GR3021828T3 - Use of rifamycin derivatives for the manufacture of a medicament for the treatment of toxoplasmosis. - Google Patents
Use of rifamycin derivatives for the manufacture of a medicament for the treatment of toxoplasmosis.Info
- Publication number
- GR3021828T3 GR3021828T3 GR960403219T GR960403219T GR3021828T3 GR 3021828 T3 GR3021828 T3 GR 3021828T3 GR 960403219 T GR960403219 T GR 960403219T GR 960403219 T GR960403219 T GR 960403219T GR 3021828 T3 GR3021828 T3 GR 3021828T3
- Authority
- GR
- Greece
- Prior art keywords
- ring
- toxoplasmosis
- treatment
- infection
- spiropiperidyl
- Prior art date
Links
- 201000005485 Toxoplasmosis Diseases 0.000 title abstract 2
- HJYYPODYNSCCOU-ODRIEIDWSA-N rifamycin SV Chemical class OC1=C(C(O)=C2C)C3=C(O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O HJYYPODYNSCCOU-ODRIEIDWSA-N 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 125000002883 imidazolyl group Chemical group 0.000 abstract 2
- BTVYFIMKUHNOBZ-ODRIEIDWSA-N Rifamycin S Chemical class O=C1C(C(O)=C2C)=C3C(=O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O BTVYFIMKUHNOBZ-ODRIEIDWSA-N 0.000 abstract 1
- 241000223997 Toxoplasma gondii Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5728893A | 1993-05-05 | 1993-05-05 | |
| US08/203,539 US5529994A (en) | 1993-05-05 | 1994-02-28 | Treatment for toxoplasmosis |
| PCT/US1994/004765 WO1994025038A1 (en) | 1993-05-05 | 1994-04-29 | Use of rifamycin derivatives for the manufacture of a medicament for the treatment of toxoplasmosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3021828T3 true GR3021828T3 (en) | 1997-02-28 |
Family
ID=26736295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR960403219T GR3021828T3 (en) | 1993-05-05 | 1996-11-28 | Use of rifamycin derivatives for the manufacture of a medicament for the treatment of toxoplasmosis. |
Country Status (14)
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9224739D0 (en) * | 1992-11-26 | 1993-01-13 | Wellcome Found | Medicaments |
| GB9424013D0 (en) * | 1994-11-29 | 1995-01-18 | Wellcome Found | Medicaments |
| US6579854B1 (en) | 1996-08-14 | 2003-06-17 | Vanderbilt University | Diagnosis and management of infection caused by chlamydia |
| US6710033B1 (en) | 1996-08-14 | 2004-03-23 | Vanderbilt University | Methods and treatment of multiple sclerosis |
| US6258532B1 (en) | 1997-08-14 | 2001-07-10 | Vanderbilt University | Methods for in vitro susceptibility testing of chlamydia |
| US6890526B2 (en) * | 1997-05-06 | 2005-05-10 | Vanderbilt University | Methods and reagents for the treatment of multiple sclerosis |
| WO2000057187A2 (en) * | 1999-03-19 | 2000-09-28 | Vanderbilt University | Diagnosis and treatment of multiple sclerosis |
| US7074832B2 (en) | 2001-09-24 | 2006-07-11 | Bradley Pharmaceuticals, Inc. | Compositions containing antimicrobials and urea for the treatment of dermatological disorders and methods for their use |
| US6429231B1 (en) * | 2001-09-24 | 2002-08-06 | Bradley Pharmaceuticals, Inc. | Compositions containing antimicrobials and urea for the treatment of dermatological disorders and methods for their use |
| JP2003327536A (ja) * | 2002-03-07 | 2003-11-19 | Kitasato Inst:The | ヒト免疫不全症候群ウイルスの感染、増殖抑制剤 |
| US6858083B2 (en) * | 2002-06-05 | 2005-02-22 | Scimed Lifesystems, Inc. | Apparatus and method for closed-loop control of RF generator for welding polymeric catheter components |
| US20030017985A1 (en) * | 2002-07-02 | 2003-01-23 | Taylor Gregory Alan | Molecules that influence pathogen resistance |
| RU2255730C1 (ru) * | 2003-10-14 | 2005-07-10 | Федеральное государственное унитарное предприятие "Всероссийкий научный центр по безопасности биологически активных веществ" (ФГУП "ВНЦ БАВ") | Стабильная фармацевтическая суспензия азитромицина и способ ее получения |
| DE102004055316A1 (de) * | 2004-11-16 | 2006-05-18 | Bayer Healthcare Ag | Verhinderung vertikaler Endoparasiten-Infektionen |
| TW201233389A (en) | 2005-10-05 | 2012-08-16 | Otsuka Pharma Co Ltd | Antituberculous therapeutic drugs and kit containing the same |
| US7799885B2 (en) | 2005-11-30 | 2010-09-21 | Corning Incorporated | Photo or electron beam curable compositions |
| US20090054380A1 (en) * | 2005-12-20 | 2009-02-26 | Greenstein Robert J | Methods for diagnosing and treating a mycobacterium avium subspecies paratuberculosis infection |
