HK1204227A1 - 苯甲酰胺衍生物 - Google Patents
苯甲酰胺衍生物Info
- Publication number
- HK1204227A1 HK1204227A1 HK15104888.0A HK15104888A HK1204227A1 HK 1204227 A1 HK1204227 A1 HK 1204227A1 HK 15104888 A HK15104888 A HK 15104888A HK 1204227 A1 HK1204227 A1 HK 1204227A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- benzamide derivatives
- benzamide
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21968109P | 2009-06-23 | 2009-06-23 | |
| PCT/US2010/038290 WO2010151441A1 (en) | 2009-06-23 | 2010-06-11 | Benzamide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1204227A1 true HK1204227A1 (zh) | 2015-11-13 |
Family
ID=43386841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15104888.0A HK1204227A1 (zh) | 2009-06-23 | 2015-05-22 | 苯甲酰胺衍生物 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US9125901B2 (zh) |
| EP (1) | EP2445345B1 (zh) |
| JP (1) | JP5868851B2 (zh) |
| CN (1) | CN104219954B (zh) |
| AU (1) | AU2010263113B2 (zh) |
| CA (1) | CA2766550C (zh) |
| HK (1) | HK1204227A1 (zh) |
| IL (1) | IL217183A (zh) |
| WO (1) | WO2010151441A1 (zh) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2445345B1 (en) * | 2009-06-23 | 2014-08-27 | The Translational Genomics Research Institute | Benzamide derivatives |
| US9957235B2 (en) * | 2014-02-11 | 2018-05-01 | Bayer Pharma Aktiengesellschaft | Benzimidazol-2-amines as mIDH1 inhibitors |
| JP6688735B2 (ja) * | 2014-02-11 | 2020-04-28 | バイエル・ファルマ・アクティエンゲゼルシャフト | ｍＩＤＨ１阻害剤としてのベンズイミダゾール−２−アミン |
| EP3209646B1 (en) | 2014-10-23 | 2020-07-22 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Benzimidazol-2-amines as midh1 inhibitors |
| CA2965213A1 (en) * | 2014-10-23 | 2016-04-28 | Bayer Pharma Aktiengesellschaft | 1-cyclohexyl-2-phenylaminobenzimidazoles as midh1 inhibitors for the treatment of tumors |
| DK3292116T3 (da) | 2015-02-02 | 2022-01-10 | Valo Health Inc | 3-aryl-4-amido-bicykliske [4,5,0]hydroxamsyrer som hdac-inhibitorer |
| AR103598A1 (es) | 2015-02-02 | 2017-05-24 | Forma Therapeutics Inc | Ácidos bicíclicos[4,6,0]hidroxámicos como inhibidores de hdac |
| WO2019051125A1 (en) * | 2017-09-06 | 2019-03-14 | Translational Drug Development, Llc | AMINOBENZIMIDAZOLE DERIVATIVES, TREATMENTS AND METHODS FOR INHIBITING HISTONE DEACETYLASE |
| CA3176224A1 (en) | 2015-05-22 | 2016-12-01 | Translational Drug Development Llc | Benzamide and active compound compositions and methods of use |
| US10370339B2 (en) | 2015-06-08 | 2019-08-06 | Bayer Pharma Aktiengesellschaft | N-Methylbenzimidazoles as mIDH1 inhibitors |
| JP6824954B2 (ja) * | 2015-07-16 | 2021-02-03 | ドイチェス クレープスフォルシュングスツェントルム シュティフトゥング デス エッフェントリッヒェン レヒツ | ｍＩＤＨ１阻害剤としての５−ヒドロキシアルキルベンズイミダゾール |
| TW201708193A (zh) * | 2015-07-27 | 2017-03-01 | 拜耳製藥公司 | 突變之異檸檬酸脫氫酶ｉｄｈ１ ｒ１３２ｈ之抑制劑 |
| TW201718513A (zh) * | 2015-07-27 | 2017-06-01 | 拜耳製藥公司 | 製備經取代之３－（２－苯胺－１－環己基－１ｈ－苯并咪唑－５－基）丙酸衍生物之方法 |
| AU2016394945A1 (en) * | 2016-03-02 | 2018-10-11 | Translational Drug Development Llc | Aminobenzimidazole derivatives |
| EP3472131B1 (en) | 2016-06-17 | 2020-02-19 | Forma Therapeutics, Inc. | 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors |
| IL300095A (en) * | 2016-11-23 | 2023-03-01 | Translational Drug Dev Llc | Compositions of benzamide and an agonist for the cancer necrosis factor receptor superfamily and uses thereof |
| KR102117083B1 (ko) * | 2018-10-30 | 2020-05-29 | 계명대학교 산학협력단 | 벤조헤테로사이클 화합물 및 이를 유효성분으로 함유하는 암질환 예방 또는 치료용 조성물 |
| CN112209884B (zh) * | 2019-07-12 | 2022-11-11 | 杭州梯诺医药科技有限公司 | 1-h苯并咪唑衍生物、制备方法及其应用 |
