HK1056514A1 - Use of kcnq potassium channel agonists for the manufacture of a medicament for modulating bladder function - Google Patents
Use of kcnq potassium channel agonists for the manufacture of a medicament for modulating bladder functionInfo
- Publication number
- HK1056514A1 HK1056514A1 HK03108976A HK03108976A HK1056514A1 HK 1056514 A1 HK1056514 A1 HK 1056514A1 HK 03108976 A HK03108976 A HK 03108976A HK 03108976 A HK03108976 A HK 03108976A HK 1056514 A1 HK1056514 A1 HK 1056514A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- medicament
- manufacture
- potassium channel
- bladder function
- channel agonists
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0684—Cells of the urinary tract or kidneys
- C12N5/0686—Kidney cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
- C12N2503/02—Drug screening
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/34—Genitourinary disorders
- G01N2800/341—Urinary incontinence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Emergency Medicine (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24107800P | 2000-10-17 | 2000-10-17 | |
US28142801P | 2001-04-04 | 2001-04-04 | |
PCT/US2001/032204 WO2002032419A2 (en) | 2000-10-17 | 2001-10-16 | Methods for modulating bladder function |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1056514A1 true HK1056514A1 (en) | 2004-02-20 |
Family
ID=26933980
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK03108976A HK1056514A1 (en) | 2000-10-17 | 2003-12-10 | Use of kcnq potassium channel agonists for the manufacture of a medicament for modulating bladder function |
Country Status (23)
Country | Link |
---|---|
US (3) | US6348486B1 (xx) |
EP (2) | EP1326597B1 (xx) |
JP (2) | JP2004511516A (xx) |
KR (1) | KR20030040540A (xx) |
CN (1) | CN1287781C (xx) |
AR (1) | AR030901A1 (xx) |
AT (1) | ATE314061T1 (xx) |
AU (2) | AU2002211758A1 (xx) |
BR (1) | BR0114718A (xx) |
CA (2) | CA2450467C (xx) |
CY (1) | CY1105353T1 (xx) |
DE (1) | DE60116352T2 (xx) |
DK (1) | DK1326597T3 (xx) |
ES (1) | ES2253432T3 (xx) |
HK (1) | HK1056514A1 (xx) |
HU (1) | HUP0303288A2 (xx) |
IL (1) | IL155090A0 (xx) |
MX (1) | MXPA03003339A (xx) |
NO (1) | NO20031580L (xx) |
NZ (1) | NZ525301A (xx) |
PL (1) | PL360903A1 (xx) |
TW (1) | TWI287984B (xx) |
WO (2) | WO2002032419A2 (xx) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6348486B1 (en) * | 2000-10-17 | 2002-02-19 | American Home Products Corporation | Methods for modulating bladder function |
AU2002338333A1 (en) * | 2001-04-04 | 2002-10-21 | Wyeth | Methods for treating hyperactive gastric motility |
GB0210397D0 (en) * | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
US7632866B2 (en) | 2002-10-21 | 2009-12-15 | Ramot At Tel Aviv University | Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators |
WO2004035037A2 (en) * | 2002-10-21 | 2004-04-29 | Ramot At Tel Aviv University Ltd. | Derivatives of n-phenylanthranilic acid and 2-benzimidazolon as potassium channel and/or cortical neuron activity modulators |
EP1631546A1 (en) * | 2003-04-25 | 2006-03-08 | H. Lundbeck A/S | Sustituted indoline and indole derivatives |
US20070292528A1 (en) * | 2003-05-06 | 2007-12-20 | University Hospital Of Basel | Kcnma1 as a Therapeutic Target in Cancer Treatment |
US20050089559A1 (en) | 2003-10-23 | 2005-04-28 | Istvan Szelenyi | Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains |
