HK1039458B - Thermoprotected microparticle compositions and process for terminal steam sterilization thereof - Google Patents

Thermoprotected microparticle compositions and process for terminal steam sterilization thereof

Info

Publication number
HK1039458B
HK1039458B HK02101080.7A HK02101080A HK1039458B HK 1039458 B HK1039458 B HK 1039458B HK 02101080 A HK02101080 A HK 02101080A HK 1039458 B HK1039458 B HK 1039458B
Authority
HK
Hong Kong
Prior art keywords
steam sterilization
thermoprotected
compositions
terminal steam
microparticle compositions
Prior art date
Application number
HK02101080.7A
Other languages
Chinese (zh)
Other versions
HK1039458A1 (en
Inventor
A‧K‧米斯拉
Original Assignee
Skyepharma Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Skyepharma Canada Inc filed Critical Skyepharma Canada Inc
Publication of HK1039458A1 publication Critical patent/HK1039458A1/en
Publication of HK1039458B publication Critical patent/HK1039458B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • External Artificial Organs (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compositions of submicron- to micron-sized particles of water-insoluble biologically active substances that are stabilized by thermoprotecting agents, can be terminally steam sterilized without any significant increase of mean particle size. These compositions display markedly reduced heat-induced coagulation, flocculation, or particle size growth during the terminal steam sterilization process.
HK02101080.7A 1998-05-29 2002-02-11 Thermoprotected microparticle compositions and process for terminal steam sterilization thereof HK1039458B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8733198P 1998-05-29 1998-05-29
PCT/US1999/011888 WO1999061001A1 (en) 1998-05-29 1999-05-28 Thermoprotected microparticle compositions and process for terminal steam sterilization thereof

Publications (2)

Publication Number Publication Date
HK1039458A1 HK1039458A1 (en) 2002-04-26
HK1039458B true HK1039458B (en) 2006-09-01

Family

ID=22204554

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02101080.7A HK1039458B (en) 1998-05-29 2002-02-11 Thermoprotected microparticle compositions and process for terminal steam sterilization thereof

Country Status (15)

Country Link
US (1) US8415329B1 (en)
EP (1) EP1079808B1 (en)
JP (1) JP2002516267A (en)
KR (1) KR100635456B1 (en)
CN (1) CN1245955C (en)
AT (1) ATE259220T1 (en)
AU (1) AU764001B2 (en)
CA (1) CA2333648C (en)
DE (1) DE69914742T2 (en)
DK (1) DK1079808T3 (en)
ES (1) ES2216517T3 (en)
HK (1) HK1039458B (en)
IL (1) IL139779A (en)
SE (1) SE0004312L (en)
WO (1) WO1999061001A1 (en)

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IL139779A (en) 2007-06-17
CA2333648A1 (en) 1999-12-02
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SE0004312L (en) 2001-01-18
KR20010043897A (en) 2001-05-25
WO1999061001A1 (en) 1999-12-02
KR100635456B1 (en) 2006-10-18
ES2216517T3 (en) 2004-10-16
ATE259220T1 (en) 2004-02-15
JP2002516267A (en) 2002-06-04
SE0004312D0 (en) 2000-11-24
EP1079808A1 (en) 2001-03-07
HK1039458A1 (en) 2002-04-26
AU4217599A (en) 1999-12-13
IL139779A0 (en) 2002-02-10
DE69914742D1 (en) 2004-03-18
AU764001B2 (en) 2003-08-07
EP1079808B1 (en) 2004-02-11
CN1245955C (en) 2006-03-22
CA2333648C (en) 2008-10-21
CN1311666A (en) 2001-09-05
US8415329B1 (en) 2013-04-09

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