GR1010621B - Solid pharmacotechnical forms of ticagrelor - Google Patents

Solid pharmacotechnical forms of ticagrelor Download PDF

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Publication number
GR1010621B
GR1010621B GR20220101055A GR20220101055A GR1010621B GR 1010621 B GR1010621 B GR 1010621B GR 20220101055 A GR20220101055 A GR 20220101055A GR 20220101055 A GR20220101055 A GR 20220101055A GR 1010621 B GR1010621 B GR 1010621B
Authority
GR
Greece
Prior art keywords
incorporate
ticagrelor
drug
varying
active substance
Prior art date
Application number
GR20220101055A
Other languages
Greek (el)
Inventor
Γεωργιος-Μαριος Μπαγουρακης
Δημητριος Πενταφραγκας
Original Assignee
Elpen Ανωνυμος Εταιρεια Φαρμακευτικη Βιομηχανια,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elpen Ανωνυμος Εταιρεια Φαρμακευτικη Βιομηχανια, filed Critical Elpen Ανωνυμος Εταιρεια Φαρμακευτικη Βιομηχανια,
Priority to GR20220101055A priority Critical patent/GR1010621B/en
Publication of GR1010621B publication Critical patent/GR1010621B/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to innovative solid pharmaceutical forms of ticagrelor, which are advantageous over the state of the art in the following points: All doses of the drug are produced following the same linear pharmaceutical composition. They can incorporate active substance characterized by a wide range of particle sizes not varying their pharmaceutical characteristics so that they can present considerable flexibility and optimal cost-effectiveness. In particular, they can incorporate coarse grains active substances not disturbing their in-vivo behavior what implies significant advantages in production processes. They can incorporate different active substance polymorphs not varying the bioavailability of the drug. They are produced through a simple production process where the final form is in the form of tablets, preferably coated tablets. They show optimal stability, satisfactory mechanical strength and flexibility of use.
GR20220101055A 2022-12-19 2022-12-19 Solid pharmacotechnical forms of ticagrelor GR1010621B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GR20220101055A GR1010621B (en) 2022-12-19 2022-12-19 Solid pharmacotechnical forms of ticagrelor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20220101055A GR1010621B (en) 2022-12-19 2022-12-19 Solid pharmacotechnical forms of ticagrelor

Publications (1)

Publication Number Publication Date
GR1010621B true GR1010621B (en) 2024-01-30

Family

ID=89983973

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20220101055A GR1010621B (en) 2022-12-19 2022-12-19 Solid pharmacotechnical forms of ticagrelor

Country Status (1)

Country Link
GR (1) GR1010621B (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140147505A1 (en) * 2009-12-23 2014-05-29 Ratiopharm Gmbh Solid pharmaceutical dosage form of ticagrelor
CN104414989A (en) * 2013-09-10 2015-03-18 四川海思科制药有限公司 Ticagrelor pharmaceutical composition and preparation method thereof
CN105832683A (en) * 2015-01-15 2016-08-10 成都国弘医药有限公司 Tablet containing ticagrelor
EP3266447A1 (en) * 2016-02-12 2018-01-10 Ali Raif Ilac San. A.S. Production process for formulations containing ticagrelor
WO2020021110A1 (en) * 2018-07-27 2020-01-30 Krka, D.D., Novo Mesto Pharmaceutical composition of ticagrelor

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140147505A1 (en) * 2009-12-23 2014-05-29 Ratiopharm Gmbh Solid pharmaceutical dosage form of ticagrelor
CN104414989A (en) * 2013-09-10 2015-03-18 四川海思科制药有限公司 Ticagrelor pharmaceutical composition and preparation method thereof
CN105832683A (en) * 2015-01-15 2016-08-10 成都国弘医药有限公司 Tablet containing ticagrelor
EP3266447A1 (en) * 2016-02-12 2018-01-10 Ali Raif Ilac San. A.S. Production process for formulations containing ticagrelor
WO2020021110A1 (en) * 2018-07-27 2020-01-30 Krka, D.D., Novo Mesto Pharmaceutical composition of ticagrelor

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PG Patent granted

Effective date: 20240209