivatives

Also Published As

Publication number Publication date
JP6008892B2 (en) 2016-10-19
CN106349201A (en) 2017-01-25
CN104761522B (en) 2017-02-15
CN106349201B (en) 2018-09-18
KR20150081220A (en) 2015-07-13
CN104761522A (en) 2015-07-08
KR101837488B1 (en) 2018-03-12
JP2015129106A (en) 2015-07-16

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