| WO2023247715A1 (de) * | 2022-06-24 | 2023-12-28 | Basf Se | Neue carboxy-liganden sowie deren verwendung in katalysatoren |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US299039A (en) * | 1884-05-20 | Electric multiple-switch-board system | ||
| FR2833948B1 (fr) * | 2001-12-21 | 2004-02-06 | Sod Conseils Rech Applic | Nouveaux derives de benzimidazole et leur utilisation en tant que medicament |
| AU2003226211B2 (en) | 2002-03-29 | 2008-05-29 | Novartis Vaccines And Diagnostics, Inc. | Substituted benzazoles and use thereof as RAF kinase inhibitors |
| PE20040844A1 (es) * | 2002-11-26 | 2004-12-30 | Novartis Ag | Acidos fenilaceticos y derivados como inhibidores de la cox-2 |
| FR2851563B1 (fr) * | 2003-02-26 | 2005-04-22 | Sod Conseils Rech Applic | Nouveaux derives de benzimidazole et d'imidazo-pyridine et leur utilisation en tant que medicament |
| DE602004021573D1 (de) | 2003-04-07 | 2009-07-30 | Pharmacyclics Inc | Hydroxamate als therapeutische mittel |
| JP2008505969A (ja) * | 2004-07-12 | 2008-02-28 | メルク エンド カムパニー インコーポレーテッド | ヒストン脱アセチル化酵素の阻害剤 |
| EP1824831A2 (en) | 2004-12-16 | 2007-08-29 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| WO2006088949A1 (en) | 2005-02-14 | 2006-08-24 | Miikana Therapeutics, Inc. | Fused heterocyclic compounds useful as inhibitors of histone deacetylase |
| CN102633783A (zh) * | 2006-02-10 | 2012-08-15 | 转化技术制药公司 | 作为Aurora激酶抑制剂的苯并唑系衍生物、组合物和使用方法 |
| US8486370B2 (en) | 2006-09-08 | 2013-07-16 | The Regents Of The University Of California | Heterocyclic ligands for integrin imaging and therapy |
| WO2008153701A1 (en) | 2007-05-24 | 2008-12-18 | Schering Corporation | Compounds for inhibiting ksp kinesin activity |
| US20090005374A1 (en) * | 2007-06-26 | 2009-01-01 | Melvin Jr Lawrence S | Imidazopyridinyl thiazolyl histone deacetylase inhibitors |
| EP2445345B1 (en) * | 2009-06-23 | 2014-08-27 | The Translational Genomics Research Institute | Benzamide derivatives |
-
2010
- 2010-06-11 EP EP20100792517 patent/EP2445345B1/en active Active
- 2010-06-11 US US13/380,213 patent/US9125901B2/en active Active
- 2010-06-11 CA CA2766550A patent/CA2766550C/en active Active
- 2010-06-11 JP JP2012517571A patent/JP5868851B2/ja active Active
- 2010-06-11 CN CN201080033226.1A patent/CN104219954B/zh active Active
- 2010-06-11 AU AU2010263113A patent/AU2010263113B2/en active Active
- 2010-06-11 WO PCT/US2010/038290 patent/WO2010151441A1/en active Application Filing
-
2011
- 2011-12-25 IL IL21718311A patent/IL217183A/en active IP Right Grant
-
2015
- 2015-05-22 HK HK15104888.0A patent/HK1204227A1/zh unknown
- 2015-06-08 US US14/733,952 patent/US9464059B2/en active Active
-
2016
- 2016-08-23 US US15/245,166 patent/US20160362382A1/en not_active Abandoned
-
2018
- 2018-10-16 US US16/161,926 patent/US10590088B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| IL217183A0 (en) | 2012-02-29 |
| US20190084940A1 (en) | 2019-03-21 |
| JP5868851B2 (ja) | 2016-02-24 |
| US20150284336A1 (en) | 2015-10-08 |
| US20120142922A1 (en) | 2012-06-07 |
| US9464059B2 (en) | 2016-10-11 |
| US10590088B2 (en) | 2020-03-17 |
| US20160362382A1 (en) | 2016-12-15 |
| US9125901B2 (en) | 2015-09-08 |
| CN104219954B (zh) | 2017-03-22 |
| WO2010151441A1 (en) | 2010-12-29 |
| EP2445345B1 (en) | 2014-08-27 |
| CA2766550C (en) | 2017-04-11 |
| CA2766550A1 (en) | 2010-12-29 |
| AU2010263113B2 (en) | 2015-11-26 |
| IL217183A (en) | 2015-02-26 |
| AU2010263113A1 (en) | 2012-02-16 |
| EP2445345A1 (en) | 2012-05-02 |
| EP2445345A4 (en) | 2013-04-24 |
| CN104219954A (zh) | 2014-12-17 |
| JP2012531416A (ja) | 2012-12-10 |
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