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Application filed by The Speywood Laboratory Ltd., Microbiological Research AuthorityfiledCriticalThe Speywood Laboratory Ltd.
Publication of HK1001036ApublicationCriticalpatent/HK1001036A/en
This invention describes a novel agent for the targeted control of a mammalian cell activity, in particular the agent is used to control the interaction of particular cell types with their external environment. The agent has applications as a pharmaceutical for the treatment of a variety of disorders. An agent according to the invention comprises three Domains B, T and E linked together in the following manner. Domain B-Domain T-Domain E where Domain B is the Binding Domain which binds the agent to a Binding Site on the cell which undergoes endocytosis to produce an endosome, Domain T is the Translocation Domain which translocates the agent (with or without the Binding Site) from within the endosome across the endosomal membrane into the cytosol of the cell, Domain E is the Effector Domain which inhibits the ability of the Recyclable Membrane Vesicles to transport the Intergral Membrane Proteins to the surface of the cell.
HK97101926.1A1993-03-191994-03-18Novel agent for controlling cell activity
HK1001036A
(en)
Polypeptides comprising multimers of nuclear localization signals or of protein transduction domains and their use for transferring molecules into cells