HK1182924A1 - Proteasome inhibitors - Google Patents

Proteasome inhibitors

Info

Publication number
HK1182924A1
HK1182924A1 HK13110199.3A HK13110199A HK1182924A1 HK 1182924 A1 HK1182924 A1 HK 1182924A1 HK 13110199 A HK13110199 A HK 13110199A HK 1182924 A1 HK1182924 A1 HK 1182924A1
Authority
HK
Hong Kong
Prior art keywords
proteasome inhibitors
proteasome
inhibitors
Prior art date
Application number
HK13110199.3A
Other languages
Chinese (zh)
Inventor
愛德華．
．奧爾哈瓦
米海阿拉．
．丹卡
Original Assignee
米倫紐姆醫藥公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38691782&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1182924(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 米倫紐姆醫藥公司 filed Critical 米倫紐姆醫藥公司
Publication of HK1182924A1 publication Critical patent/HK1182924A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK13110199.3A 2007-08-06 2013-09-02 Proteasome inhibitors HK1182924A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2007801001423A CN101772507B (en) 2007-08-06 2007-08-06 Proteasome inhibitors
PCT/US2007/017440 WO2009020448A1 (en) 2007-08-06 2007-08-06 Proteasome inhibitors

Publications (1)

Publication Number Publication Date
HK1182924A1 true HK1182924A1 (en) 2013-12-13

Family

ID=38691782

Family Applications (2)

Application Number Title Priority Date Filing Date
HK10110167.4A HK1143595A1 (en) 2007-08-06 2010-10-28 Proteasome inhibitors
HK13110199.3A HK1182924A1 (en) 2007-08-06 2013-09-02 Proteasome inhibitors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK10110167.4A HK1143595A1 (en) 2007-08-06 2010-10-28 Proteasome inhibitors

Country Status (33)

Country Link
EP (3) EP2178888B1 (en)
JP (1) JP5261488B2 (en)
KR (6) KR20150010802A (en)
CN (1) CN101772507B (en)
AU (1) AU2007357338B2 (en)
BR (1) BRPI0721905B8 (en)
CA (1) CA2695082C (en)
CY (2) CY1113386T1 (en)
DK (1) DK2178888T3 (en)
EA (1) EA028622B1 (en)
EC (1) ECSP10010015A (en)
ES (1) ES2390606T3 (en)
FR (1) FR17C1011I2 (en)
GE (1) GEP20125599B (en)
HK (2) HK1143595A1 (en)
HR (1) HRP20120745T1 (en)
HU (1) HUS1700018I1 (en)
IL (4) IL203641A (en)
LT (1) LTC2178888I2 (en)
LU (1) LUC00013I2 (en)
MY (1) MY161991A (en)
NL (1) NL300871I2 (en)
NZ (1) NZ582693A (en)
PH (1) PH12014500053B1 (en)
PL (1) PL2178888T3 (en)
PT (1) PT2178888E (en)
RS (1) RS52435B (en)
SG (1) SG10201508712QA (en)
SI (1) SI2178888T1 (en)
TN (1) TN2010000060A1 (en)
UA (1) UA97536C2 (en)
WO (1) WO2009020448A1 (en)
ZA (1) ZA201000348B (en)

