GR29331B - METHOD OF PREPARATION OF QUARTERLY AMMONIA COMPOUNDS. - Google Patents

METHOD OF PREPARATION OF QUARTERLY AMMONIA COMPOUNDS.

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Publication number
GR29331B
GR29331B GR600129331A GR600129331A GR29331B GR 29331 B GR29331 B GR 29331B GR 600129331 A GR600129331 A GR 600129331A GR 600129331 A GR600129331 A GR 600129331A GR 29331 B GR29331 B GR 29331B
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GR
Greece
Prior art keywords
alkyl
nitro
methylmercapto
alkoxy
cyano
Prior art date
Application number
GR600129331A
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Greek (el)
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The Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by The Wellcome Foundation Ltd filed Critical The Wellcome Foundation Ltd
Publication of GR29331B publication Critical patent/GR29331B/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D27/00—Details of garments or of their making
    • A41D27/02—Linings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/20—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Textile Engineering (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

έθοδος προς παρασκευήν τεταρτοταγών-αμμωνιακών ενώσεων χαρακτηριζομένη εκ του ότι παρασκευάζονται ενώσεις περιέχουσαι κατιόν του τύπου: R. W. CH2. CH2. NXY. CH2.L. ένθα το είναι δακτύλιος φαινυλίου υποκατεστημένος εις την θέσιν μετα ή παραδι'ενός ατόμου αλογόνου ή αλκυλο-, αλκοξυ-, αλληλοξυ-, μεθυλομερκαπτο-, υδροξυ-, φορμυλο-, ακετυλο-, αλκοξυκαρβονυλο-, αμινο-, μεθυλαμινο-, ακεταμιδο-, κυανο-, νιτρο-, ή νιτρωδομάδος οπότε το L είναι δακτύλιος φαινυλίου υποκατασταθείς κατ'επιλογήν εις τηνθέσιν ορθο, μετα, παρα δι'ενός ενός ατόμου αλογόνου ή αλκυλο-, αλκοξυ-, μεθυλομερκαπτο-, κυανο-, ή νιτρομάδος, ή οπότε το L είναι θειενυλο-, ή φουρυλομάς υποκατασταθείσα κατ'επιλογήν εις την 5 θέσιν διενός ατόμου αλογόνου ή μιάς νιτρομάδος, ή το R είναι δακτύλιος φαινυλίου υποκατασταθείς κατ'επιλογήν εις την θέσιν ορθο δι'ενός ατόμου αλογόνου ή αλκυλο-, αλκοξυ-, αλλυλοξυ-, μεθυλομερκαπτο-, υδροξυ-, φορμυλο-, ακετυλο-, αλκοξυκαρβονυλο-, αμινο-, μεθυλαμινο-, ακεταμιδο-, κυανο-, νιτρο-, ή νιτρωδομάδος οπότε το L είναι δακτύλιος φαινυλίου υποκατεστημένος εις την θέσιν μετα ή παρα δι' ενός ατόμου αλογόνου ή αλκυλο-, αλκοξυ-, μεθυλομερκαπτο-κυανο-ή νιτρομάδος, το W είναι ευθεία κεκορεσμένη άλυσις η οποία περιέχει 1 έως 3 μη παρακείμενα άτομα οξυγόνου και 0 έως 16 άτομα άνθρακος, τα δε Χ και Υ είναι τα αυτά ή διάφορα και έκαστον εξ αυτών είναιαλκυλο-, αλληλο-, προπαργυλ-ή-υδροξυαλκυλομάς, διάφορος μιάς α-υδροξυαλκυομάδος ή το ΧΥ είναι ομάς τετραμεθυλενίου, πενταμεθυλενίου ή 3-οξαπενταμεθυλενίου και ένθα τα "αλκυο-", "αλκοξυ-", "αλκοξυκαρβονυλο-" και "υδροξυαλκυλο" σημαίνουσιν αντιστοίχωςκεκορεσμένον υδρογονάνθρακα, αιθέρα, εστέρα και αλκυλομάδας περιέχουσας έν έως τέσσερα άτομα, ενώσεις, διαφόρους των ενώσεων αι οποίαι περιέχουσι κατιόν Ν-5-π-χλωροφαινολυ-3-οξαέντυλο-Ν-π-χλωροβενζυλο-Ν, Ν-διμεθυλαμμωνίου, Ν-βενζυλο-Ν-5-π-μεθυλοφαινοξυ-3-οξαπεντυλο-Ν, Ν-διμεθυλαμμωνίου, Ν-βενζυλο-Ν, Ν-διαθυλο-Ν-2-μεθοξυφαινοξυαιθυλαμμωνίου ή Ν βενζυλο-Ν, Ν διαιθυλο-Ν-2-μ-βοετυξυαιθυλαμμωνίουprocess for the preparation of quaternary ammonia compounds, characterized in that compounds containing a cation of the formula are prepared: R. W. CH2. CH2. NXY. CH2.L. wherein it is a phenyl ring substituted at the post or delivery position of a halogen or alkyl-, alkoxy-, allyloxy-, methylmercapto-, hydroxy-, formyl-, acetyl-, alkoxycarbonyl-, amino-, amino cyano-, nitro-, or nitro group where L is a phenyl ring optionally substituted ortho, then by a halogen or alkyl-, alkoxy-, methylmercapto-, cyano-, or nitro L is thienyl-, or furyloma optionally substituted at the 5-position of a halogen atom or a nitro group, or R is a phenyl ring optionally substituted at the ortho position by a halo-, alkyl, or alkyl, alkyl or alkyl atom. , methylmercapto-, hydroxy-, formyl-, acetyl-, alkoxycarbonyl-, amino-, methylamino-, acetamido-, cyano-, nitro-, or nitro group where L is a phenyl ring substituted by a substituted substituent on halogen or alkyl-, alkoxy-, methylmercapto-cyano- or nitro group, W is a straight saturated chain containing 1 to 3 non-adjacent oxygen atoms and 0 to 16 carbon atoms, and X and Y are the same or different and each of which is alkyl-, allel-, propargyl-or-hydroxyalkyl, other than a -hydroxyalkylo group or XY is a group of tetramethylene, pentamethylene or 3-oxapentamethylene and includes "alkyo-", "alkoxy-", "alkoxycarbonyl-" and "hydroxyalkyl" atoms, respectively, compounds, other than those containing the N-5-p-chlorophenol-3-oxaethyl-N-p-chlorobenzyl-N, N-dimethylammonium, N-benzyl-N-5-n-methylphenoxy-3-oxapentyl cation cation , N-dimethylammonium, N-benzyl-N, N-diethyl-N-2-methoxyphenoxyethylammonium or N-benzyl-N, N diethyl-N-2-m-boethoxyethylammonium

