HK1012016A1 - Polyethyleneglycol hirudin conjugate, process of preparation and use in the cure of thrombosis - Google Patents

Polyethyleneglycol hirudin conjugate, process of preparation and use in the cure of thrombosis

Info

Publication number
HK1012016A1
HK1012016A1 HK98113235A HK98113235A HK1012016A1 HK 1012016 A1 HK1012016 A1 HK 1012016A1 HK 98113235 A HK98113235 A HK 98113235A HK 98113235 A HK98113235 A HK 98113235A HK 1012016 A1 HK1012016 A1 HK 1012016A1
Authority
HK
Hong Kong
Prior art keywords
preparation
polyethyleneglycol
thrombosis
cure
conjugate
Prior art date
Application number
HK98113235A
Other languages
English (en)
Inventor
Rainer Bischoff
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of HK1012016A1 publication Critical patent/HK1012016A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/30—Post-polymerisation treatment, e.g. recovery, purification, drying
HK98113235A 1992-02-20 1998-12-11 Polyethyleneglycol hirudin conjugate, process of preparation and use in the cure of thrombosis HK1012016A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9201938A FR2687681B1 (fr) 1992-02-20 1992-02-20 Conjugues polyethyleneglycol-hirudine, leur procede de preparation et leur emploi pour le traitement des thromboses.

Publications (1)

Publication Number Publication Date
HK1012016A1 true HK1012016A1 (en) 1999-07-23

Family

ID=9426838

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98113235A HK1012016A1 (en) 1992-02-20 1998-12-11 Polyethyleneglycol hirudin conjugate, process of preparation and use in the cure of thrombosis

Country Status (11)

Country Link
US (1) US5362858A (xx)
EP (1) EP0557199B1 (xx)
JP (1) JP3584358B2 (xx)
AT (1) ATE212360T1 (xx)
CA (1) CA2089853C (xx)
DE (1) DE69331479T2 (xx)
DK (1) DK0557199T3 (xx)
ES (1) ES2169037T3 (xx)
FR (1) FR2687681B1 (xx)
HK (1) HK1012016A1 (xx)
PT (1) PT557199E (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4404168A1 (de) * 1994-02-10 1995-08-17 Hoechst Ag Hirudinderivate und Verfahren zu deren Herstellung
AU5893796A (en) * 1995-06-07 1996-12-30 Novo Nordisk A/S Modification of polypeptides
WO1996040791A1 (en) * 1995-06-07 1996-12-19 Novo Nordisk A/S Modification of polypeptides
DE19533817C2 (de) * 1995-09-13 1999-12-09 Max Planck Gesellschaft Komplex-gebundene Hemmstoffe aktivierbarer Stoffwechselenzyme als molekulare Marker zur Diagnostik und Therapieüberwachung
AU4648697A (en) 1996-09-23 1998-04-14 Chandrashekar Pathak Methods and devices for preparing protein concentrates
EP0922446A1 (en) * 1997-12-03 1999-06-16 Applied Research Systems Ars Holding N.V. Solution-phase site-specific preparation of GRF-PEG conjugates
DE19915862A1 (de) * 1999-04-08 2000-10-12 Max Planck Gesellschaft Verwendung von molekulargewichtserweitertem Hirudin als Antikoagulans bei der extrakorporalen Nierenersatztherapie
US6809076B2 (en) * 2000-03-20 2004-10-26 Abbott Gmbh & Co. Kg Use of anticoagulant agents in the extracorporeal treatment of blood
GB0202906D0 (en) * 2002-02-07 2002-03-27 Univ London Prevention of myocardial damage
WO2006045503A1 (en) 2004-10-19 2006-05-04 Lonza Ag Method for solid phase peptide synthesis
US9707252B2 (en) 2005-02-09 2017-07-18 Covidien Lp Synthetic sealants
JP2008533114A (ja) * 2005-03-18 2008-08-21 ユーシーエル ビジネス パブリック リミテッド カンパニー メカノ成長因子ペプチドおよびその使用
CN108395475B (zh) * 2018-03-29 2021-09-10 苏州至汇生物科技有限公司 一种基于亲和层析的水蛭素分离纯化方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57206622A (en) * 1981-06-10 1982-12-18 Ajinomoto Co Inc Blood substitute
JPH084504B2 (ja) * 1985-04-26 1996-01-24 味の素株式会社 安定化ス−パ−オキサイドジスムタ−ゼ
DE3675588D1 (de) * 1985-06-19 1990-12-20 Ajinomoto Kk Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
US4766106A (en) * 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US5006333A (en) * 1987-08-03 1991-04-09 Ddi Pharmaceuticals, Inc. Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
IE64284B1 (en) * 1987-08-03 1995-07-26 Ddi Pharmaceuticals Conjugates of superoxide dismutase
CA1308377C (en) * 1987-08-21 1992-10-06 Henry Berger, Jr. Complex of polyethyleneglycol and tissue plasminogen activator
US4847325A (en) * 1988-01-20 1989-07-11 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
US4902502A (en) * 1989-01-23 1990-02-20 Cetus Corporation Preparation of a polymer/interleukin-2 conjugate
WO1991008229A1 (de) * 1989-12-01 1991-06-13 Basf Aktiengesellschaft Hirudinpolyalkylenglykolkonjugate
DE69213628T2 (de) * 1991-03-05 1997-04-24 Fuji Yakuhin Kogyo Kk Hirudinanalog oder dessen salz, dessen herstellung und das als aktiven bestandteil enthaltende antikoagulanz
US5169627A (en) * 1991-10-28 1992-12-08 Mount Sinai School Of Medicine Of The City University Of New York Oral pharmaceutical composition containing a polyethylene glycol-immunoglobulin G conjugate for reconstitution of secretory immunity and method of reconstituting secretory immunity

Also Published As

Publication number Publication date
PT557199E (pt) 2002-06-28
CA2089853C (fr) 2005-01-25
JP3584358B2 (ja) 2004-11-04
FR2687681A1 (fr) 1993-08-27
FR2687681B1 (fr) 1995-10-13
ATE212360T1 (de) 2002-02-15
DE69331479T2 (de) 2002-08-22
CA2089853A1 (fr) 1993-08-21
US5362858A (en) 1994-11-08
DE69331479D1 (de) 2002-03-14
DK0557199T3 (da) 2002-04-29
EP0557199A1 (fr) 1993-08-25
ES2169037T3 (es) 2002-07-01
EP0557199B1 (fr) 2002-01-23
JPH069700A (ja) 1994-01-18

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20120218