HK1127776A1 - 2,4-diaminoquinazolines for spinal muscular atrophy 24- - Google Patents
2,4-diaminoquinazolines for spinal muscular atrophy 24-Info
- Publication number
- HK1127776A1 HK1127776A1 HK09106930.1A HK09106930A HK1127776A1 HK 1127776 A1 HK1127776 A1 HK 1127776A1 HK 09106930 A HK09106930 A HK 09106930A HK 1127776 A1 HK1127776 A1 HK 1127776A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- diaminoquinazolines
- muscular atrophy
- spinal muscular
- spinal
- atrophy
- Prior art date
Links
- XELRMPRLCPFTBH-UHFFFAOYSA-N quinazoline-2,4-diamine Chemical class C1=CC=CC2=NC(N)=NC(N)=C21 XELRMPRLCPFTBH-UHFFFAOYSA-N 0.000 title 1
- 208000002320 spinal muscular atrophy Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82108806P | 2006-08-01 | 2006-08-01 | |
| US88235506P | 2006-12-28 | 2006-12-28 | |
| PCT/US2007/074971 WO2008016973A1 (en) | 2006-08-01 | 2007-08-01 | 2,4-diaminoquinazolines for spinal muscular atrophy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1127776A1 true HK1127776A1 (en) | 2009-10-09 |
Family
ID=38596338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK09106930.1A HK1127776A1 (en) | 2006-08-01 | 2009-07-28 | 2,4-diaminoquinazolines for spinal muscular atrophy 24- |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7985755B2 (de) |
| EP (2) | EP2069316B1 (de) |
| JP (2) | JP5349305B2 (de) |
| AU (1) | AU2007281217B2 (de) |
| CA (1) | CA2659376C (de) |
| ES (1) | ES2560512T3 (de) |
| HK (1) | HK1127776A1 (de) |
| NZ (1) | NZ575198A (de) |
| WO (1) | WO2008016973A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2569763C (en) * | 2004-06-08 | 2013-03-12 | Decode Chemistry, Inc. | 2,4-diaminoquinazolines for spinal muscular atrophy |
| WO2009120700A2 (en) * | 2008-03-26 | 2009-10-01 | Families Of Spinal Muscular Atrophy | Inhibition of dcps |
| EP2512241A4 (de) * | 2009-12-15 | 2013-04-03 | Neurop Inc | Verbindungen zur behandlung von neurologischen erkrankungen |
| US9212209B2 (en) * | 2012-07-13 | 2015-12-15 | Indiana University Research And Technology Corporation | Screening methods for spinal muscular atrophy |
| US10987370B2 (en) * | 2012-12-24 | 2021-04-27 | Ramot At Tel-Aviv University Ltd. | Methods of inducing read-through of a nonsense mutation associated with ataxia telangiectasia, Rett syndrome or spinal muscular atrophy by erythromycin or azithromycin |
| CA3005434A1 (en) | 2015-11-16 | 2017-05-26 | Ohio State Innovation Foundation | Methods and compositions for treating disorders and diseases using survival motor neuron (smn) protein |
| US11634404B2 (en) | 2016-04-14 | 2023-04-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Selective D3 dopamine receptor agonists and methods of their use |
| KR20200112906A (ko) * | 2018-01-25 | 2020-10-05 | 바이오젠 엠에이 인코포레이티드 | 척추 근위축증의 치료 방법 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8910722D0 (en) * | 1989-05-10 | 1989-06-28 | Smithkline Beckman Intercredit | Compounds |
| IL108630A0 (en) * | 1993-02-18 | 1994-05-30 | Fmc Corp | Insecticidal substituted 2,4-diaminoquinazolines |
| US6096499A (en) * | 1996-03-22 | 2000-08-01 | Geron Corporation | Mammalian DNA primase screen and activity modulating agents |
