GR22816B - METHOD OF PREPARATION OF NEW ANTIPERTENSION COMPOSITIONS. - Google Patents

METHOD OF PREPARATION OF NEW ANTIPERTENSION COMPOSITIONS.

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Publication number
GR22816B
GR22816B GR610122816A GR610122816A GR22816B GR 22816 B GR22816 B GR 22816B GR 610122816 A GR610122816 A GR 610122816A GR 610122816 A GR610122816 A GR 610122816A GR 22816 B GR22816 B GR 22816B
Authority
GR
Greece
Prior art keywords
collectively
active ingredients
antipertension
compositions
preparation
Prior art date
Application number
GR610122816A
Other languages
Greek (el)
Original Assignee
Merck & Co, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co, Inc. filed Critical Merck & Co, Inc.
Priority to GR610122816A priority Critical patent/GR22816B/en
Publication of GR22816B publication Critical patent/GR22816B/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

έθοδος παρασκευής αντι-υπερτασικής συνθέσεως ήτιςπεριλαμβάνει ανάμιξιν μεθ' ενός φαρμακευτικού εκδόχου ενεργών συστατικών εχόντων συλλογικώς αμφότερα τα επόμενα χαρακτηριστικά : (1) την ιδιότητα εξαντλήσεως in vivo της ποσότητος νοραδρεναλίνης εν τοίς καρδιακοίς ιστοίς, (2) την ιδιότητα αναστολής in vivo της ενζυματικη ενεργείας της των θηλαστικών αποκαρβοξυλάσης επί της διυδροξυφαινυλαλανίνης και 4-υδροξυθρυπτοφάνης, εκάστης των ειρημένων ιδιοτήτων αποτελούσης χαρακτηριστικόν γνώρισμα το ελάχιστον μιάς ενώσεως περιλαμβανομένης είς τα ειρημένα ενεργά συστατικά, των ειρημένων ενεργών συστατικών υπαρχόντων είς ποσότητα το ελάχιστιον 50% της αποτελεσματικής πρός αναστολήν της αποκαρβοξυλάσης δόσεως της ευρεθείσης διά τα ειρημένα ενεργά συστατικά συλλογικώς κατά την μνησθείσαν δοκιμασίαν, των εν λόγω ενεργών συστατικών εχόντων συλλογικώς μίαν κατά 50% αποτελεσματικήν πρός εξάντλησιν κατεχολαμινών δόσιν το ελάχιστιον δέκα φοράς την τοιαύτην πρός αναστολήν της αποκαρβοξυλάσης. A method of preparing an antihypertensive composition comprising mixing with a pharmaceutical excipient active ingredients having collectively both of the following characteristics: (1) of decarboxylase mammals on dihydroxyphenylalanine and 4-hydroxytryptophan, each of the said properties being a feature of at least one compound Said active ingredients collectively in the assayed test, said active ingredients having collectively a 50% effective catecholamine depletion dose at least ten times the same to inhibit decarboxylase.

GR610122816A 1961-06-08 1961-06-08 METHOD OF PREPARATION OF NEW ANTIPERTENSION COMPOSITIONS. GR22816B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GR610122816A GR22816B (en) 1961-06-08 1961-06-08 METHOD OF PREPARATION OF NEW ANTIPERTENSION COMPOSITIONS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR610122816A GR22816B (en) 1961-06-08 1961-06-08 METHOD OF PREPARATION OF NEW ANTIPERTENSION COMPOSITIONS.

Publications (1)

Publication Number Publication Date
GR22816B true GR22816B (en) 1962-02-03

Family

ID=36863645

Family Applications (1)

Application Number Title Priority Date Filing Date
GR610122816A GR22816B (en) 1961-06-08 1961-06-08 METHOD OF PREPARATION OF NEW ANTIPERTENSION COMPOSITIONS.

Country Status (1)

Country Link
GR (1) GR22816B (en)

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