HK1007431A1 - Acid stable dideoxynucleosides active against the cytopathic effects of human immunodefiency virus - Google Patents
Acid stable dideoxynucleosides active against the cytopathic effects of human immunodefiency virusInfo
- Publication number
- HK1007431A1 HK1007431A1 HK98105811A HK98105811A HK1007431A1 HK 1007431 A1 HK1007431 A1 HK 1007431A1 HK 98105811 A HK98105811 A HK 98105811A HK 98105811 A HK98105811 A HK 98105811A HK 1007431 A1 HK1007431 A1 HK 1007431A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- dideoxynucleosides
- active against
- acid stable
- cytopathic effects
- chem
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- AIDS & HIV (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3940287A | 1987-04-17 | 1987-04-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1007431A1 true HK1007431A1 (en) | 1999-04-09 |
Family
ID=21905250
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK98105811A HK1007431A1 (en) | 1987-04-17 | 1998-06-20 | Acid stable dideoxynucleosides active against the cytopathic effects of human immunodefiency virus |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0287313B1 (xx) |
JP (2) | JPH0613547B2 (xx) |
AT (1) | ATE116656T1 (xx) |
AU (1) | AU603219B2 (xx) |
CA (1) | CA1340645C (xx) |
DE (1) | DE3852665T2 (xx) |
HK (1) | HK1007431A1 (xx) |
IL (1) | IL86040A (xx) |
WO (1) | WO1988007861A1 (xx) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5077279A (en) * | 1986-05-01 | 1991-12-31 | University Of Georgia Research Foundation, Inc. | 3'-azido-2',3'-dideoxy-5-methylcytidine anti-viral composition |
US5084445A (en) * | 1986-05-01 | 1992-01-28 | University Of Georgia Research Foundation, Inc. | 3'-azido-2',3'-dideoxy-5-methylcytidine |
NZ226672A (en) * | 1987-10-30 | 1991-07-26 | Hoffmann La Roche | 6-amino-9-(2,3-dideoxy-2-fluoro-b-d-threopentofuranosyl)-9h-purine derivatives and pharmaceutical compositions |
US4908440A (en) * | 1987-11-12 | 1990-03-13 | Bristol Myers Company | 2',3'-dideoxy-2'-fluoroarabinopyrimidine nucleosides |
US5644043A (en) * | 1988-02-16 | 1997-07-01 | Eli Lilly And Company | 2',3'-dideoxy-2',2'-difluoronucleosides and intermediates |
DE68924319T2 (de) * | 1988-03-16 | 1996-05-15 | Scripps Research Inst | Als therapeutische mittel verwendbare substituierte adeninderivate. |
JPH0232093A (ja) * | 1988-06-08 | 1990-02-01 | Merrell Dow Pharmaceut Inc | 抗レトロウィルスジフルオロ化ヌクレオシド類 |
GB8816345D0 (en) * | 1988-07-08 | 1988-08-10 | Hoffmann La Roche | Purine derivatives |
US6207650B1 (en) | 1989-05-15 | 2001-03-27 | Bristol-Myers Squibb Company | Antiviral, highly water soluble, stable, crystalline salts of 2′, 3′-dideoxyinosine, 2′, 3′-dideoxy-2′, 3′-didehydrothymidine and 2′, 3′-dideoxy-2′-fluoroinosine |
FI95269C (fi) * | 1989-05-15 | 1996-01-10 | Squibb Bristol Myers Co | 2',3'-dideoksi-inosiinimonohydraatin, 2',3'-dideoksi-2',3'-didehydrot ymidiinimonohydraatin ja 2',3'-dideoksi-2'-fluori-inosiinihemihydraatin antiviraalisia, hyvin vesiliukoisia, stabiileja, kiteisiä suoloja |
GB8920534D0 (en) * | 1989-09-11 | 1989-10-25 | Wellcome Found | Antiviral compounds |
HU906976D0 (en) * | 1989-11-13 | 1991-05-28 | Bristol Myers Squibb Co | Process for producing 2', 3'-didesoxy-2'-fluoarabinonucleoside analogues |
US5859221A (en) * | 1990-01-11 | 1999-01-12 | Isis Pharmaceuticals, Inc. | 2'-modified oligonucleotides |
US5914396A (en) * | 1990-01-11 | 1999-06-22 | Isis Pharmaceuticals, Inc. | 2'-O-modified nucleosides and phosphoramidites |
US5872232A (en) * | 1990-01-11 | 1999-02-16 | Isis Pharmaceuticals Inc. | 2'-O-modified oligonucleotides |
US6399754B1 (en) | 1991-12-24 | 2002-06-04 | Isis Pharmaceuticals, Inc. | Sugar modified oligonucleotides |
US5670633A (en) * | 1990-01-11 | 1997-09-23 | Isis Pharmaceuticals, Inc. | Sugar modified oligonucleotides that detect and modulate gene expression |
US6005087A (en) * | 1995-06-06 | 1999-12-21 | Isis Pharmaceuticals, Inc. | 2'-modified oligonucleotides |
US5610289A (en) | 1990-07-27 | 1997-03-11 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogues |
US5677437A (en) * | 1990-07-27 | 1997-10-14 | Isis Pharmaceuticals, Inc. | Heteroatomic oligonucleoside linkages |
US5378825A (en) * | 1990-07-27 | 1995-01-03 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs |
US5618704A (en) * | 1990-07-27 | 1997-04-08 | Isis Pharmacueticals, Inc. | Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling |
US5792844A (en) * | 1990-07-27 | 1998-08-11 | Isis Pharmaceuticals, Inc. | Oligonucleoside linkages containing adjacent nitrogen atoms |