GR600129331A 1959-03-13 1960-03-08 METHOD OF PREPARATION OF QUARTERLY AMMONIA COMPOUNDS. GR29331B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8878/59A GB924961A (en) 1959-03-13 1959-03-13 Quaternary ammonium compounds, the preparation thereof and pharmaceutical compositions thereof
GB887959 1959-03-13
GB3955859 1959-11-20
GB3955959 1959-11-20

Publications (1)

Publication Number Publication Date
GR29331B true GR29331B (en) 1965-12-29

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Application Number Title Priority Date Filing Date
GR600129331A GR29331B (en) 1959-03-13 1960-03-08 METHOD OF PREPARATION OF QUARTERLY AMMONIA COMPOUNDS.

Country Status (10)

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BE (1) BE588558A (en)
CH (2) CH422758A (en)
DE (1) DE1238485C2 (en)
DK (1) DK104353C (en)
ES (1) ES256264A1 (en)
FR (2) FR1421206A (en)
GB (1) GB924961A (en)
GR (1) GR29331B (en)
LU (1) LU38374A1 (en)
NL (2) NL129619C (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES410734A1 (en) * 1973-01-18 1976-01-01 Rocador Sa Butacaine pamoate
US3956369A (en) * 1973-05-18 1976-05-11 Ozeretskovskaya Natalia Nikola N-β-(2-acetyl-4-chlorophenoxy)-ethyl-N,N-dimethyl-N-benzyl-ammonium-p-chlorobenzene sulphonate, method for preparing same and medicinal preparation based thereon
FR2387213A2 (en) * 1977-04-12 1978-11-10 Nattermann A & Cie Smooth-muscle relaxant quat. ammonium salts - derived from aminoalkoxy-di:phenyl-propiolophenone derivs.
DE2913523A1 (en) 1979-04-04 1980-10-23 Basf Ag SUBSTITUTED ALKYLAMONIUM SALTS, THEIR PRODUCTION AND USE FOR REGULATING PLANT GROWTH
DE3233828A1 (en) * 1982-09-11 1984-03-15 Basf Ag, 6700 Ludwigshafen ARYLOXYALKYLAMINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE FOR CONTROLLING UNWANTED PLANT GROWTH
GB9321812D0 (en) * 1993-10-22 1993-12-15 Smithkline Beecham Plc Pharmaceuticals
GB9321811D0 (en) * 1993-10-22 1993-12-15 Smithkline Beecham Plc Pharmaceuticals
EP0982300A3 (en) * 1998-07-29 2000-03-08 Societe Civile Bioprojet Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications
EP0978512A1 (en) * 1998-07-29 2000-02-09 Societe Civile Bioprojet Non-imidazole aryloxy (or arylthio) alkylamines as histamine H3-receptor antagonists and their therapeutic applications
DE10235312A1 (en) 2002-08-01 2004-02-12 Basf Ag Process for the preparation of aminoalkoxybenzylamines and aminoalkoxybenzonitriles as intermediates
EP2619171A2 (en) * 2010-09-21 2013-07-31 GE Healthcare UK Limited Novel precursor
EP4118070A4 (en) * 2020-03-11 2024-04-10 Nocion Therapeutics, Inc. CHARGED ION CHANNEL BLOCKERS AND METHODS OF USE
US12162851B2 (en) 2020-03-11 2024-12-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use

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Publication number Priority date Publication date Assignee Title
DE1117600B (en) 1956-03-29 1961-11-23 Wellcome Found Process for the preparation of quaternary ammonium salts effective against nematodes

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NL129619C (en) 1970-08-18
DE1238485C2 (en) 1967-10-26
ES256264A1 (en) 1960-08-16
FR1421206A (en) 1965-12-17
CH422758A (en) 1966-10-31
BE588558A (en) 1960-09-12
LU38374A1 (en) 1960-09-12
DK104353C (en) 1966-05-09
CH436259A (en) 1967-05-31
DE1238485B (en) 1967-04-13
NL6909922A (en) 1969-10-27
GB924961A (en) 1963-05-01
FR558M (en) 1961-05-29

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