US20060148782A1 (en) * | 2003-11-10 | 2006-07-06 | Lundeen James E | Method and medicine for treating a mammal presenting urinary incontinence, urinary urgency, or both |
ES2260563T3 (es) * | 2003-11-13 | 2006-11-01 | Ferring B.V. | Paquete de blister y forma farmaceutica solida para ello. |
EP1688141A1 (en) * | 2005-01-31 | 2006-08-09 | elbion AG | The use of flupirtine for the treatment of overactive bladder and associated diseases, and for the treatment of irritable bowel syndrome |
US7517960B2 (en) | 2006-01-19 | 2009-04-14 | Wyeth | Rat KCNQ5 voltage-gated potassium channel |
SE528446C2 (sv) * | 2006-03-02 | 2006-11-14 | Ferring Int Ct Sa | Farmaceutisk sammansättning innefattande desmopressin, kiseldioxid och stärkelse |
US7960436B2 (en) * | 2006-06-05 | 2011-06-14 | Valeant Pharmaceuticals International | Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators |
US20080045534A1 (en) * | 2006-08-18 | 2008-02-21 | Valeant Pharmaceuticals North America | Derivatives of 1,3-diamino benzene as potassium channel modulators |
US8993593B2 (en) * | 2006-08-23 | 2015-03-31 | Valeant Pharmaceuticals International | N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators |
BRPI0716715B1 (pt) * | 2006-08-23 | 2021-07-06 | Xenon Pharmaceuticals, Inc | Derivados de 4-(n-azacicloalquil) anilidas como moduladores de canal de potássio, seus usos, produto, composição, comprimido e cápsula |
US8722929B2 (en) * | 2006-10-10 | 2014-05-13 | Valeant Pharmaceuticals International | N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators |
KR20090083479A (ko) * | 2006-11-28 | 2009-08-03 | 밸리언트 파마슈티컬즈 인터내셔널 | 칼륨 채널 조절제로서의 1,4 디아미노 이환 레티가빈 유사체 |
DE102007012029A1 (de) | 2007-03-13 | 2008-09-18 | Grünenthal GmbH | Verfahren zur Identifizierung der agonistischen Aktivität einer Zielverbindung auf einen Kaliumkanal |
US8367684B2 (en) * | 2007-06-13 | 2013-02-05 | Valeant Pharmaceuticals International | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
US8563566B2 (en) | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
JP5451613B2 (ja) | 2007-08-06 | 2014-03-26 | アラーガン、インコーポレイテッド | デスモプレシン薬物送達のための方法及びデバイス |
US7786146B2 (en) * | 2007-08-13 | 2010-08-31 | Valeant Pharmaceuticals International | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators |
WO2009037707A2 (en) | 2007-09-20 | 2009-03-26 | Ramot At Tel Aviv University Ltd. | N-phenyl anthranilic acid derivatives and uses thereof |
US11963995B2 (en) | 2008-05-21 | 2024-04-23 | Ferring B.V. | Methods comprising desmopressin |
US20100286045A1 (en) | 2008-05-21 | 2010-11-11 | Bjarke Mirner Klein | Methods comprising desmopressin |
LT2712622T (lt) * | 2008-05-21 | 2016-09-26 | Ferring B.V. | Burnoje disperguojamas desmopresinas, skirtas nikturijos netrikdomo miego pirminio periodo pailginimui |
EA201170230A1 (ru) * | 2008-07-18 | 2011-08-30 | Вэлиант Фармасьютикалс Интернешнл | Препарат с модифицированной кинетикой высвобождения и способы его использования |
US20100323015A1 (en) * | 2008-07-18 | 2010-12-23 | Biljana Nadjsombati | Modified release formulation and methods of use |
US20100323016A1 (en) * | 2008-07-18 | 2010-12-23 | Biljana Nadjsombati | Modified release formulation and methods of use |
US20130131164A1 (en) * | 2010-02-19 | 2013-05-23 | Medichem, S.A. | Stabilized phenylcarbamate derivative in solid state |
KR20150053257A (ko) * | 2012-04-30 | 2015-05-15 | 사이플루어 라이프 사이언시즈, 엘엘씨 | 플루오르화 2-아미노-4-(벤질아미노)페닐카르바메이트 유도체 |
