HK1047957A1 - 克拉伏拉尼克酸產量的提高 - Google Patents

克拉伏拉尼克酸產量的提高

Info

Publication number
HK1047957A1
HK1047957A1 HK02109461.9A HK02109461A HK1047957A1 HK 1047957 A1 HK1047957 A1 HK 1047957A1 HK 02109461 A HK02109461 A HK 02109461A HK 1047957 A1 HK1047957 A1 HK 1047957A1
Authority
HK
Hong Kong
Prior art keywords
improvement
acid production
clavulanic acid
clavulanic
production
Prior art date
Application number
HK02109461.9A
Other languages
English (en)
Inventor
A Townsend Craig
Li Rongfeng
Khaleeli Nusrat
Original Assignee
The Johns-Hopkins Univ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Johns-Hopkins Univ filed Critical The Johns-Hopkins Univ
Publication of HK1047957A1 publication Critical patent/HK1047957A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HK02109461.9A 1999-09-16 2002-12-31 克拉伏拉尼克酸產量的提高 HK1047957A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15421399P 1999-09-16 1999-09-16
PCT/US2000/025186 WO2001019959A1 (en) 1999-09-16 2000-09-15 Improvement of clavulanic acid production

Publications (1)

Publication Number Publication Date
HK1047957A1 true HK1047957A1 (zh) 2003-03-14

Family

ID=22550464

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02109461.9A HK1047957A1 (zh) 1999-09-16 2002-12-31 克拉伏拉尼克酸產量的提高

Country Status (4)

Country Link
EP (1) EP1218486A4 (zh)
AU (1) AU7983400A (zh)
HK (1) HK1047957A1 (zh)
WO (1) WO2001019959A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100355895C (zh) * 2004-12-17 2007-12-19 天津科技大学 棒状链霉菌lat基因缺失的质粒、衍生物及其构建方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8813055D0 (en) * 1988-06-02 1988-07-06 Beecham Group Plc Novel substance
JP3558295B2 (ja) * 1992-12-02 2004-08-25 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー クラブラン酸の製法
CA2108113C (en) * 1993-10-08 2006-12-05 Susan E. Jensen Dna sequence encoding enzymes of clavulanic acid biosynthesis
GB9702218D0 (en) * 1997-02-04 1997-03-26 Smithkline Beecham Plc Novel product
ES2131001B1 (es) * 1997-06-16 2000-04-01 Antibioticos Sau Procedimiento para incrementar la produccion de acido clavulanico mediante la expresion de genes reguladores y biosinteticos de streptomyces clavuligerus.

Also Published As

Publication number Publication date
EP1218486A1 (en) 2002-07-03
WO2001019959A1 (en) 2001-03-22
EP1218486A4 (en) 2002-11-04
AU7983400A (en) 2001-04-17

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