GR20060100539A - ΧΙΜΑΙΡΕΣ GnRH -ΛΕΥΚΟΤΟΞΙΝΩΝ - Google Patents
ΧΙΜΑΙΡΕΣ GnRH -ΛΕΥΚΟΤΟΞΙΝΩΝInfo
- Publication number
- GR20060100539A GR20060100539A GR20060100539A GR20060100539A GR20060100539A GR 20060100539 A GR20060100539 A GR 20060100539A GR 20060100539 A GR20060100539 A GR 20060100539A GR 20060100539 A GR20060100539 A GR 20060100539A GR 20060100539 A GR20060100539 A GR 20060100539A
- Authority
- GR
- Greece
- Prior art keywords
- gnrh
- leukotoxin
- sequences
- same
- multimer
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- Mycology (AREA)
- Reproductive Health (AREA)
- Peptides Or Proteins (AREA)
Abstract
Περιγράφονται νέα συστήματα ανοσολογικών φορέων, το DNA που τα κωδικοποιεί, καθώς και η χρήση των εν λόγω συστημάτων. Τα συστήματα φορέων περιλαμβάνουν χιμαιρικές πρωτεΐνες οι οποίες περιλαμβάνουν ένα πολυπεπτίδιο λευκοτοξίνης που είναι συντηγμένο σε ένα ή περισσότερα επιλεγμένα πολυμερή GnRH multimers τα οποία περιλαμβάνουν τουλάχιστον μία επαναληπτική αλληλουχία δεκαπεπτιδίων GnRH ή τουλάχιστονμια επαναληπτική μονάδα αλληλουχίας που αντιστοιχεί σε τουλάχιστον έναν επίτοπο ενός επιλεγμένου μορίου GnRH. Σύμφωνα με την εφεύρεση, οι επιλεγμένεςαλληλουχίες GnRH μπορούν να είναι όλες πανομοιότυπες ή να αντιστουχούν σε διαφορετικά παράγωγα, ανάλογα, παραλλαγές ή επιτόπους της GnRH εφόσον οι αλληλουχίες GnRH είναι ικανές να προκαλέσουν ανοσοαντίδραση. Η λευκοτοξίνη συμβάλει στην αύξηση της ανοσογονικότητας των συντηγμένων πολυμερών GnRH.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR20060100539A GR20060100539A (el) | 2006-09-29 | 2006-09-29 | ΧΙΜΑΙΡΕΣ GnRH -ΛΕΥΚΟΤΟΞΙΝΩΝ |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR20060100539A GR20060100539A (el) | 2006-09-29 | 2006-09-29 | ΧΙΜΑΙΡΕΣ GnRH -ΛΕΥΚΟΤΟΞΙΝΩΝ |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR20060100539A true GR20060100539A (el) | 2008-04-15 |
Family
ID=39345393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR20060100539A GR20060100539A (el) | 2006-09-29 | 2006-09-29 | ΧΙΜΑΙΡΕΣ GnRH -ΛΕΥΚΟΤΟΞΙΝΩΝ |
Country Status (1)
| Country | Link |
|---|---|
| GR (1) | GR20060100539A (el) |
-
2006
- 2006-09-29 GR GR20060100539A patent/GR20060100539A/el not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ML | Lapse due to non-payment of fees |
Effective date: 20110404 |