GR20160100582A - Formulation of tblets acting against blood sugar value increase - Google Patents
Formulation of tblets acting against blood sugar value increaseInfo
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- GR20160100582A GR20160100582A GR20160100582A GR20160100582A GR20160100582A GR 20160100582 A GR20160100582 A GR 20160100582A GR 20160100582 A GR20160100582 A GR 20160100582A GR 20160100582 A GR20160100582 A GR 20160100582A GR 20160100582 A GR20160100582 A GR 20160100582A
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- diabetic
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- tblets
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- 210000004369 blood Anatomy 0.000 title claims description 9
- 239000000203 mixture Substances 0.000 title claims description 7
- 238000009472 formulation Methods 0.000 title description 2
- 240000003537 Ficus benghalensis Species 0.000 claims description 10
- 235000012097 Eugenia cumini Nutrition 0.000 claims description 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 7
- 239000008103 glucose Substances 0.000 claims description 7
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- 241001465754 Metazoa Species 0.000 description 1
- 244000302512 Momordica charantia Species 0.000 description 1
- 235000009811 Momordica charantia Nutrition 0.000 description 1
- 102000012435 Phosphofructokinase-1 Human genes 0.000 description 1
- 108010022684 Phosphofructokinase-1 Proteins 0.000 description 1
- 244000178134 Salvia coccinea Species 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
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- 208000001848 dysentery Diseases 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229960004580 glibenclamide Drugs 0.000 description 1
- 230000001890 gluconeogenic effect Effects 0.000 description 1
- ZNNLBTZKUZBEKO-UHFFFAOYSA-N glyburide Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZNNLBTZKUZBEKO-UHFFFAOYSA-N 0.000 description 1
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- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
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- 239000000047 product Substances 0.000 description 1
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 1
- 229960001052 streptozocin Drugs 0.000 description 1
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- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000001313 trigonella foenum graecum l. seed extract Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Σύνθεσης προϊόντος για την αντιμετώπιση των αυξημένων τιμών σακχάρου σε διαβητικούς με αντιδιαβητική χορήγηση σε μορφή χαπιών Product composition for the treatment of increased sugar values in diabetics with antidiabetic administration in the form of pills
Ο σακχαρώδης διαβήτης είναι μία από τις πιο συνήθεις διαταραχές στις αναπτυγμένες και στις υπό ανάπτυξη χώρες, με ραγδαία αύξηση στο μεγαλύτερο μέρος του κόσμου. Υπολογίζεται ότι το ένα τρίτο των ασθενών με σακχαρώδη διαβήτη χρησιμοποιούν κάποια μορφή συμπληρωματικής και εναλλακτικής θεραπείας. Diabetes mellitus is one of the most common disorders in developed and developing countries, with a rapid increase in most of the world. It is estimated that one third of diabetes patients use some form of complementary and alternative therapy.