| US5874438A (en) * | 1996-10-11 | 1999-02-23 | Bayer Aktiengesellschaft | 2,2'-bridged bis-2,4-diaminoquinazolines |
| US5760230A (en) * | 1996-10-11 | 1998-06-02 | Bayer Aktiengesellschaft | 4, 4'-bridged bis-2, 4-diaminoquinazolines |
| EP1014953B1 (de) | 1997-03-05 | 2012-04-25 | Sugen, Inc. | Hydrophobe pharmazeutische wirkstoffe enthaltende zubereitungen |
| AR012634A1 (es) | 1997-05-02 | 2000-11-08 | Sugen Inc | Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcion |
| CA2338328A1 (en) * | 1998-07-21 | 2000-02-03 | Thomas Jefferson University | Small molecule inhibitors of bcl-2 proteins |
| CA2361734A1 (en) | 1999-01-26 | 2000-10-12 | Andre Rosowsky | Pharmaceutically active compounds and methods of use thereof |
| JP2003518023A (ja) * | 1999-11-30 | 2003-06-03 | パーカー ヒューズ インスティテュート | トロンビン誘導血小板凝集の阻害剤 |
| WO2003097615A1 (en) | 2002-05-17 | 2003-11-27 | Scios, Inc. | TREATMENT OF FIBROPROLIFERATIVE DISORDERS USING TGF-β INHIBITORS |
| US20050123724A1 (en) * | 2002-06-19 | 2005-06-09 | Mars Incorporated | Apparatus for producing scored lines in a film |
| JP4616643B2 (ja) | 2002-06-28 | 2011-01-19 | バーテックス ファーマシューティカルズ インコーポレイテッド | カスパーゼインヒビターおよびそれらの用途 |
| CA2516942A1 (en) | 2003-02-04 | 2004-08-19 | Mcmaster University | Use of quinazoline derivatives or other compounds for inhibiting dihydrofolate reduxtase; screening assay for the identification of novel therapeutics and their cellular targets |
| US7465738B2 (en) * | 2003-06-16 | 2008-12-16 | Vertex Pharmaceuticals Incorporated | Compounds useful as promoters of SMN2 |
| CA2569763C (en) * | 2004-06-08 | 2013-03-12 | Decode Chemistry, Inc. | 2,4-diaminoquinazolines for spinal muscular atrophy |
-
2007
- 2007-08-01 EP EP07813646.2A patent/EP2069316B1/de not_active Not-in-force
- 2007-08-01 AU AU2007281217A patent/AU2007281217B2/en not_active Ceased
- 2007-08-01 CA CA2659376A patent/CA2659376C/en active Active
- 2007-08-01 WO PCT/US2007/074971 patent/WO2008016973A1/en active Application Filing
- 2007-08-01 JP JP2009523039A patent/JP5349305B2/ja not_active Expired - Fee Related
- 2007-08-01 NZ NZ575198A patent/NZ575198A/en not_active IP Right Cessation
- 2007-08-01 EP EP13152024.9A patent/EP2615086A1/de not_active Withdrawn
- 2007-08-01 US US11/832,255 patent/US7985755B2/en not_active Expired - Fee Related
- 2007-08-01 ES ES07813646.2T patent/ES2560512T3/es active Active
-
2009
- 2009-07-28 HK HK09106930.1A patent/HK1127776A1/xx not_active IP Right Cessation
-
2013
- 2013-03-27 JP JP2013065719A patent/JP2013151536A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2659376C (en) | 2014-10-14 |
| WO2008016973A1 (en) | 2008-02-07 |
| CA2659376A1 (en) | 2008-02-07 |
| JP2013151536A (ja) | 2013-08-08 |
| ES2560512T3 (es) | 2016-02-19 |
| US20090042900A1 (en) | 2009-02-12 |
| JP2009545617A (ja) | 2009-12-24 |
| NZ575198A (en) | 2012-05-25 |
| JP5349305B2 (ja) | 2013-11-20 |
| AU2007281217A1 (en) | 2008-02-07 |
| EP2069316B1 (de) | 2015-10-07 |
| AU2007281217B2 (en) | 2013-09-12 |
| EP2069316A1 (de) | 2009-06-17 |
| EP2615086A1 (de) | 2013-07-17 |
| US7985755B2 (en) | 2011-07-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20190805 |