GR890100048A - Process for preparing ergoline derivatives - Google Patents

Process for preparing ergoline derivatives

Info

Publication number
GR890100048A
GR890100048A GR890100048A GR890100048A GR890100048A GR 890100048 A GR890100048 A GR 890100048A GR 890100048 A GR890100048 A GR 890100048A GR 890100048 A GR890100048 A GR 890100048A GR 890100048 A GR890100048 A GR 890100048A
Authority
GR
Greece
Prior art keywords
ergoline derivatives
substituted
free base
preparing
preparing ergoline
Prior art date
Application number
GR890100048A
Other languages
Greek (el)
Inventor
Roland Dr Achini
Rene Dr Amstutz
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of GR890100048A publication Critical patent/GR890100048A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

Παράγωγα εργολίνης μη υποκαταστημένης στην θέση 8 και υποκαταστημένης στην θέση 9 παρέχονται σε μορφή ελεύθερης βάσης ή αλατιού προσθήκης οξέος, όπως επίσης μία μέθοδος για την παραγωγή τους, που περιλαμβάνει το στάδιο της οξείδωσης μιας αντίστοιχης 2, 3-διϋδροεργολίνης και ανάκτηση της ένωσης που προκύπτει με μορφή ελεύθερης βάσης ή αλατιού προσθήκης οξέος. Παρέχοντος επίσης φαρμακευτικές συνθέσεις που περιλαμβάνουν μία ένωση σύμφωνα με την εφεύρεση σε συνδυασμό με τουλάχιστον ένα φαρμακευτικό φορέα ή διαλύτη. Οι παραπάνω εμφανίζουν ντοπαμινεργική, αντικαταθλιπτική, αγχολυτική, αντι-παχυσαρκιακή και καρδιο-αγγειακή ενεργότητες και είναι χρήσιμες, όταν χορηγούνται σε θεραπευτικά αποτελεσματικές ποσότητες, στην θεραπεία των αντιστοίχων νόσων.ωErgoline derivatives not substituted in position 8 and substituted in position 9 are provided in the form of a free base or acid addition salt, as well as a method for their production, which includes the oxidation stage of a corresponding 2, 3-dihydroergoline and recovery of the resulting compound. in the form of a free base or acid additive. Also available pharmaceutical compositions that include a compound according to the invention in combination with at least one pharmaceutical carrier or solvent. The above have dopaminergic, antidepressant, anxiolytic, anti-obesity and cardiovascular effects and are useful when administered in therapeutic amounts, in the treatment of the corresponding diseases.

GR890100048A 1988-01-26 1989-01-25 Process for preparing ergoline derivatives GR890100048A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3802178 1988-01-26

Publications (1)

Publication Number Publication Date
GR890100048A true GR890100048A (en) 1994-03-31

Family

ID=6345984

Family Applications (1)

Application Number Title Priority Date Filing Date
GR890100048A GR890100048A (en) 1988-01-26 1989-01-25 Process for preparing ergoline derivatives

Country Status (17)

Country Link
JP (1) JPH01224374A (en)
KR (1) KR890011882A (en)
AU (1) AU2872489A (en)
DK (1) DK32389A (en)
ES (1) ES2011986A6 (en)
FI (1) FI890337A (en)
FR (1) FR2626177B1 (en)
GB (1) GB2214183A (en)
GR (1) GR890100048A (en)
HU (1) HUT51275A (en)
IL (1) IL89063A0 (en)
IT (1) IT1229537B (en)
LU (1) LU87439A1 (en)
NL (1) NL8900185A (en)
PT (1) PT89518B (en)
SE (1) SE8900256L (en)
ZA (1) ZA89640B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4033496A1 (en) * 1990-10-20 1992-04-23 Sandoz Ag NEW ERGOL DERIVATIVES, THEIR PRODUCTION AND USE
TW224091B (en) * 1992-04-03 1994-05-21 Lilly Co Eli

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CLAIMS SEARCHED: ALL *
No relevant documents have been disclosed. *

Also Published As

Publication number Publication date
PT89518B (en) 1994-02-28
JPH01224374A (en) 1989-09-07
DK32389D0 (en) 1989-01-25
FR2626177B1 (en) 1992-07-31
FI890337A0 (en) 1989-01-24
IT1229537B (en) 1991-09-04
AU2872489A (en) 1989-07-27
IT8947562A0 (en) 1989-01-24
LU87439A1 (en) 1989-08-30
FR2626177A1 (en) 1989-07-28
SE8900256L (en) 1989-07-27
IL89063A0 (en) 1989-08-15
ES2011986A6 (en) 1990-02-16
DK32389A (en) 1989-07-27
KR890011882A (en) 1989-08-23
FI890337A (en) 1989-07-27
PT89518A (en) 1989-10-04
HUT51275A (en) 1990-04-28
GB8901440D0 (en) 1989-03-15
NL8900185A (en) 1989-08-16
GB2214183A (en) 1989-08-31
SE8900256D0 (en) 1989-01-25
ZA89640B (en) 1990-09-26

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