HK1192282A1 - Method for expanding activated lymphocyte by serum-free culture - Google Patents

Method for expanding activated lymphocyte by serum-free culture

Info

Publication number
HK1192282A1
HK1192282A1 HK14105496.2A HK14105496A HK1192282A1 HK 1192282 A1 HK1192282 A1 HK 1192282A1 HK 14105496 A HK14105496 A HK 14105496A HK 1192282 A1 HK1192282 A1 HK 1192282A1
Authority
HK
Hong Kong
Prior art keywords
serum
free culture
activated lymphocyte
expanding activated
expanding
Prior art date
Application number
HK14105496.2A
Other languages
Chinese (zh)
Inventor
邵誼
Original Assignee
北京賽諾泰生物科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 北京賽諾泰生物科技有限公司 filed Critical 北京賽諾泰生物科技有限公司
Publication of HK1192282A1 publication Critical patent/HK1192282A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2302—Interleukin-2 (IL-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2307—Interleukin-7 (IL-7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/24—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/515—CD3, T-cell receptor complex

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HK14105496.2A 2013-08-02 2014-06-11 Method for expanding activated lymphocyte by serum-free culture HK1192282A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201310334666.6A CN103436492B (en) 2013-08-02 2013-08-02 By the method for serum-free culture amplifying activated lymphocyte

Publications (1)

Publication Number Publication Date
HK1192282A1 true HK1192282A1 (en) 2014-08-15

Family

ID=49690210

Family Applications (1)

Application Number Title Priority Date Filing Date
HK14105496.2A HK1192282A1 (en) 2013-08-02 2014-06-11 Method for expanding activated lymphocyte by serum-free culture

Country Status (3)

Country Link
CN (1) CN103436492B (en)
HK (1) HK1192282A1 (en)
WO (1) WO2015014291A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201421716D0 (en) * 2014-12-05 2015-01-21 King S College London Cell expansion procedure
CN112251407A (en) * 2020-11-03 2021-01-22 广州康琪莱精准医疗科技有限公司 Amplification culture method of umbilical cord blood CIK cells
CN112662625B (en) * 2021-01-18 2023-03-17 曹彤 T cell culture medium and method for expanding and culturing T cells by using same
WO2023125696A2 (en) * 2021-12-28 2023-07-06 北京永泰生物制品有限公司 Activated lymphocyte expansion method having stable and controllable quality, and anti-tumor use thereof
CN116355846A (en) * 2021-12-28 2023-06-30 北京永泰生物制品有限公司 Method for amplifying activated lymphocytes with stable and controllable quality and application of method in preventing and treating neurologic diseases
CN114984048A (en) * 2022-06-16 2022-09-02 浙江百越生物技术有限公司 Cell therapy for preventing and treating senile tarnish
WO2024114809A1 (en) * 2022-12-02 2024-06-06 上海药明巨诺生物医药研发有限公司 Composition for cell culture

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008501697A (en) * 2004-06-04 2008-01-24 セル‐サイ コーポレイション Methods of changing the CD4 / CD8 ratio and mononuclear cell infiltration into tumors
EP1966370B1 (en) * 2005-12-21 2013-02-20 SentoClone International AB Method for obtaining T-lymphocytes
CN1990044A (en) * 2005-12-30 2007-07-04 上海中科英达生物技术有限公司 Preparation and use of human body immunocompetent cell DCCIK anti-tumor cell preparation
CN101063108A (en) * 2007-04-25 2007-10-31 哈尔滨医科大学 Preparation method for CIK cell with high proliferation and high cell cytotoxic activity
CN101418283A (en) * 2007-10-23 2009-04-29 范云峰 A kind of method of simple high efficiently preparing CIK cell
CN101386840A (en) * 2008-10-31 2009-03-18 江苏省人民医院 Construction method of CD3<->CD56<+>NK cell high-efficient multiplication culture system
EP2539442A1 (en) * 2010-02-24 2013-01-02 Ingo Schmidt-Wolf Method for the generation of a cik cell and nk cell population
CN102174469B (en) * 2011-01-26 2012-11-21 宋鑫 Method for effectively culturing tumor infiltrating lymphocytes (TILs)
CN102352342B (en) * 2011-09-30 2013-05-22 上海柯莱逊生物技术有限公司 Method for amplifying cytokine induced kill cells (CIK) and CIK cell preparation
CN102517213B (en) * 2011-12-29 2013-09-11 辽宁迈迪生物科技有限公司 In vitro culture kit for T-lymphocyte cells
CN102827808B (en) * 2012-09-27 2014-06-18 高岱清 Method for preparing cytokine-induced killer cells
CN103013914B (en) * 2012-12-13 2014-12-03 吉林省拓华生物科技有限公司 Method for in-vitro culture of killer T cells

Also Published As

Publication number Publication date
CN103436492A (en) 2013-12-11
WO2015014291A1 (en) 2015-02-05
CN103436492B (en) 2016-03-02

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