GR3025246T3 - METHOD FOR PREPARING A PROTEIN SELECTED FROM THE CYTOKINE GROUP, COMPRISING AT LEAST ONE INTRAMOLECULAR DISULPHIDE BOND BY OXIDATION, AT A pH OF LESS THAN 5.0, OF THE REDUCED RECOMBINANT PROTEIN - Google Patents

METHOD FOR PREPARING A PROTEIN SELECTED FROM THE CYTOKINE GROUP, COMPRISING AT LEAST ONE INTRAMOLECULAR DISULPHIDE BOND BY OXIDATION, AT A pH OF LESS THAN 5.0, OF THE REDUCED RECOMBINANT PROTEIN

Info

Publication number
GR3025246T3
GR3025246T3 GR970402882T GR970402882T GR3025246T3 GR 3025246 T3 GR3025246 T3 GR 3025246T3 GR 970402882 T GR970402882 T GR 970402882T GR 970402882 T GR970402882 T GR 970402882T GR 3025246 T3 GR3025246 T3 GR 3025246T3
Authority
GR
Greece
Prior art keywords
protein
oxidation
less
preparing
pct
Prior art date
Application number
GR970402882T
Other languages
English (en)
Inventor
Pierre-Yves Abecassis
Jacques Leclaire
Philippe Riberon
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of GR3025246T3 publication Critical patent/GR3025246T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GR970402882T 1990-11-23 1997-11-05 METHOD FOR PREPARING A PROTEIN SELECTED FROM THE CYTOKINE GROUP, COMPRISING AT LEAST ONE INTRAMOLECULAR DISULPHIDE BOND BY OXIDATION, AT A pH OF LESS THAN 5.0, OF THE REDUCED RECOMBINANT PROTEIN GR3025246T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/FR1990/000843 WO1992009623A1 (fr) 1990-11-23 1990-11-23 PROCEDE DE PREPARATION D'UNE PROTEINE COMPORTANT AU MOINS UN PONT DISULFURE INTRAMOLECULAIRE PAR OXYDATION, A UN pH INFERIEUR A 5,0, DE LA PROTEINE RECOMBINANTE REDUITE CORRESPONDANTE

Publications (1)

Publication Number Publication Date
GR3025246T3 true GR3025246T3 (en) 1998-02-27

Family

ID=9393086

Family Applications (1)

Application Number Title Priority Date Filing Date
GR970402882T GR3025246T3 (en) 1990-11-23 1997-11-05 METHOD FOR PREPARING A PROTEIN SELECTED FROM THE CYTOKINE GROUP, COMPRISING AT LEAST ONE INTRAMOLECULAR DISULPHIDE BOND BY OXIDATION, AT A pH OF LESS THAN 5.0, OF THE REDUCED RECOMBINANT PROTEIN

Country Status (10)

Country Link
US (1) US5252708A (el)
EP (1) EP0511964B1 (el)
JP (1) JP3021040B2 (el)
AT (1) ATE159260T1 (el)
CA (1) CA2073564A1 (el)
DE (1) DE69031596T2 (el)
DK (1) DK0511964T3 (el)
ES (1) ES2107449T3 (el)
GR (1) GR3025246T3 (el)
WO (1) WO1992009623A1 (el)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2358609A1 (en) * 1999-01-07 2000-07-13 Takeda Chemical Industries, Ltd. Process for producing activated protein
JP3734634B2 (ja) * 1999-03-03 2006-01-11 ヒゲタ醤油株式会社 タンパク質の活性化方法及び該装置
CN1845914A (zh) * 2003-09-02 2006-10-11 默克公司 用于治疗眼压过高的眼用组合物
KR20190140090A (ko) 2007-07-09 2019-12-18 제넨테크, 인크. 폴리펩티드의 재조합 생산 동안의 디술피드 결합 환원의 방지

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450103A (en) * 1982-03-01 1984-05-22 Cetus Corporation Process for recovering human IFN-β from a transformed microorganism
US4530787A (en) * 1984-03-28 1985-07-23 Cetus Corporation Controlled oxidation of microbially produced cysteine-containing proteins
US4569790A (en) * 1984-03-28 1986-02-11 Cetus Corporation Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions
DE3583880D1 (de) * 1984-04-09 1991-10-02 Takeda Chemical Industries Ltd Stabile interleukin-2-zusammensetzung.
US4572798A (en) * 1984-12-06 1986-02-25 Cetus Corporation Method for promoting disulfide bond formation in recombinant proteins
US4752585A (en) * 1985-12-17 1988-06-21 Cetus Corporation Oxidation-resistant muteins
FR2635527B1 (fr) * 1988-07-28 1992-06-12 Roussel Uclaf Il2 humaine recombinante non glycosylee sous forme reduite, son procede d'obtention et son application comme medicament
CA1340586C (en) * 1988-09-23 1999-06-08 Cetus Corporation Process for recovering microbially produced interferon-beta

Also Published As

Publication number Publication date
DE69031596T2 (de) 1998-02-26
JP3021040B2 (ja) 2000-03-15
ES2107449T3 (es) 1997-12-01
US5252708A (en) 1993-10-12
DE69031596D1 (de) 1997-11-20
CA2073564A1 (fr) 1992-05-24
WO1992009623A1 (fr) 1992-06-11
DK0511964T3 (da) 1998-06-02
ATE159260T1 (de) 1997-11-15
EP0511964B1 (fr) 1997-10-15
JPH05503004A (ja) 1993-05-27
EP0511964A1 (fr) 1992-11-11

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GR3025246T3 (en) METHOD FOR PREPARING A PROTEIN SELECTED FROM THE CYTOKINE GROUP, COMPRISING AT LEAST ONE INTRAMOLECULAR DISULPHIDE BOND BY OXIDATION, AT A pH OF LESS THAN 5.0, OF THE REDUCED RECOMBINANT PROTEIN
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