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AU2007261345B2 (en) 2006-06-19 2012-02-23 Onyx Therapeutics, Inc. Peptide epoxyketones for proteasome inhibition
US7442830B1 (en) 2007-08-06 2008-10-28 Millenium Pharmaceuticals, Inc. Proteasome inhibitors
KR20170125413A (en) 2007-10-04 2017-11-14 오닉스 세라퓨틱스, 인크. Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides
GEP20135847B (en) 2008-06-17 2013-06-10 Millennium Pharm Inc Boronate ester compounds and pharmaceutical compositions containing them
AR075090A1 (en) 2008-09-29 2011-03-09 Millennium Pharm Inc ACID DERIVATIVES 1-AMINO-2-CYCLLOBUTILETILBORONICO PROTEOSOMA INHIBITORS, USEFUL AS ANTI-BANKER AGENTS, AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM.
CA2741312C (en) 2008-10-21 2020-10-27 Onyx Therapeutics, Inc. Combination therapy with peptide epoxyketones
TWI504598B (en) 2009-03-20 2015-10-21 Onyx Therapeutics Inc Crystalline tripeptide epoxy ketone protease inhibitors
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JP5944986B2 (en) * 2011-06-22 2016-07-05 セファロン、インク． Proteasome inhibitors and processes for their preparation, purification, and use
EP4144354A1 (en) * 2011-08-30 2023-03-08 Trustees Of Tufts College Fap-activated proteasome inhibitors for treating solid tumors
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JP2015524394A (en) 2012-07-09 2015-08-24 オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． Prodrugs of peptide epoxyketone protease inhibitors
CN109096370B (en) * 2012-07-26 2022-03-18 圣特莱国际公司 Polypeptide epoxy ketone compound
JP2013006855A (en) * 2012-09-03 2013-01-10 Millennium Pharmaceuticals Inc Proteasome inhibitor
JP6018319B2 (en) * 2012-12-03 2016-11-02 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Substituted triazole boronic acid compounds
WO2015051067A1 (en) 2013-10-03 2015-04-09 Millennium Pharmaceuticals, Inc. Method for the prophylaxis or treatment of systemic lupus erythematosus and/or lupus nephritis
SG10202003693RA (en) 2014-05-20 2020-05-28 Millennium Pharm Inc Boron-containing proteasome inhibitors for use after primary cancer therapy
WO2016022955A1 (en) 2014-08-07 2016-02-11 Mayo Foundation For Medical Education And Research Compounds and methods for treating cancer
MA41555A (en) * 2015-02-17 2017-12-26 Millennium Pharm Inc POLYTHERAPY FOR CANCER TREATMENT
US10144761B2 (en) 2015-06-19 2018-12-04 Hanlin Scientific Inc. Chiral specific boron-containing compounds and their use in treating cancer or amyloidosis
CN106608883A (en) * 2015-10-21 2017-05-03 北京大学 Synthetic method of proteasome inhibitor MLN9708
WO2017198194A1 (en) * 2016-05-19 2017-11-23 成都奥璟生物科技有限公司 Boronic acid and borate ester compound and applications thereof
CN106008572B (en) * 2016-05-23 2018-08-17 成都千禧莱医药科技有限公司 A kind of dipeptide boronic acid compound and preparation method and purposes
UA124672C2 (en) 2016-06-21 2021-10-27 Оріон Офтальмолоджі Ллс Heterocyclic prolinamide derivatives
JP7164521B2 (en) 2016-06-21 2022-11-01 オリオン・オフサルモロジー・エルエルシー carbocyclic prolinamide derivatives
CN108368134B (en) * 2016-07-25 2019-06-14 深圳市塔吉瑞生物医药有限公司 A kind of substituted boronic acid compounds and the medical composition and its use comprising the compound
TW201831191A (en) * 2017-01-23 2018-09-01 大陸商成都奥璟生物科技有限公司 Novel boric acid derivative and pharmaceutical composition using same
WO2018160717A1 (en) 2017-02-28 2018-09-07 Mayo Foundation For Medical Education And Research Compounds and methods for treating cancer
CN108794516A (en) * 2017-04-26 2018-11-13 上海时莱生物技术有限公司 Boric acid and boric acid ester compound and its preparation method and application
US11414437B2 (en) 2017-07-28 2022-08-16 Chengdu Origin Biotechnology Limited Company Borate compound, and synthesis method therefor and uses thereof
WO2019038406A1 (en) 2017-08-25 2019-02-28 Synthon B.V. Process for making ixazomib or intermediates therefor
JP2018024694A (en) * 2017-10-03 2018-02-15 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Proteasome inhibitor
US11243207B2 (en) 2018-03-29 2022-02-08 Mayo Foundation For Medical Education And Research Assessing and treating cancer
CN115403603A (en) * 2018-09-14 2022-11-29 成都奥璟生物科技有限公司 Boric acid ester medicine and application thereof
CN110357787A (en) * 2019-08-02 2019-10-22 苏州艾和医药科技有限公司 Yi Shazuo meter synthesising process research
EP4041246A4 (en) * 2019-10-07 2023-11-01 Cornell University Antimicrobial and antiviral effects of c2-c7alkyl boronic acids
CN110950897B (en) * 2019-12-12 2021-05-28 山东大学 Histone deacetylase, protease double-target inhibitor, preparation method and application thereof

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Also Published As

Publication number Publication date
CY1113386T1 (en) 2016-06-22
BRPI0721905A2 (en) 2014-02-25
IL242291A (en) 2017-12-31
GEP20125599B (en) 2012-08-10
EA201070247A1 (en) 2010-06-30
KR20170004031A (en) 2017-01-10
AU2007357338B2 (en) 2014-03-20
PT2178888E (en) 2012-10-04
CY2017016I2 (en) 2017-07-12
WO2009020448A1 (en) 2009-02-12
HRP20120745T1 (en) 2012-10-31
LTPA2017010I1 (en) 2017-05-10
SI2178888T1 (en) 2012-11-30
CY2017016I1 (en) 2017-07-12
EP2178888A1 (en) 2010-04-28
DK2178888T3 (en) 2012-10-01
LTC2178888I2 (en) 2018-03-12
EP2527347A1 (en) 2012-11-28
KR20140042933A (en) 2014-04-07
EP3210987A1 (en) 2017-08-30
BRPI0721905B8 (en) 2021-05-25
NL300871I2 (en) 2017-12-07
SG10201508712QA (en) 2015-11-27
LUC00013I2 (en) 2017-06-19
FR17C1011I1 (en) 2017-05-26
CN101772507B (en) 2012-12-12
KR20100059811A (en) 2010-06-04
IL203641A (en) 2015-11-30
ECSP10010015A (en) 2010-04-30
IL242291A0 (en) 2015-11-30
IL242290A (en) 2017-12-31
CA2695082A1 (en) 2009-02-12
IL242290A0 (en) 2015-11-30
NZ582693A (en) 2012-01-12
ZA201000348B (en) 2011-03-30
AU2007357338A1 (en) 2009-02-12
LUC00013I1 (en) 2017-04-06
PL2178888T3 (en) 2012-11-30
CA2695082C (en) 2015-07-28
CN101772507A (en) 2010-07-07
IL242292A (en) 2017-12-31
KR101831674B1 (en) 2018-02-23
KR20140042932A (en) 2014-04-07
RS52435B (en) 2013-02-28
PH12014500053A1 (en) 2015-03-30
FR17C1011I2 (en) 2018-04-27
UA97536C2 (en) 2012-02-27
JP5261488B2 (en) 2013-08-14
BRPI0721905B1 (en) 2020-11-17
KR20160040735A (en) 2016-04-14
HK1143595A1 (en) 2011-01-07
KR101474831B1 (en) 2014-12-19
ES2390606T3 (en) 2012-11-14
MY161991A (en) 2017-05-31
HUS1700018I1 (en) 2017-05-29
KR20150010802A (en) 2015-01-28
TN2010000060A1 (en) 2011-09-26
IL242292A0 (en) 2015-11-30
PH12014500053B1 (en) 2015-03-30
EP2178888B1 (en) 2012-07-04
EA028622B1 (en) 2017-12-29
JP2010535759A (en) 2010-11-25

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