Τα φυτικά συστατικά μας που έχουν λάβει ιδιαίτερη προσοχή λόγω των αντιδιαβητικών τους ιδιοτήτων είναι: Coccina Indica (C.I), Eugenia Jambolana (E J), Ficus Bengalensis (F. B), Trigonella Foenum-graecum (T. F). Τα ενεργά συστατικά που υπάρχουν στη σύνθεση έχουν αναφερθεί ότι έχουν ευεργετικές ιδιότητες κατά του σακχαρώδη διαβήτη, που είναι μία κοινή πάθηση, που προκαλείται από ανεπάρκεια έκκρισης ή δράσης της παγκρεατικής ορμόνης ινσουλίνης. Στον διαβήτη, το επίπεδο του σακχάρου στο αίμα αυξάνεται, δεδομένου της αδυναμίας της ινσουλίνης να ανταποκριθεί στο έργο της , με αποτέλεσμα την υπεργλυκαιμία, η οποία επιβαρύνεται και από τον μηχανισμό της γλυκογένεσης στο συκώτι και στους νεφρούς, καθώς τίθεται σε λειτουργεία η μόνη πηγή γλυκόζης για την ανθρώπινη επιβίωση σε περιόδους μακράς ασητίας. Τα φυτικά φάρμακα είναι πολύ γνωστά στον κόσμο για την αντιμετώπιση πολλών περίπλοκων ασθενειών παράλληλα με την σύγχρονη ιατρική περίθαλψη. Υπάρχουν πολλοί τύποι χορηγούμενων φαρμάκων δια στόματος, για την μείωση της υπογλυκαιμίας σε διαβητικούς. Ωστόσο δεν είναι επαρκεί. Έτσι είναι απαραίτητο να σχεδιαστεί ένα πρωτοποριακό σκεύασμα με τις αντιδιαβητικές ιδιότητες των Coccina Indica, Eugenia Jambolana, Ficus Bengalensis, Trigonella Foenum-Graecum Our herbal ingredients that have received special attention due to their antidiabetic properties are: Coccina Indica (C.I), Eugenia Jambolana (E J), Ficus Bengalensis (F. B), Trigonella Foenum-graecum (T. F). The active ingredients present in the composition have been reported to have beneficial properties against diabetes mellitus, which is a common condition caused by a deficiency in the secretion or action of the pancreatic hormone insulin. In diabetes, the level of sugar in the blood increases, given the inability of insulin to respond to its work, resulting in hyperglycemia, which is also burdened by the mechanism of glycogenesis in the liver and kidneys, as the only source of glucose is put into operation for human survival in periods of long folly. Herbal medicines are well known in the world for treating many complex diseases alongside modern medical treatment. There are many types of oral medications to reduce hypoglycemia in diabetics. However, it is not enough. Thus it is necessary to design an innovative formulation with the antidiabetic properties of Coccina Indica, Eugenia Jambolana, Ficus Bengalensis, Trigonella Foenum-Graecum
Σ Υ Ν Θ Ε Σ Η: COMPOSITION:
ΣΥΣΤΑΤΙΚΟ ΠΟΣΟΤΗΤΑ INGREDIENT QUANTITY
Coccina indica 133.33 mg Coccina indica 133.33 mg
Eugenia jambolana 100.00 mg Eugenia jambolana 100.00 mg
Ficus bengalensis 166.67 mg Ficus bengalensis 166.67 mg
Trigonella foenum-graecm 166.67 mg Trigonella foenum-graecm 166.67 mg
Επιλέχθηκαν τα φυτικά συστατικά με τις οδηγίες και πάντοτε σύμφωνα με τον μηχανισμό δράσης αυτών. Τα βασικά συστατικά τα οποία επελέγησαν είναι τα κάτωθι: Coccina Indica, Eugenia Jambolana, Ficus Bengalensis, Trigonella Foenum-raecum. Ως προς τις ιδιότητές των ακολουθούνται οι ενδείξεις της διεθνούς βιβλιογραφίας. The herbal ingredients were selected according to the instructions and always according to their mechanism of action. The main ingredients chosen are the following: Coccina Indica, Eugenia Jambolana, Ficus Bengalensis, Trigonella Foenum-raecum. Regarding their properties, the indications of the international literature are followed.