| SG10201405158QA (en) * | 2006-02-24 | 2014-10-30 | Callida Genomics Inc | High throughput genome sequencing on dna arrays |
| RU2320337C1 (ru) * | 2006-06-09 | 2008-03-27 | Федеральное государственное унитарное предприятие "Государственный научный центр по антибиотикам" | Способ получения антимикробной композиции с рифабутином |
| FR2944014A1 (fr) | 2009-04-06 | 2010-10-08 | Univ Grenoble 1 | Peptides cycliques a activite antiparasitaire |
| CN114601840A (zh) * | 2020-12-08 | 2022-06-10 | 复旦大学附属中山医院 | 一种联合用药,用于治疗卡氏肺孢子虫肺炎 |
| CN113230248A (zh) * | 2021-06-18 | 2021-08-10 | 宁波大学 | 利卡灵-b及其组合物在制备治疗或预防弓形虫病药物中的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3644616A (en) * | 1969-03-24 | 1972-02-22 | Ciba Geigy Corp | Synergistic composition of rifampicin and streptomycin |
| US4054663A (en) * | 1974-12-23 | 1977-10-18 | Sankyo Company Limited | Pyridine derivatives and their use as anticoccidial agents |
| US4094982A (en) * | 1975-05-15 | 1978-06-13 | Sankyo Company Limited | Pyridine sulfonamides and their use as anticoccidial agents |
| IT1056272B (it) * | 1975-06-13 | 1982-01-30 | Archifar Ind Chim Trentino | Prodotti derivati dalle amine aromatiche |
| IT1135270B (it) * | 1980-04-12 | 1986-08-20 | Erba Farmitalia | 3-amidino-ansamicine |
| US5175319A (en) * | 1983-04-14 | 1992-12-29 | Burroughs Wellcome Co. | Naphthoquinone derivatives |
| US5053432A (en) * | 1983-04-14 | 1991-10-01 | Burroughs Wellcome Co. | Naphthoquinone derivatives |
| DE3512194A1 (de) * | 1985-04-03 | 1986-10-09 | Hoechst Ag, 6230 Frankfurt | Ein neues ansamycin-antibiotikum, ein mikrobielles verfahren zu seiner herstellung und seine verwendung als arzneimittel |
| WO1989002271A1 (en) * | 1987-09-10 | 1989-03-23 | Pfizer | Azithromycin and derivatives as antiprotozoal agents |
| GB9000241D0 (en) * | 1990-01-05 | 1990-03-07 | Coopers Animal Health | Pharmaceutical use |
| US5529994A (en) * | 1993-05-05 | 1996-06-25 | Palo Alto Medical Foundation | Treatment for toxoplasmosis |
-
1994
- 1994-04-29 AU AU69050/94A patent/AU669300B2/en not_active Ceased
- 1994-04-29 RU RU95105973A patent/RU2121838C1/ru active
- 1994-04-29 AT AT94917283T patent/ATE143601T1/de not_active IP Right Cessation
- 1994-04-29 DE DE69400631T patent/DE69400631T2/de not_active Expired - Fee Related
- 1994-04-29 ES ES94917283T patent/ES2095772T3/es not_active Expired - Lifetime
- 1994-04-29 CA CA002138643A patent/CA2138643A1/en not_active Abandoned
- 1994-04-29 WO PCT/US1994/004765 patent/WO1994025038A1/en active IP Right Grant
- 1994-04-29 EP EP94917283A patent/EP0648121B1/en not_active Expired - Lifetime
- 1994-04-29 JP JP6524580A patent/JPH07509003A/ja active Pending
- 1994-04-29 DK DK94917283.7T patent/DK0648121T3/da active
- 1994-05-04 IL IL109543A patent/IL109543A/en not_active IP Right Cessation
-
1995
- 1995-01-04 NO NO950030A patent/NO950030D0/no unknown
- 1995-06-07 US US08/476,508 patent/US5670496A/en not_active Expired - Fee Related
- 1995-06-07 US US08/487,721 patent/US5665707A/en not_active Expired - Fee Related
- 1995-06-07 US US08/481,741 patent/US5650405A/en not_active Expired - Fee Related
- 1995-06-07 US US08/474,998 patent/US5648345A/en not_active Expired - Fee Related
- 1995-06-07 US US08/481,689 patent/US5641769A/en not_active Expired - Fee Related
-
1996
- 1996-11-28 GR GR960403219T patent/GR3021828T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2138643A1 (en) | 1994-11-10 |
| AU669300B2 (en) | 1996-05-30 |
| RU2121838C1 (ru) | 1998-11-20 |
| ATE143601T1 (de) | 1996-10-15 |
| US5648345A (en) | 1997-07-15 |
| US5670496A (en) | 1997-09-23 |
| WO1994025038A1 (en) | 1994-11-10 |
| US5665707A (en) | 1997-09-09 |
| NO950030L (no) | 1995-01-04 |
| US5641769A (en) | 1997-06-24 |
| ES2095772T3 (es) | 1997-02-16 |
| IL109543A (en) | 1998-06-15 |
| DE69400631T2 (de) | 1997-02-27 |
| EP0648121A1 (en) | 1995-04-19 |
| IL109543A0 (en) | 1994-08-26 |
| DK0648121T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1997-02-24 |
| EP0648121B1 (en) | 1996-10-02 |
| DE69400631D1 (de) | 1996-11-07 |
| RU95105973A (ru) | 1997-01-20 |
| AU6905094A (en) | 1994-11-21 |
| JPH07509003A (ja) | 1995-10-05 |
| NO950030D0 (no) | 1995-01-04 |
| US5650405A (en) | 1997-07-22 |
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