WO2016077724A1 (en) | 2014-11-13 | 2016-05-19 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | (2-amino-4(arylamino)phenyl) carbamates |
WO2019203951A1 (en) | 2018-04-20 | 2019-10-24 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Selective potassium channel agonists |
EP3912625A1 (en) | 2020-05-20 | 2021-11-24 | Kaerus Bioscience Limited | Novel maxi-k potassium channel openers for the treatment of fragile x associated disorders |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US37460A (en) * | 1863-01-20 | Improvement in meat-broilers | ||
GB9220570D0 (en) * | 1991-10-21 | 1992-11-11 | Ici Plc | Therapeutic agent |
DE4200259A1 (de) | 1992-01-08 | 1993-07-15 | Asta Medica Ag | Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung |
US5565483A (en) * | 1995-06-07 | 1996-10-15 | Bristol-Myers Squibb Company | 3-substituted oxindole derivatives as potassium channel modulators |
DE19539861A1 (de) | 1995-10-26 | 1997-04-30 | Asta Medica Ag | Verwendung von 4-Amino-4-(4-fluorbenzylamino)-1-ethoxy-carbonylaminobenzen zur Prophylaxe und Behandlung der Folgen der akuten und chronischen zerebralen Minderdurchblutung sowie neurodegenerativer Erkrankungen |
US6277978B1 (en) * | 1995-12-22 | 2001-08-21 | University Of Utah Research Foundation | KVLQT1—a long QT syndrome gene |
DE19701694A1 (de) | 1997-01-20 | 1998-07-23 | Asta Medica Ag | Neue Modifikationen des 2-Amino-4-(4-fluorbenzylamino)-l-ethoxycarbonyl-aminobenzen sowie Verfahren zu ihrer Herstellung |
DK1007638T3 (da) | 1997-08-12 | 2007-05-21 | Bristol Myers Squibb Co | KCNQ-kaliumkanaler og fremgangsmåde til modulering deraf |
US6413719B1 (en) * | 1997-10-24 | 2002-07-02 | University Of Utah Research Foundation | KCNQ2 and KCNQ3-potassium channel genes which are mutated in benign familial neonatal convulsions (BFNC) and other epilepsies |
AU2532299A (en) * | 1998-02-17 | 1999-08-30 | Astrazeneca Uk Limited | Potassium channel polypeptide |
US6133275A (en) * | 1998-05-06 | 2000-10-17 | Abbott Laboratories | 3-phenylpyrrolidine alpha-1 adrenergic compounds |
WO2000044786A1 (en) * | 1999-01-26 | 2000-08-03 | Neurosearch A/S | Novel potassium channels and genes encoding these potassium channels |
US6794161B1 (en) | 1999-01-26 | 2004-09-21 | Neurosearch A/S | Potassium channels and genes encoding these potassium channels |
IT1312224B1 (it) * | 1999-03-23 | 2002-04-09 | Cit Alcatel | Circuito pre/post-distorcitore particolarmente per sistemi aradiofrequenza microonde. |
GB9915414D0 (en) | 1999-07-01 | 1999-09-01 | Glaxo Group Ltd | Medical use |
US6117900A (en) | 1999-09-27 | 2000-09-12 | Asta Medica Aktiengesellschaft | Use of retigabine for the treatment of neuropathic pain |
US6617131B2 (en) * | 2000-03-21 | 2003-09-09 | Aventis Pharma Deutschland Gmbh | Nucleic acid molecule encoding the potassium channel protein, KCNQ5 |
AU2001251283A1 (en) * | 2000-04-03 | 2001-10-15 | Lexicon Genetics Incorporated | Human ion channel protein and polynucleotides encoding the same |
US6455568B2 (en) * | 2000-07-06 | 2002-09-24 | Wyeth | Combination therapy for inhibiting sphincter incontinence |
US6376486B1 (en) * | 2000-07-06 | 2002-04-23 | American Home Products Corporation | Methods of inhibiting sphincter incontinence |
WO2002015902A1 (en) * | 2000-08-23 | 2002-02-28 | Merck & Co., Inc. | Method of treating or preventing urinary incontinence using prostanoid ep1 receptor antagonists |