Τ Ε Χ Ν Ι Κ Α Χ Α Ρ Α ΚΤ Η Ρ Ι Σ Τ Ι Κ Α SPECIFICATIONS
ΑΝΤΙΔΙΑΒΗΤΙΚΗ ΕΠΙΔΡΑΣΗ TOY C.I: Τα επίπεδα γλυκόζης στο αίμα ήταν σημαντικά μειωμένα τόσο στων φυσιολογικών όσο και στων διαβητικών αρουραίων μετά την από του στόματος χορήγηση του εκχυλίσματος του C. Indica ANTI-DIABETIC EFFECT OF C.I: Blood glucose levels were significantly reduced in both normal and diabetic rats after oral administration of the extract of C. Indica
Η μείωση στο επίπεδο της γλυκόζης στο αίμα ήταν πολύ πιο σημαντική στα διαβητικούς αρουραίους (28%, p <0,001) σε σύγκριση με τους κανονικούς (23%, p<0,01).( JPMA November 2012. Shibid BA effect of coccinia indica extract on blood glucose, fatty acid and hepaticphosphofructo kinase-1 of both normal and diabetic rats. Bangladesh j med sci. 2005;2;106-11. Hossain NZ, Hypoglycemic effects of coccinia indica: inhibition of key gluconeogenenic enzyme, glucose-6-phosphatasse. India J Exp Biol. 1992; 30:418-20. Shibib BA hypoglyceamic activity of coccinia indica and momordica charantia in diabetic rats. Biochem J 1993; 292:267-7) The reduction in blood glucose level was much more significant in diabetic rats (28%, p <0.001) compared to normal rats (23%, p<0.01).( JPMA November 2012. Shibid BA effect of coccinia indica extract on blood glucose, fatty acid and hepaticphosphofructo kinase-1 of both normal and diabetic rats. Bangladesh j med sci. 2005;2;106-11. Hossain NZ, Hypoglycemic effects of coccinia indica: inhibition of key gluconeogenic enzyme, glucose-6 -phosphatasse. India J Exp Biol. 1992; 30:418-20. Shibib BA hypoglyceamic activity of coccinia indica and momordica charantia in diabetic rats. Biochem J 1993; 292:267-7)
ΑΝΤΙΔΙΑΒΗΤΙΚΗ ΕΠΙΔΡΑΣΗ της Eugenia Jambolana αποδείχθηκε σε μία μελέτη που δημοσιεύτηκε τον Απρίλιο του 2009 στο "Indian journal of physiology and pharmacology". Σε αυτή τη μελέτη σε ζώα, δόσεις των 200mg /κιλό βάρους, μείωσε τα επίπεδα του σακχάρου στο αίμα κατά την 10η μέρα της χορήγησης. Ακόμα προστάτευσε από στομαχικά έλκη που προκαλούνται από υπερχλωριδίαση. ANTI-DIABETIC EFFECT of Eugenia Jambolana was proven in a study published in April 2009 in "Indian journal of physiology and pharmacology". In this animal study, doses of 200mg/kg of body weight reduced blood sugar levels on the 10th day of administration. It also protected against stomach ulcers caused by hyperchlorination.
(An antidiabetic and antiulcer effects of Eugenia jamb. Seed in mild diabetic rats: study on gastric mucosal offensive acid-pepsin.2009 Indian Jphysiol (An antidiabetic and antiulcer effects of Eugenia jamb. Seed in mild diabetic rats: study on gastric mucosal offensive acid-pepsin. 2009 Indian Jphysiol
Pharmac. APRIL-JUN;53(2) : 137-46. Shekelle PG. Are ayuvedic herbs for diabetes effective? J Fam Pract. 2005 oct;54(10):876-86.) Pharmac. APRIL-JUN;53(2) : 137-46. Shekelle PG. Are ayuvedic herbs for diabetes effective? J Fam Pract. 2005 Oct;54(10):876-86.)
