HK1173149A1 - 喜樹碱衍生物 - Google Patents

喜樹碱衍生物

Info

Publication number
HK1173149A1
HK1173149A1 HK13100453.5A HK13100453A HK1173149A1 HK 1173149 A1 HK1173149 A1 HK 1173149A1 HK 13100453 A HK13100453 A HK 13100453A HK 1173149 A1 HK1173149 A1 HK 1173149A1
Authority
HK
Hong Kong
Prior art keywords
camptothecin derivatives
camptothecin
derivatives
Prior art date
Application number
HK13100453.5A
Other languages
English (en)
Inventor
蔡曉宏
段建新
馬克．馬泰烏齊
曹冶宇
矯海龍
Original Assignee
四川恒康發展有限責任公司 號
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 四川恒康發展有限責任公司 號 filed Critical 四川恒康發展有限責任公司 號
Publication of HK1173149A1 publication Critical patent/HK1173149A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK13100453.5A 2009-06-17 2013-01-11 喜樹碱衍生物 HK1173149A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21804309P 2009-06-17 2009-06-17
US32522310P 2010-04-16 2010-04-16
PCT/US2010/038890 WO2010148138A2 (en) 2009-06-17 2010-06-16 Camptothecin derivatives

Publications (1)

Publication Number Publication Date
HK1173149A1 true HK1173149A1 (zh) 2013-05-10

Family

ID=43357035

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13100453.5A HK1173149A1 (zh) 2009-06-17 2013-01-11 喜樹碱衍生物

Country Status (5)

Country Link
US (1) US8575188B2 (zh)
EP (1) EP2443125B1 (zh)
CN (1) CN102574866B (zh)
HK (1) HK1173149A1 (zh)
WO (1) WO2010148138A2 (zh)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2862571A4 (en) * 2012-06-18 2016-03-16 Li Yuliang CAMPTOTHECIN COMPOUND, AND ITS MANUFACTURE AND USE
US20140073793A1 (en) * 2012-09-07 2014-03-13 BioNumeric Pharmaceuticals, Inc. Germanium-containing camptothecin analogues
WO2014062856A1 (en) 2012-10-16 2014-04-24 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
CN103848856B (zh) * 2012-11-30 2016-08-03 苏州汉德景曦新药研发有限公司 具有抗肿瘤活性的喜树碱衍生物
TWI526446B (zh) * 2013-09-27 2016-03-21 中國醫藥大學附設醫院 喜樹鹼的新穎２０（ｓ）－磺基脒衍生物及其抗腫瘤劑的用途
WO2016183359A1 (en) 2015-05-12 2016-11-17 Blinkbio, Inc. Silicon based drug conjugates and methods of using same
CN106543195A (zh) * 2015-09-16 2017-03-29 四川赛诺唯新生物技术有限公司 喜树碱衍生物的晶型及其制备方法与应用
CN106551910A (zh) * 2015-09-17 2017-04-05 四川赛诺唯新生物技术有限公司 一种含喜树碱衍生物的注射制剂、其注射液、制备和应用
US11103159B2 (en) * 2016-03-04 2021-08-31 United States Of America As Represented By The Secretary Of The Air Force Exhaled breath hypoxia biomarkers
WO2017214491A1 (en) * 2016-06-09 2017-12-14 Blinkbio, Inc. Silanol based therapeutic payloads
CN110590796B (zh) * 2018-06-12 2022-07-15 青岛海洋生物医药研究院股份有限公司 喜树碱衍生物及其制备方法和应用
CN111689977A (zh) * 2019-03-11 2020-09-22 兰州大学 一种喜树碱20-位修饰的磺酰脲类化合物及其制备方法和用途
MX2023008895A (es) * 2021-02-09 2023-08-09 Medilink Therapeutics Suzhou Co Ltd Conjugado de sustancia bioactiva, metodo de preparacion y uso del mismo.
WO2023173026A1 (en) 2022-03-10 2023-09-14 Sorrento Therapeutics, Inc. Antibody-drug conjugates and uses thereof
WO2024012524A1 (zh) * 2022-07-14 2024-01-18 苏州宜联生物医药有限公司 抗体药物偶联物及其制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5180722A (en) * 1987-04-14 1993-01-19 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs
US5459269A (en) * 1992-06-18 1995-10-17 North Carolina State University 14-halo-camptothecins
US5391745A (en) * 1992-07-23 1995-02-21 Sloan-Kettering Institute For Cancer Research Methods of preparation of camptothecin analogs
US6403604B1 (en) 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US7875602B2 (en) 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
BRPI0709447A2 (pt) * 2006-03-30 2011-07-12 Diatos Sa conjugado, composição farmacêutica, uso e composto

Also Published As

Publication number Publication date
US20120165522A1 (en) 2012-06-28
CN102574866B (zh) 2015-02-18
EP2443125B1 (en) 2014-11-26
EP2443125A2 (en) 2012-04-25
WO2010148138A2 (en) 2010-12-23
US8575188B2 (en) 2013-11-05
CN102574866A (zh) 2012-07-11
EP2443125A4 (en) 2012-12-12
WO2010148138A3 (en) 2011-05-12

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20190616