US5623070A (en) * | 1990-07-27 | 1997-04-22 | Isis Pharmaceuticals, Inc. | Heteroatomic oligonucleoside linkages |
US5420115A (en) * | 1990-09-10 | 1995-05-30 | Burroughs Wellcome Co. | Method for the treatment of protoza infections with 21 -deoxy-21 -fluoropurine nucleosides |
US5965722A (en) * | 1991-05-21 | 1999-10-12 | Isis Pharmaceuticals, Inc. | Antisense inhibition of ras gene with chimeric and alternating oligonucleotides |
US7119184B2 (en) | 1991-08-12 | 2006-10-10 | Isis Pharmaceuticals, Inc. | Oligonucleotides having A-DNA form and B-DNA form conformational geometry |
US6307040B1 (en) | 1992-03-05 | 2001-10-23 | Isis Pharmaceuticals, Inc. | Sugar modified oligonucleotides that detect and modulate gene expression |
US9096636B2 (en) | 1996-06-06 | 2015-08-04 | Isis Pharmaceuticals, Inc. | Chimeric oligomeric compounds and their use in gene modulation |
US5898031A (en) | 1996-06-06 | 1999-04-27 | Isis Pharmaceuticals, Inc. | Oligoribonucleotides for cleaving RNA |
US7812149B2 (en) | 1996-06-06 | 2010-10-12 | Isis Pharmaceuticals, Inc. | 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations |
WO2004044136A2 (en) | 2002-11-05 | 2004-05-27 | Isis Pharmaceuticals, Inc. | Compositions comprising alternating 2’-modified nucleosides for use in gene modulation |
US8569474B2 (en) | 2004-03-09 | 2013-10-29 | Isis Pharmaceuticals, Inc. | Double stranded constructs comprising one or more short strands hybridized to a longer strand |
US8394947B2 (en) | 2004-06-03 | 2013-03-12 | Isis Pharmaceuticals, Inc. | Positionally modified siRNA constructs |
US7884086B2 (en) | 2004-09-08 | 2011-02-08 | Isis Pharmaceuticals, Inc. | Conjugates for use in hepatocyte free uptake assays |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2928773A (en) * | 1958-11-17 | 1960-03-15 | It Prodotti Schering Soc | Process for preparing inosine |
JPS5686200A (en) * | 1979-12-17 | 1981-07-13 | Yamasa Shoyu Co Ltd | Adenine nucleoside and its preparation |
US4357824A (en) * | 1980-09-15 | 1982-11-09 | General Electric Company | Method for determining volatilization rates of dissolved volatiles from solid waste materials |
US4652554A (en) * | 1982-02-22 | 1987-03-24 | St. Jude Children's Research Hospital | Nitro-substituted 1-β-D-arabinofuranosylcytosines |
US4594339A (en) * | 1982-04-06 | 1986-06-10 | Sloan-Kettering Institute For Cancer Research | Anti-herpes virus compositions containing 5-substituted 1-2'(deoxy-2-'-substituted-β-d-arabinofuranosyl)pyrimedene nucleosides |
US4489052A (en) * | 1982-09-15 | 1984-12-18 | Sloan-Kettering For Cancer Research | Quantitative autoradiographic mapping of focal herpes simplex virus encephalitis using a radiolabeled antiviral drug |
US4526988A (en) * | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
AU575918B2 (en) * | 1984-03-06 | 1988-08-11 | Sloan-Kettering Institute For Cancer Research | Hepatitis treatment with pyrimidine nucleoside compounds |
GB8712115D0 (en) * | 1987-05-22 | 1987-06-24 | Hoffmann La Roche | Pyrimidine derivatives |
-
1988
- 1988-04-06 CA CA000563370A patent/CA1340645C/en not_active Expired - Lifetime
- 1988-04-12 EP EP88303248A patent/EP0287313B1/en not_active Expired - Lifetime
- 1988-04-12 AT AT88303248T patent/ATE116656T1/de not_active IP Right Cessation
- 1988-04-12 IL IL86040A patent/IL86040A/xx not_active IP Right Cessation
- 1988-04-12 DE DE3852665T patent/DE3852665T2/de not_active Expired - Fee Related
- 1988-04-13 WO PCT/US1988/001165 patent/WO1988007861A1/en unknown
- 1988-04-13 AU AU16844/88A patent/AU603219B2/en not_active Expired
- 1988-04-13 JP JP63503764A patent/JPH0613547B2/ja not_active Expired - Lifetime
-
1992
- 1992-05-19 JP JP4151312A patent/JPH069680A/ja active Pending
-
1998
- 1998-06-20 HK HK98105811A patent/HK1007431A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0287313B1 (en) | 1995-01-04 |
IL86040A (en) | 1993-03-15 |
ATE116656T1 (de) | 1995-01-15 |
AU1684488A (en) | 1988-11-04 |
JPH069680A (ja) | 1994-01-18 |
EP0287313A3 (en) | 1989-06-14 |
JPH0613547B2 (ja) | 1994-02-23 |
JPH01501628A (ja) | 1989-06-08 |
DE3852665T2 (de) | 1995-05-11 |
EP0287313A2 (en) | 1988-10-19 |
WO1988007861A1 (en) | 1988-10-20 |
AU603219B2 (en) | 1990-11-08 |
CA1340645C (en) | 1999-07-13 |
IL86040A0 (en) | 1988-09-30 |
DE3852665D1 (de) | 1995-02-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PF | Patent in force | ||
PE | Patent expired |
Effective date: 20080411 |