HK1136816A - Water-soluble prodrugs of florfenicol and its analogs - Google Patents

Water-soluble prodrugs of florfenicol and its analogs Download PDF

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Publication number
HK1136816A
HK1136816A HK10100550.0A HK10100550A HK1136816A HK 1136816 A HK1136816 A HK 1136816A HK 10100550 A HK10100550 A HK 10100550A HK 1136816 A HK1136816 A HK 1136816A
Authority
HK
Hong Kong
Prior art keywords
florfenicol
analogs
water
prodrug
prodrugs
Prior art date
Application number
HK10100550.0A
Other languages
Chinese (zh)
Inventor
Tomasz W. Glinka
Jason Zhang
Original Assignee
Schering-Plough Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering-Plough Ltd. filed Critical Schering-Plough Ltd.
Publication of HK1136816A publication Critical patent/HK1136816A/en

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Abstract

The present invention discloses certain novel prodrugs of florfenicol and/or of florfenicol analogs, including prodrugs of salts pharmaceutically acceptable salts of florfenicol and its analogs, including nitrogen-containing esters of the secondary alcohol group of florfenicol and of its analogs, and pharmaceutically acceptable salts thereof, compositions containing them, and methods of administering them to subjects. In particular embodiments the prodrugs are sufficiently water-soluble to serve the functions needed of a water-soluble prodrug of florfenicol or of a water-soluble prodrug of a florfenicol analog. A certain subclass of the compounds also possesses the hydrolytic stability needed to maintain the prodrug in solution in the subject's system until appropriate conditions exist when the prodrug can hydrolyze, releasing florfenicol or the florfenicol analog in question.
HK10100550.0A 2006-12-13 2007-12-11 Water-soluble prodrugs of florfenicol and its analogs HK1136816A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US874864P 2006-12-13

Publications (1)

Publication Number Publication Date
HK1136816A true HK1136816A (en) 2010-07-09

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