ΑΝΤΙΔΙΑΒΗΤΙΚΗ ΕΠΙΔΡΑΣΗ TOY F.B: To Ficus Bengalensis είναι ένα μεγάλο αειθαλές δέντρο που βρίσκεται παντού στην Ινδία. Το φυτό αυτό θεωρείται πολύ αποτελεσματικό σε διάφορες θεραπείες όπως της δυσεντερίας, της διάρροιας και του διαβήτη. To Ficus χρησιμοποιείται ευρέως στους διαβητικούς. Υδατικό εκχύλισμα χορηγήθηκε δια στόματος σε νηστικούς και υπερφορτωμένους με γλυκόζη διαβητικούς ποντικούς, με αποτέλεσμα την σημαντική μείωση του σακχάρου στο αίμα στις πέντε ώρες μετά τη χορήγηση, και αντικατέστησε το επίπεδο των ηλεκτρολυτών, γλυκολυτικών ενζύμων και ηπατικών ενζυμικών συστημάτων που εξαρτώνται από το κυτόχρωμα p-450. Και τέλος μείωσε την δημιουργία ηπατικών και νεφρικών λιπιδικών υπεροξειδίων κατά το τέλος της 12ης εβδομάδας χορήγησης. Το υδατικό εκχύλισμα του ficus bengalensis σε δοσολογία των 500mg/ανά κιλό βάρους/την ημέρα δείχνει σημαντική αντιδιαβητική και βελτιωτική δράση που αποδεικνύεται από ιστολογικές μελέτες σε φυσιολογικούς και στρεπτοζοτοκινικούς (με επαγωγή) ποντικούς.( Baby Joseph.ficus bengalensis linn, volume 6, jan- febr. 2011; Article-005.Geetha BS, Hypoglycemic effects of leukodelphinidin derivative isolate from ficus bengalensis. Indian J Phisiol. Pharm. :38(3): 1994,220. Mahalingam Gayathri. Antidiabetic and ameliorative potential of ficus bengalensis bark extract in streptozotocin induced diabetic rats.Indian J Clin. Biochemistry 23(4)394-400.) ANTI-DIABETIC EFFECT OF F.B: Ficus Bengalensis is a large evergreen tree found everywhere in India. This plant is considered very effective in various treatments such as dysentery, diarrhea and diabetes. Ficus is widely used in diabetics. Aqueous extract was administered orally to fasted and glucose-loaded diabetic mice, resulting in a significant decrease in blood sugar at five hours after administration, and replaced the level of electrolytes, glycolytic enzymes, and cytochrome p-dependent hepatic enzyme systems. 450. And finally it reduced the generation of hepatic and renal lipid peroxides at the end of the 12th week of administration. The aqueous extract of ficus bengalensis at a dosage of 500mg/per kg of weight/day shows significant antidiabetic and ameliorative activity as evidenced by histological studies in normal and streptozotocinic (induced) mice. (Baby Joseph.ficus bengalensis linn, volume 6, jan - febr. 2011; Article-005.Geetha BS, Hypoglycemic effects of leukodelphinidin derivative isolate from ficus bengalensis. Indian J Physiol. Pharm. :38(3): 1994,220. Mahalingam Gayathri. Antidiabetic and ameliorative potential of ficus bengalensis bark extract in streptozotocin induced diabetic rats. Indian J Clin. Biochemistry 23(4)394-400.)
ΑΝΤΙΔΙΑΒΗΤΙΚΗ ΕΠΙΔΡΑΣΗ TOY TF: To φυτό Trigonella foenum Αποτέλεσε το επίκεντρο πολλών μελετών σχετικά με την θεραπεία του διαβήτη. Συμπληρωματική χρήση των σπόρων Foenum Trigonella βελτιώνει τον γλυκαιμικό έλεγχο και μειώνει την αντίσταση στην ινσουλίνη σε ήπιους τύπου 2 διαβητικούς ασθενείς.( Gupta A, Gupta r, Effect of Trogonella foenum-graecum (fenugreek) on glycemic control and insulin resistance in type 2 diabetes mellitus: a double blind placebo controlled study. J. Assoc. Physicians India 2001 Nov; 49:1057-61. There is a study that evaluate the effect of fenugreek seed extract in combination with swimming exercise compare to glibenclamide consumption on type 2 diabetic rats. Arsadi S, Azarbayiani MA. Food nutr.RES 2015 Dec 22; 59:29715) ANTI-DIABETIC EFFECT OF TF: The plant Trigonella foenum has been the focus of many studies on the treatment of diabetes. Supplemental use of Foenum Trigonella seeds improves glycemic control and reduces insulin resistance in mild type 2 diabetic patients. (Gupta A, Gupta r, Effect of Trogonella foenum-graecum (fenugreek) on glycemic control and insulin resistance in type 2 diabetes mellitus : a double blind placebo controlled study. J. Assoc. Physicians India 2001 Nov; 49:1057-61. There is a study that evaluates the effect of fenugreek seed extract in combination with swimming exercise compared to glibenclamide consumption on type 2 diabetic rats. Arsadi S, Azarbayiani MA. Food nutr. RES 2015 Dec 22; 59:29715)
Ε Ν Δ Ε Ι Ξ Ε Ι Σ E N D E I X E I S
Συμπλήρωμα τροφής για την αντιμετώπιση της υπεργλυκαιμίας σε άτομα με σακχαρώδη διαβήτη υπο φαρμακευτική αγωγή από του στόματος χορήγηση. Food supplement for the treatment of hyperglycemia in people with diabetes under oral medication.
