HK1205189A1 - 用於調節因子 表達的方法和組合物 - Google Patents
用於調節因子 表達的方法和組合物Info
- Publication number
- HK1205189A1 HK1205189A1 HK15105748.7A HK15105748A HK1205189A1 HK 1205189 A1 HK1205189 A1 HK 1205189A1 HK 15105748 A HK15105748 A HK 15105748A HK 1205189 A1 HK1205189 A1 HK 1205189A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- vii
- compositions
- methods
- expression
- modulating factor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261596688P | 2012-02-08 | 2012-02-08 | |
PCT/US2013/025381 WO2013119979A1 (en) | 2012-02-08 | 2013-02-08 | Methods and compositions for modulating factor vii expression |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1205189A1 true HK1205189A1 (zh) | 2015-12-11 |
Family
ID=48948061
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15105748.7A HK1205189A1 (zh) | 2012-02-08 | 2015-06-17 | 用於調節因子 表達的方法和組合物 |
Country Status (7)
Country | Link |
---|---|
US (1) | US20150031747A1 (zh) |
EP (1) | EP2812433A4 (zh) |
JP (1) | JP2015507924A (zh) |
AU (1) | AU2013216852A1 (zh) |
CA (1) | CA2863958A1 (zh) |
HK (1) | HK1205189A1 (zh) |
WO (1) | WO2013119979A1 (zh) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2013346767B2 (en) | 2012-11-15 | 2019-04-11 | Roche Innovation Center Copenhagen A/S | Oligonucleotide conjugates |
DK2951305T3 (en) | 2013-01-30 | 2018-10-29 | Hoffmann La Roche | LNA oligonucleotide KULHYDRATKONJUGATER |
AU2014259755B2 (en) | 2013-05-01 | 2018-08-30 | Ionis Pharmaceuticals, Inc. | Compositions and methods for modulating apolipoprotein (a) expression |
SG10201809953QA (en) | 2014-05-01 | 2018-12-28 | Ionis Pharmaceuticals Inc | Compositions and methods for modulating complement factor b expression |
EP3974534A1 (en) | 2014-05-01 | 2022-03-30 | Ionis Pharmaceuticals, Inc. | Compositions and methods for modulating growth hormone receptor expression |
BR122020024443B1 (pt) | 2014-05-01 | 2022-02-22 | Ionis Pharmaceuticals, Inc | Composto e composição farmacêutica para modulação da expressão de angptl3 |
US10570169B2 (en) | 2014-05-22 | 2020-02-25 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
BR112018003291A2 (pt) | 2015-11-06 | 2018-09-25 | Ionis Pharmaceuticals, Inc. | modulando a expressão da apolipoproteina (a) |
WO2018067900A1 (en) | 2016-10-06 | 2018-04-12 | Ionis Pharmaceuticals, Inc. | Method of conjugating oligomeric compounds |
EP4035659A1 (en) | 2016-11-29 | 2022-08-03 | PureTech LYT, Inc. | Exosomes for delivery of therapeutic agents |
AR112779A1 (es) | 2017-08-08 | 2019-12-11 | Wave Life Sciences Ltd | Composiciones de nucleótidos y métodos relacionados |
WO2019168402A1 (en) * | 2018-03-02 | 2019-09-06 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | Inhibition of polyomavirus replication |
JP7247227B2 (ja) * | 2018-05-22 | 2023-03-28 | アイオニス・ファーマシューティカルズ・インコーポレイテッド | Apol1発現のモジュレーター |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008109506A1 (en) * | 2007-03-02 | 2008-09-12 | Mdrna, Inc. | Nucleic acid compounds for inhibiting jun gene expression and uses thereof |
KR20100105550A (ko) * | 2007-11-09 | 2010-09-29 | 아이시스 파마수티컬즈 인코포레이티드 | 7 인자 발현 조절 |
US20120214862A1 (en) * | 2009-07-16 | 2012-08-23 | Isis Pharmaceuticals, Inc. | Modulation of factor 7 expression |
WO2013173789A2 (en) * | 2012-05-17 | 2013-11-21 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide compositions |
-
2013
- 2013-02-08 US US14/377,614 patent/US20150031747A1/en not_active Abandoned
- 2013-02-08 CA CA2863958A patent/CA2863958A1/en not_active Abandoned
- 2013-02-08 AU AU2013216852A patent/AU2013216852A1/en not_active Abandoned
- 2013-02-08 WO PCT/US2013/025381 patent/WO2013119979A1/en active Application Filing
- 2013-02-08 EP EP13746652.0A patent/EP2812433A4/en not_active Withdrawn
- 2013-02-08 JP JP2014556737A patent/JP2015507924A/ja not_active Ceased
-
2015
- 2015-06-17 HK HK15105748.7A patent/HK1205189A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CA2863958A1 (en) | 2013-08-15 |
EP2812433A1 (en) | 2014-12-17 |
WO2013119979A1 (en) | 2013-08-15 |
US20150031747A1 (en) | 2015-01-29 |
AU2013216852A1 (en) | 2014-08-21 |
EP2812433A4 (en) | 2016-01-20 |
JP2015507924A (ja) | 2015-03-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL264288B2 (en) | Methods and preparations for regulating expression of apolipoprotein(a) | |
HK1212597A1 (zh) | 用於調節 表達的組合物 | |
AP2014008100A0 (en) | Compositions and methods for modulating hemoglobingene family expression | |
EP2850184A4 (en) | COMPOSITIONS AND METHOD FOR MODULATING GENE EXPRESSION | |
EP2850183A4 (en) | COMPOSITIONS AND METHOD FOR MODULATING GENE EXPRESSION | |
ZA201409229B (en) | Compositions and methods for modulating utrn expression | |
EP2850190A4 (en) | COMPOSITIONS AND METHOD FOR MODULATING MECP2 EXPRESSION | |
IL238488B (en) | Preparations and methods for modulating cell signaling | |
EP2850189A4 (en) | COMPOSITIONS AND METHODS FOR MODULATING GENE EXPRESSION | |
EP2850182A4 (en) | COMPOSITIONS AND METHODS FOR MODULATING THE EXPRESSION OF ATP2A2 | |
EP2850187A4 (en) | COMPOSITIONS AND METHODS FOR PTEN EXPRESSION MODULATION | |
HK1205189A1 (zh) | 用於調節因子 表達的方法和組合物 | |
EP2836212A4 (en) | NOVEL COMPOSITIONS AND METHOD | |
EP2906696A4 (en) | METHODS FOR MODULATING THE EXPRESSION OF C90RF72 | |
ZA201408594B (en) | Xylitol-based anti-mucosal compositions and related methods and compositions | |
EP2849800A4 (en) | COMPOUNDS AND METHOD FOR MODULATING BDNF EXPRESSION | |
HK1208702A1 (zh) | 用於調節 的表達的組合物和方法 | |
GB201315350D0 (en) | Methods and compositions | |
GB201315347D0 (en) | Methods and compositions | |
GB201222820D0 (en) | Woolscouring method and composition | |
GB201206859D0 (en) | Method and composition | |
ZA201500172B (en) | Plant-disease-control composition and plant-disease-control method | |
HUE032878T2 (hu) | Bõrvédõ és bõrkiegyensúlyozó készítmény | |
EP2827861A4 (en) | COMPOSITION AND METHODS FOR CELLULAR MODULATION | |
GB201222810D0 (en) | Woolscouring method and composition |