GR20278B - HEAT EXCHANGE. - Google Patents
HEAT EXCHANGE.Info
- Publication number
- GR20278B GR20278B GR590120278A GR590120278A GR20278B GR 20278 B GR20278 B GR 20278B GR 590120278 A GR590120278 A GR 590120278A GR 590120278 A GR590120278 A GR 590120278A GR 20278 B GR20278 B GR 20278B
- Authority
- GR
- Greece
- Prior art keywords
- alkyl group
- attached
- alkyl
- compound
- group attached
- Prior art date
Links
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- Steroid Compounds (AREA)
Abstract
μέθοδος ήτις περιλαμβάνει την υποβολήν μιας αλκυλοοξαλικής ενώσεως εις αντίδρασιν μετά της 3α-ακυλοξυ-11,20-πρεγκνανοδιόνης εχούσης προσηρτημένην εις την 16-θέσιν τουλάχιστον μίαν αλκυλικήν ομάδα προς σχηματισμόν ενός αλκυλεστέρος της 3α-ακυλοξυ-11,20-δίοξο-21-πρεγκνανογλοοξυλικής ενώσεως, όστις έχει προσηρτημένην εις την 16-θέσιν τουλάχιστον μίαν αλκυλικήν ομάδα, την υδρόλυσιν της τελευταίας ταύτης ενώσεως προς σχηματισμόν του 3α-υδροξυ-11,20-διόξο-21-πρεγκνανογλυοξυλικού οξέος έχοντος προσηρτημένην εις την 16-θέσιν τουλάχιστον μίαν αλκυλικήν ομάδα, την υποβολήν της τελευταίας ταύτης ενώσεως εις αντίδρασιν μετ' αλκυλικού ανυδρίτου παρουσίαενός καταλύτου εξ ισχυρού οξέος προς σχηματισμόν ενός ισομερούς μίγματος της 3α,23-διακυλοξυ-21-νορμοθυλο-11-οξο-17(20), 22-χολαδιενο-24(20)-λακτόνηςεχούσης προσηρτημένην εις την 16-θέσιν τουλάχιστον μίαν αλκυλικήν ομάδα, την υποβολήν του τελευταίου τούτου μίγματος εις αντίδρασιν με εν υπεροξύ προς σχηματισμόν ενός ισομερούς μίγματος της 3α,23-διακυλοξυ-17(20)-εποξειδο-21-νορμεθυλο-11-οξο-22-χολενο-24(20)-λακτόνης εχούσης προσηρτημένην εις την 16-θέσιν τουλάχιστον μίαν αλκυλικην ομάδα, και τηνυδρόλυσιν του τελευταίου τούτου μίγματος προς σχηματισμόν της 3α,17α-διϋδροξυ-11,20-πρεγκνανοδιόνηςεχούσης προσηρτημένην εις την 16-θέσιν τουλάχιστον μίαν αλκυλικήν ομάδα. Method comprising subjecting an alkyl oxalate compound to a reaction after 3α-acyloxy-11,20-pregnanodione having at the 16-position attached to at least one alkyl group to form an alkyl ester of 3α-acyloxy-11-20-yloxy-21- of the compound having at least one alkyl group attached to the 16-position, the hydrolysis of the latter compound to form 3α-hydroxy-11,20-dioxo-21-pregnanoglyoxylic acid having at least one alkyl group attached to the 16-position, Substitution of the latter compound with alkyl anhydride in the presence of a strong acid catalyst to form an isomeric mixture of 3α, 23-diacyloxy-21-normothyl-11-oxo-17 (20), 22-choladieno-24 (20) -lactone having at least one alkyl group attached to the 16-position, reacting the latter mixture with a peracid to form an isomeric mixture of 3α, 23-cycl oxy-17 (20) -epoxide-21-normethyl-11-oxo-22-choleno-24 (20) -lactone having at the 16-position attached to at least one alkyl group, and the hydrolysis of the latter mixture to form 3a, 17α-dihydroxy-11,20-pregnanodione having at least one alkyl group attached to the 16-position.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR590120278A GR20278B (en) | 1959-04-08 | 1959-04-08 | HEAT EXCHANGE. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR590120278A GR20278B (en) | 1959-04-08 | 1959-04-08 | HEAT EXCHANGE. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR20278B true GR20278B (en) | 1959-11-18 |
Family
ID=36861369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR590120278A GR20278B (en) | 1959-04-08 | 1959-04-08 | HEAT EXCHANGE. |
Country Status (1)
| Country | Link |
|---|---|
| GR (1) | GR20278B (en) |
-
1959
- 1959-04-08 GR GR590120278A patent/GR20278B/en unknown
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