Β Ι Β Λ Ι Ο Γ Ρ Α Φ Ι Α: BIBLIOGRAPHY:
l:Brahmachari HD,Augusti ΚΤ, Oraly effective hypoglycemic principles from Coccinia indica.J.Pharm Pharmacol. 1963 ;15:411-412. l:Brahmachari HD, Augusti KT, Orally effective hypoglycemic principles from Coccinia indica. J. Pharm Pharmacol. 1963;15:411-412.
2:Azad Khan AK,Akhtar S. Coccinia indica in the treatment of patients with diabetes mellitus.Bangladesh Med Res Counc Bull 1979;5:60-66 2:Azad Khan AK, Akhtar S. Coccinia indica in the treatment of patients with diabetes mellitus. Bangladesh Med Res Counc Bull 1979;5:60-66
3:Khan AK.Mahtad H. Treatment of diabetes mellitus with coccina indica. Br.Med.J1980;280: 1044. 3: Khan AK. Mahtad H. Treatment of diabetes mellitus with coccina indica. Br.Med.J1980;280:1044.
4:Shibib BA,Uddin MN. Effect of coccinia indica extract on blood glucose, fatty acid and hepatic phosphofructo Kinase-1 of both normal and diabetic rats.Bangladesh J Med Sci 2005;2:106-111 4: Shibib BA, Uddin MN. Effect of coccinia indica extract on blood glucose, fatty acid and hepatic phosphofructo Kinase-1 of both normal and diabetic rats. Bangladesh J Med Sci 2005;2:106-111
5:Chaturvedi A,Bhawani G.Antidiabetic and antiulcer effects of extract of Eugenia jambolana seed in mild diabetic rats:st;udy on gastric mucosal offensive acid-pepsin secretion. indian j physiol. Pharmacol. 2009 apr-jun;53(2): 137-146 5: Chaturvedi A, Bhawani G. Antidiabetic and antiulcer effects of extract of Eugenia jambolana seed in mild diabetic rats: study on gastric mucosal offensive acid-pepsin secretion. indian j physiol. Pharmacol. 2009 apr-jun;53(2): 137-146
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| US20030185913A1 (en) * | 2002-03-26 | 2003-10-02 | Palpu Pushpangadan | Herbal health protective and promotive nutraceutical formulation for diabetics and process for preparing the same |
| WO2006078848A1 (en) * | 2005-01-21 | 2006-07-27 | Western Holdings, Llc | Compositions containing botanical extracts rich in phlorizin and methods for using such compositions in blood glucose modification and to affect aging |
| EP1974737A1 (en) * | 2007-03-23 | 2008-10-01 | Phyto Health Pharma B.V. | Composition for the treatment of diabetes mellitus and metabolic syndrome |
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| US20030185913A1 (en) * | 2002-03-26 | 2003-10-02 | Palpu Pushpangadan | Herbal health protective and promotive nutraceutical formulation for diabetics and process for preparing the same |
| WO2006078848A1 (en) * | 2005-01-21 | 2006-07-27 | Western Holdings, Llc | Compositions containing botanical extracts rich in phlorizin and methods for using such compositions in blood glucose modification and to affect aging |
| EP1974737A1 (en) * | 2007-03-23 | 2008-10-01 | Phyto Health Pharma B.V. | Composition for the treatment of diabetes mellitus and metabolic syndrome |
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