HK1101326A1 - Diastereoselective addition of lithiated n-methylimidazole on sulfinimines - Google Patents
Diastereoselective addition of lithiated n-methylimidazole on sulfiniminesInfo
- Publication number
- HK1101326A1 HK1101326A1 HK07109245.7A HK07109245A HK1101326A1 HK 1101326 A1 HK1101326 A1 HK 1101326A1 HK 07109245 A HK07109245 A HK 07109245A HK 1101326 A1 HK1101326 A1 HK 1101326A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- sulfinimines
- lithiated
- methylimidazole
- methyl
- diastereoselective addition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Lubricants (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04076320 | 2004-05-03 | ||
| PCT/EP2005/051928 WO2005105782A1 (en) | 2004-05-03 | 2005-04-28 | Diastereoselective addition of lithiated n-methylimidazole on sulfinimines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1101326A1 true HK1101326A1 (en) | 2007-10-12 |
Family
ID=34968457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK07109245.7A HK1101326A1 (en) | 2004-05-03 | 2007-08-24 | Diastereoselective addition of lithiated n-methylimidazole on sulfinimines |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7524961B2 (de) |
| EP (1) | EP1758885B1 (de) |
| JP (1) | JP4917021B2 (de) |
| CN (1) | CN100567290C (de) |
| AT (1) | ATE398612T1 (de) |
| AU (1) | AU2005238221B2 (de) |
| CA (1) | CA2563805C (de) |
| DE (1) | DE602005007604D1 (de) |
| ES (1) | ES2308500T3 (de) |
| HK (1) | HK1101326A1 (de) |
| WO (1) | WO2005105782A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602005021878D1 (de) * | 2004-05-03 | 2010-07-29 | Janssen Pharmaceutica Nv | Diastereoselektives syntheseverfahren mit 6-brom-4-(3-chlorphenyl)-2-methoxychinolin |
| AU2005238221B2 (en) * | 2004-05-03 | 2010-09-30 | Janssen Pharmaceutica N.V. | Diastereoselective addition of lithiated N-methylimidazole on sulfinimines |
| EP3385395B9 (de) | 2015-08-17 | 2020-05-20 | Kura Oncology, Inc. | Verfahren zur behandlung von krebspatienten mit farnesyl-transferase-inhibitoren |
| WO2018085518A2 (en) | 2016-11-03 | 2018-05-11 | Kura Oncology, Inc. | Methods of treating cancer patients with farnesyltransferase inhibitors |
| CA3100706A1 (en) * | 2018-05-18 | 2019-11-21 | Kura Oncology, Inc. | Synthesis of tipifarnib |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE321757T1 (de) | 1995-12-08 | 2006-04-15 | Janssen Pharmaceutica Nv | (imidazol-5-yl)methyl-2-chinolinonderivate als farnesyl protein transferase inhibitoren |
| WO2001051126A1 (en) * | 2000-01-12 | 2001-07-19 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| WO2001051127A1 (en) * | 2000-01-12 | 2001-07-19 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| HN2000000266A (es) | 2000-01-21 | 2001-05-21 | Pfizer Prod Inc | Compuesto anticanceroso y metodo de separacion de enantiomeros util para sintetizar dicho compuesto. |
| AU2001290588A1 (en) * | 2000-09-05 | 2002-03-22 | Merck And Co., Inc. | Inhibitors of prenyl-protein transferase |
| PL208238B1 (pl) * | 2001-03-12 | 2011-04-29 | Janssen Pharmaceutica Nv | Sposób wytwarzania 4- (3-chlorofenylo) -6- [ (4-chlorofenylo) hydroksy (1-metylo-1H-imidazol-5-ilo) metylo] -1-metylo-2 (1H) -chinolinonu |
| AU2002254375A1 (en) * | 2001-03-30 | 2002-10-15 | Merck And Co., Inc. | Inhibitors of prenyl-protein transferase |
| WO2004037816A1 (en) * | 2002-10-28 | 2004-05-06 | Chugai Seiyaku Kabushiki Kaisha | Benzofuran compounds having antitumor activity |
| WO2004076446A1 (ja) * | 2003-02-27 | 2004-09-10 | Chugai Seiyaku Kabushiki Kaisha | ベンゾチオフェン誘導体 |
| AU2005238221B2 (en) * | 2004-05-03 | 2010-09-30 | Janssen Pharmaceutica N.V. | Diastereoselective addition of lithiated N-methylimidazole on sulfinimines |
-
2005
- 2005-04-28 AU AU2005238221A patent/AU2005238221B2/en active Active
- 2005-04-28 CN CNB2005800124249A patent/CN100567290C/zh active Active
- 2005-04-28 EP EP05747389A patent/EP1758885B1/de active Active
- 2005-04-28 ES ES05747389T patent/ES2308500T3/es active Active
- 2005-04-28 WO PCT/EP2005/051928 patent/WO2005105782A1/en active IP Right Grant
- 2005-04-28 AT AT05747389T patent/ATE398612T1/de not_active IP Right Cessation
- 2005-04-28 CA CA2563805A patent/CA2563805C/en active Active
- 2005-04-28 DE DE602005007604T patent/DE602005007604D1/de active Active
- 2005-04-28 JP JP2007512168A patent/JP4917021B2/ja active Active
- 2005-04-28 US US11/568,415 patent/US7524961B2/en active Active
-
2007
- 2007-08-24 HK HK07109245.7A patent/HK1101326A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP4917021B2 (ja) | 2012-04-18 |
| AU2005238221A1 (en) | 2005-11-10 |
| WO2005105782A1 (en) | 2005-11-10 |
| JP2007536333A (ja) | 2007-12-13 |
| CN100567290C (zh) | 2009-12-09 |
| CA2563805A1 (en) | 2005-11-10 |
| EP1758885A1 (de) | 2007-03-07 |
| AU2005238221B2 (en) | 2010-09-30 |
| DE602005007604D1 (de) | 2008-07-31 |
| CA2563805C (en) | 2012-11-13 |
| ATE398612T1 (de) | 2008-07-15 |
| ES2308500T3 (es) | 2008-12-01 |
| CN1946709A (zh) | 2007-04-11 |
| EP1758885B1 (de) | 2008-06-18 |
| US7524961B2 (en) | 2009-04-28 |
| US20070293679A1 (en) | 2007-12-20 |
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