US6348486B1 (en) * | 2000-10-17 | 2002-02-19 | American Home Products Corporation | Methods for modulating bladder function |
US6613786B2 (en) * | 2001-11-02 | 2003-09-02 | Bristol-Myers Squibb Company | Thiophenyl triazol-3-one derivatives as smooth muscle relaxants |
WO2004065576A2 (en) * | 2003-01-15 | 2004-08-05 | Millennium Pharmaceuticals, Inc. | Methods and compositions for the treatment of urological disorder using differential expressed polypeptides |
CA2531019A1 (en) * | 2003-06-30 | 2005-01-06 | Takeda Pharmaceutical Company Limited | Preventive/remedy for urinary disturbance |
EP1663237B1 (en) * | 2003-09-10 | 2013-06-19 | Icagen, Inc. | Fused ring heterocycles as potassium channel modulators |
TW200716106A (en) * | 2005-04-24 | 2007-05-01 | Wyeth Corp | Methods for modulating bladder function |
US7517960B2 (en) * | 2006-01-19 | 2009-04-14 | Wyeth | Rat KCNQ5 voltage-gated potassium channel |
-
2001
- 2001-10-15 US US09/977,828 patent/US6348486B1/en not_active Expired - Fee Related
- 2001-10-15 TW TW090125411A patent/TWI287984B/zh not_active IP Right Cessation
- 2001-10-16 JP JP2002535657A patent/JP2004511516A/ja not_active Ceased
- 2001-10-16 DK DK01979836T patent/DK1326597T3/da active
- 2001-10-16 CA CA2450467A patent/CA2450467C/en not_active Expired - Fee Related
- 2001-10-16 AR ARP010104848A patent/AR030901A1/es not_active Application Discontinuation
- 2001-10-16 BR BR0114718-8A patent/BR0114718A/pt not_active Application Discontinuation
- 2001-10-16 WO PCT/US2001/032204 patent/WO2002032419A2/en active IP Right Grant
- 2001-10-16 HU HU0303288A patent/HUP0303288A2/hu unknown
- 2001-10-16 PL PL01360903A patent/PL360903A1/xx not_active Application Discontinuation
- 2001-10-16 MX MXPA03003339A patent/MXPA03003339A/es active IP Right Grant
- 2001-10-16 DE DE60116352T patent/DE60116352T2/de not_active Expired - Lifetime
- 2001-10-16 AT AT01979836T patent/ATE314061T1/de not_active IP Right Cessation
- 2001-10-16 CN CNB018175597A patent/CN1287781C/zh not_active Expired - Fee Related
- 2001-10-16 KR KR10-2003-7005291A patent/KR20030040540A/ko not_active Application Discontinuation
- 2001-10-16 NZ NZ525301A patent/NZ525301A/en unknown
- 2001-10-16 EP EP01979836A patent/EP1326597B1/en not_active Expired - Lifetime
- 2001-10-16 AU AU2002211758A patent/AU2002211758A1/en not_active Abandoned
- 2001-10-16 ES ES01979836T patent/ES2253432T3/es not_active Expired - Lifetime
- 2001-10-16 IL IL15509001A patent/IL155090A0/xx unknown
- 2001-10-17 CA CA002425742A patent/CA2425742A1/en not_active Abandoned
- 2001-10-17 US US10/399,489 patent/US7160684B2/en not_active Expired - Fee Related
- 2001-10-17 EP EP01981678A patent/EP1328550A2/en not_active Withdrawn
- 2001-10-17 JP JP2002536341A patent/JP2004529611A/ja active Pending
- 2001-10-17 WO PCT/US2001/032371 patent/WO2002032960A2/en active Application Filing
- 2001-10-17 AU AU2002213308A patent/AU2002213308A1/en not_active Abandoned
-
2003
- 2003-04-08 NO NO20031580A patent/NO20031580L/no not_active Application Discontinuation
- 2003-12-10 HK HK03108976A patent/HK1056514A1/xx not_active IP Right Cessation
-
2006
- 2006-02-08 CY CY20061100173T patent/CY1105353T1/el unknown
- 2006-05-22 US US11/419,714 patent/US20060252104A1/en not_active Abandoned
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PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20091016 |